Open Access

The effectiveness of alprostadil in treating coronary microcirculation dysfunction following ST‑segment elevation myocardial infarction in a pig model

  • Authors:
    • Tianbing Duan
    • Jinxia Zhang
    • Ranran Kong
    • Rui Song
    • Weilong Huang
    • Dingcheng Xiang
  • View Affiliations

  • Published online on: October 14, 2021     https://doi.org/10.3892/etm.2021.10884
  • Article Number: 1449
  • Copyright: © Duan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Though alprostadil has been reported to improve the impaired microcirculation of patients with pulmonary arterial hypertension, its effectiveness as a treatment for coronary microvasculature dysfunction (CMD) following ST‑segment elevation myocardial infarction (STEMI) is unknown. A total of 18 miniature pigs with CMD following STEMI were randomized into three groups that received an intracoronary injection of 5 ml of normal saline, 2 mg of nicorandil or 10 µg of alprostadil immediately after measurement of the index of microcirculatory resistance (IMR) and then an intravenous drip containing 5 ml of normal saline, 2 mg of nicorandil or 10 µg of alprostadil once a day for 6 days. The IMR, cardiac function using ultrasound, infarct areas and heparanase levels in infarct areas were measured and compared between the three groups. The IMR decreased markedly 10 min after alprostadil or nicorandil intracoronary injection (both P<0.05) but not following saline injection (P>0.05). After 7 days, the IMR was substantially lower in the alprostadil and nicorandil groups compared with the saline group (both P<0.05) and the ejection fraction was considerably higher in the alprostadil and nicorandil groups compared with the saline group (both P<0.05). Differences in infarct areas and the relative heparanase expression levels among the 3 groups were similar to the differences in the ejection fraction. No significant differences in the above assessment indexes were identified in the alprostadil and nicorandil groups. Alprostadil infusion improved coronary microcirculation function, reduced the infarct area and limited left ventricular dilatation in a pig coronary microvasculature dysfunction model following STEMI.
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December-2021
Volume 22 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Duan T, Zhang J, Kong R, Song R, Huang W and Xiang D: The effectiveness of alprostadil in treating coronary microcirculation dysfunction following ST‑segment elevation myocardial infarction in a pig model. Exp Ther Med 22: 1449, 2021
APA
Duan, T., Zhang, J., Kong, R., Song, R., Huang, W., & Xiang, D. (2021). The effectiveness of alprostadil in treating coronary microcirculation dysfunction following ST‑segment elevation myocardial infarction in a pig model. Experimental and Therapeutic Medicine, 22, 1449. https://doi.org/10.3892/etm.2021.10884
MLA
Duan, T., Zhang, J., Kong, R., Song, R., Huang, W., Xiang, D."The effectiveness of alprostadil in treating coronary microcirculation dysfunction following ST‑segment elevation myocardial infarction in a pig model". Experimental and Therapeutic Medicine 22.6 (2021): 1449.
Chicago
Duan, T., Zhang, J., Kong, R., Song, R., Huang, W., Xiang, D."The effectiveness of alprostadil in treating coronary microcirculation dysfunction following ST‑segment elevation myocardial infarction in a pig model". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1449. https://doi.org/10.3892/etm.2021.10884