Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2021 Volume 22 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2021 Volume 22 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Tat‑thioredoxin 1 reduces inflammation by inhibiting pro‑inflammatory cytokines and modulating MAPK signaling

  • Authors:
    • Eun Ji Yeo
    • Min Jea Shin
    • Hyeon Ji Yeo
    • Yeon Joo Choi
    • Eun Jeong Sohn
    • Lee Re Lee
    • Hyun Jung Kwon
    • Hyun Ju Cha
    • Sung Ho Lee
    • Sunghou Lee
    • Yeon Hee Yu
    • Duk-Soo Kim
    • Dae Won Kim
    • Jinseu Park
    • Kyu Hyung Han
    • Won Sik Eum
    • Soo Young Choi
  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of Korea, Department of Biochemistry and Molecular Biology, Research Institute of Oral Sciences, College of Dentistry, Gangneung‑Wonju National University, Gangneung, Gangwon 25457, Republic of Korea, Department of Green Chemical Engineering, Sangmyung University, Cheonan, Chungcheongnam 31066, Republic of Korea, Department of Anatomy and BK21 FOUR Project, College of Medicine, Soonchunhyang University, Cheonan, Chungcheongnam 31538, Republic of Korea
  • Article Number: 1395
    |
    Published online on: October 1, 2021
       https://doi.org/10.3892/etm.2021.10831
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Thioredoxin 1 (Trx1) serves a central role in redox homeostasis. It is involved in numerous other processes, including oxidative stress and apoptosis. However, to the best of our knowledge, the role of Trx1 in inflammation remains to be explored. The present study investigated the function and mechanism of cell permeable fused Tat‑Trx1 protein in macrophages and a mouse model. Transduction levels of Tat‑Trx1 were determined via western blotting. Cellular distribution of transduced Tat‑Trx1 was determined by fluorescence microscopy. 2',7'‑Dichlorofluorescein diacetate and TUNEL staining were performed to determine the production of reactive oxygen species and DNA fragmentation. Protein and gene expression were measured by western blotting and reverse transcription‑quantitative PCR (RT‑qPCR), respectively. Effects of skin inflammation were determined using hematoxylin and eosin staining, changes in ear weight and ear thickness, and RT‑qPCR in ear edema animal models. Transduced Tat‑Trx1 inhibited lipopolysaccharide‑induced cytotoxicity and activation of NF‑κB, MAPK and Akt. Additionally, Tat‑Trx1 markedly reduced the production of inducible nitric oxide synthase, cyclooxygenase‑2, IL‑1β, IL‑6 and TNF‑α in macrophages. In a 12‑O‑tetradecanoylphorbol‑13‑acetate‑induced mouse model, Tat‑Trx1 reduced inflammatory damage by inhibiting inflammatory mediator and cytokine production. Collectively, these results demonstrated that Tat‑Trx1 could exert anti‑inflammatory effects by inhibiting the production of pro‑inflammatory mediators and cytokines and by modulating MAPK signaling. Therefore, Tat‑Trx1 may be a useful therapeutic agent for diseases induced by inflammatory damage.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Kolaczkowska E and Kubes P: Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol. 13:159–175. 2013.PubMed/NCBI View Article : Google Scholar

2 

Nathan C and Ding A: Nonresolving inflammation. Cell. 140:871–882. 2010.PubMed/NCBI View Article : Google Scholar

3 

Libby P, Ridker PM and Maseri A: Inflammation and atherosclerosis. Circulation. 105:1135–1143. 2002.PubMed/NCBI View Article : Google Scholar

4 

Straub RH and Schradin C: Chronic inflammatory systemic diseases: An evolutionary trade-off between acutely beneficial but chronically harmful programs. Evol Med Public Health. 2016:37–51. 2016.PubMed/NCBI View Article : Google Scholar

5 

Grivennikov SI, Greten FR and Karin M: Immunity, inflammation, and cancer. Cell. 140:883–899. 2010.PubMed/NCBI View Article : Google Scholar

6 

Corriveau CC and Danner RL: Endotoxin as a therapeutic target in septic shock. Infect Agents Dis. 2:35–43. 1993.PubMed/NCBI

7 

Won AN, Kim SA, Ahn JY, Han JH, Kim CH, Lee JH and Kim DI: HO-1 induction by Selaginella tamariscina extract inhibits inflammatory response in lipopolysacchraride-stimulated RAW 264.7 macrophages. Evid Complement Alternat Med. 2018(7816923)2018.PubMed/NCBI View Article : Google Scholar

8 

Fujihara M, Muroi M, Tanamoto K, Suzuki T, Azuma H and Ikeda H: Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: Roles of the receptor complex. Pharmacol Ther. 100:171–194. 2003.PubMed/NCBI View Article : Google Scholar

9 

Duffield JS: The inflammatory macrophage: A story of Jekyll and Hyde. Clin Sci (Lond). 104:27–38. 2003.PubMed/NCBI

10 

Korhonen R, Lahti A, Kankaanranta H and Moilanen E: Nitric oxide production and signaling in inflammation. Curr Drug Targets Inflamm Allergy. 4:471–479. 2005.PubMed/NCBI View Article : Google Scholar

11 

Luedde T and Schwabe RF: NF-κB in the liver - linking injury, fibrosis and hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol. 8:108–118. 2011.PubMed/NCBI View Article : Google Scholar

12 

Lee IT, Shih RH, Lin CC, Chen JT and Yang CM: Role of TLR4/NADPH oxidase/ROS-activated p38 MAPK in VCAM-1 expression induced by lipopolysaccharide in human renal mesangial cells. Cell Commun Signal. 10(33)2012.PubMed/NCBI View Article : Google Scholar

13 

Kim HJ, Lee HS, Chong YH and Kang JL: p38 Mitogen-activated protein kinase up-regulates LPS-induced NF-kappaB activation in the development of lung injury and RAW 264.7 macrophages. Toxicology. 225:36–47. 2006.PubMed/NCBI View Article : Google Scholar

14 

Zucoloto AZ, Manchope MF, Staurengo-Ferrari L, Pinho-Ribeiro FA, Zarpelon AC, Saraiva ALL, Cecílio NT, Alves-Filho JC, Cunha TM, Menezes GB, et al: Probucol attenuates lipopolysaccharide-induced leukocyte recruitment and inflammatory hyperalgesia: Effect on NF-кB activation and cytokine production. Eur J Pharmacol. 809:52–63. 2017.PubMed/NCBI View Article : Google Scholar

15 

Afonina IS, Zhong Z, Karin M and Beyaert R: Limiting inflammation-the negative regulation of NF-κB and the NLRP3 inflammasome. Nat Immunol. 18:861–869. 2017.PubMed/NCBI View Article : Google Scholar

16 

Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K and Cobb MH: Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions. Endocr Rev. 22:153–183. 2001.PubMed/NCBI View Article : Google Scholar

17 

Scherle PA, Jones EA, Favata MF, Daulerio AJ, Covington MB, Nurnberg SA, Magolda RL and Trzaskos JM: Inhibition of MAP kinase kinase prevents cytokine and prostaglandin E2 production in lipopolysaccharide-stimulated monocytes. J Immunol. 161:5681–5686. 1998.PubMed/NCBI

18 

Loftis JM, Choi D, Hoffman W and Huckans MS: Methamphetamine causes persistent immune dysregulation: A cross-species, translational report. Neurotox Res. 20:59–68. 2011.PubMed/NCBI View Article : Google Scholar

19 

Bai J, Nakamura H, Kwon YW, Tanito M, Ueda S, Tanaka T, Hattori I, Ban S, Momoi T, Kitao Y, et al: Does thioredoxin-1 prevent mitochondria- and endoplasmic reticulum-mediated neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine? Antioxid Redox Signal. 9:603–608. 2007.PubMed/NCBI View Article : Google Scholar

20 

Wu XL, Li X, Li Y, Kong LP, Fang JL, Zhou XS, Li M, Jia JJ and Bai J: The overexpression of Thioredoxin-1 suppressing inflammation induced by methamphetamine in spleen. Drug Alcohol Depend. 159:66–71. 2016.PubMed/NCBI View Article : Google Scholar

21 

Chen G, Li X, Huang M, Li M, Zhou X, Li Y and Bai J: Thioredoxin-1 increases survival in sepsis by inflammatory response through suppressing endoplasmic reticulum stress. Shock. 46:67–74. 2016.PubMed/NCBI View Article : Google Scholar

22 

Yeo HJ, Shin MJ, You JH, Kim JS, Kim MY, Kim DW, Kim DS, Eum WS and Choi SY: Transduced Tat-CIAPIN1 reduces the inflammatory response on LPS- and TPA-induced damages. BMB Rep. 52:695–699. 2019.PubMed/NCBI View Article : Google Scholar

23 

Youn GS, Park JK, Lee CY, Jang JH, Yun SH, Kwon HY, Choi SY and Park J: MicroRNA-22 negatively regulates LPS-induced inflammatory responses by targeting HDAC6 in macrophages. BMB Rep. 53:223–228. 2020.PubMed/NCBI View Article : Google Scholar

24 

Shin MJ, Kim DW, Choi YJ, Cha HJ, Lee SH, Park J, Han KH, Eum WS and Choi SY: PEP-1-GLRX1 protein exhibits anti-inflammatory effects by inhibiting the activation of MAPK and NF-κB pathways in Raw 264.7 cells. BMB Rep. 53:106–111. 2020.PubMed/NCBI View Article : Google Scholar

25 

Shin MJ, Kim DW, Lee YP, Ahn EH, Jo HS, Kim DS, Kwon OS, Kang TC, Cho YJ, Park J, et al: Tat-glyoxalase protein inhibits against ischemic neuronal cell damage and ameliorates ischemic injury. Free Radic Biol Med. 67:195–210. 2014.PubMed/NCBI View Article : Google Scholar

26 

Kim SJ, Shin MJ, Kim DW, Yeo HJ, Yeo EJ, Choi YJ, Sohn EJ, Han KH, Park J, Lee KW, et al: Tat-biliverdin reductase A exerts a protective role in oxidative stress-induced hippocampal neuronal cell damage by regulating the apoptosis and MAPK signaling. Int J Mol Sci. 21(2672)2020.PubMed/NCBI View Article : Google Scholar

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

28 

Stanley PL, Steiner S, Havens M and Tramposch KM: Mouse skin inflammation induced by multiple topical applications of 12-O-tetradecanoylphorbol-13-acetate. Skin Pharmacol. 4:262–271. 1991.PubMed/NCBI View Article : Google Scholar

29 

American Veterinary Medical Association: AVMA Guidelines for the Euthanasia of Animals: 2020 Edition. https://www.avma.org/KB/Policies/Documents/euthanasia.pdf. Accessed March 2020.

30 

Shou J, Kong X, Wang X, Tang Y, Wang C, Wang M, Zhang L, Liu Y, Fei C, Xue F, et al: Tizoxanide inhibits inflammation in LPS-activated RAW264.7 macrophages via the suppression of NF-κB and MAPK activation. Inflammation. 42:1336–1349. 2019.PubMed/NCBI View Article : Google Scholar

31 

Barton GM and Medzhitov R: Toll-like receptor signaling pathways. Science. 300:1524–1525. 2003.PubMed/NCBI View Article : Google Scholar

32 

Langford MP, McGee DJ, Ta KH, Redens TB and Texada DE: Multiple caspases mediate acute renal cell apoptosis induced by bacterial cell wall components. Ren Fail. 33:192–206. 2011.PubMed/NCBI View Article : Google Scholar

33 

Medzhitov R: Origin and physiological roles of inflammation. Nature. 454:428–435. 2008.PubMed/NCBI View Article : Google Scholar

34 

Tsaryk R, Peters K, Barth S, Unger RE, Scharnweber D and Kirkpatrick CJ: The role of oxidative stress in pro-inflammatory activation of human endothelial cells on Ti6Al4V alloy. Biomaterials. 34:8075–8085. 2013.PubMed/NCBI View Article : Google Scholar

35 

Ferrero-Miliani L, Nielsen OH, Andersen PS and Girardin SE: Chronic inflammation: Importance of NOD2 and NALP3 in interleukin-1beta generation. Clin Exp Immunol. 147:227–235. 2007.PubMed/NCBI View Article : Google Scholar

36 

Glass CK, Saijo K, Winner B, Marchetto MC and Gage FH: Mechanisms underlying inflammation in neurodegeneration. Cell. 140:918–934. 2010.PubMed/NCBI View Article : Google Scholar

37 

Booze ML, Hansen JM and Vitiello PF: A novel mouse model for the identification of thioredoxin-1 protein interactions. Free Radic Biol Med. 99:533–543. 2016.PubMed/NCBI View Article : Google Scholar

38 

Susanti D, Wong JH, Vensel WH, Loganathan U, DeSantis R, Schmitz RA, Balsera M, Buchanan BB and Mukhopadhyay B: Thioredoxin targets fundamental processes in a methane-producing archaeon, Methanocaldococcus jannaschii. Proc Natl Acad Sci USA. 111:2608–2613. 2014.PubMed/NCBI View Article : Google Scholar

39 

Nadeau PJ, Charette SJ, Toledano MB and Landry J: Disulfide Bond-mediated multimerization of Ask1 and its reduction by thioredoxin-1 regulate H(2)O(2)-induced c-Jun NH(2)-terminal kinase activation and apoptosis. Mol Biol Cell. 18:3903–3913. 2007.PubMed/NCBI View Article : Google Scholar

40 

Ueda S, Masutani H, Nakamura H, Tanaka T, Ueno M and Yodoi J: Redox control of cell death. Antioxid Redox Signal. 4:405–414. 2002.PubMed/NCBI View Article : Google Scholar

41 

Couchie D, Vaisman B, Abderrazak A, Mahmood DFD, Hamza MM, Canesi F, Diderot V, El Hadri K, Nègre-Salvayre A, Le Page A, et al: Human plasma thioredoxin-80 increases with age and in ApoE-/- mice induces inflammation, angiogenesis, and atherosclerosis. Circulation. 136:464–475. 2017.PubMed/NCBI View Article : Google Scholar

42 

Cerrato CP, Pirisinu M, Vlachos EN and Langel Ü: Novel cell-penetrating peptide targeting mitochondria. FASEB J. 29:4589–4599. 2015.PubMed/NCBI View Article : Google Scholar

43 

Moon JI, Han MJ, Yu SH, Lee EH, Kim SM, Han K, Park CH and Kim CH: Enhanced delivery of protein fused to cell penetrating peptides to mammalian cells. BMB Rep. 52:324–329. 2019.PubMed/NCBI View Article : Google Scholar

44 

Li Q, Hao X, Zaidi SSA, Guo J, Ren X, Shi C, Zhang W and Feng Y: Oligohistidine and targeting peptide functionalized TAT-NLS for enhancing cellular uptake and promoting angiogenesis in vivo. J Nanobiotechnology. 16(29)2018.PubMed/NCBI View Article : Google Scholar

45 

Wu H, You C, Chen F, Jiao J, Gao Z, An P, Sun B and Chen R: Enhanced cellular uptake of near-infrared triggered targeted nanoparticles by cell-penetrating peptide TAT for combined chemo/photothermal/photodynamic therapy. Mater Sci Eng C. 103(109738)2019.PubMed/NCBI View Article : Google Scholar

46 

Yue LH, Zhao YL, Chen J and Lu DR: Effect of fusion protein TAT and heme oxygenase-1 on liver sinusoidal endothelial cells apoptosis during preservation injury. Chin Med J (Engl). 123:68–73. 2010.PubMed/NCBI

47 

Kubo E, Fatma N, Akagi Y, Beier DR, Singh SP and Singh DP: TAT-mediated PRDX6 protein transduction protects against eye lens epithelial cell death and delays lens opacity. Am J Physiol Cell Physiol. 294:C842–C855. 2008.PubMed/NCBI View Article : Google Scholar

48 

Kim HR, Kim DW, Jo HS, Cho SB, Park JH, Lee CH, Choi YJ, Yeo EJ, Park SY, Kim ST, et al: Tat-biliverdin reductase A inhibits inflammatory response by regulation of MAPK and NF-κB pathways in Raw 264.7 cells and edema mouse model. Mol Immunol. 63:355–366. 2015.PubMed/NCBI View Article : Google Scholar

49 

Yeo HJ, Shin MJ, Yeo EJ, Choi YJ, Kim DW, Kim DS, Eum WS and Choi SY: Tat-CIAPIN1 inhibits hippocampal neuronal cell damage through the MAPK and apoptotic signaling pathways. Free Radic Biol Med. 135:68–78. 2019.PubMed/NCBI View Article : Google Scholar

50 

Eum WS, Shin MJ, Lee CH, Yeo HJ, Yeo EJ, Choi YJ, Kwon HJ, Kim DS, Kwon OS, Lee KW, et al: Neuroprotective effects of Tat-ATOX1 protein against MPP+-induced SH-SY5Y cell deaths and in MPTP-induced mouse model of Parkinson's disease. Biochimie. 156:158–168. 2019.PubMed/NCBI View Article : Google Scholar

51 

Takeuchi O and Akira S: Pattern recognition receptors and inflammation. Cell. 140:805–820. 2010.PubMed/NCBI View Article : Google Scholar

52 

Kim SM, Ha JS, Han AR, Cho SW and Yang SJ: Effects of α-lipoic acid on LPS-induced neuroinflammation and NLRP3 inflammasome activation through the regulation of BV-2 microglial cells activation. BMB Rep. 52:613–618. 2019.PubMed/NCBI View Article : Google Scholar

53 

Nishio K, Horie M, Akazawa Y, Shichiri M, Iwahashi H, Hagihara Y, Yoshida Y and Niki E: Attenuation of lipopolysaccharide (LPS)-induced cytotoxicity by tocopherols and tocotrienols. Redox Biol. 1:97–103. 2013.PubMed/NCBI View Article : Google Scholar

54 

Wang M, Zhu K, Zhang L, Li L and Zhao J: Thioredoxin 1 protects astrocytes from oxidative stress by maintaining peroxiredoxin activity. Mol Med Rep. 13:2864–2870. 2016.PubMed/NCBI View Article : Google Scholar

55 

Stosic-Grujicic S, Stojanovic I, Maksimovic-Ivanic D, Momcilovic M, Popadic D, Harhaji L, Miljkovic D, Metz C, Mangano K, Papaccio G, et al: Macrophage migration inhibitory factor (MIF) is necessary for progression of autoimmune diabetes mellitus. J Cell Physiol. 215:665–675. 2008.PubMed/NCBI View Article : Google Scholar

56 

Yamamoto M, Yamato E, Toyoda S, Tashiro F, Ikegami H, Yodoi J and Miyazaki J: Transgenic expression of antioxidant protein thioredoxin in pancreatic beta cells prevents progression of type 2 diabetes mellitus. Antioxid Redox Signal. 10:43–49. 2008.PubMed/NCBI View Article : Google Scholar

57 

Sharif O, Bolshakov VN, Raines S, Newham P and Perkins ND: Transcriptional profiling of the LPS induced NF-kappaB response in macrophages. BMC Immunol. 8(1)2007.PubMed/NCBI View Article : Google Scholar

58 

Gilmore TD: Introduction to NF-kappaB: Players, pathways, perspectives. Oncogene. 25:6680–6684. 2006.PubMed/NCBI View Article : Google Scholar

59 

Saccani S, Pantano S and Natoli G: p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment. Nat Immunol. 3:69–75. 2002.PubMed/NCBI View Article : Google Scholar

60 

Zhang W and Liu HT: MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res. 12:9–18. 2002.PubMed/NCBI View Article : Google Scholar

61 

Liu HT, Du YG, He JL, Chen WJ, Li WM, Yang Z, Wang YX and Yu C: Tetramethylpyrazine inhibits production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through blockade of MAPK and PI3K/Akt signaling pathways, and suppression of intracellular reactive oxygen species. J Ethnopharmacol. 129:335–343. 2010.PubMed/NCBI View Article : Google Scholar

62 

Bald T, Landsberg J, Jansen P, Gaffal E and Tüting T: Phorbol ester-induced neutrophilic inflammatory responses selectively promote metastatic spread of melanoma in a TLR4-dependent manner. OncoImmunology. 5(e1078964)2015.PubMed/NCBI View Article : Google Scholar

63 

Kuo DH, Lai YS, Lo CY, Cheng AC, Wu H and Pan MH: Inhibitory effect of magnolol on TPA-induced skin inflammation and tumor promotion in mice. J Agric Food Chem. 58:5777–5783. 2010.PubMed/NCBI View Article : Google Scholar

64 

Kim MJ, Kim DW, Park JH, Kim SJ, Lee CH, Yong JI, Ryu EJ, Cho SB, Yeo HJ, Hyeon J, et al: PEP-1-SIRT2 inhibits inflammatory response and oxidative stress-induced cell death via expression of antioxidant enzymes in murine macrophages. Free Radic Biol Med. 63:432–445. 2013.PubMed/NCBI View Article : Google Scholar

65 

Sun J, Zhao Y, Jin H and Hu J: Curcumin relieves TPA-induced Th1 inflammation in K14-VEGF transgenic mice. Int Immunopharmacol. 25:235–241. 2015.PubMed/NCBI View Article : Google Scholar

66 

Lee DY, Choo BK, Yoon T, Cheon MS, Lee HW, Lee AY and Kim HK: Anti-inflammatory effects of Asparagus cochinchinensis extract in acute and chronic cutaneous inflammation. J Ethnopharmacol. 121:28–34. 2009.PubMed/NCBI View Article : Google Scholar

67 

Murakawa M, Yamaoka K, Tanaka Y and Fukuda Y: Involvement of tumor necrosis factor (TNF)-alpha in phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin edema in mice. Biochem Pharmacol. 71:1331–1336. 2006.PubMed/NCBI View Article : Google Scholar

68 

Song HY, Lee JA, Ju SM, Yoo KY, Won MH, Kwon HJ, Eum WS, Jang SH, Choi SY and Park J: Topical transduction of superoxide dismutase mediated by HIV-1 Tat protein transduction domain ameliorates 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. Biochem Pharmacol. 75:1348–1357. 2008.PubMed/NCBI View Article : Google Scholar

69 

Xian YF, Hu Z, Ip SP, Chen JN, Su ZR, Lai XP and Lin ZX: Comparison of the anti-inflammatory effects of Sinapis alba and Brassica juncea in mouse models of inflammation. Phytomedicine. 50:196–204. 2018.PubMed/NCBI View Article : Google Scholar

70 

Kundu JK, Shin YK and Surh YJ: Resveratrol modulates phorbol ester-induced pro-inflammatory signal transduction pathways in mouse skin in vivo: NF-kappaB and AP-1 as prime targets. Biochem Pharmacol. 72:1506–1515. 2006.PubMed/NCBI View Article : Google Scholar

71 

Xian YF, Mao QQ, Ip SP, Lin ZX and Che CT: Comparison on the anti-inflammatory effect of Cortex Phellodendri Chinensis and Cortex Phellodendri Amurensis in 12-O-tetradecanoyl-phorbol-13-acetate-induced ear edema in mice. J Ethnopharmacol. 137:1425–1430. 2011.PubMed/NCBI View Article : Google Scholar

72 

He XY, Liu QC, Peng W, Huang YL and Wu CJ: Bioactivities and serum pharmacochemistry of Qi-Wei-Xiao-Yan-Tang. Pharm Biol. 51:629–634. 2013.PubMed/NCBI View Article : Google Scholar

73 

Chang SN, Khan I, Dey DK, Cho KH, Hwang BS, Bae KB, Kang SC and Park JG: Decursinol angelate ameliorates 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced NF-κB activation on mice ears by inhibiting exaggerated inflammatory cell infiltration, oxidative stress and pro-inflammatory cytokine production. Food Chem Toxicol. 132(110699)2019.PubMed/NCBI View Article : Google Scholar

74 

Xu XT, Mou XQ, Xi QM, Liu WT, Liu WF, Sheng ZJ, Zheng X, Zhang K, Du ZY, Zhao SQ, et al: Anti-inflammatory activity effect of 2-substituted-1,4,5,6-tetrahydrocyclopenta[b]pyrrole on TPA-induced skin inflammation in mice. Bioorg Med Chem Lett. 26:5334–5339. 2016.PubMed/NCBI View Article : Google Scholar

75 

Wu JY, Chen YJ, Bai L, Liu YX, Fu XQ, Zhu PL, Li JK, Chou JY, Yin CL, Wang YP, et al: Chrysoeriol ameliorates TPA-induced acute skin inflammation in mice and inhibits NF-κB and STAT3 pathways. Phytomedicine. 68(153173)2020.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yeo EJ, Shin MJ, Yeo HJ, Choi YJ, Sohn EJ, Lee LR, Kwon HJ, Cha HJ, Lee SH, Lee S, Lee S, et al: Tat‑thioredoxin 1 reduces inflammation by inhibiting pro‑inflammatory cytokines and modulating MAPK signaling. Exp Ther Med 22: 1395, 2021.
APA
Yeo, E.J., Shin, M.J., Yeo, H.J., Choi, Y.J., Sohn, E.J., Lee, L.R. ... Choi, S.Y. (2021). Tat‑thioredoxin 1 reduces inflammation by inhibiting pro‑inflammatory cytokines and modulating MAPK signaling. Experimental and Therapeutic Medicine, 22, 1395. https://doi.org/10.3892/etm.2021.10831
MLA
Yeo, E. J., Shin, M. J., Yeo, H. J., Choi, Y. J., Sohn, E. J., Lee, L. R., Kwon, H. J., Cha, H. J., Lee, S. H., Lee, S., Yu, Y. H., Kim, D., Kim, D. W., Park, J., Han, K. H., Eum, W. S., Choi, S. Y."Tat‑thioredoxin 1 reduces inflammation by inhibiting pro‑inflammatory cytokines and modulating MAPK signaling". Experimental and Therapeutic Medicine 22.6 (2021): 1395.
Chicago
Yeo, E. J., Shin, M. J., Yeo, H. J., Choi, Y. J., Sohn, E. J., Lee, L. R., Kwon, H. J., Cha, H. J., Lee, S. H., Lee, S., Yu, Y. H., Kim, D., Kim, D. W., Park, J., Han, K. H., Eum, W. S., Choi, S. Y."Tat‑thioredoxin 1 reduces inflammation by inhibiting pro‑inflammatory cytokines and modulating MAPK signaling". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1395. https://doi.org/10.3892/etm.2021.10831
Copy and paste a formatted citation
x
Spandidos Publications style
Yeo EJ, Shin MJ, Yeo HJ, Choi YJ, Sohn EJ, Lee LR, Kwon HJ, Cha HJ, Lee SH, Lee S, Lee S, et al: Tat‑thioredoxin 1 reduces inflammation by inhibiting pro‑inflammatory cytokines and modulating MAPK signaling. Exp Ther Med 22: 1395, 2021.
APA
Yeo, E.J., Shin, M.J., Yeo, H.J., Choi, Y.J., Sohn, E.J., Lee, L.R. ... Choi, S.Y. (2021). Tat‑thioredoxin 1 reduces inflammation by inhibiting pro‑inflammatory cytokines and modulating MAPK signaling. Experimental and Therapeutic Medicine, 22, 1395. https://doi.org/10.3892/etm.2021.10831
MLA
Yeo, E. J., Shin, M. J., Yeo, H. J., Choi, Y. J., Sohn, E. J., Lee, L. R., Kwon, H. J., Cha, H. J., Lee, S. H., Lee, S., Yu, Y. H., Kim, D., Kim, D. W., Park, J., Han, K. H., Eum, W. S., Choi, S. Y."Tat‑thioredoxin 1 reduces inflammation by inhibiting pro‑inflammatory cytokines and modulating MAPK signaling". Experimental and Therapeutic Medicine 22.6 (2021): 1395.
Chicago
Yeo, E. J., Shin, M. J., Yeo, H. J., Choi, Y. J., Sohn, E. J., Lee, L. R., Kwon, H. J., Cha, H. J., Lee, S. H., Lee, S., Yu, Y. H., Kim, D., Kim, D. W., Park, J., Han, K. H., Eum, W. S., Choi, S. Y."Tat‑thioredoxin 1 reduces inflammation by inhibiting pro‑inflammatory cytokines and modulating MAPK signaling". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1395. https://doi.org/10.3892/etm.2021.10831
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team