Open Access

Transient receptor potential ankyrin 1 and calcium: Interactions and association with disease (Review)

  • Authors:
    • Fangyan Hu
    • Xiaohua Song
    • Dingxin Long
  • View Affiliations

  • Published online on: October 20, 2021     https://doi.org/10.3892/etm.2021.10897
  • Article Number: 1462
  • Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Calcium (Ca2+) is an essential signaling molecule in all cells. It is involved in numerous fundamental functions, including cell life and death. Abnormal regulation of Ca2+ homeostasis may cause human diseases. Usually known as a member of the transient receptor potential (TRP) family, TRP ankyrin 1 (TRPA1) is the only member of the ankyrin subfamily identified in mammals so far and widely expressed in cells and tissues. As it is involved in numerous sensory disorders such as pain and pruritus, TRPA1 is a potential target for the treatment of neuropathy. The functions of TRP family members are closely related to Ca2+. TRPA1 has a high permeability to Ca2+, sodium and potassium ions as a non‑selective cation channel and the Ca2+ influx mediated by TRPA1 is involved in a variety of biological processes. In the present review, research on the relationship between the TRPA1 channel and Ca2+ ions and their interaction in disease‑associated processes was summarised. The therapeutic potential of the TRPA1 channel is highlighted, which is expected to become a novel direction for the prevention and treatment of health conditions such as cancer and neurodegenerative diseases.
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December-2021
Volume 22 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Hu F, Song X and Long D: Transient receptor potential ankyrin 1 and calcium: Interactions and association with disease (Review). Exp Ther Med 22: 1462, 2021
APA
Hu, F., Song, X., & Long, D. (2021). Transient receptor potential ankyrin 1 and calcium: Interactions and association with disease (Review). Experimental and Therapeutic Medicine, 22, 1462. https://doi.org/10.3892/etm.2021.10897
MLA
Hu, F., Song, X., Long, D."Transient receptor potential ankyrin 1 and calcium: Interactions and association with disease (Review)". Experimental and Therapeutic Medicine 22.6 (2021): 1462.
Chicago
Hu, F., Song, X., Long, D."Transient receptor potential ankyrin 1 and calcium: Interactions and association with disease (Review)". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1462. https://doi.org/10.3892/etm.2021.10897