A rare complication of uterine leiomyomata: Severe haemoperitoneum caused by the rupture of an overlying subserosa variceal vein: A case report

Popovici,Razvan; Pristavu,Anda; Andronic,Dan-Constantin; Zan,Paula; Riey,Benedicte; Mara,Murarasu; Mogos,Raluca; Himiniuc,Loredana Maria; Grigore,Mihaela

doi:10.3892/etm.2021.10804

December-2021 Volume 22 Issue 6

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

December-2021 Volume 22 Issue 6

Full Size Image

Case Report

A rare complication of uterine leiomyomata: Severe haemoperitoneum caused by the rupture of an overlying subserosa variceal vein: A case report

Authors:
- Razvan Popovici
- Anda Pristavu
- Dan-Constantin Andronic
- Paula Zan
- Benedicte Riey
- Murarasu Mara
- Raluca Mogos
- Loredana Maria Himiniuc
- Mihaela Grigore
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynaecology, ‘Grigore T. Popa’, University of Medicine and Pharmacy, 700015 Iasi, Romania, Department of Surgery, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700015 Iasi, Romania, Department of Obstetrics and Gynaecology, ‘Cuza Voda’ Clinical Hospital of Obstetrics and Gynaecology, 700038 Iasi, Romania
Article Number: 1370
|
Published online on: September 27, 2021

https://doi.org/10.3892/etm.2021.10804
Expand metrics +

Abstract

The rupture of a subserosa variceal vein overlying a uterine myoma is a rare complication and a less common cause of gynecologic haemoperitoneum. The literature data are scarce regarding this condition and less than 100 cases have been reported (including those occurring during pregnancy). The present case is of a 48‑year‑old woman, with a history of asymptomatic uterine myoma, who was hospitalised for severe abdominal pain with sudden onset and signs of hypovolemic shock. The emergency conventional imaging exams confirmed the diagnosis of uterine myoma and haemoperitoneum, but did not reveal the source of bleeding. The cause of haemoperitoneum was detected by means of emergency laparotomy. In order to obtain quick hemostasis, in the settings of a rapid deteriorating hypovolemic shock, a supracervical hysterectomy was performed. The aim of the article is to raise awareness to gynecologists regarding this extremely rare life‑threatening complication of the most common benign tumor of the uterus.

View Figures

View References

1	Buttery BW: Spontaneous haemoperitoneum complicating uterine fibromyoma. Aust N Z J Obstet Gynaecol. 12:210–213. 1972.PubMed/NCBI View Article : Google Scholar
2	Porpora MG, Musacchio L, Piacenti I, D'Alessandris N, Pecorini F, Iafrate F and Benedetti Panici P: Massive haemoperitoneum caused by uterine leiomyoma: A case report. J Obstet Gynaecol. 40:735–736. 2020.PubMed/NCBI View Article : Google Scholar
3	Saidi F, Constable JD and Ulfelder H: Massive intraperitoneal hemorrhage due to uterine fibroids. Am J Obstet Gynecol. 82:367–374. 1961.PubMed/NCBI
4	Akahira J, Ito K, Nakamura R and Yajima A: Massive intraperitoneal hemorrhage and hypovolemic shock due to rupture of a coronary vessel of a uterine leiomyoma: A report of two cases. Tohoku J Exp Med. 185:217–222. 1998.PubMed/NCBI View Article : Google Scholar
5	Jain P, Pradhan P, Cietak KA and Anyanwu L: Acute abdomen following spontaneous variceal rupture overlying uterine leiomyoma. J Obstet Gynaecol. 24(589)2004.PubMed/NCBI View Article : Google Scholar
6	Jenayah AA, Saoudi S, Sferi N, Skander R, Marzouk SB, Cherni A, Sfar E, Chelli D and Boudaya F: Spontaneous subserosal venous rupture overlying a uterine leiomyoma in a young woman. Pan Afr Med J. 28(205)2017.PubMed/NCBI View Article : Google Scholar
7	Ihama Y, Miyazaki T and Fuke C: Hemoperitoneum due to rupture of a subserosal vein overlying a uterine leiomyoma. Am J Forensic Med Pathol. 29:177–180. 2008.PubMed/NCBI View Article : Google Scholar
8	Althobaiti FA, Alsaadi KK and Althobaiti AA: A case of hemoperitoneum due to spontaneous bleeding from a uterine leiomyoma. Am J Case Rep. 20:167–170. 2019.PubMed/NCBI View Article : Google Scholar
9	Rokhgireh S, Kashi AM, Kermansaravi M, Tajbakhsh B, Allahqoli L, Alkatout I and Khodaverdi S: Hemoperitoneum due to bleeding from a vein overlying a subserous uterine myoma: A case report. J Med Case Rep. 14(55)2020.PubMed/NCBI View Article : Google Scholar
10	Elkbuli A, Shaikh S, McKenney M and Boneva D: Life-threatening hemoperitoneum secondary to rupture of a uterine leiomyoma: A case report and review of the literature. Int J Surg Case Rep. 61:51–55. 2019.PubMed/NCBI View Article : Google Scholar
11	Dasari P and Maurya DK: Hemoperitoneum associated with fibroid uterus. J Obstet Gynecol India. 55:553–554. 2005.
12	Sneha S, Munikrishna M and Sheela SR: A rare case of hemoperitoneum due to rupture of vessels over the surface of leiomyoma. J Clin Biomed Sci. 9:23–24. 2019.
13	Aydin C, Şen Selim H, Eriş S and Yalçin Y: Haemoperitoneum: An extremely rare complication of leiomyoma. J Obstet Gynaecol. 35:109–110. 2015.PubMed/NCBI View Article : Google Scholar
14	Horowitz E, Dekel A, Feldberg D and Rabinerson D: Massive hemoperitoneum due to rupture of an artery overlying a uterine leiomyoma: A case report. Acta Obstet Gynecol Scand. 84:408–409. 2005.PubMed/NCBI View Article : Google Scholar
15	Tang A, Rao S and Cawdell G: Massive intra-abdominal haemorrhage due to spontaneous bleeding from fibroids in a post-menopausal woman. J Obstet Gynaecol. 28:244–245. 2008.PubMed/NCBI View Article : Google Scholar
16	Dahan MH and Ahmadi R: Spontaneous subserosal venous rupture overlying a uterine leiomyoma. A case report. J Rep Med. 47:419–420. 2002.PubMed/NCBI
17	Kassegne I, Kolani K, Tchangai B, Kanassoua K, Adabra K, Alassani F, Amavi AK and Dosseh EDJ: Myomectomies for massive hemoperitoneum from spontaneous bleeding of a uterine myoma. J Surg Case Rep. 2017(rjx127)2017.PubMed/NCBI View Article : Google Scholar