Transient receptor potential ankyrin 1 and calcium: Interactions and association with disease (Review)

Hu,Fangyan; Song,Xiaohua; Long,Dingxin

doi:10.3892/etm.2021.10897

December-2021 Volume 22 Issue 6

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December-2021 Volume 22 Issue 6

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Review Open Access

Transient receptor potential ankyrin 1 and calcium: Interactions and association with disease (Review)

Authors:
- Fangyan Hu
- Xiaohua Song
- Dingxin Long
View Affiliations / Copyright

Affiliations: Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, P.R. China

Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 1462
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Published online on: October 20, 2021

https://doi.org/10.3892/etm.2021.10897
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Abstract

Calcium (Ca²⁺) is an essential signaling molecule in all cells. It is involved in numerous fundamental functions, including cell life and death. Abnormal regulation of Ca²⁺ homeostasis may cause human diseases. Usually known as a member of the transient receptor potential (TRP) family, TRP ankyrin 1 (TRPA1) is the only member of the ankyrin subfamily identified in mammals so far and widely expressed in cells and tissues. As it is involved in numerous sensory disorders such as pain and pruritus, TRPA1 is a potential target for the treatment of neuropathy. The functions of TRP family members are closely related to Ca²⁺. TRPA1 has a high permeability to Ca²⁺, sodium and potassium ions as a non‑selective cation channel and the Ca²⁺ influx mediated by TRPA1 is involved in a variety of biological processes. In the present review, research on the relationship between the TRPA1 channel and Ca²⁺ ions and their interaction in disease‑associated processes was summarised. The therapeutic potential of the TRPA1 channel is highlighted, which is expected to become a novel direction for the prevention and treatment of health conditions such as cancer and neurodegenerative diseases.

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