Pharmacological effects of Picrasma quassioides (D. Don) Benn for inflammation, cancer and neuroprotection (Review)
- Authors:
- Jaihyung Lee
- Yi-Xi Gong
- Hyunjeong Jeong
- Hoyoung Seo
- Dan-Ping Xie
- Hu-Nan Sun
- Taeho Kwon
-
Affiliations: Epigenetics Drug Discovery Center, Hwalmyeong Convalescence Hospital, Gapyeong, Gyeonggi 12458, Republic of Korea, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang 163319, P.R. China, Primate Resources Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup‑si, Jeonbuk 56216, Republic of Korea - Published online on: September 24, 2021 https://doi.org/10.3892/etm.2021.10792
- Article Number: 1357
-
Copyright: © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
National Pharmacopoeia Committee. Pharmacopoeia of the people's Republic of China, volume I (2010 edition), pp186, 2010. | |
Jiao WH, Gao H, Zhao F, Lin HW, Pan YM, Zhou GX and Yao XS: Anti-inflammatory alkaloids from the stems of Picrasma quassioides BENNET. Chem Pharm Bull (Tokyo). 59:359–364. 2011.PubMed/NCBI View Article : Google Scholar | |
Liang WF: Anti-snake bite action of Picrasma quassioides. Zhong Yao Tong Bao. 12(54)1987.PubMed/NCBI(In Chinese). | |
Mohd Jamil MDH, Taher M, Susanti D, Rahman MA and Zakaria ZA: Phytochemistry, traditional use and pharmacological activity of Picrasma quassioides: A critical reviews. Nutrients. 12(2584)2020.PubMed/NCBI View Article : Google Scholar | |
Jung YS, Eun CS, Jung YT, Kim HJ and Yu MH: Anti-inflammatory effects of Picrasma quassioides (D. DON) BENN leaves extracts. J Life Sci. 23:629–636. 2013. | |
Liu C, Cheng RR, Yang L, Song ZC and Wang ZT: Inhibition of CYP450 enzymes by quassinoids from Picrasma quassioides leaves. Phytochem Lett. 30:138–142. 2019. | |
Jiao WH, Gao H, Li CY, Zhou GX, Kitanaka S, Ohmura A and Yao XS: Beta-carboline alkaloids from the stems of Picrasma quassioides. Magn Reson Chem. 48:490–495. 2010.PubMed/NCBI View Article : Google Scholar | |
Sung Y, Koike K, Nikaido T, Ohmoto T and Sankawa U: Inhibitors of cyclic AMP phosphodiesterase in Picrasma quassioides Bennet, and inhibitory activities of related beta-carboline alkaloids. Chem Pharm Bull (Tokyo). 32:1872–1877. 1984.PubMed/NCBI View Article : Google Scholar | |
Zhao WY, Song XY, Zhao L, Zou CX, Zhou WY, Lin B, Yao GD, Huang XX and Song SJ: Quassinoids from Picrasma quassioides and their neuroprotective effects. J Nat Prod. 82:714–723. 2019.PubMed/NCBI View Article : Google Scholar | |
Xu J, Xiao D, Lin QH, He JF, Liu WY, Xie N, Feng F and Qu W: Cytotoxic tirucallane and apotirucallane triterpenoids from the stems of Picrasma quassioides. J Nat Prod. 79:1899–1910. 2016.PubMed/NCBI View Article : Google Scholar | |
Aggarwal NR, King LS and D'Alessio FR: Diverse macrophage populations mediate acute lung inflammation and resolution. Am J Physiol Lung Cell Mol Physiol. 306:L709–L725. 2014.PubMed/NCBI View Article : Google Scholar | |
Fahy JV: Type 2 inflammation in asthma-present in most, absent in many. Nat Rev Immunol. 15:57–65. 2015.PubMed/NCBI View Article : Google Scholar | |
Lontchi-Yimagou E, Sobngwi E, Matsha TE and Kengne AP: Diabetes mellitus and inflammation. Curr Diab Rep. 13:435–444. 2013.PubMed/NCBI View Article : Google Scholar | |
Agita A and Alsagaff MT: Inflammation, immunity, and hypertension. Acta Med Indones. 49:158–165. 2017.PubMed/NCBI | |
Mason A, Holmes C and Edwards CJ: Inflammation and dementia: Using rheumatoid arthritis as a model to develop treatments? Autoimmun Rev. 17:919–925. 2018.PubMed/NCBI View Article : Google Scholar | |
Taleb S: Inflammation in atherosclerosis. Arch Cardiovasc Dis. 109:708–715. 2016.PubMed/NCBI View Article : Google Scholar | |
Fonceca AM, Zosky GR, Bozanich EM, Sutanto EN, Kicic A, McNamara PS, Knight DA, Sly PD, Turner DJ and Stick SM: Accumulation mode particles and LPS exposure induce TLR-4 dependent and independent inflammatory responses in the lung. Respir Res. 19(15)2018.PubMed/NCBI View Article : Google Scholar | |
Olmos-Ortiz A, Déciga-García M, Preciado-Martínez E, Bermejo-Martínez L, Flores-Espinosa P, Mancilla-Herrera I, Irles C, Helguera-Repetto AC, Quesada-Reyna B, Goffin V, et al: Prolactin decreases LPS-induced inflammatory cytokines by inhibiting TLR-4/NFκB signaling in the human placenta. Mol Hum Reprod. 25:660–667. 2019.PubMed/NCBI View Article : Google Scholar | |
Lai JL, Liu YH, Liu C, Qi MP, Liu RN, Zhu XF, Zhou QG, Chen YY, Guo AZ and Hu CM: Indirubin inhibits LPS-induced inflammation via TLR4 abrogation mediated by the NF-κB and MAPK signaling pathways. Inflammation. 40:1–12. 2017.PubMed/NCBI View Article : Google Scholar | |
Yu Q, Zeng K, Ma X, Song F, Jiang Y, Tu P and Wang X: Resokaempferol-mediated anti-inflammatory effects on activated macrophages via the inhibition of JAK2/STAT3, NF-κB and JNK/p38 MAPK signaling pathways. Int Immunopharmacol. 38:104–114. 2016.PubMed/NCBI View Article : Google Scholar | |
Kwon MY, Park J, Kim SM, Lee J, Cho H, Park JH and Han IO: An alpha-lipoic acid-decursinol hybrid compound attenuates lipopolysaccharide-mediated inflammation in BV2 and RAW264.7 cells. BMB Rep. 52:508–513. 2019.PubMed/NCBI View Article : Google Scholar | |
Liang M, Wang X, Yuan Y, Zhou Q, Tong C and Jiang W: Different effect of glutamine on macrophage tumor necrosis factor-alpha release and heat shock protein 72 expression in vitro and in vivo. Acta Biochim Biophys Sin (Shanghai). 41:171–177. 2009.PubMed/NCBI View Article : Google Scholar | |
Balkwill F: TNF-alpha in promotion and progression of cancer. Cancer Metastasis Rev. 25:409–416. 2006.PubMed/NCBI View Article : Google Scholar | |
Floros T and Tarhini AA: Anticancer cytokines: Biology and clinical effects of interferon-α2, interleukin (IL)-2, IL-15, IL-21, and IL-12. Semin Oncol. 42:539–548. 2015.PubMed/NCBI View Article : Google Scholar | |
Nagayama M, Niwa K, Nagayama T, Ross ME and Iadecola C: The cyclooxygenase-2 inhibitor NS-398 ameliorates ischemic brain injury in wild-type mice but not in mice with deletion of the inducible nitric oxide synthase gene. J Cereb Blood Flow Metab. 19:1213–1219. 1999.PubMed/NCBI View Article : Google Scholar | |
Shin NR, Shin IS, Jeon CM, Hong JM, Oh SR, Hahn KW and Ahn KS: Inhibitory effects of Picrasma quassioides (D. Don) Benn. On airway inflammation in a murine model of allergic asthma. Mol Med Rep. 10:1495–1500. 2014.PubMed/NCBI View Article : Google Scholar | |
Zhao F, Gao Z, Jiao W, Chen L, Chen L and Yao X: In vitro anti-inflammatory effects of beta-carboline alkaloids, isolated from Picrasma quassioides, through inhibition of the iNOS pathway. Planta Med. 78:1906–1911. 2012.PubMed/NCBI View Article : Google Scholar | |
Wirtz S, Popp V, Kindermann M, Gerlach K, Weigmann B, Fichtner-Feigl S and Neurath MF: Chemically induced mouse models of acute and chronic intestinal inflammation. Nat Protoc. 12:1295–1309. 2017.PubMed/NCBI View Article : Google Scholar | |
Zhao W, He J, Zhang Y, Ito Y, Su Q and Sun W: Preparative isolation and purification of alkaloids from Picrasma quassioides (D. Don) Benn. By high-speed countercurrent chromatography. J Liq Chromatogr Relat Technol. 35:1597–1606. 2012.PubMed/NCBI View Article : Google Scholar | |
Liu P, Li H, Luan R, Huang G, Liu Y, Wang M, Chao Q, Wang L, Li D, Fan H, et al: Identification of β-carboline and canthinone alkaloids as anti-inflammatory agents but with different inhibitory profile on the expression of iNOS and COX-2 in lipopolysaccharide-activated RAW 264.7 macrophages. J Nat Med. 73:124–130. 2019.PubMed/NCBI View Article : Google Scholar | |
Fan H, Qi D, Yang M, Fang H, Liu K and Zhao F: In vitro and in vivo anti-inflammatory effects of 4-methoxy-5-hydroxycanthin-6-one, a natural alkaloid from Picrasma quassioides. Phytomedicine. 20:319–323. 2013.PubMed/NCBI View Article : Google Scholar | |
Zhao W, Yu J, Su Q, Liang J, Zhao L, Zhang Y and Sun W: Antihypertensive effects of extract from Picrasma quassioides (D. Don) Benn. In spontaneously hypertensive rats. J Ethnopharmacol. 145:187–192. 2013.PubMed/NCBI View Article : Google Scholar | |
Liu JF, Shao M, Zhai DW, Liu K and Wu LJ: Protective effect of 4-methoxy-5-hydroxycanthin-6-one, a natural alkaloid, on dextran sulfate sodium-induced rat colitis. Planta Med. 75:142–145. 2009.PubMed/NCBI View Article : Google Scholar | |
Noldin VF, de Oliveira Martins DT, Marcello CM, da Silva Lima JC, Delle Monache F and Cechinel Filho V: Phytochemical and antiulcerogenic properties of rhizomes from Simaba ferruginea St. Hill. (Simaroubaceae). Z Naturforsch C J Biosci. 60:701–706. 2005.PubMed/NCBI View Article : Google Scholar | |
de Souza Almeida ES, Filho VC, Niero R, Clasen BK, Balogun SO and de Oliveira Martins DT: Pharmacological mechanisms underlying the anti-ulcer activity of methanol extract and canthin-6-one of Simaba ferruginea A. St-Hil. in animal models. J Ethnopharmacol. 134:630–636. 2011.PubMed/NCBI View Article : Google Scholar | |
Sasaki T, Li W, Higai K and Koike K: Canthinone alkaloids are novel protein tyrosine phosphatase 1B inhibitors. Bioorg Med Chem Lett. 25:1979–1981. 2015.PubMed/NCBI View Article : Google Scholar | |
Ono H: Molecular mechanisms of hypothalamic insulin resistance. Int J Mol Sci. 20(1317)2019.PubMed/NCBI View Article : Google Scholar | |
Legrand N, Bretscher CL, Zielke S, Wilke B, Daude M, Fritz B, Diederich WE and Adhikary T: PPARβ/δ recruits NCOR and regulates transcription reinitiation of ANGPTL4. Nucleic Acids Res. 47:9573–9591. 2019.PubMed/NCBI View Article : Google Scholar | |
Jiao WH, Gao H, Li CY, Zhao F, Jiang RW, Wang Y, Zhou GX and Yao XS: Quassidines A-D, bis-beta-carboline alkaloids from the stems of Picrasma quassioides. J Nat Prod. 73:167–171. 2010.PubMed/NCBI View Article : Google Scholar | |
Zhao S, Kanno Y, Li W, Sasaki T, Zhang X, Wang J, Cheng M, Koike K, Nemoto K and Li H: Identification of picrasidine C as a subtype-selective PPARα agonist. J Nat Prod. 79:3127–3133. 2016.PubMed/NCBI View Article : Google Scholar | |
Zhao S, Kanno Y, Li W, Wakatabi H, Sasaki T, Koike K, Nemoto K and Li H: Picrasidine N Is a subtype-selective PPARβ/δ agonist. J Nat Prod. 79:879–885. 2016.PubMed/NCBI View Article : Google Scholar | |
Chong HC, Chan JS, Goh CQ, Gounko NV, Luo B, Wang X, Foo S, Wong MT, Choong C, Kersten S and Tan NS: Angiopoietin-like 4 stimulates STAT3-mediated iNOS expression and enhances angiogenesis to accelerate wound healing in diabetic mice. Mol Ther. 22:1593–1604. 2014.PubMed/NCBI View Article : Google Scholar | |
Georgiadi A, Wang Y, Stienstra R, Tjeerdema N, Janssen A, Stalenhoef A, van der Vliet JA, de Roos A, Tamsma JT, Smit JW, et al: Overexpression of angiopoietin-like protein 4 protects against atherosclerosis development. Arterioscler Thromb Vasc Biol. 33:1529–1537. 2013.PubMed/NCBI View Article : Google Scholar | |
Zhao F, Chen L, Bi C, Zhang M, Jiao W and Yao X: In vitro anti-inflammatory effect of picrasmalignan A by the inhibition of iNOS and COX-2 expression in LPS-activated macrophage RAW 264.7 cells. Mol Med Rep. 8:1575–1579. 2013.PubMed/NCBI View Article : Google Scholar | |
Jemal A, Center MM, DeSantis C and Ward EM: Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev. 19:1893–1907. 2010.PubMed/NCBI View Article : Google Scholar | |
Subramani R, Nandy SB, Pedroza DA and Lakshmanaswamy R: Role of growth hormone in breast cancer. Endocrinology. 158:1543–1555. 2017.PubMed/NCBI View Article : Google Scholar | |
Takano T: Natural history of thyroid cancer (Review). Endocr J. 64:237–244. 2017.PubMed/NCBI View Article : Google Scholar | |
Pramesh CS, Mistry RC and Laskar SG: Neoadjuvant chemoradiotherapy in resectable oesophageal cancer. Lancet Oncol. 6:824–826. 2005. | |
Siddiqui NS, Godara A, Byrne MM and Saif MW: Capecitabine for the treatment of pancreatic cancer. Expert Opin Pharmacother. 20:399–409. 2019.PubMed/NCBI View Article : Google Scholar | |
Suroowan S and Mahomoodally MF: Herbal medicine of the 21st century: A focus on the chemistry, pharmacokinetics and toxicity of five widely advocated phytotherapies. Curr Top Med Chem. 19:2718–2738. 2019.PubMed/NCBI View Article : Google Scholar | |
Sun Y, Xun K, Wang Y and Chen X: A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs. Anticancer Drugs. 20:757–769. 2009.PubMed/NCBI View Article : Google Scholar | |
Sun W, Yu J, Gao H, Wu X, Wang S, Hou Y, Lu JJ and Chen X: Inhibition of lung cancer by 2-Methoxy-6-Acetyl-7-methyljuglone through induction of necroptosis by targeting receptor-interacting protein 1. Antioxid Redox Signal. 31:93–108. 2019.PubMed/NCBI View Article : Google Scholar | |
Wang Q, Mo J, Zhao C, Huang K, Feng M, He W, Wang J, Chen S, Xie Z, Ma J and Fan S: Raddeanin A suppresses breast cancer-associated osteolysis through inhibiting osteoclasts and breast cancer cells. Cell Death Dis. 9(376)2018.PubMed/NCBI View Article : Google Scholar | |
Zang M, Hu L, Zhang B, Zhu Z, Li J, Zhu Z, Yan M and Liu B: Luteolin suppresses angiogenesis and vasculogenic mimicry formation through inhibiting notch1-VEGF signaling in gastric cancer. Biochem Biophys Res Commun. 490:913–919. 2017.PubMed/NCBI View Article : Google Scholar | |
Yang S, Li X, Dou H, Hu Y, Che C and Xu D: Sesamin induces A549 cell mitophagy and mitochondrial apoptosis via a reactive oxygen species-mediated reduction in mitochondrial membrane potential. Korean J Physiol Pharmacol. 24:223–232. 2020.PubMed/NCBI View Article : Google Scholar | |
Ni Y, Zhang H and Li Z and Li Z: Connective tissue growth factor (CCN2) inhibits TNF-α-induced apoptosis by enhancing autophagy through the Akt and Erk pathways in osteoblasts. Pharmazie. 75:213–217. 2020.PubMed/NCBI View Article : Google Scholar | |
Wang HF, Wang ZQ, Ding Y, Piao MH, Feng CS, Chi GF, Luo YN and Ge PF: Endoplasmic reticulum stress regulates oxygen-glucose deprivation-induced parthanatos in human SH-SY5Y cells via improvement of intracellular ROS. CNS Neurosci Ther. 24:29–38. 2018.PubMed/NCBI View Article : Google Scholar | |
Matt S and Hofmann TG: The DNA damage-induced cell death response: A roadmap to kill cancer cells. Cell Mol Life Sci. 73:2829–2850. 2016.PubMed/NCBI View Article : Google Scholar | |
Liao NC, Shih YL, Chou JS, Chen KW, Chen YL, Lee MH, Peng SF, Leu SJ and Chung JG: Cardamonin induces cell cycle arrest, apoptosis and alters apoptosis associated gene expression in WEHI-3 mouse leukemia cells. Am J Chin Med. 47:635–656. 2019.PubMed/NCBI View Article : Google Scholar | |
Sun Y, Liu WZ, Liu T, Feng X, Yang N and Zhou HF: Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis. J Recept Signal Transduct Res. 35:600–604. 2015.PubMed/NCBI View Article : Google Scholar | |
Su D, Zhou Y, Hu S, Guan L, Shi C, Wang Q, Chen Y, Lu C, Li Q and Ma X: Role of GAB1/PI3K/AKT signaling high glucose-induced cardiomyocyte apoptosis. Biomed Pharmacother. 93:1197–1204. 2017.PubMed/NCBI View Article : Google Scholar | |
Yang X, Tang S, Li D, Yu X, Wang F and Xiao X: DIDS inhibits overexpression BAK1-induced mitochondrial apoptosis through GSK3β/β-catenin signaling pathway. J Cell Physiol. 233:5070–5077. 2018.PubMed/NCBI View Article : Google Scholar | |
Lee HE, Choi ES, Shin JA, Kim LH, Cho NP and Cho SD: Apoptotic effect of methanol extract of Picrasma quassioides by regulating specificity protein 1 in human cervical cancer cells. Cell Biochem Funct. 32:229–235. 2014.PubMed/NCBI View Article : Google Scholar | |
Gong YX, Liu Y, Jin YH, Jin MH, Han YH, Li J, Shen GN, Xie DP, Ren CX, Yu LY, et al: Picrasma quassioides extract elevates the cervical cancer cell apoptosis through ROS-mitochondrial axis activated p38 MAPK signaling pathway. In Vivo. 34:1823–1833. 2020.PubMed/NCBI View Article : Google Scholar | |
Xie DP, Gong YX, Jin YH, Ren CX, Liu Y, Han YH, Jin MH, Zhu D, Pan QZ, Yu LY, et al: Anti-tumor properties of Picrasma quassioides extracts in H-RasG12V liver cancer are mediated through ROS-dependent mitochondrial dysfunction. Anticancer Res. 40:3819–3830. 2020.PubMed/NCBI View Article : Google Scholar | |
Xiao X, Si X, Tong X and Li G: Ultrasonic microwave-assisted extraction coupled with high-speed counter-current chromatography for the preparation of nigakinones from Picrasma quassioides (D. Don) Benn. Phytochem Anal. 23:540–546. 2012.PubMed/NCBI View Article : Google Scholar | |
Kwon HS, Lee H, Lee JS, Lee K, Choi JH and Jang DS: Two new β-carboline alkaloids from the stems of Picrasma quassioides. Arch Pharm Res. 41:513–518. 2018.PubMed/NCBI View Article : Google Scholar | |
Lai ZQ, Liu WH, Ip SP, Liao HJ, Yi YY, Qin Z, Lai XP, Su ZR and Lin ZX: Seven alkaloids from Picrasma quassioides and their cytotoxic activities. Chem Nat Compd. 50:884–888. 2014. | |
Kuo PC, Shi LS, Damu AG, Su CR, Huang CH, Ke CH, Wu JB, Lin AJ, Bastow KF, Lee KH and Wu TS: Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia. J Nat Prod. 66:1324–1327. 2003.PubMed/NCBI View Article : Google Scholar | |
Jiang MX and Zhou YJ: Canthin-6-one alkaloids from Picrasma quassioides and their cytotoxic activity. J Asian Nat Prod Res. 10:1009–1012. 2008.PubMed/NCBI View Article : Google Scholar | |
Daoud A, Song J, Xiao F and Shang J: B-9-3, a novel β-carboline derivative exhibits anti-cancer activity via induction of apoptosis and inhibition of cell migration in vitro. Eur J Pharmacol. 724:219–230. 2014.PubMed/NCBI View Article : Google Scholar | |
Jiao WH, Chen GD, Gao H, Li J, Gu BB, Xu TT, Yu HB, Shi GH, Yang F, Yao XS and Lin HW: (±)-Quassidines I and J, two pairs of cytotoxic bis-β-carboline alkaloid enantiomers from Picrasma quassioides. J Nat Prod. 78:125–130. 2015.PubMed/NCBI View Article : Google Scholar | |
Yamashita N, Kondo M, Zhao S, Li W, Koike K, Nemoto K and Kanno Y: Picrasidine G decreases viability of MDA-MB 468 EGFR-overexpressing triple-negative breast cancer cells through inhibition of EGFR/STAT3 signaling pathway. Bioorg Med Chem Lett. 27:2608–2612. 2017.PubMed/NCBI View Article : Google Scholar | |
Zhao WY, Chen JJ, Zou CX, Zhang YY, Yao GD, Wang XB, Huang XX, Lin B and Song SJ: New tirucallane triterpenoids from Picrasma quassioides with their potential antiproliferative activities on hepatoma cells. Bioorg Chem. 84:309–318. 2019.PubMed/NCBI View Article : Google Scholar | |
Guo E, Hu Y, Du T, Zhu H, Chen L, Qu W, Zhang J, Xie N, Liu W, Feng F and Xu J: Effects of Picrasma quassioides and its active constituents on Alzheimer's disease in vitro and in vivo. Bioorg Chem. 92(103258)2019.PubMed/NCBI View Article : Google Scholar | |
Koe BK and Lebel LA: Contrasting effects of ethyl beta-carboline-3-carboxylate (beta CCE) and diazepam on cerebellar cyclic GMP content and antagonism of both effects by Ro 15-1788, a specific benzodiazepine receptor blocker. Eur J Pharmacol. 90:97–102. 1983.PubMed/NCBI View Article : Google Scholar | |
File SE and Lister RG: Interactions of ethyl-beta- carboline-3-carboxylate and Ro 15-1788 with CGS 8216 in an animal model of anxiety. Neurosci Lett. 39:91–94. 1983.PubMed/NCBI View Article : Google Scholar | |
Manzoor S and Hoda N: A comprehensive review of monoamine oxidase inhibitors as anti-Alzheimer's disease agents: A review. Eur J Med Chem. 206(112787)2020.PubMed/NCBI View Article : Google Scholar | |
Kumar MJ and Andersen JK: Perspectives on MAO-B in aging and neurological disease: Where do we go from here? Mol Neurobiol. 30:77–89. 2004.PubMed/NCBI View Article : Google Scholar | |
Singh A, Kukreti R, Saso L and Kukreti S: Oxidative stress: A key modulator in neurodegenerative diseases. Molecules. 24(1583)2019.PubMed/NCBI View Article : Google Scholar | |
Simpson DSA and Oliver PL: ROS generation in microglia: Understanding oxidative stress and inflammation in neurodegenerative disease. Antioxidants (Basel). 9(743)2020.PubMed/NCBI View Article : Google Scholar | |
Kerr JS, Adriaanse BA, Greig NH, Mattson MP, Cader MZ, Bohr VA and Fang EF: Mitophagy and Alzheimer's disease: Cellular and molecular mechanisms. Trends Neurosci. 40:151–166. 2017.PubMed/NCBI View Article : Google Scholar | |
Reniers J, Robert S, Frederick R, Masereel B, Vincent S and Wouters J: Synthesis and evaluation of β-carboline derivatives as potential monoamine oxidase inhibitors. Bioorg Med Chem. 19:134–144. 2011.PubMed/NCBI View Article : Google Scholar | |
Sasaki T, Li W, Ohmoto T and Koike K: Evaluation of canthinone alkaloids as cerebral protective agents. Bioorg Med Chem Lett. 26:4992–4995. 2016.PubMed/NCBI View Article : Google Scholar | |
Zhu C, Deng G and Lin C: Study on chemical constituents of Picrasma quassioides. Zhongguo Zhong Yao Za Zhi. 36:886–890. 2011.PubMed/NCBI(In Chinese). | |
Matsuzaki T, Fukamiya N, Okano M, Fujita T, Tagahara K and Lee KH: Picrasinoside H, a new quassinoid glucoside, and related compounds from the stem wood of Picrasma ailanthoides. J Nat Prod. 54:844–848. 1991.PubMed/NCBI View Article : Google Scholar | |
He C, Wang Y, Yang T, Wang H, Liao H and Liang D: Quassinoids with insecticidal activity against diaphorina citri kuwayama and neuroprotective activities from Picrasma quassioides. J Agric Food Chem. 68:117–127. 2020.PubMed/NCBI View Article : Google Scholar | |
Houël E, Stien D, Bourdy G and Deharo E: Quassinoids: anticancer and antimalarial activities. In: Natural Products: Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes. Ramawat KG and Mérillon JM (eds). Berlin, Heidelberg: Springer Berlin Heidelberg, pp3775-3802, 2013. | |
Houël E, Bertani S, Bourdy G, Deharo E, Jullian V, Valentin A, Chevalley S and Stien D: Quassinoid constituents of Quassia amara L. leaf herbal tea. Impact on its antimalarial activity and cytotoxicity. J Ethnopharmacol. 126:114–118. 2009.PubMed/NCBI View Article : Google Scholar | |
Niiho Y, Mitsunaga K, Koike K and Ohmoto T: Studies on the gastric antiulcer components from the woods of Picrasma quassioides (simaroubaceae). Nat Med. 48:116–121. 1994. | |
Teja Sri K, Bhargavi S, Ushasri S, Amareswara Reddy B and Geethika Priscilla M: Antiulcer herbal drugs-A compilation. Int J Uni Pharm Bio Sci. 2:285–297. 2013. | |
Huang X, Su Z, Shen X, Tang Q, Xie Y, Liu Z and Lai X: Determination of andrographolides and alkaloids in Xiaoyanlidan tablets by RP-HPLC. Chin Tradit Pat Med. 6:451–454. 2003. | |
Yang N, Xiong A, Wang R, Yang L and Wang Z: Quality evaluation of traditional Chinese medicine compounds in Xiaoyan Lidan tablets: Fingerprint and quantitative analysis using UPLC-MS. Molecules. 21(83)2016.PubMed/NCBI View Article : Google Scholar | |
Renliu X: TLC identification and determination of deoxyandrographolide of compound kumuxiaoyan tablets. Chin Tradit Pat Med, 1992. | |
Saiin C, Rattanajak R, Kamchonwongpaisan S, Ingkaninan K, Sukontason K, Baramee A and Sirithunyalug B: Isolation and in vitro antimalarial activity of hexane extract from Thai Picrasma javanica B1 stembark. Southeast Asian J Trop Med Public Health. 34 (Suppl 2):S51–S55. 2003.PubMed/NCBI | |
Rahman S, Fukamiya N, Okano M, Tagahara K and Lee KH: Anti-tuberculosis activity of quassinoids. Chem Pharm Bull (Tokyo). 45:1527–1529. 1997.PubMed/NCBI View Article : Google Scholar | |
Ohmoto T, Nikaido T, Koike K, Kohda K and Sankawa U: Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase by alkaloids. II. Chem Pharm Bull (Tokyo). 36:4588–4592. 1988.PubMed/NCBI View Article : Google Scholar | |
Zhao L, Zhao Y, Guo L and Zhang L: Pharmacokinetic and bioavailability study of 5-hydroxy-4-methoxycanthin-6-one, a typical canthinone alkaloid, in rats using ultra-high performance liquid chromatography/electrospray ionization tandem mass spectrometry. Biomed Chromatogr. 34(e4830)2020.PubMed/NCBI View Article : Google Scholar | |
Xuan YH and Jin Y, Row KH and Jin Y: Antioxidant and anticancer activities of extracts from Picrasma quassioides (D. Don) Benn. Asian J Chem. 22:7219–7226. 2010. |