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Effects of Psoralea corylifolia L. seed extract on AGEs‑induced cell proliferation and fibrotic factor expression in mesangial cells

  • Authors:
    • Hyunah Chung
    • Eunhui Seo
    • Hee-Sook Jun
  • View Affiliations / Copyright

    Affiliations: College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 21936, Republic of Korea
    Copyright: © Chung et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1332
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    Published online on: September 20, 2021
       https://doi.org/10.3892/etm.2021.10767
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Abstract

Diabetic nephropathy is a microvascular complication of diabetes that is characterized by mesangial expansion and thickening of the glomerular basement membrane. The production of advanced glycation end products (AGEs) increases in diabetic patients. Activation of the receptor of AGE (RAGE) signaling pathway induces mesangial expansion via the reactive oxygen species (ROS)‑mediated production of pro‑inflammatory and extracellular matrix molecules. The Psoralea corylifolia L. seed (PCS) is a widely used herbal medicine with various biological activities. The current study investigated the effect of PCS extract on mesangial cell proliferation and the RAGE signaling pathway in SV40 MES 13 cells. SV40 MES 13 cells were harvested after treatment with various concentrations of PCS extract at 10 µg/ml AGEs for 24 h. The results revealed that the PCS extract inhibited AGEs‑induced mesangial cell proliferation and cyclin protein expression in a concentration‑dependent manner. In addition, the AGEs‑induced expression of fibrotic factors, such as transforming growth factor β, fibronectin and collagen, was reduced in mesangial cells after exposure to the PCS extract. The PCS extract also reduced RAGE expression and inhibited the expression of its downstream signaling pathways, such as NADPH oxidase, intracellular ROS and phospho‑NF‑κB. In conclusion, the data suggested that the PCS extract attenuated AGEs‑induced renal mesangial cell proliferation and fibrosis via the suppression of oxidative stress and the downregulation of inflammatory and fibrotic factor expression.
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1 

Bhattacharjee N, Barma S, Konwar N, Dewanjee S and Manna P: Mechanistic insight of diabetic nephropathy and its pharmacotherapeutic targets: An update. Eur J Pharmacol. 791:8–24. 2016.PubMed/NCBI View Article : Google Scholar

2 

Tung CW, Hsu YC, Shih YH, Chang PJ and Lin CL: Glomerular mesangial cell and podocyte injuries in diabetic nephropathy. Nephrology (Carlton). 23 (Suppl 4):S32–S37. 2018.PubMed/NCBI View Article : Google Scholar

3 

Kawanami D, Matoba K and Utsunomiya K: Signaling pathways in diabetic nephropathy. Histol Histopathol. 31:1059–1067. 2016.PubMed/NCBI View Article : Google Scholar

4 

Huebschmann AG, Regensteiner JG, Vlassara H and Reusch JE: Diabetes and advanced glycoxidation end products. Diabetes Care. 29:1420–1432. 2006.PubMed/NCBI View Article : Google Scholar

5 

Bellier J, Nokin MJ, Larde E, Karoyan P, Peulen O, Castronovo V and Bellahcène A: Methylglyoxal, a potent inducer of AGEs, connects between diabetes and cancer. Diabetes Res Clin Pract. 148:200–211. 2019.PubMed/NCBI View Article : Google Scholar

6 

Rehman S, Faisal M, Alatar AA and Ahmad S: Physico-chemical changes induced in serum proteins, immunoglobulin-G and fibrinogen by reactive carbonyl species, Methylglyoxal. Curr Protein Pept Sci. 21:916–923. 2019.PubMed/NCBI View Article : Google Scholar

7 

Ott C, Jacobs K, Haucke E, Navarrete Santos A, Grune T and Simm A: Role of advanced glycation end products in cellular signaling. Redox Biol. 2:411–429. 2014.PubMed/NCBI View Article : Google Scholar

8 

Gruden G, Perin PC and Camussi G: Insight on the pathogenesis of diabetic nephropathy from the study of podocyte and mesangial cell biology. Curr Diabetes Rev. 1:27–40. 2005.PubMed/NCBI View Article : Google Scholar

9 

Thallas-Bonke V, Thorpe SR, Coughlan MT, Fukami K, Yap FY, Sourris KC, Penfold SA, Bach LA, Cooper ME and Forbes JM: Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-alpha-dependent pathway. Diabetes. 57:460–469. 2008.PubMed/NCBI View Article : Google Scholar

10 

Rios JL, Francini F and Schinella GR: Natural products for the treatment of type 2 diabetes mellitus. Planta Med. 81:975–994. 2015.PubMed/NCBI View Article : Google Scholar

11 

Choudhury H, Pandey M, Hua CK, Mun CS, Jing JK, Kong L, Ern LY, Ashraf NA, Kit SW, Yee TS, et al: An update on natural compounds in the remedy of diabetes mellitus: A systematic review. J Tradit Complement Med. 8:361–376. 2018.PubMed/NCBI View Article : Google Scholar

12 

Seo E, Oh YS, Kim D, Lee MY, Chae S and Jun HS: Protective role of Psoralea corylifolia L. seed extract against hepatic mitochondrial dysfunction induced by oxidative stress or aging. Evid Based Complement Alternat Med. 2013(678028)2013.PubMed/NCBI View Article : Google Scholar

13 

Heo J: Donguibogam. Namsandang, Seoul, 1980 (original work published, 1610) (In Korean).

14 

Khushboo PS, Jadhav VM, Kadam VJ and Sathe NS: Psoralea corylifolia Linn.-‘Kushtanashini’. Pharmacogn Rev. 4:69–76. 2010.

15 

Seo E, Kang H, Oh YS and Jun HS: Psoralea corylifolia L. seed extract attenuates diabetic nephropathy by inhibiting renal fibrosis and apoptosis in streptozotocin-induced diabetic mice. Nutrients. 9(828)2017.PubMed/NCBI View Article : Google Scholar

16 

Seo E, Oh YS and Jun HS: Psoralea corylifolia L. seed extract attenuates nonalcoholic fatty liver disease in high-fat diet-induced obese mice. Nutrients. 8(83)2016.PubMed/NCBI View Article : Google Scholar

17 

Adisakwattana S, Thilavech T and Chusak C: Mesona Chinensis Benth extract prevents AGE formation and protein oxidation against fructose-induced protein glycation in vitro. BMC Complement Altern Med. 14(130)2014.PubMed/NCBI View Article : Google Scholar

18 

Sharaf H, Matou-Nasri S, Wang Q, Rabhan Z, Al-Eidi H, Al Abdulrahman A and Ahmed N: Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231. Biochim Biophys Acta. 1852:429–441. 2015.PubMed/NCBI View Article : Google Scholar

19 

Chiang CK, Wang CC, Lu TF, Huang KH, Sheu ML, Liu SH and Hung KY: Involvement of endoplasmic reticulum stress, autophagy, and apoptosis in advanced glycation end products-induced glomerular mesangial cell injury. Sci Rep. 6(34167)2016.PubMed/NCBI View Article : Google Scholar

20 

Jiang W, Wang R, Liu D, Zuo M, Zhao C, Zhang T and Li W: Protective effects of kaempferitrin on advanced glycation end products induce mesangial cell apoptosis and oxidative stress. Int J Mol Sci. 19(3334)2018.PubMed/NCBI View Article : Google Scholar

21 

Thomasova D and Anders HJ: Cell cycle control in the kidney. Nephrol Dial Transplant. 30:1622–1630. 2015.PubMed/NCBI View Article : Google Scholar

22 

Koulis C, Watson AMD, Gray SP and Jandeleit-Dahm KA: Linking RAGE and Nox in diabetic micro- and macrovascular complications. Diabetes Metab. 41:272–281. 2015.PubMed/NCBI View Article : Google Scholar

23 

Sedeek M, Callera G, Montezano A, Gutsol A, Heitz F, Szyndralewiez C, Page P, Kennedy CR, Burns KD, Touyz RM and Hébert RL: Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: Implications in type 2 diabetic nephropathy. Am J Physiol Renal Physiol. 299:F1348–F1358. 2010.PubMed/NCBI View Article : Google Scholar

24 

Ha H and Lee HB: Oxidative stress in diabetic nephropathy: Basic and clinical information. Curr Diab Rep. 1:282–287. 2001.PubMed/NCBI View Article : Google Scholar

25 

Scindia YM, Deshmukh US and Bagavant H: Mesangial pathology in glomerular disease: Targets for therapeutic intervention. Adv Drug Deliv Rev. 62:1337–1343. 2010.PubMed/NCBI View Article : Google Scholar

26 

Schlöndorff D and Banas B: The mesangial cell revisited: No cell is an island. J Am Soc Nephrol. 20:1179–1187. 2009.PubMed/NCBI View Article : Google Scholar

27 

Rhee SY and Kim YS: The role of advanced glycation end products in diabetic vascular complications. Diabetes Metab J. 42:188–195. 2018.PubMed/NCBI View Article : Google Scholar

28 

Lee EJ, Kang MK, Kim DY, Kim YH, Oh H and Kang YH: Chrysin inhibits advanced glycation end products-induced kidney fibrosis in renal mesangial cells and diabetic kidneys. Nutrients. 10(882)2018.PubMed/NCBI View Article : Google Scholar

29 

Qiu YY, Tang LQ and Wei W: Berberine exerts renoprotective effects by regulating the AGEs-RAGE signaling pathway in mesangial cells during diabetic nephropathy. Mol Cell Endocrinol. 443:89–105. 2017.PubMed/NCBI View Article : Google Scholar

30 

Bourajjaj M, Stehouwer CD, van Hinsbergh VW and Schalkwijk CG: Role of methylglyoxal adducts in the development of vascular complications in diabetes mellitus. Biochem Soc Trans. 31:1400–1402. 2003.PubMed/NCBI View Article : Google Scholar

31 

Sherr CJ: Mammalian G1 cyclins. Cell. 73:1059–1065. 1993.PubMed/NCBI View Article : Google Scholar

32 

Haberstroh U, Zahner G, Disser M, Thaiss F, Wolf G and Stahl RA: TGF-beta stimulates rat mesangial cell proliferation in culture: Role of PDGF beta-receptor expression. Am J Physiol. 264:F199–F205. 1993.PubMed/NCBI View Article : Google Scholar

33 

Lang S, Hartner A, Sterzel RB and Schöcklmann HO: Requirement of cyclin D1 in mesangial cell mitogenesis. J Am Soc Nephrol. 11:1398–1408. 2000.PubMed/NCBI View Article : Google Scholar

34 

Schöcklmann HO, Lang S and Sterzel RB: Regulation of mesangial cell proliferation. Kidney Int. 56:1199–1207. 1999.PubMed/NCBI View Article : Google Scholar

35 

Sureshbabu A, Muhsin SA and Choi ME: TGF-β signaling in the kidney: Profibrotic and protective effects. Am J Physiol Renal Physiol. 310:F596–F606. 2016.PubMed/NCBI View Article : Google Scholar

36 

Yu L, Border WA, Huang Y and Noble NA: TGF-beta isoforms in renal fibrogenesis. Kidney Int. 64:844–856. 2003.PubMed/NCBI View Article : Google Scholar

37 

Rajaram RD, Dissard R, Jaquet V and de Seigneux S: Potential benefits and harms of NADPH oxidase type 4 in the kidneys and cardiovascular system. Nephrol Dial Transplant. 34:567–576. 2019.PubMed/NCBI View Article : Google Scholar

38 

Takac I, Schröder K, Zhang L, Lardy B, Anilkumar N, Lambeth JD, Shah AM, Morel F and Brandes RP: The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4. J Biol Chem. 286:13304–13313. 2011.PubMed/NCBI View Article : Google Scholar

39 

Ratliff BB, Abdulmahdi W, Pawar R and Wolin MS: Oxidant mechanisms in renal injury and disease. Antioxid Redox Signal. 25:119–146. 2016.PubMed/NCBI View Article : Google Scholar

40 

Iglesias-De La Cruz MC, Ruiz-Torres P, Alcamí J, Díez-Marqués L, Ortega-Velázquez R, Chen S, Rodríguez-Puyol M, Ziyadeh FN and Rodríguez-Puyol D: Hydrogen peroxide increases extracellular matrix mRNA through TGF-beta in human mesangial cells. Kidney Int. 59:87–95. 2001.PubMed/NCBI View Article : Google Scholar

41 

Fukami K, Taguchi K, Yamagishi S and Okuda S: Receptor for advanced glycation endproducts and progressive kidney disease. Curr Opin Nephrol Hypertens. 24:54–60. 2015.PubMed/NCBI View Article : Google Scholar

42 

Sanz AB, Sanchez-Niño MD, Ramos AM, Moreno JA, Santamaria B, Ruiz-Ortega M, Egido J and Ortiz A: NF-kappaB in renal inflammation. J Am Soc Nephrol. 21:1254–1262. 2010.PubMed/NCBI View Article : Google Scholar

43 

Yang J, Zeng Z, Wu T, Yang Z, Liu B and Lan T: Emodin attenuates high glucose-induced TGF-β1 and fibronectin expression in mesangial cells through inhibition of NF-κB pathway. Exp Cell Res. 319:3182–3189. 2013.PubMed/NCBI View Article : Google Scholar

44 

Wang BF, Xu HS, Li YJ, Ye RG, Kong QY and Yu XQ: Role of Akt/NF-kappa B signal transduction pathway in murine glomerular mesangial cell proliferation induced by immune complex. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 20:314–318. 2004.PubMed/NCBI(In Chinese).

45 

Truong CS, Seo E and Jun HS: Psoralea corylifolia L. seed extract attenuates methylglyoxal-induced insulin resistance by inhibition of advanced glycation end product formation. Oxid Med Cell Longev. 2019(4310319)2019.PubMed/NCBI View Article : Google Scholar

46 

Sen Z, Weida W, Jie M, Li S, Dongming Z and Xiaoguang C: Coumarin glycosides from Hydrangea paniculata slow down the progression of diabetic nephropathy by targeting Nrf2 anti-oxidation and smad2/3-mediated profibrosis. Phytomedicine. 57:385–395. 2019.PubMed/NCBI View Article : Google Scholar

47 

Zhang S, Xin H, Li Y, Zhang D, Shi J, Yang J and Chen X: Skimmin, a coumarin from Hydrangea paniculata, slows down the progression of membranous glomerulonephritis by anti-inflammatory effects and inhibiting immune complex deposition. Evid Based Complement Alternat Med. 2013(819296)2013.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Chung H, Seo E and Jun H: Effects of <em>Psoralea corylifolia </em>L. seed extract on AGEs‑induced cell proliferation and fibrotic factor expression in mesangial cells. Exp Ther Med 22: 1332, 2021.
APA
Chung, H., Seo, E., & Jun, H. (2021). Effects of <em>Psoralea corylifolia </em>L. seed extract on AGEs‑induced cell proliferation and fibrotic factor expression in mesangial cells. Experimental and Therapeutic Medicine, 22, 1332. https://doi.org/10.3892/etm.2021.10767
MLA
Chung, H., Seo, E., Jun, H."Effects of <em>Psoralea corylifolia </em>L. seed extract on AGEs‑induced cell proliferation and fibrotic factor expression in mesangial cells". Experimental and Therapeutic Medicine 22.5 (2021): 1332.
Chicago
Chung, H., Seo, E., Jun, H."Effects of <em>Psoralea corylifolia </em>L. seed extract on AGEs‑induced cell proliferation and fibrotic factor expression in mesangial cells". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1332. https://doi.org/10.3892/etm.2021.10767
Copy and paste a formatted citation
x
Spandidos Publications style
Chung H, Seo E and Jun H: Effects of <em>Psoralea corylifolia </em>L. seed extract on AGEs‑induced cell proliferation and fibrotic factor expression in mesangial cells. Exp Ther Med 22: 1332, 2021.
APA
Chung, H., Seo, E., & Jun, H. (2021). Effects of <em>Psoralea corylifolia </em>L. seed extract on AGEs‑induced cell proliferation and fibrotic factor expression in mesangial cells. Experimental and Therapeutic Medicine, 22, 1332. https://doi.org/10.3892/etm.2021.10767
MLA
Chung, H., Seo, E., Jun, H."Effects of <em>Psoralea corylifolia </em>L. seed extract on AGEs‑induced cell proliferation and fibrotic factor expression in mesangial cells". Experimental and Therapeutic Medicine 22.5 (2021): 1332.
Chicago
Chung, H., Seo, E., Jun, H."Effects of <em>Psoralea corylifolia </em>L. seed extract on AGEs‑induced cell proliferation and fibrotic factor expression in mesangial cells". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1332. https://doi.org/10.3892/etm.2021.10767
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