Rare case of metachronous tumor: Nasopharyngeal and colorectal carcinoma

Jicman (Stan),Daniela; Niculet,Elena; Lungu,Mihaela; Onisor,Cristian; Rebegea,Laura; Bobeica,Carmen; Elisei,Alina Mihaela; Anghel,Lucretia; Tatu,Alin Laurentiu

doi:10.3892/etm.2021.10852

Rare case of metachronous tumor: Nasopharyngeal and colorectal carcinoma

Authors:
- Daniela Jicman (Stan)
- Elena Niculet
- Mihaela Lungu
- Cristian Onisor
- Laura Rebegea
- Carmen Bobeica
- Alina Mihaela Elisei
- Lucretia Anghel
- Alin Laurentiu Tatu
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Affiliations: Department of Otorhinolaringology, ‘Sfantul Apostol Andrei’ Emergency Clinical Hospital, 800578 Galati, Romania, Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, ‘Dunarea de Jos’ University of Galati, 800010 Galati, Romania, Department of Neurology, ‘Sfantul Apostol Andrei’ Emergency Clinical Hospital, 800578 Galati, Romania, Clinical Medical Department, Faculty of Medicine and Pharmacy, ‘Dunarea de Jos’ University, 800010 Galati, Romania, Medical and Pharmaceutical Research Unit/Competitive, Interdisciplinary Research Integrated Platform ‘Dunărea de Jos’, ReForm‑UDJG, 800010 Galati, Romania
Published online on: October 8, 2021 https://doi.org/10.3892/etm.2021.10852
Article Number: 1417
Copyright: © Jicman (Stan) et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The study presents an unusual case of a patient with a personal history of a rectal malignant tumor in 2013, who after a period of 6 years, was diagnosed with an advanced nasopharyngeal carcinoma, locally and regionally invasive. It is possible that the colorectal malignant tumor affected the development of the nasopharyngeal carcinoma, or the other way around, depending on the presence of genetic instabilities. These two types of malignant tumors share a series of genes that can influence their progression, i.e., SPINK‑6 and Bcl‑2. The particularity of this case stems from the development of a metachronous tumor, a rectal adenocarcinoma and nasopharyngeal carcinoma, two malignant tumors with different patient prognosis and disease progression. Research needs to be continued on the multidisciplinary therapeutic management of nasopharyngeal cancer and the ways of identifying this cancer type in its early stages, considering that most patients come from a rural environment, have poor medical education, a number of comorbidities, and who frequently ignore the signs, symptoms and sometimes the treatment offered.

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1	Wu L, Li C and Pan L: Nasopharyngeal carcinoma: A review of current updates. Exp Ther Med. 15:3687–3692. 2018.PubMed/NCBI View Article : Google Scholar
2	Spano JP, Busson P, Atlan D, Bourhis J, Pignon JP, Esteban C and Armand JP: Nasopharyngeal carcinomas: An update. Eur J Cancer. 39:2121–2135. 2003.PubMed/NCBI View Article : Google Scholar
3	Thompson LD: Update on nasopharyngeal carcinoma. Head Neck Pathol. 1:81–86. 2007.PubMed/NCBI View Article : Google Scholar
4	Tatu A, Radaschin D, Constantin V, Stana P and Ardeleanu V: Laser therapy in superficial morphea lesions-indications, limitations and therapeutic alternatives. J Mind Med Sci. 7:46–51. 2020.
5	Draganescu M, Baroiu L, Iancu A, Dumitru C, Radaschin D, Polea ED, Bobeica C, Tatu AL, Niculet E and Fekete GL: Perspectives on skin disorder diagnosis among people living with HIV in southeastern Romania. Exp Ther Med. 21(97)2021.PubMed/NCBI View Article : Google Scholar
6	Rebegea LF, Firescu D, Dumitru M and Patrascu A: Skin spiradenocarcinoma-case presentation. Rom J Morphol Embryol. 57:327–330. 2016.PubMed/NCBI
7	Rebegea LF, Dumitru M, Serban C, Firescu D, Ivan I, Craescu M and Romila A: Survival and toxicity after treatment with sorafenib in unresectable hepatocellular carcinoma. Acta Medica Mediterranea. 4:2113–2118. 2019.
8	Craescu M, Rebegea L, Ivan I, Dumitru M, Serban C and Firescu D: Therapeutic challenges in a case of trachea neuroendocrine tumor. Acta Medica Mediterranea,. 3(1493)2019.
9	Tatu AL, Elisei AM, Chioncel V, Miulescu M and Nwabudike LC: Immunologic adverse reactions of β-blockers and the skin (Review). Exp Ther Med. 18:955–959. 2019.PubMed/NCBI View Article : Google Scholar
10	EI-Naggar AK, Chan JKC, Grandis JR, Takata T and Slootweg PJ (eds): World Health Organization Classification of Head and Neck Tumours. IARC Press, Lyon, France, pp. 65-70, 2017.
11	Weiland LH: The histopathological spectrum of nasopharyngeal carcinoma. IARC Sci Publ: 41-50, 1978.
12	Nwabudike LC and Tatu AL: Reply to Gambichler T et al. Altered epigenetic pathways and cell cycle dysregulation in healthy appearing skin of patients with koebnerized squamous cell carcinomas following skin surgery. J Eur Acad Dermatol Venereol. 33:e3–e4. 2019.PubMed/NCBI View Article : Google Scholar
13	Nwabudike LC and Tatu AL: Reply to Happle R et al. Koebner's sheep in Wolf's clothing: Does the isotopic response exist as a distinct phenomenon? J Eur Acad Dermatol Venereol. 32:e336–e337. 2018.PubMed/NCBI View Article : Google Scholar
14	Ardeleanu V, Georgescu C, Frîncu LD, Frîncu LL and Vesa D: Angiogenesis as prospective molecular biology technique for cancer study. Rom Biotechnol Lett. 19:9637–9648. 2014.
15	Niculet E, Chioncel V, Elisei AM, Miulescu M, Buzia OD, Nwabudike LC, Craescu M, Draganescu M, Bujoreanu F, Marinescu E, et al: Multifactorial expression of IL-6 with update on COVID-19 and the therapeutic strategies of its blockade (Review). Exp Ther Med. 21(263)2021.PubMed/NCBI View Article : Google Scholar
16	Muzaffar R, Vacca F, Guo H, Mhapsekar R and Osman M: Pediatric nasopharyngeal carcinoma as seen on 18F-FDG PET/CT. Front Oncol. 9(110)2019.PubMed/NCBI View Article : Google Scholar
17	Looi L: Tumor-associated tissue eosinophilia in nasopharyngeal carcinoma. A pathologic study of 422 primary and 138 metastatic tumors. Cancer. 59:466–470. 1987.PubMed/NCBI View Article : Google Scholar
18	Tatu AL: Umbilicated blue black lesion on the lateral thorax. J Cutan Med Surg. 21(252)2017.PubMed/NCBI View Article : Google Scholar
19	Tatu AL: Black nodule on the forearm. J Cutan Med Surg. 21(157)2017.PubMed/NCBI View Article : Google Scholar
20	Zheng LS, Yang JP, Cao Y, Peng LX, Sun R, Xie P, Wang MY, Meng DF, Luo DH, Zou X, et al: SPINK6 promotes metastasis of nasopharyngeal carcinoma via binding and activation of epithelial growth factor receptor. Cancer Res. 77:579–589. 2016.PubMed/NCBI View Article : Google Scholar
21	Gouyer V, Fontaine D, Dumont P, de Wever O, Fontayne-Devaud H, Leteurtre E, Truant S, Delacour D, Drobecq H, Kerckaert JP, et al: Autocrine induction of invasion and metastasis by tumor-associated trypsin inhibitor in human colon cancer cells. Oncogene. 27:4024–4033. 2008.PubMed/NCBI View Article : Google Scholar
22	Lu X, Lamontagne J, Lu F and Block TM: Tumor-associated protein SPIK/TATI suppresses serine protease dependent cell apoptosis. Apoptosis. 13:483–494. 2008.PubMed/NCBI View Article : Google Scholar
23	Testa U, Pelosi E and Castelli G: Colorectal Cancer: Genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells. Med Sci (Basel). 6(31)2018.PubMed/NCBI View Article : Google Scholar
24	Dong SS, Wang N, Yang CP, Zhang GC, Liang WH, Zhao J and Qi Y: Giant cell-rich solitary fibrous tumor in the nasopharynx: Case report and literature review. Onco Targets Ther. 13:6819–6826. 2020.PubMed/NCBI View Article : Google Scholar
25	Ismail NI, Othman I, Abas F, Lajis NH and Naidu R: Mechanism of apoptosis induced by curcumin in colorectal cancer. Int J Mol Sci. 20(2454)2019.PubMed/NCBI View Article : Google Scholar
26	Geramizadeh B, Marzban M and Churg A: Role of immunohistochemistry in the diagnosis of solitary fibrous tumor, a review. Iran J Pathol. 11:195–203. 2016.PubMed/NCBI
27	Mathew DG, Rooban T, Janani V, Joshua E, Rao U and Ranganathan K: Review of paraneoplastic syndromes associated with oropharyngeal squamous cell carcinoma. J Oral Maxillofac Pathol. 14:41–47. 2010.PubMed/NCBI View Article : Google Scholar
28	Tatu AL and Nwabudike LC: The treatment options of male genital lichen sclerosus et atrophicus short title for a running head: Treatments of genital lichen sclerosus. In: Proceedings of the 14th National Congress of Urogynecology and the National Conference of the Romanian Association for the Study of Pain, pp262-264, 2017.
29	Tatu AL and Ionescu MA: Multiple autoimmune syndrome type III-thyroiditis, vitiligo and alopecia areata. Acta Endocrinol (Buchar). 13:124–125. 2017.PubMed/NCBI View Article : Google Scholar
30	Mihăilă B, Dinică RM, Tatu AL and Buzia OD: New insights in vitiligo treatments using bioactive compounds from Piper nigrum. Exp Ther Med. 17:1039–1044. 2019.PubMed/NCBI View Article : Google Scholar
31	Alter M, Mengoni M and Gaffal E: Cutaneous manifestations of internal malignancy. J Dtsch Dermatol Ges. 18:456–469. 2020.PubMed/NCBI View Article : Google Scholar
32	Tatu AL, Ciobotaru OR, Miulescu M, Buzia OD, Elisei AM, Mardare N, Diaconu C, Robu S and Nwabudike LC: Hydrochlorothiazide: Chemical structure, therapeutic, phototoxic and carcinogenetic effects in dermatology. Rev Chim. 69:2110–2124. 2018.
33	Nwabudike LC, Elisei A, Buzia OD, Miulescu M and Tatu A: Statins. A review on structural perspectives, adverse reactions and relations with non-melanoma skin cancer. Rev Chim. 69(2557)2018.
34	Nwabudike LC and Tatu AL: Response to-Chronic exposure to tetracyclines and subsequent diagnosis for non-melanoma skin cancer in a large Mid-Western US population. J Eur Acad Dermatol Venereol. 32(e159)2018.PubMed/NCBI View Article : Google Scholar
35	Rebegea L, Firescu D, Baciu G and Ciubara A: Psycho-oncology support. Brain. 10:77–88. 2019.