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HOXC11 positively regulates the long non-coding RNA HOTAIR and is associated with poor prognosis in colon adenocarcinoma

  • Authors:
    • Nana Gong
    • Fei Li
    • Yanan Wang
    • Zizi Li
    • Wanqiu Wang
    • Tingting Gong
    • Xiaojun Meng
    • Hongtao Chen
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong 519000, P.R. China, Department of Pharmacy, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong 519000, P.R. China, Department of Pathology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong 519000, P.R. China, Department of Ultrasound, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong 519000, P.R. China, Department of Endocrinology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong 519000, P.R. China
    Copyright: © Gong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1310
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    Published online on: September 16, 2021
       https://doi.org/10.3892/etm.2021.10745
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Abstract

Colorectal cancer ranks third in terms of incidence and second in terms of mortality worldwide. The homeobox transcript antisense intergenic RNA (HOTAIR), which was found to be located on the antisense chain of the homeobox C (HOXC) gene cluster, is a long non‑coding RNA involved in multiple types of tumors. The role of HOXC11 in tumors remains unclear. Reverse transcription‑quantitative PCR was performed to detect the expression level of HOXC11 in colon adenocarcinoma. Cell proliferation and invasion were assessed. RNase protection assay was used to test the possibility of RNA duplex formation. The increased expression and co‑expression trend of HOXC11 and HOTAIR were identified in multiple types of cancer from The Cancer Genome Atlas and the results were validated in 12 colon adenocarcinoma and paired non‑tumor tissue samples. The expression of HOXC11 and HOTAIR was found to be associated with poor prognosis in colon adenocarcinoma and kidney renal clear cell carcinoma. Furthermore, HOXC11 was found to positively regulate HOTAIR by RNA duplex formation and promoted the proliferation and invasion of colon adenocarcinoma cells.
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Copy and paste a formatted citation
Spandidos Publications style
Gong N, Li F, Wang Y, Li Z, Wang W, Gong T, Meng X and Chen H: HOXC11 positively regulates the long non-coding RNA HOTAIR and is associated with poor prognosis in colon adenocarcinoma. Exp Ther Med 22: 1310, 2021.
APA
Gong, N., Li, F., Wang, Y., Li, Z., Wang, W., Gong, T. ... Chen, H. (2021). HOXC11 positively regulates the long non-coding RNA HOTAIR and is associated with poor prognosis in colon adenocarcinoma. Experimental and Therapeutic Medicine, 22, 1310. https://doi.org/10.3892/etm.2021.10745
MLA
Gong, N., Li, F., Wang, Y., Li, Z., Wang, W., Gong, T., Meng, X., Chen, H."HOXC11 positively regulates the long non-coding RNA HOTAIR and is associated with poor prognosis in colon adenocarcinoma". Experimental and Therapeutic Medicine 22.5 (2021): 1310.
Chicago
Gong, N., Li, F., Wang, Y., Li, Z., Wang, W., Gong, T., Meng, X., Chen, H."HOXC11 positively regulates the long non-coding RNA HOTAIR and is associated with poor prognosis in colon adenocarcinoma". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1310. https://doi.org/10.3892/etm.2021.10745
Copy and paste a formatted citation
x
Spandidos Publications style
Gong N, Li F, Wang Y, Li Z, Wang W, Gong T, Meng X and Chen H: HOXC11 positively regulates the long non-coding RNA HOTAIR and is associated with poor prognosis in colon adenocarcinoma. Exp Ther Med 22: 1310, 2021.
APA
Gong, N., Li, F., Wang, Y., Li, Z., Wang, W., Gong, T. ... Chen, H. (2021). HOXC11 positively regulates the long non-coding RNA HOTAIR and is associated with poor prognosis in colon adenocarcinoma. Experimental and Therapeutic Medicine, 22, 1310. https://doi.org/10.3892/etm.2021.10745
MLA
Gong, N., Li, F., Wang, Y., Li, Z., Wang, W., Gong, T., Meng, X., Chen, H."HOXC11 positively regulates the long non-coding RNA HOTAIR and is associated with poor prognosis in colon adenocarcinoma". Experimental and Therapeutic Medicine 22.5 (2021): 1310.
Chicago
Gong, N., Li, F., Wang, Y., Li, Z., Wang, W., Gong, T., Meng, X., Chen, H."HOXC11 positively regulates the long non-coding RNA HOTAIR and is associated with poor prognosis in colon adenocarcinoma". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1310. https://doi.org/10.3892/etm.2021.10745
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