Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2021 Volume 22 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2021 Volume 22 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Adipose‑derived mesenchymal stem cell exosomes inhibit transforming growth factor‑β1‑induced collagen synthesis in oral mucosal fibroblasts

  • Authors:
    • Junjie Liu
    • Fuxingzi Li
    • Binjie Liu
    • Zhigang Yao
    • Long Li
    • Gui Liu
    • Lei Peng
    • Yuxin Wang
    • Junhui Huang
  • View Affiliations / Copyright

    Affiliations: Hunan Key Laboratory of Oral Health Research, Hunan Xiangya Stomatological Hospital, Central South University, Changsha, Hunan 410000, P.R. China, Department of Endocrinology and Metabolism, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China, Department of Urban Palliative Home Care, Grey Nuns Community Hospital, Edmonton, AB T5J3E4, Canada, Department of Stomatology, Changsha Central Hospital, Changsha, Hunan 410018, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1419
    |
    Published online on: October 11, 2021
       https://doi.org/10.3892/etm.2021.10854
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Oral submucosal fibrosis (OSF) is a potentially malignant oral disorder that requires the further development of advanced treatment strategies. TGF‑β1 has been reported to be the main trigger for the increased collagen production and reduced activity of matrix degradation pathways in OSF. Exosomes are key mediators of paracrine signaling that have been proposed for direct use as therapeutic agents for tissue repair and regeneration. The present study aimed to investigate the effects of human adipose‑derived mesenchymal stem cell (ADSC) exosomes (ADSC‑Exos) on TGF‑β1‑treated oral fibroblasts in vitro and to unravel the potential underlying mechanism of action. Oral mucosal fibroblasts were obtained from the buccal tissues of patients without OSF during extraction of the third molar. ADSCs were obtained from three healthy female individuals during liposuction procedures. ADSC‑Exos were isolated by ultracentrifugation and identified by electron microscopy, nanoparticle tracking and western blotting. Immunofluorescence and immunocytochemistry staining were performed to measure the expression levels of vimentin and α‑smooth muscle actin in the fibroblasts. Reverse transcription‑quantitative PCR and western blotting were used to determine the expression levels of mRNAs and proteins associated with collagen production. The p38 MAPK activator anisomycin was used to identify the underlying mechanisms of the effects of ADSC‑Exos on TGF‑β1‑induced collagen synthesis in oral mucosal fibroblasts. The results of the present study revealed that ADSC‑Exos exhibited a cup‑ or sphere‑shaped morphology, with a mean diameter of 58.01±16.17 nm. ADSC‑Exos were also found to be positive for CD63 and tumor susceptibility 101 expression. ADSC‑Exos treatment reversed the TGF‑β1‑induced upregulation of collagen I and III protein expression. In addition, in the presence of TGF‑β1, the expression levels of collagen type I α 1 chain and collagen type III α 1 chain mRNA were downregulated, whilst the expression levels of matrix metalloproteinase (MMP)1 and MMP3 were upregulated following ADSC‑Exos treatment. The TGF‑β1‑induced upregulation in the phosphorylation of p38 in addition to the increased protein expression of collagens I and III were also reversed in fibroblasts following ADSC‑Exos treatment. However, anisomycin treatment alleviated these ADSC‑Exos‑induced changes. In conclusion, findings from the present study suggest that ADSC‑Exos may represent a promising strategy for OSF treatment by targeting the p38 MAPK signaling pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Yang PY, Chen YT, Wang YH, Su NY, Yu HC and Chang YC: Malignant transformation of oral submucous fibrosis in Taiwan: A nationwide population-based retrospective cohort study. J Oral Pathol Med. 46:1040–1045. 2017.PubMed/NCBI View Article : Google Scholar

2 

Pindborg JJ and Sirsat SM: Oral submucous fibrosis. Oral Surg Oral Med Oral Pathol. 22:764–779. 1966.PubMed/NCBI View Article : Google Scholar

3 

Shen YW, Shih YH, Fuh LJ and Shieh TM: Oral Submucous Fibrosis: A Review on Biomarkers, Pathogenic Mechanisms, and Treatments. Int J Mol Sci. 21(7231)2020.PubMed/NCBI View Article : Google Scholar

4 

Arakeri G, Rai KK, Hunasgi S, Merkx MA, Gao S and Brennan PA: Oral submucous fibrosis: An update on current theories of pathogenesis. J Oral Pathol Med. 46:406–412. 2017.PubMed/NCBI View Article : Google Scholar

5 

Yoithapprabhunath TR, Maheswaran T, Dineshshankar J, Anusushanth A, Sindhuja P and Sitra G: Pathogenesis and therapeutic intervention of oral submucous fibrosis. J Pharm Bioallied Sci. 5 (Suppl 1):S85–S88. 2013.PubMed/NCBI View Article : Google Scholar

6 

Hashimoto S, Gon Y, Takeshita I, Matsumoto K, Maruoka S and Horie T: Transforming growth Factor-beta1 induces phenotypic modulation of human lung fibroblasts to myofibroblast through a c-Jun-NH2-terminal kinase-dependent pathway. Am J Respir Crit Care Med. 163:152–157. 2001.PubMed/NCBI View Article : Google Scholar

7 

Wei Y, Kim TJ, Peng DH, Duan D, Gibbons DL, Yamauchi M, Jackson JR, Le Saux CJ, Calhoun C, Peters J, et al: Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis. J Clin Invest. 127:3675–3688. 2017.PubMed/NCBI View Article : Google Scholar

8 

Tilakaratne WM, Klinikowski MF, Saku T, Peters TJ and Warnakulasuriya S: Oral submucous fibrosis: Review on aetiology and pathogenesis. Oral Oncol. 42:561–568. 2006.PubMed/NCBI View Article : Google Scholar

9 

Rajalalitha P and Vali S: Molecular pathogenesis of oral submucous fibrosis - a collagen metabolic disorder. J Oral Pathol Med. 34:321–328. 2005.PubMed/NCBI View Article : Google Scholar

10 

Kale AD, Mane DR and Shukla D: Expression of transforming growth factor β and its correlation with lipodystrophy in oral submucous fibrosis: An immunohistochemical study. Med Oral Patol Oral Cir Bucal. 18:e12–e18. 2013.PubMed/NCBI View Article : Google Scholar

11 

Pant I, Rao SG and Kondaiah P: Role of areca nut induced JNK/ATF2/Jun axis in the activation of TGF-β pathway in precancerous Oral Submucous Fibrosis. Sci Rep. 6(34314)2016.PubMed/NCBI View Article : Google Scholar

12 

Hsieh YP, Chen HM, Lin HY, Yang H and Chang JZ: Epigallocatechin-3-gallate inhibits transforming-growth-factor-β1-induced collagen synthesis by suppressing early growth response-1 in human buccal mucosal fibroblasts. J Formos Med Assoc. 116:107–113. 2017.PubMed/NCBI View Article : Google Scholar

13 

Li J, Zhao TT, Zhang P, Xu CJ, Rong ZX, Yan ZY and Fang CY: Autophagy mediates oral submucous fibrosis. Exp Ther Med. 11:1859–1864. 2016.PubMed/NCBI View Article : Google Scholar

14 

Chang JZ, Yang WH, Deng YT, Chen HM and Kuo MY: EGCG blocks TGFβ1-induced CCN2 by suppressing JNK and p38 in buccal fibroblasts. Clin Oral Investig. 17:455–461. 2013.PubMed/NCBI View Article : Google Scholar

15 

Tkach M and Théry C: Communication by Extracellular Vesicles: Where We Are and Where We Need to Go. Cell. 164:1226–1232. 2016.PubMed/NCBI View Article : Google Scholar

16 

Hu Y, Rao SS, Wang ZX, Cao J, Tan YJ, Luo J, Li HM, Zhang WS, Chen CY and Xie H: Exosomes from human umbilical cord blood accelerate cutaneous wound healing through miR-21-3p-mediated promotion of angiogenesis and fibroblast function. Theranostics. 8:169–184. 2018.PubMed/NCBI View Article : Google Scholar

17 

Chen CY, Rao SS, Ren L, Hu XK, Tan YJ, Hu Y, Luo J, Liu YW, Yin H, Huang J, et al: Exosomal DMBT1 from human urine-derived stem cells facilitates diabetic wound repair by promoting angiogenesis. Theranostics. 8:1607–1623. 2018.PubMed/NCBI View Article : Google Scholar

18 

Sjoqvist S, Kasai Y, Shimura D, Ishikawa T, Ali N, Iwata T and Kanai N: Oral keratinocyte-derived exosomes regulate proliferation of fibroblasts and epithelial cells. Biochem Biophys Res Commun. 514:706–712. 2019.PubMed/NCBI View Article : Google Scholar

19 

Lou G, Yang Y, Liu F, Ye B, Chen Z, Zheng M and Liu Y: MiR-122 modification enhances the therapeutic efficacy of adipose tissue-derived mesenchymal stem cells against liver fibrosis. J Cell Mol Med. 21:2963–2973. 2017.PubMed/NCBI View Article : Google Scholar

20 

Qu Y, Zhang Q, Cai X, Li F, Ma Z, Xu M and Lu L: Exosomes derived from miR-181-5p-modified adipose-derived mesenchymal stem cells prevent liver fibrosis via autophagy activation. J Cell Mol Med. 21:2491–2502. 2017.PubMed/NCBI View Article : Google Scholar

21 

Zhu F, Chong Lee Shin OL, Pei G, Hu Z, Yang J, Zhu H, Wang M, Mou J, Sun J, Wang Y, et al: Adipose-derived mesenchymal stem cells employed exosomes to attenuate AKI-CKD transition through tubular epithelial cell dependent Sox9 activation. Oncotarget. 8:70707–70726. 2017.PubMed/NCBI View Article : Google Scholar

22 

Wang L, Hu L, Zhou X, Xiong Z, Zhang C, Shehada HM, Hu B, Song J and Chen L: Exosomes secreted by human adipose mesenchymal stem cells promote scarless cutaneous repair by regulating extracellular matrix remodelling. Sci Rep. 7(13321)2017.PubMed/NCBI View Article : Google Scholar

23 

Khan I, Kumar N, Pant I, Narra S and Kondaiah P: Activation of TGF-β pathway by areca nut constituents: A possible cause of oral submucous fibrosis. PLoS One. 7(e51806)2012.PubMed/NCBI View Article : Google Scholar

24 

Yang SF, Hsieh YS, Tsai CH, Chen YJ and Chang YC: Increased plasminogen activator inhibitor-1/tissue type plasminogen activator ratio in oral submucous fibrosis. Oral Dis. 13:234–238. 2007.PubMed/NCBI View Article : Google Scholar

25 

Ni WF, Tsai CH, Yang SF and Chang YC: Elevated expression of NF-kappaB in oral submucous fibrosis - evidence for NF-kappaB induction by safrole in human buccal mucosal fibroblasts. Oral Oncol. 43:557–562. 2007.PubMed/NCBI View Article : Google Scholar

26 

Li X, Xie X, Lian W, Shi R, Han S, Zhang H, Lu L and Li M: Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat model. Exp Mol Med. 50:1–14. 2018.PubMed/NCBI View Article : Google Scholar

27 

Han P, Lai A, Salomon C and Ivanovski S: Detection of salivary small extracellular vesicles associated inflammatory cytokines gene methylation in gingivitis. Int J Mol Sci. 21(5273)2020.PubMed/NCBI View Article : Google Scholar

28 

Chomczynski P and Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162:156–159. 1987.PubMed/NCBI View Article : Google Scholar

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real time quantitative PCR and the 2 (Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

30 

Rao AR and Das P: Evaluation of the carcinogenicity of different preparations of areca nut in mice. Int J Cancer. 43:728–732. 1989.PubMed/NCBI View Article : Google Scholar

31 

Gupta PC and Warnakulasuriya S: Global epidemiology of areca nut usage. Addict Biol. 7:77–83. 2002.PubMed/NCBI View Article : Google Scholar

32 

Cox SC and Walker DM: Oral submucous fibrosis. A review. Aust Dent J. 41:294–299. 1996.PubMed/NCBI View Article : Google Scholar

33 

Chang MC, Lin LD, Wu HL, Ho YS, Hsien HC, Wang TM, Jeng PY, Cheng RH, Hahn LJ and Jeng JH: Areca nut-induced buccal mucosa fibroblast contraction and its signaling: A potential role in oral submucous fibrosis - a precancer condition. Carcinogenesis. 34:1096–1104. 2013.PubMed/NCBI View Article : Google Scholar

34 

Chang YC, Tsai CH, Lai YL, Yu CC, Chi WY, Li JJ and Chang WW: Arecoline-induced myofibroblast transdifferentiation from human buccal mucosal fibroblasts is mediated by ZEB1. J Cell Mol Med. 18:698–708. 2014.PubMed/NCBI View Article : Google Scholar

35 

Kondaiah P, Pant I and Khan I: Molecular pathways regulated by areca nut in the etiopathogenesis of oral submucous fibrosis. Periodontol 2000. 80:213–224. 2019.PubMed/NCBI View Article : Google Scholar

36 

Han CY, Koo JH, Kim SH, Gardenghi S, Rivella S, Strnad P, Hwang SJ and Kim SG: Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt. Nat Commun. 7(13817)2016.PubMed/NCBI View Article : Google Scholar

37 

Hu C, Dandapat A, Sun L, Khan JA, Liu Y, Hermonat PL and Mehta JL: Regulation of TGFbeta1-mediated collagen formation by LOX-1: Studies based on forced overexpression of TGFbeta1 in wild-type and lox-1 knock-out mouse cardiac fibroblasts. J Biol Chem. 283:10226–10231. 2008.PubMed/NCBI View Article : Google Scholar

38 

Sheppard D: Transforming growth factor beta: A central modulator of pulmonary and airway inflammation and fibrosis. Proc Am Thorac Soc. 3:413–417. 2006.PubMed/NCBI View Article : Google Scholar

39 

Angadi PV, Kale AD and Hallikerimath S: Evaluation of myofibroblasts in oral submucous fibrosis: Correlation with disease severity. J Oral Pathol Med. 40:208–213. 2011.PubMed/NCBI View Article : Google Scholar

40 

Wynn TA and Ramalingam TR: Mechanisms of fibrosis: Therapeutic translation for fibrotic disease. Nat Med. 18:1028–1040. 2012.PubMed/NCBI View Article : Google Scholar

41 

Dai JP, Zhu DX, Sheng JT, Chen XX, Li WZ, Wang GF, Li KS and Su Y: Inhibition of Tanshinone IIA, salvianolic acid A and salvianolic acid B on Areca nut extract-induced oral submucous fibrosis in vitro. Molecules. 20:6794–6807. 2015.PubMed/NCBI View Article : Google Scholar

42 

Teixeira FG, Carvalho MM, Sousa N and Salgado AJ: Mesenchymal stem cells secretome: A new paradigm for central nervous system regeneration? Cell Mol Life Sci. 70:3871–3882. 2013.PubMed/NCBI View Article : Google Scholar

43 

Xin H, Li Y and Chopp M: Exosomes/miRNAs as mediating cell-based therapy of stroke. Front Cell Neurosci. 8(377)2014.PubMed/NCBI View Article : Google Scholar

44 

De Jong OG, Van Balkom BW, Schiffelers RM, Bouten CV and Verhaar MC: Extracellular vesicles: Potential roles in regenerative medicine. Front Immunol. 5:608. 2014.PubMed/NCBI View Article : Google Scholar

45 

Xie C, Ji N, Tang Z, Li J and Chen Q: The role of extracellular vesicles from different origin in the microenvironment of head and neck cancers. Mol Cancer. 18:83. 2019.PubMed/NCBI View Article : Google Scholar

46 

Sun X, Meng H, Wan W, Xie M and Wen C: Application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases. Stem Cell Res Ther. 10:8. 2019.PubMed/NCBI View Article : Google Scholar

47 

Li FX, Liu JJ, Xu F, Lin X, Zhong JY, Wu F and Yuan LQ: Role of tumor-derived exosomes in bone metastasis. Oncol Lett. 18:3935–3945. 2019.PubMed/NCBI View Article : Google Scholar

48 

Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ and Lötvall JO: Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 9:654–659. 2007.PubMed/NCBI View Article : Google Scholar

49 

Illeperuma RP, Ryu MH, Kim KY, Tilakaratne WM and Kim J: Relationship of fibrosis and the expression of TGF-β1, MMP-1, and TIMP-1 with epithelial dysplasia in oral submucous fibrosis. Oral Med Pathol. 15:21–28. 2010.

50 

Hu L, Wang J, Zhou X, Xiong Z, Zhao J, Yu R, Huang F, Zhang H and Chen L: Exosomes derived from human adipose mensenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts. Sci Rep. 6(32993)2016.PubMed/NCBI View Article : Google Scholar

51 

Cai Y, Li J, Jia C, He Y and Deng C: Therapeutic applications of adipose cell-free derivatives: A review. Stem Cell Res Ther. 11(312)2020.PubMed/NCBI View Article : Google Scholar

52 

Li Y, Zhang W, Gao J, Liu J, Wang H, Li J, Yang X, He T, Guan H, Zheng Z, et al: Adipose tissue-derived stem cells suppress hypertrophic scar fibrosis via the p38/MAPK signaling pathway. Stem Cell Res Ther. 7(102)2016.PubMed/NCBI View Article : Google Scholar

53 

Chai CY, Song J, Tan Z, Tai IC, Zhang C and Sun S: Adipose tissue-derived stem cells inhibit hypertrophic scar (HS) fibrosis via p38/MAPK pathway. J Cell Biochem. 120:4057–4064. 2019.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu J, Li F, Liu B, Yao Z, Li L, Liu G, Peng L, Wang Y and Huang J: Adipose‑derived mesenchymal stem cell exosomes inhibit transforming growth factor‑β1‑induced collagen synthesis in oral mucosal fibroblasts. Exp Ther Med 22: 1419, 2021.
APA
Liu, J., Li, F., Liu, B., Yao, Z., Li, L., Liu, G. ... Huang, J. (2021). Adipose‑derived mesenchymal stem cell exosomes inhibit transforming growth factor‑β1‑induced collagen synthesis in oral mucosal fibroblasts. Experimental and Therapeutic Medicine, 22, 1419. https://doi.org/10.3892/etm.2021.10854
MLA
Liu, J., Li, F., Liu, B., Yao, Z., Li, L., Liu, G., Peng, L., Wang, Y., Huang, J."Adipose‑derived mesenchymal stem cell exosomes inhibit transforming growth factor‑β1‑induced collagen synthesis in oral mucosal fibroblasts". Experimental and Therapeutic Medicine 22.6 (2021): 1419.
Chicago
Liu, J., Li, F., Liu, B., Yao, Z., Li, L., Liu, G., Peng, L., Wang, Y., Huang, J."Adipose‑derived mesenchymal stem cell exosomes inhibit transforming growth factor‑β1‑induced collagen synthesis in oral mucosal fibroblasts". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1419. https://doi.org/10.3892/etm.2021.10854
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Li F, Liu B, Yao Z, Li L, Liu G, Peng L, Wang Y and Huang J: Adipose‑derived mesenchymal stem cell exosomes inhibit transforming growth factor‑β1‑induced collagen synthesis in oral mucosal fibroblasts. Exp Ther Med 22: 1419, 2021.
APA
Liu, J., Li, F., Liu, B., Yao, Z., Li, L., Liu, G. ... Huang, J. (2021). Adipose‑derived mesenchymal stem cell exosomes inhibit transforming growth factor‑β1‑induced collagen synthesis in oral mucosal fibroblasts. Experimental and Therapeutic Medicine, 22, 1419. https://doi.org/10.3892/etm.2021.10854
MLA
Liu, J., Li, F., Liu, B., Yao, Z., Li, L., Liu, G., Peng, L., Wang, Y., Huang, J."Adipose‑derived mesenchymal stem cell exosomes inhibit transforming growth factor‑β1‑induced collagen synthesis in oral mucosal fibroblasts". Experimental and Therapeutic Medicine 22.6 (2021): 1419.
Chicago
Liu, J., Li, F., Liu, B., Yao, Z., Li, L., Liu, G., Peng, L., Wang, Y., Huang, J."Adipose‑derived mesenchymal stem cell exosomes inhibit transforming growth factor‑β1‑induced collagen synthesis in oral mucosal fibroblasts". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1419. https://doi.org/10.3892/etm.2021.10854
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team