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Diagnostic value and significance of serum miR‑132 combined with miR‑223 for sepsis‑induced cardiomyopathy

  • Authors:
    • Yanping Li
    • Bin Lu
    • Muming Yu
    • Jianhua Zhai
    • Ying Yao
    • Yanfen Chai
  • View Affiliations / Copyright

    Affiliations: Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1396
    |
    Published online on: October 1, 2021
       https://doi.org/10.3892/etm.2021.10832
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Abstract

In previous studies, miR‑132 and miR‑223 were considered to be involved in cellular and pathological processes of diseases. However, the role of early diagnosis and prognosis evaluation in sepsis‑induced cardiomyopathy (SIC) remains unknown. The present study aimed to explore the diagnostic value of combined detection of miR‑132 and miR‑223 for SIC and their correlation with creatine kinase‑MB (CK‑MB), cardiac troponin I (cTnI), tumor necrosis factor α (TNF‑α), and interleukin‑6 (IL)‑6. SIC patients (n=80) admitted to Tianjin Medical University General Hospital were assigned to the research group (RG), while 60 healthy participants receiving physical examinations at the same period were assigned to the control group (CG). Serum expression profiles of miR‑132 and miR‑223 were detected by the RT‑qPCR. CK‑MB and cTnI were assessed using chemiluminescence assay, and TNF‑α and IL‑6 by enzyme‑linked immunosorbent assay (ELISA). Serum miR‑132 and miR‑223 levels were significantly lower in the RG than in the CG (P<0.001). The sensitivity and specificity for the diagnosis of SIC were 82.50 and 71.67% for miR‑132, 95.00 and 61.67% for miR‑223, as well as 86.25 and 86.67% for miR‑132 combined with miR‑223. Serum miR‑132 and miR‑223 levels were significantly higher in the survivor group than in the deceased group (P<0.001). The sensitivity and specificity for the prognosis of SIC were 85.96 and 65.22% for miR‑132 combined with miR‑223. Serum miR‑132 and miR‑223 were negatively correlated with serum CK‑MB, cTnI, TNF‑α, and IL‑6 (P<0.001). miR‑132 combined with miR‑223 can be used for early diagnosis and prognostic evaluation of SIC, and the two are correlated with CK‑MB, cTnI, TNF‑α, and IL‑6.
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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Lu B, Yu M, Zhai J, Yao Y and Chai Y: Diagnostic value and significance of serum miR‑132 combined with miR‑223 for sepsis‑induced cardiomyopathy. Exp Ther Med 22: 1396, 2021.
APA
Li, Y., Lu, B., Yu, M., Zhai, J., Yao, Y., & Chai, Y. (2021). Diagnostic value and significance of serum miR‑132 combined with miR‑223 for sepsis‑induced cardiomyopathy. Experimental and Therapeutic Medicine, 22, 1396. https://doi.org/10.3892/etm.2021.10832
MLA
Li, Y., Lu, B., Yu, M., Zhai, J., Yao, Y., Chai, Y."Diagnostic value and significance of serum miR‑132 combined with miR‑223 for sepsis‑induced cardiomyopathy". Experimental and Therapeutic Medicine 22.6 (2021): 1396.
Chicago
Li, Y., Lu, B., Yu, M., Zhai, J., Yao, Y., Chai, Y."Diagnostic value and significance of serum miR‑132 combined with miR‑223 for sepsis‑induced cardiomyopathy". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1396. https://doi.org/10.3892/etm.2021.10832
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Lu B, Yu M, Zhai J, Yao Y and Chai Y: Diagnostic value and significance of serum miR‑132 combined with miR‑223 for sepsis‑induced cardiomyopathy. Exp Ther Med 22: 1396, 2021.
APA
Li, Y., Lu, B., Yu, M., Zhai, J., Yao, Y., & Chai, Y. (2021). Diagnostic value and significance of serum miR‑132 combined with miR‑223 for sepsis‑induced cardiomyopathy. Experimental and Therapeutic Medicine, 22, 1396. https://doi.org/10.3892/etm.2021.10832
MLA
Li, Y., Lu, B., Yu, M., Zhai, J., Yao, Y., Chai, Y."Diagnostic value and significance of serum miR‑132 combined with miR‑223 for sepsis‑induced cardiomyopathy". Experimental and Therapeutic Medicine 22.6 (2021): 1396.
Chicago
Li, Y., Lu, B., Yu, M., Zhai, J., Yao, Y., Chai, Y."Diagnostic value and significance of serum miR‑132 combined with miR‑223 for sepsis‑induced cardiomyopathy". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1396. https://doi.org/10.3892/etm.2021.10832
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