Open Access

Nevi, biologics for psoriasis and the risk for skin cancer: A real concern? (Case presentation and short review)

  • Authors:
    • Florin Ciprian Bujoreanu
    • Laura Bezman
    • Diana Sabina Radaschin
    • Elena Niculet
    • Carmen Bobeica
    • Mihaela Craescu
    • Thomas Nadasdy
    • Daniela Stan Jicman
    • Valeriu Ardeleanu
    • Lawrence Chukwudi Nwabudike
    • Silviu Adrian Marinescu
    • Alin Laurentiu Tatu
  • View Affiliations

  • Published online on: September 23, 2021     https://doi.org/10.3892/etm.2021.10789
  • Article Number: 1354
  • Copyright: © Bujoreanu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Psoriasis is a systemic inflammatory cutaneous disease that affects approximately 2% of the world's population. Systemic treatments and biologic treatment therapies are a powerful option for patients with moderate to severe psoriasis. Some studies from the literature indicate an overall small, but increased, risk of neoplasia in patients with psoriasis treated with phototherapy or systemic medication. The relationship between psoriasis and malignancy is not very well established; there are few studies with conflicting results. We present the case of a 31‑year‑old male patient, diagnosed with psoriasis, who was deemed eligible for systemic therapy. Treatment with methotrexate was initiated, but without a satisfactory outcome. Given the patient's resistant disease involving 15% of his body surface, his desire to have a clear skin, besides his being naïve to biologic therapy, he was proposed to start treatment with secukinumab 300 mg monthly. The patient experienced complete clearance of lesions and was followed‑up on the basis of clinical and biological parameters. There are limited data concerning the relationship between melanocytic lesions, psoriasis and melanoma. Immunologic pathways implicated in psoriasis induce a reduction in the number of melanocytic nevi. Nevertheless, little is known concerning the association of melanocytic nevi with psoriasis. Thorough skin examination, meaning clinical and dermoscopic evaluation of melanocytic lesions, must be encouraged in patients treated with systemic therapies such as biologic agents.
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December-2021
Volume 22 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Bujoreanu FC, Bezman L, Radaschin DS, Niculet E, Bobeica C, Craescu M, Nadasdy T, Jicman DS, Ardeleanu V, Nwabudike LC, Nwabudike LC, et al: Nevi, biologics for psoriasis and the risk for skin cancer: A real concern? (Case presentation and short review). Exp Ther Med 22: 1354, 2021
APA
Bujoreanu, F.C., Bezman, L., Radaschin, D.S., Niculet, E., Bobeica, C., Craescu, M. ... Tatu, A.L. (2021). Nevi, biologics for psoriasis and the risk for skin cancer: A real concern? (Case presentation and short review). Experimental and Therapeutic Medicine, 22, 1354. https://doi.org/10.3892/etm.2021.10789
MLA
Bujoreanu, F. C., Bezman, L., Radaschin, D. S., Niculet, E., Bobeica, C., Craescu, M., Nadasdy, T., Jicman, D. S., Ardeleanu, V., Nwabudike, L. C., Marinescu, S. A., Tatu, A. L."Nevi, biologics for psoriasis and the risk for skin cancer: A real concern? (Case presentation and short review)". Experimental and Therapeutic Medicine 22.6 (2021): 1354.
Chicago
Bujoreanu, F. C., Bezman, L., Radaschin, D. S., Niculet, E., Bobeica, C., Craescu, M., Nadasdy, T., Jicman, D. S., Ardeleanu, V., Nwabudike, L. C., Marinescu, S. A., Tatu, A. L."Nevi, biologics for psoriasis and the risk for skin cancer: A real concern? (Case presentation and short review)". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1354. https://doi.org/10.3892/etm.2021.10789