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Article

Zinc status, insulin resistance and glycoxidative stress in elderly subjects with type 2 diabetes mellitus

  • Authors:
    • Daniela Grădinaru
    • Denisa Margină
    • Anca Ungurianu
    • Georgiana Nițulescu
    • Cătălina Monica Pena
    • Constantin Ionescu‑Tîrgoviște
    • Rucsandra Dănciulescu Miulescu
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Faculty of Pharmacy, ‘Carol Davila’ University of Medicine and Pharmacy, 020956 Bucharest, Romania, Department of Pharmaceutical Technology, Faculty of Pharmacy, ‘Carol Davila’ University of Medicine and Pharmacy, 020956 Bucharest, Romania, Biology of Aging Department, ‘Ana Aslan’ National Institute of Gerontology and Geriatrics, 011241 Bucharest, Romania, Clinical Department, ‘Nicolae Paulescu’ Institute of Diabetes, Metabolic and Nutrition Diseases, 020475 Bucharest, Romania
  • Article Number: 1393
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    Published online on: September 30, 2021
       https://doi.org/10.3892/etm.2021.10829
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Abstract

Zinc deficiencies have been reported in numerous pathologies, such as diabetes mellitus, but also in the physiological process of ageing. Similarly, the end products of glycoxidation processes, advanced glycation end products (AGEs), are damaging compounds, a myriad of reports linking them to the development and progression of several age‑associated chronic diseases. The aim of the present study was to analyze the relationships between zinc status, glycoxidative stress and insulin resistance (IR) in elderly subjects with type 2 diabetes mellitus (T2DM). A group of 52 non‑smoking subjects (9 men and 43 women, aged 65‑83 years) were enrolled in this cross‑sectional study: 27 patients with T2DM, and 25 apparently healthy control subjects. Serum zinc (Zn) levels were assessed using a commercial kit based on an end‑point colorimetric method, and serum AGEs were evaluated with a fluorimetric analytic procedure. The calculated glucose‑to‑zinc ratio (Gly/Zn), insulin‑to‑zinc ratio (Ins/Zn) and insulin‑zinc resistance index (HOMA‑IR/Zn) were further used to study the associations between serum Zn levels, secretory function of β‑pancreatic cells and AGEs. T2DM patients presented significantly higher serum insulin and Zn levels, as compared to the controls. We found a significant inverse correlation between Zn and AGEs, and a strong positive correlation between AGEs and the Gly/Zn ratio, suggesting that both Zn and AGEs are biomarkers that could reflect the persistence of hyperglycemia. We identified new surrogate biomarkers useful for the assessment of glycemic control with great potential for the development of preventive and therapeutic strategies for elderly diabetics, based on the evaluation of serum Zn levels.
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1 

Mocchegiani E, Romeo J, Malavolta M, Costarelli L, Giacconi R, Diaz LE and Marcos A: Zinc: Dietary intake and impact of supplementation on immune function in elderly. Age (Dordr). 35:839–860. 2013.PubMed/NCBI View Article : Google Scholar

2 

Maret W: Zinc in pancreatic islet biology, insulin sensitivity, and diabetes. Prev Nutr Food Sci. 22:1–8. 2017.PubMed/NCBI View Article : Google Scholar

3 

Huang Q, Du J, Merriman C and Gong Z: Genetic, functional, and immunological study of ZnT8 in diabetes. Int J Endocrinol. 2019(1524905)2019.PubMed/NCBI View Article : Google Scholar

4 

Giacconi R, Costarelli L, Piacenza F, Basso A, Rink L, Mariani E, Fulop T, Dedoussis G, Herbein G, Provinciali M, et al: Main biomarkers associated with age-related plasma zinc decrease and copper/zinc ratio in healthy elderly from ZincAge study. Eur J Nutr. 56:2457–2466. 2017.PubMed/NCBI View Article : Google Scholar

5 

Malavolta M, Piacenza F, Basso A, Giacconi R, Costarelli L and Mocchegiani E: Serum copper to zinc ratio: Relationship with aging and health status. Mech Ageing Dev. 151:93–100. 2015.PubMed/NCBI View Article : Google Scholar

6 

Giacconi R, Costarelli L, Piacenza F, Basso A, Burkle A, Moreno-Villanueva M, Grune T, Weber D, Stuetz W, Gonos ES, et al: Zinc-induced metallothionein in centenarian offspring from a large European population: The MARK-AGE Project. J Gerontol A Biol Sci Med Sci. 73:745–753. 2018.PubMed/NCBI View Article : Google Scholar

7 

Giacconi R, Cai L, Costarelli L, Cardelli M, Malavolta M, Piacenza F and Provinciali M: Implications of impaired zinc homeostasis in diabetic cardiomyopathy and nephropathy. Biofactors. 43:770–784. 2017.PubMed/NCBI View Article : Google Scholar

8 

Kloubert V and Rink L: Zinc as a micronutrient and its preventive role of oxidative damage in cells. Food Funct. 6:3195–3204. 2015.PubMed/NCBI View Article : Google Scholar

9 

Skalny AV, Rink L, Ajsuvakova OP, Aschner M, Gritsenko VA, Alekseenko SI, Svistunov AA, Petrakis D, Spandidos DA, Aaseth J, et al: Zinc and respiratory tract infections: Perspectives for COVID19 (Review). Int J Mol Med. 46:17–26. 2020.PubMed/NCBI View Article : Google Scholar

10 

Rios-Lugo MJ, Madrigal-Arellano C, Gaytán-Hernández D, Hernández-Mendoza H and Romero-Guzmán ET: Association of serum zinc levels in overweight and obesity. Biol Trace Elem Res. 198:51–57. 2020.PubMed/NCBI View Article : Google Scholar

11 

Rajaee E, Mowla K, Ghorbani A, Dargahi-Malamir M, Zarei M and Rahimikhah FA: The relationship between serum zinc levels and rheumatoid arthritis activity. Front Biol. 13:51–55. 2018.

12 

Choi S, Liu X and Pan Z: Zinc deficiency and cellular oxidative stress: Prognostic implications in cardiovascular diseases. Acta Pharmacol Sin. 39:1120–1132. 2018.PubMed/NCBI View Article : Google Scholar

13 

Farhood HB, Balas M, Gradinaru D, Margina D and Dinischiotu A: Hepatoprotective effects of chlorogenic acid under hyperglycemic conditions. Rom Biotechnol Lett. 24:301–307. 2019.

14 

Farhood HB, Balas MR, Gradinaru D, Margina D and Dinischiotu A: Effects of chlorogenic acid on the liver cell metabolism under high glucose conditions. Rom Biotechnol Lett. 24:883–892. 2019.

15 

Ungurianu A, Seremet O, Gradinaru D, Ionescu-Tirgoviste C, Margina D and Danciulescu Miulescu R: Spectrophotometric versus spectrofluorometric assessment in the study of the relationships between lipid peroxidation and metabolic dysregulation. Chem Biol Drug Des. 93:1026–1035. 2019.PubMed/NCBI View Article : Google Scholar

16 

Ungurianu A, Margina D, Gradinaru D, Bacanu C, Ilie M, Tsitsimpikou C, Tsarouhas K, Spandidos DA and Tsatsakis AM: Lipoprotein redox status evaluation as a marker of cardiovascular disease risk in patients with inflammatory disease. Mol Med Rep. 15:256–262. 2017.PubMed/NCBI View Article : Google Scholar

17 

Gradinaru D, Borsa C, Ionescu C and Margina D: Advanced oxidative and glycoxidative protein damage markers in the elderly with type 2 diabetes. J Proteomics. 92:313–322. 2013.PubMed/NCBI View Article : Google Scholar

18 

Margina D, Ilie M and Gradinaru D: Quercetin and epigallocatechin gallate induce in vitro a dose-dependent stiffening and hyperpolarizing effect on the cell membrane of human mononuclear blood cells. Int J Mol Sci. 13:4839–4859. 2012.PubMed/NCBI View Article : Google Scholar

19 

Gradinaru D, Margina D and Borsa C: In vitro studies regarding the antioxidant effects of procaine, Gerovital H3 and Aslavital. Rev Roum Chim. 54:761–766. 2009.

20 

Gradinaru D, Khaddour H, Margina D, Ungurianu A, Borsa C, Ionescu C, Prada GI, Usher J and Elshimali Y: Insulin-leptin axis, cardiometabolic risk and oxidative stress in elderly with metabolic syndrome. Exp Clin Endocrinol Diabetes: Feb 8, 2018. (Epub ahead of print). doi: 10.1055/s-0043-123825 2018.

21 

Gradinaru D, Margina D, Borsa C, Ionescu C, Ilie M, Costache M, Dinischiotu A and Prada GI: Adiponectin: Possible link between metabolic stress and oxidative stress in the elderly. Aging Clin Exp Res. 29:621–629. 2017.PubMed/NCBI View Article : Google Scholar

22 

Gradinaru D, Margina D, Ilie M, Borsa C, Ionescu C and Prada GI: Correlation between erythropoietin serum levels and erythrocyte susceptibility to lipid peroxidation in elderly with type 2 diabetes. Acta Physiol Hung. 102:400–408. 2015.PubMed/NCBI View Article : Google Scholar

23 

Borșa C, Gradinaru D, Margina D, Prada GI and Pena C: Receptor of advanced glycation end products and cardiovascular risk in elderly with type 2 diabetes mellitus. J Biol Res. 90:81–86. 2017.

24 

Margina D, Gradinaru D and Mitrea N: Development of a potentiometric method for the evaluation of redox status in human serum. Rev Roum Chim. 54:45–48. 2009.

25 

Zanfirescu A, Cristea AN, Nitulescu GM, Velescu BS and Gradinaru D: Chronic monosodium glutamate administration induced hyperalgesia in mice. Nutrients. 10(1)2017.PubMed/NCBI View Article : Google Scholar

26 

Zanfirescu A, Ungurianu A, Tsatsakis AM, Nitulescu GM, Kouretas D, Veskoukis A, Tsoukalas D, Engin AB, Aschner M and Margina D: A review of the alleged health hazards of monosodium glutamate. Compr Rev Food Sci Food Saf. 18:1111–1134. 2019.PubMed/NCBI View Article : Google Scholar

27 

Ungurianu A, Seremet O, Gagniuc E, Olaru OT, Gutu C, Gradinaru D, Ionescu-Tirgoviste C, Margina D and Danciulescu-Miulescu R: Preclinical and clinical results regarding the effects of a plant-based antidiabetic formulation versus well established antidiabetic molecules. Pharmacol Res. 150(104522)2019.PubMed/NCBI View Article : Google Scholar

28 

American Diabetes Association. Improving care and promoting health in populations: Standards of medical care in diabetes-2020. Diabetes Care. 43 (Suppl 1):S7–S13. 2020.PubMed/NCBI View Article : Google Scholar

29 

Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF and Turner RC: Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 28:412–419. 1985.PubMed/NCBI View Article : Google Scholar

30 

Skalnaya MG, Skalny AV and Tinkov AA: Serum copper, zinc, and iron levels, and markers of carbohydrate metabolism in postmenopausal women with prediabetes and type 2 diabetes mellitus. J Trace Elem Med Biol. 43:46–51. 2017.PubMed/NCBI View Article : Google Scholar

31 

Bandeira VDS, Pires LV, Hashimoto LL, Alencar LL, Almondes KGS, Lottenberg SA and Cozzolino SMF: Association of reduced zinc status with poor glycemic control in individuals with type 2 diabetes mellitus. J Trace Elem Med Biol. 44:132–136. 2017.PubMed/NCBI View Article : Google Scholar

32 

Sobczak AIS, Stefanowicz F, Pitt SJ, Ajjan RA and Stewart AJ: Total plasma magnesium, zinc, copper and selenium concentrations in type-I and type-II diabetes. Biometals. 32:123–138. 2019.PubMed/NCBI View Article : Google Scholar

33 

Farooq DM, Alamri AF, Alwhahabi BK, Metwally AM and Kareem KA: The status of zinc in type 2 diabetic patients and its association with glycemic control. J Family Community Med. 27:29–36. 2020.PubMed/NCBI View Article : Google Scholar

34 

Yin J, Hong X, Ma J, Bu Y and Liu R: Serum trace elements in patients with polycystic ovary syndrome: A systematic review and meta-analysis. Front Endocrinol (Lausanne). 11(572384)2020.PubMed/NCBI View Article : Google Scholar

35 

Pearsey HM, Henson J, Sargeant JA, Davies MJ, Khunti K, Suzuki T, Bowden-Davies KA, Cuthbertson DJ and Yates TE: Zinc-alpha2-glycoprotein, dysglycaemia and insulin resistance: A systematic review and meta-analysis. Rev Endocr Metab Disord. 21:569–575. 2020.PubMed/NCBI View Article : Google Scholar

36 

Capdor J, Foster M, Petocz P and Samman S: Zinc and glycemic control: A meta-analysis of randomised placebo controlled supplementation trials in humans. J Trace Elem Med Biol. 27:137–142. 2013.PubMed/NCBI View Article : Google Scholar

37 

Vashum KP, McEvoy M, Milton AH, Islam MR, Hancock S and Attia J: Is serum zinc associated with pancreatic beta cell function and insulin sensitivity in pre-diabetic and normal individuals? Findings from the Hunter Community Study. PLoS One. 9(e83944)2014.PubMed/NCBI View Article : Google Scholar

38 

Watada H and Tamura Y: Impaired insulin clearance as a cause rather than a consequence of insulin resistance. J Diabetes Investig. 8:723–725. 2017.PubMed/NCBI View Article : Google Scholar

39 

Kheirouri S, Alizadeh M and Maleki V: Zinc against advanced glycation end products. Clin Exp Pharmacol Physiol. 45:491–498. 2018.PubMed/NCBI View Article : Google Scholar

40 

Qu C, Zhou X, Yang G, Li L, Liu H and Liang Z: The natural logarithm of zinc-α2-glycoprotein/HOMA-IR is a better predictor of insulin sensitivity than the product of triglycerides and glucose and the other lipid ratios. Cytokine. 79:96–102. 2016.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Grădinaru D, Margină D, Ungurianu A, Nițulescu G, Pena CM, Ionescu‑Tîrgoviște C and Dănciulescu Miulescu R: Zinc status, insulin resistance and glycoxidative stress in elderly subjects with type 2 diabetes mellitus. Exp Ther Med 22: 1393, 2021.
APA
Grădinaru, D., Margină, D., Ungurianu, A., Nițulescu, G., Pena, C.M., Ionescu‑Tîrgoviște, C., & Dănciulescu Miulescu, R. (2021). Zinc status, insulin resistance and glycoxidative stress in elderly subjects with type 2 diabetes mellitus. Experimental and Therapeutic Medicine, 22, 1393. https://doi.org/10.3892/etm.2021.10829
MLA
Grădinaru, D., Margină, D., Ungurianu, A., Nițulescu, G., Pena, C. M., Ionescu‑Tîrgoviște, C., Dănciulescu Miulescu, R."Zinc status, insulin resistance and glycoxidative stress in elderly subjects with type 2 diabetes mellitus". Experimental and Therapeutic Medicine 22.6 (2021): 1393.
Chicago
Grădinaru, D., Margină, D., Ungurianu, A., Nițulescu, G., Pena, C. M., Ionescu‑Tîrgoviște, C., Dănciulescu Miulescu, R."Zinc status, insulin resistance and glycoxidative stress in elderly subjects with type 2 diabetes mellitus". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1393. https://doi.org/10.3892/etm.2021.10829
Copy and paste a formatted citation
x
Spandidos Publications style
Grădinaru D, Margină D, Ungurianu A, Nițulescu G, Pena CM, Ionescu‑Tîrgoviște C and Dănciulescu Miulescu R: Zinc status, insulin resistance and glycoxidative stress in elderly subjects with type 2 diabetes mellitus. Exp Ther Med 22: 1393, 2021.
APA
Grădinaru, D., Margină, D., Ungurianu, A., Nițulescu, G., Pena, C.M., Ionescu‑Tîrgoviște, C., & Dănciulescu Miulescu, R. (2021). Zinc status, insulin resistance and glycoxidative stress in elderly subjects with type 2 diabetes mellitus. Experimental and Therapeutic Medicine, 22, 1393. https://doi.org/10.3892/etm.2021.10829
MLA
Grădinaru, D., Margină, D., Ungurianu, A., Nițulescu, G., Pena, C. M., Ionescu‑Tîrgoviște, C., Dănciulescu Miulescu, R."Zinc status, insulin resistance and glycoxidative stress in elderly subjects with type 2 diabetes mellitus". Experimental and Therapeutic Medicine 22.6 (2021): 1393.
Chicago
Grădinaru, D., Margină, D., Ungurianu, A., Nițulescu, G., Pena, C. M., Ionescu‑Tîrgoviște, C., Dănciulescu Miulescu, R."Zinc status, insulin resistance and glycoxidative stress in elderly subjects with type 2 diabetes mellitus". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1393. https://doi.org/10.3892/etm.2021.10829
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