Keratosis pilaris atrophicans faciei: An observational, descriptive, retrospective clinical study

Fekete,Gyula László; Fekete,László; Neagu,Nicoleta; Bacârea,Vladimir; Drăgănescu,Miruna; Brihan,Ilarie

doi:10.3892/etm.2021.10766

November-2021 Volume 22 Issue 5

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November-2021 Volume 22 Issue 5

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Article

Keratosis pilaris atrophicans faciei: An observational, descriptive, retrospective clinical study

Authors:
- Gyula László Fekete
- László Fekete
- Nicoleta Neagu
- Vladimir Bacârea
- Miruna Drăgănescu
- Ilarie Brihan
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Affiliations: Department of Dermatology, Dermatology Clinic, ‘George Emil Palade’ University of Medicine, Pharmacy, Science and Technology, 540139 Târgu Mureș, Romania, Department of Dermatology, Mureș County Hospital, 540015 Târgu Mures, Romania, Department of Medical Research Methodology, ‘George Emil Palade’ University of Medicine, Pharmacy, Science and Technology, 540139 Târgu Mureș, Romania, Faculty of Medicine and Pharmacy, Medical Department, ‘Dunărea de Jos’ University, 800010 Galati, Romania, Department of Dermatology, Dermatology Clinic, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania
Article Number: 1331
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Published online on: September 20, 2021

https://doi.org/10.3892/etm.2021.10766
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Abstract

Keratosis pilaris atrophicans faciei (KPAF) is a hereditary follicular disorder, an atrophicans subtype of keratosis pilaris (KP) with a highly elusive diagnosis. Clinically, it presents with follicular, horny papules surrounded by an erythematous halo of the cheeks, forehead, chin and eyebrows, and it is followed by a gradual hair loss on the lateral margins of the eyebrows. The onset is as early as a few months after birth, but it is mainly diagnosed in children and adolescents and it can persist through adulthood. At present, the natural progression of the disease is poorly understood, which makes a correct diagnosis highly unlikely. The aim of the present study was to describe the clinical characteristics of KPAF in patients encountered in daily practice, in order to find common characteristics that may aid in the earlier recognition of the disease. An observational, descriptive, retrospective study was performed on 14 patients diagnosed with KPAF between January 2000 and December 2020. The mean age at diagnosis was 17.04 years and the onset of clinical symptoms appeared at a mean age of 4.85 years. The first clinical symptom was KP involving either the upper or lower limbs, or both. Then, erythema of the face appeared at a mean age of 7.21 years, keratotic papules on the face at a mean age of 8.35 years and, finally, loss of hair on the lateral margins of the eyebrows at a mean age of 14 years. The patients also had concomitant xerosis cutis, multiple mole syndrome, acne, contact dermatitis and Laugier‑Hunziker syndrome. Evidence of disease progression, associations, as well as efficacious treatment measures are lacking. An earlier diagnosis potentially allows for a more efficacious, targeted treatment option. Either topical emollients, systemic retinoids or laser therapy may prove effective for each patient individually.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Keratosis pilaris atrophicans faciei: An observational, descriptive, retrospective clinical study

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