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Dietary Bacillus subtilis supplementation alleviates alcohol‑induced liver injury by maintaining intestinal integrity and gut microbiota homeostasis in mice

  • Authors:
    • Meiqi Zhao
    • Chuanai Chen
    • Zhoujie Yuan
    • Wenwen Li
    • Mohan Zhang
    • Nailing Cui
    • Yitao Duan
    • Xiaoqian Zhang
    • Peng Zhang
  • View Affiliations / Copyright

    Affiliations: School of Clinical Medicine, Weifang Medical University, Weifang, Shandong 261031, P.R. China, School of Medicine, Nankai University, Tianjin 300071, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1312
    |
    Published online on: September 16, 2021
       https://doi.org/10.3892/etm.2021.10747
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Abstract

Alcoholic liver disease (ALD) is a worldwide health problem with limited therapeutic options, which is associated with gut‑derived endotoxins, particularly lipopolysaccharide (LPS) and intestinal microbiota dysbiosis. Recently, probiotics, synbiotics and other food additive interventions have been shown to be effective in decreasing or preventing the progression of ALD. Bacillus subtilis (B. subtilis) and its metabolic products are widely used as food additives to maintain intestinal health, but the protective effects of B. subtilis against alcohol‑induced liver injury are poorly understood. In the present study a chronic alcohol‑induced liver injury model was constructed based on the Lieber‑DeCarli diet and it aimed to determine whether dietary B. subtilis supplementation may alleviate alcohol‑induced liver injury. Results revealed that prophylactic B. subtilis supplementation partially restored gut microbiota homeostasis and relieved alcohol‑induced intestinal barrier injury, which significantly decreased the translocation of bacterial endotoxins to the blood. In addition, the decreased serum LPS alleviated hepatic inflammation via the toll‑like receptor 4 pathway, resulting in improved hepatic structure and function. These results demonstrated that dietary B. subtilis supplementation imparts novel hepatoprotective functions by improving intestinal permeability and homeostasis.
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1 

World Health Organization (WHO): Global status report on alcohol and health 2018. WHO, Geneva, Switzerland, 2018.

2 

Vassallo G, Mirijello A, Ferrulli A, Antonelli M, Landolfi R, Gasbarrini A and Addolorato G: Review article: Alcohol and gut microbiota-the possible role of gut microbiota modulation in the treatment of alcoholic liver disease. Aliment Pharmacol Ther. 41:917–927. 2015.PubMed/NCBI View Article : Google Scholar

3 

Avila MA, Dufour JF, Gerbes AL, Zoulim F, Bataller R, Burra P, Cortez-Pinto H, Gao B, Gilmore I, Mathurin P, et al: Recent advances in alcohol-related liver disease (ALD): Summary of a gut round table meeting. Gut. 69:764–780. 2020.PubMed/NCBI View Article : Google Scholar

4 

Bajaj JS: Alcohol, liver disease and the gut microbiota. Nat Rev Gastroenterol Hepatol. 16:235–246. 2019.PubMed/NCBI View Article : Google Scholar

5 

Zhong W and Zhou Z: Alterations of the gut microbiome and metabolome in alcoholic liver disease. World J Gastrointest Pathophysiol. 5:514–522. 2014.PubMed/NCBI View Article : Google Scholar

6 

Cai X, Bao L, Wang N, Ren J, Chen Q, Xu M, Li D, Mao R and Li Y: Dietary nucleotides protect against alcoholic liver injury by attenuating inflammation and regulating gut microbiota in rats. Food Funct. 7:2898–2908. 2016.PubMed/NCBI View Article : Google Scholar

7 

Chen J, Xuan YH, Luo MX, Ni XG, Ling LQ, Hu SJ, Chen JQ, Xu JY, Jiang LY, Si WZ, et al: Kaempferol alleviates acute alcoholic liver injury in mice by regulating intestinal tight junction proteins and butyrate receptors and transporters. Toxicology. 429(152338)2020.PubMed/NCBI View Article : Google Scholar

8 

Zhou Z and Zhong W: Targeting the gut barrier for the treatment of alcoholic liver disease. Liver Res. 1:197–207. 2017.PubMed/NCBI View Article : Google Scholar

9 

Jiang Y, Chen B, Duan C, Sun B, Yang J and Yang S: Multigene editing in the escherichia coli genome via the CRISPR-Cas9 system. Appl Environ Microbiol. 81:2506–2514. 2015.PubMed/NCBI View Article : Google Scholar

10 

Addolorato G, Ponziani FR, Dionisi T, Mosoni C, Vassallo GA, Sestito L, Petito V, Picca A, Marzetti E, Tarli C, et al: Gut microbiota compositional and functional fingerprint in patients with alcohol use disorder and alcohol-associated liver disease. Liver Int. 40:878–888. 2020.PubMed/NCBI View Article : Google Scholar

11 

Parlesak A, Schafer C, Schutz T, Bode JC and Bode C: Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease. J Hepatol. 32:742–747. 2000.PubMed/NCBI View Article : Google Scholar

12 

Hoque R, Farooq A, Ghani A, Gorelick F and Mehal WZ: Lactate reduces liver and pancreatic injury in Toll-like receptor- and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity. Gastroenterology. 146:1763–1774. 2014.PubMed/NCBI View Article : Google Scholar

13 

Kageyama S, Nakamura K, Fujii T, Ke B, Sosa RA, Reed EF, Datta N, Zarrinpar A, Busuttil RW and Kupiec-Weglinski JW: Recombinant relaxin protects liver transplants from ischemia damage by hepatocyte glucocorticoid receptor: From bench-to-bedside. Hepatology. 68:258–273. 2018.PubMed/NCBI View Article : Google Scholar

14 

Cui K, Yan G, Xu C, Chen Y, Wang J, Zhou R, Bai L, Lian Z, Wei H, Sun R and Tian Z: Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice. J Hepatol. 62:1311–1318. 2015.PubMed/NCBI View Article : Google Scholar

15 

Wieser V, Tymoszuk P, Adolph TE, Grander C, Grabherr F, Enrich B, Pfister A, Lichtmanegger L, Gerner R, Drach M, et al: Lipocalin 2 drives neutrophilic inflammation in alcoholic liver disease. J Hepatol. 64:872–880. 2016.PubMed/NCBI View Article : Google Scholar

16 

Osna NA, Donohue TM Jr and Kharbanda KK: Alcoholic liver disease: Pathogenesis and current management. Alcohol Res. 38:147–161. 2017.PubMed/NCBI

17 

You Y, Li WZ, Zhang S, Hu B, Li YX, Li HD, Tang HH, Li QW, Guan YY, Liu LX, et al: SNX10 mediates alcohol-induced liver injury and steatosis by regulating the activation of chaperone-mediated autophagy. J Hepatol. 69:129–141. 2018.PubMed/NCBI View Article : Google Scholar

18 

You M and Arteel GE: Effect of ethanol on lipid metabolism. J Hepatol. 70:237–248. 2019.PubMed/NCBI View Article : Google Scholar

19 

Valenzuela R and Videla LA: The importance of the long-chain polyunsaturated fatty acid n-6/n-3 ratio in development of non-alcoholic fatty liver associated with obesity. Food Funct. 2:644–648. 2011.PubMed/NCBI View Article : Google Scholar

20 

Zhang W, Sun Q, Zhong W, Sun X and Zhou Z: Hepatic peroxisome proliferator-activated receptor gamma signaling contributes to alcohol-induced hepatic steatosis and inflammation in mice. Alcohol Clin Exp Res. 40:988–999. 2016.PubMed/NCBI View Article : Google Scholar

21 

Mandrekar P and Szabo G: Signalling pathways in alcohol-induced liver inflammation. J Hepatol. 50:1258–1266. 2009.PubMed/NCBI View Article : Google Scholar

22 

Shimizu H, Masujima Y, Ushiroda C, Mizushima R, Taira S, Ohue-Kitano R and Kimura I: Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3. Sci Rep. 9:16574. 2019.PubMed/NCBI View Article : Google Scholar

23 

Makki K, Deehan EC, Walter J and Bäckhed F: The impact of dietary fiber on gut microbiota in host health and disease. Cell Host Microbe. 23:705–715. 2018.PubMed/NCBI View Article : Google Scholar

24 

Tsai YL, Lin TL, Chang CJ, Wu TR, Lai WF, Lu CC and Lai HC: Probiotics, prebiotics and amelioration of diseases. J Biomed Sci. 26(3)2019.PubMed/NCBI View Article : Google Scholar

25 

Vétizou M, Pitt JM, Daillère R, Lepage P, Waldschmitt N, Flament C, Rusakiewicz S, Routy B, Roberti MP, Duong CP, et al: Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science. 350:1079–1084. 2015.PubMed/NCBI View Article : Google Scholar

26 

Khochamit N, Siripornadulsil S, Sukon P and Siripornadulsil W: Antibacterial activity and genotypic-phenotypic characteristics of bacteriocin-producing Bacillus subtilis KKU213: Potential as a probiotic strain. Microbiol Res. 170:36–50. 2015.PubMed/NCBI View Article : Google Scholar

27 

Compaoré CS, Nielsen DS, Ouoba LII, Berner TS, Nielsen KF, Sawadogo-Lingani H, Diawara B, Ouédraogo GA, Jakobsen M and Thorsen L: Co-production of surfactin and a novel bacteriocin by Bacillus subtilis subsp. subtilis H4 isolated from Bikalga, an African alkaline Hibiscus sabdariffa seed fermented condiment. Int J Food Microbiol. 162:297–307. 2013.PubMed/NCBI View Article : Google Scholar

28 

Elshaghabee FMF, Rokana N, Gulhane RD, Sharma C and Panwar H: Bacillus as potential probiotics: Status, concerns, and future perspectives. Front Microbiol. 8(1490)2017.PubMed/NCBI View Article : Google Scholar

29 

Horosheva TV, Vodyanoy V and Sorokulova I: Efficacy of Bacillus probiotics in prevention of antibiotic-associated diarrhoea: A randomized, double-blind, placebo-controlled clinical trial. JMM Case Rep. 1:2014.

30 

Hickson M: Probiotics in the prevention of antibiotic-associated diarrhoea and Clostridium difficile infection. Therap Adv Gastroenterol. 4:185–197. 2011.PubMed/NCBI View Article : Google Scholar

31 

Bertola A, Mathews S, Ki SH, Wang H and Gao B: Mouse model of chronic and binge ethanol feeding (the NIAAA model). Nat Protoc. 8:627–637. 2013.PubMed/NCBI View Article : Google Scholar

32 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

33 

Caporaso JG, Kuczynski J, Stombaugh J, Bittinger K, Bushman FD, Costello EK, Fierer N, Peña AG, Goodrich JK, Gordon JI, et al: QIIME allows analysis of high-throughput community sequencing data. Nat Methods. 7:335–336. 2010.PubMed/NCBI View Article : Google Scholar

34 

Hill TC, Walsh KA, Harris JA and Moffett BF: Using ecological diversity measures with bacterial communities. FEMS Microbiol Ecol. 43:1–11. 2003.PubMed/NCBI View Article : Google Scholar

35 

Cho YE and Song BJ: Pomegranate prevents binge alcohol-induced gut leakiness and hepatic inflammation by suppressing oxidative and nitrative stress. Redox Biol. 18:266–278. 2018.PubMed/NCBI View Article : Google Scholar

36 

Shao T, Zhao C, Li F, Gu Z, Liu L, Zhang L, Wang Y, He L, Liu Y, Liu Q, et al: Intestinal HIF-1α deletion exacerbates alcoholic liver disease by inducing intestinal dysbiosis and barrier dysfunction. J Hepatol. 69:886–895. 2018.PubMed/NCBI View Article : Google Scholar

37 

Antón M, Rodríguez-González A, Ballesta A, González N, Del Pozo A, de Fonseca FR, Gómez-Lus ML, Leza JC, García-Bueno B, Caso JR and Orio L: Alcohol binge disrupts the rat intestinal barrier: The partial protective role of oleoylethanolamide. Br J Pharmacol. 175:4464–4479. 2018.PubMed/NCBI View Article : Google Scholar

38 

Ambade A, Lowe P, Kodys K, Catalano D, Gyongyosi B, Cho Y, Iracheta-Vellve A, Adejumo A, Saha B, Calenda C, et al: Pharmacological inhibition of CCR2/5 signaling prevents and reverses alcohol-induced liver damage, steatosis, and inflammation in mice. Hepatology. 69:1105–1121. 2019.PubMed/NCBI View Article : Google Scholar

39 

Ferrere G, Wrzosek L, Cailleux F, Turpin W, Puchois V, Spatz M, Ciocan D, Rainteau D, Humbert L, Hugot C, et al: Fecal microbiota manipulation prevents dysbiosis and alcohol-induced liver injury in mice. J Hepatol. 66:806–815. 2017.PubMed/NCBI View Article : Google Scholar

40 

Arab JP, Arrese M and Shah VH: Gut microbiota in non-alcoholic fatty liver disease and alcohol-related liver disease: Current concepts and perspectives. Hepatol Res. 50:407–418. 2020.PubMed/NCBI View Article : Google Scholar

41 

Dubinkina VB, Tyakht AV, Odintsova VY, Yarygin KS, Kovarsky BA, Pavlenko AV, Ischenko DS, Popenko AS, Alexeev DG, Taraskina AY, et al: Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease. Microbiome. 5(141)2017.PubMed/NCBI View Article : Google Scholar

42 

Vital M, Penton CR, Wang Q, Young VB, Antonopoulos DA, Sogin ML, Morrison HG, Raffals L, Chang EB, Huffnagle GB, et al: A gene-targeted approach to investigate the intestinal butyrate-producing bacterialcommunity. Microbiome. 1(8)2013.PubMed/NCBI View Article : Google Scholar

43 

Yan AW, Fouts DE, Brandl J, Stärkel P, Torralba M, Schott E, Tsukamoto H, Nelson KE, Brenner DA and Schnabl B: Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Hepatology. 53:96–105. 2011.PubMed/NCBI View Article : Google Scholar

44 

Mutlu EA, Gillevet PM, Rangwala H, Sikaroodi M, Naqvi A, Engen PA, Kwasny M, Lau CK and Keshavarzian A: Colonic microbiome is altered in alcoholism. Am J Physiol Gastrointest Liver Physiol. 302:G966–G978. 2012.PubMed/NCBI View Article : Google Scholar

45 

Wang L, Fouts DE, Stärkel P, Hartmann P, Chen P, Llorente C, DePew J, Moncera K, Ho SB, Brenner DA, et al: Intestinal REG3 lectins protect against alcoholic steatohepatitis by reducing mucosa-associated microbiota and preventing bacterial translocation. Cell Host Microbe. 19:227–239. 2016.PubMed/NCBI View Article : Google Scholar

46 

Tilg H, Cani PD and Mayer EA: Gut microbiome and liver diseases. Gut. 65:2035–2044. 2016.PubMed/NCBI View Article : Google Scholar

47 

Wells JM, Brummer RJ, Derrien M, MacDonald TT, Troost F, Cani PD, Theodorou V, Dekker J, Méheust A, de Vos WM, et al: Homeostasis of the gut barrier and potential biomarkers. Am J Physiol Gastrointest Liver Physiol. 312:G171–G193. 2017.PubMed/NCBI View Article : Google Scholar

48 

Lindner C, Thomsen I, Wahl B, Ugur M, Sethi MK, Friedrichsen M, Smoczek A, Ott S, Baumann U, Suerbaum S, et al: Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota. Nat Immunol. 16:880–888. 2015.PubMed/NCBI View Article : Google Scholar

49 

Rogier EW, Frantz AL, Bruno ME, Wedlund L, Cohen DA, Stromberg AJ and Kaetzel CS: Secretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expression. Proc Natl Acad Sci USA. 111:3074–3079. 2014.PubMed/NCBI View Article : Google Scholar

50 

Brown GD, Willment JA and Whitehead L: C-type lectins in immunity and homeostasis. Nat Rev Immunol. 18:374–389. 2018.PubMed/NCBI View Article : Google Scholar

51 

Seo GY, Giles DA and Kronenberg M: The role of innate lymphoid cells in response to microbes at mucosal surfaces. Mucosal Immunol. 13:399–412. 2020.PubMed/NCBI View Article : Google Scholar

52 

Guerville M, Leroy A, Sinquin A, Laugerette F, Michalski MC and Boudry G: Western-diet consumption induces alteration of barrier function mechanisms in the ileum that correlates with metabolic endotoxemia in rats. Am J Physiol Endocrinol Metab. 313:E107–E120. 2017.PubMed/NCBI View Article : Google Scholar

53 

van Ampting MT, Loonen LM, Schonewille AJ, Konings I, Vink C, Iovanna J, Chamaillard M, Dekker J, van der Meer R, Wells JM and Bovee-Oudenhoven IMJ: Intestinally secreted C-type lectin Reg3b attenuates salmonellosis but not listeriosis in mice. Infect Immun. 80:1115–1120. 2012.PubMed/NCBI View Article : Google Scholar

54 

Eslamparast T, Eghtesad S, Hekmatdoost A and Poustchi H: Probiotics and nonalcoholic fatty liver disease. Middle East J Dig Dis. 5:129–136. 2013.PubMed/NCBI

55 

Koutnikova H, Genser B, Monteiro-Sepulveda M, Faurie MJ, Rizkalla S, Schrezenmeir J and Clément K: Impact of bacterial probiotics on obesity, diabetes and non-alcoholic fatty liver disease related variables: A systematic review and meta-analysis of randomised controlled trials. BMJ Open. 9(e017995)2019.PubMed/NCBI View Article : Google Scholar

56 

Hong M, Han DH, Hong J, Kim DJ and Suk KT: Are probiotics effective in targeting alcoholic liver diseases? Probiotics Antimicrob Proteins. 11:335–347. 2019.PubMed/NCBI View Article : Google Scholar

57 

Wang J, Dong X, Shao Y, Guo H, Pan L, Hui W, Kwok LY, Zhang H and Zhang W: Genome adaptive evolution of Lactobacillus casei under long-term antibiotic selection pressures. BMC Genomics. 18(320)2017.PubMed/NCBI View Article : Google Scholar

58 

Koga H, Tamiya Y, Mitsuyama K, Ishibashi M, Matsumoto S, Imaoka A, Hara T, Nakano M, Ooeda K, Umezaki Y and Sata M: Probiotics promote rapid-turnover protein production by restoring gut flora in patients with alcoholic liver cirrhosis. Hepatol Int. 7:767–774. 2013.PubMed/NCBI View Article : Google Scholar

59 

Forsyth CB, Farhadi A, Jakate SM, Tang Y, Shaikh M and Keshavarzian A: Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis. Alcohol. 43:163–172. 2009.PubMed/NCBI View Article : Google Scholar

60 

Gao B, Xu MJ, Bertola A, Wang H, Zhou Z and Liangpunsakul S: Animal models of alcoholic liver disease: Pathogenesis and clinical relevance. Gene Expr. 17:173–186. 2017.PubMed/NCBI View Article : Google Scholar

61 

Barrera C, Valenzuela R, Rincón M, Espinosa A, Echeverria F, Romero N, Gonzalez-Mañan D and Videla LA: Molecular mechanisms related to the hepatoprotective effects of antioxidant-rich extra virgin olive oil supplementation in rats subjected to short-term iron administration. Free Radic Biol Med. 126:313–321. 2018.PubMed/NCBI View Article : Google Scholar

62 

Valenzuela R, Illesca P, Echeverría F, Espinosa A, Rincón-Cervera MA, Ortiz M, Hernandez-Rodas MC, Valenzuela A and Videla LA: Molecular adaptations underlying the beneficial effects of hydroxytyrosol in the pathogenic alterations induced by a high-fat diet in mouse liver: PPAR-α and Nrf2 activation, and NF-κB down-regulation. Food Funct. 8:1526–1537. 2017.PubMed/NCBI View Article : Google Scholar

63 

Ortiz M, Soto-Alarcón SA, Orellana P, Espinosa A, Campos C, López-Arana S, Rincón MA, Illesca P, Valenzuela R and Videla LA: Suppression of high-fat diet-induced obesity-associated liver mitochondrial dysfunction by docosahexaenoic acid and hydroxytyrosol co-administration. Dig Liver Dis. 52:895–904. 2020.PubMed/NCBI View Article : Google Scholar

64 

Soto-Alarcón SA, Ortiz M, Orellana P, Echeverría F, Bustamante A, Espinosa A, Illesca P, Gonzalez-Mañán D, Valenzuela R and Videla LA: Docosahexaenoic acid and hydroxytyrosol co-administration fully prevents liver steatosis and related parameters in mice subjected to high-fat diet: A molecular approach. Biofactors. 45:930–943. 2019.PubMed/NCBI View Article : Google Scholar

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Spandidos Publications style
Zhao M, Chen C, Yuan Z, Li W, Zhang M, Cui N, Duan Y, Zhang X and Zhang P: Dietary <em>Bacillus subtilis</em> supplementation alleviates alcohol‑induced liver injury by maintaining intestinal integrity and gut microbiota homeostasis in mice. Exp Ther Med 22: 1312, 2021.
APA
Zhao, M., Chen, C., Yuan, Z., Li, W., Zhang, M., Cui, N. ... Zhang, P. (2021). Dietary <em>Bacillus subtilis</em> supplementation alleviates alcohol‑induced liver injury by maintaining intestinal integrity and gut microbiota homeostasis in mice. Experimental and Therapeutic Medicine, 22, 1312. https://doi.org/10.3892/etm.2021.10747
MLA
Zhao, M., Chen, C., Yuan, Z., Li, W., Zhang, M., Cui, N., Duan, Y., Zhang, X., Zhang, P."Dietary <em>Bacillus subtilis</em> supplementation alleviates alcohol‑induced liver injury by maintaining intestinal integrity and gut microbiota homeostasis in mice". Experimental and Therapeutic Medicine 22.5 (2021): 1312.
Chicago
Zhao, M., Chen, C., Yuan, Z., Li, W., Zhang, M., Cui, N., Duan, Y., Zhang, X., Zhang, P."Dietary <em>Bacillus subtilis</em> supplementation alleviates alcohol‑induced liver injury by maintaining intestinal integrity and gut microbiota homeostasis in mice". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1312. https://doi.org/10.3892/etm.2021.10747
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao M, Chen C, Yuan Z, Li W, Zhang M, Cui N, Duan Y, Zhang X and Zhang P: Dietary <em>Bacillus subtilis</em> supplementation alleviates alcohol‑induced liver injury by maintaining intestinal integrity and gut microbiota homeostasis in mice. Exp Ther Med 22: 1312, 2021.
APA
Zhao, M., Chen, C., Yuan, Z., Li, W., Zhang, M., Cui, N. ... Zhang, P. (2021). Dietary <em>Bacillus subtilis</em> supplementation alleviates alcohol‑induced liver injury by maintaining intestinal integrity and gut microbiota homeostasis in mice. Experimental and Therapeutic Medicine, 22, 1312. https://doi.org/10.3892/etm.2021.10747
MLA
Zhao, M., Chen, C., Yuan, Z., Li, W., Zhang, M., Cui, N., Duan, Y., Zhang, X., Zhang, P."Dietary <em>Bacillus subtilis</em> supplementation alleviates alcohol‑induced liver injury by maintaining intestinal integrity and gut microbiota homeostasis in mice". Experimental and Therapeutic Medicine 22.5 (2021): 1312.
Chicago
Zhao, M., Chen, C., Yuan, Z., Li, W., Zhang, M., Cui, N., Duan, Y., Zhang, X., Zhang, P."Dietary <em>Bacillus subtilis</em> supplementation alleviates alcohol‑induced liver injury by maintaining intestinal integrity and gut microbiota homeostasis in mice". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1312. https://doi.org/10.3892/etm.2021.10747
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