Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
January-2022 Volume 23 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2022 Volume 23 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Influence of atherosclerosis on the molecular expression of the TRPC1/BK signal complex in the aortic smooth muscles of mice

  • Authors:
    • Lian-Fa Wang
    • Dong-Yun Ling
    • Meng-Xun Huang
    • Li-Wei Tao
    • Quan-Xiu Tong
    • Yong Hou
    • Hua Li
    • Zhen Chen
    • Bang-Zhu Zhang
    • Hong-Tao Lu
    • Yun-Fei Wang
    • Xian-Ge Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The 901st Hospital of Joint Logistics Support Force of PLA, Hefei, Anhui 230031, P.R. China, Department of Cardiology, The Second People's Hospital of Hefei City, Hefei, Anhui 230011, P.R. China, Department of Cardiothoracic Surgery, The Second People's Hospital of Fuyang City, Fuyang, Anhui 236000, P.R. China, Institute of Public Health and Nursing Research, Department of Healthcare Management, University of Bremen, 28359 Bremen, Germany
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 4
    |
    Published online on: October 26, 2021
       https://doi.org/10.3892/etm.2021.10926
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Atherosclerosis (AS) is one a disease that seriously endangers human health. Previous studies have demonstrated that transient receptor potential channel‑1 (TRPC1)/large conductance Ca2+ activated K+ channel (BK) signal complex is widely distributed in arteries. Therefore, it was hypothesized that TRPC1‑BK signal complex may be a new target for the treatment of AS‑related diseases. Apolipoprotein E‑/‑ (ApoE‑/‑) mice were used to establish an atherosclerotic animal model in the present study, and the association between AS and the TRPC1‑BK signal complex was examined. The present study aimed to compare the differences in the expression levels of mRNAs and proteins of the TRPC1‑BK signal complex expressed in the aortic vascular smooth muscle tissue, between mice with AS and control mice. There were 10 mice in each group. Reverse transcription PCR, western blotting and immunohistochemistry were used to detect the differences in the mRNA and protein expression levels of TRPC1, BKα (the α subunit of BK) and BKβ1 (the β1 subunit of BK). The mRNA expression level of TRPC1 in AS model mice was significantly higher compared with that in the control group (P<0.05). However, the mRNA expression levels of BKα and BKβ1 were lower compared with those in the controls (both P<0.01). The mice in the ApoE‑/‑ group successfully developed AS. In this group, the protein expression level of TRPC1 was significantly higher than that in the control group (P<0.01), while the protein expression levels of BKα and BKβ1 were lower compared with those in the control group (P<0.01 and P<0.05, respectively). Collectively, it was identified that the protein and mRNA expression levels of the TRPC1/BK signal complex in the aortic vascular smooth muscle tissue could be influenced by the development of AS in mice. Hence, the TRPC1/BK signal complex may be a potential therapeutic target for the prevention and treatment of AS‑related complications in the future.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Falk E: Pathogenesis of atherosclerosis. J Am Coll Cardiol. 47 (Suppl 8):C7–12. 2006.PubMed/NCBI View Article : Google Scholar

2 

Peng R, Ji H, Jin L, Lin S, Huang Y, Xu K, Yang Q, Sun D and Wu W: Macrophage-Based Therapies for Atherosclerosis Management. J Immunol Res. 2020(8131754)2020.PubMed/NCBI View Article : Google Scholar

3 

Bai X, Wang WX, Fu RJ, Yue SJ, Gao H, Chen YY and Tang YP: Therapeutic Potential of Hydroxysafflor Yellow A on Cardio-Cerebrovascular Diseases. Front Pharmacol. 11(01265)2020.PubMed/NCBI View Article : Google Scholar

4 

Nicholls SJ, Ballantyne CM, Barter PJ, Chapman MJ, Erbel RM, Libby P, Raichlen JS, Uno K, Borgman M, Wolski K, et al: Effect of two intensive statin regimens on progression of coronary disease. N Engl J Med. 365:2078–2087. 2011.PubMed/NCBI View Article : Google Scholar

5 

Clapham DE: TRP channels as cellular sensors. Nature. 426:517–524. 2003.PubMed/NCBI View Article : Google Scholar

6 

Reyes RC, Verkhratsky A and Parpura V: TRPC1-mediated Ca2+ and Na+ signalling in astroglia: Differential filtering of extracellular cations. Cell Calcium. 54:120–125. 2013.PubMed/NCBI View Article : Google Scholar

7 

Zhu Y, Ye P, Chen SL and Zhang DM: Functional regulation of large conductance Ca2+-activated K+ channels in vascular diseases. Metabolism. 83:75–80. 2018.PubMed/NCBI View Article : Google Scholar

8 

Ferguson SD, Zhou S, Xiu J, Hashimoto Y, Sanai N, Kim L, Kesari S, de Groot J, Spetzler D and Heimberger AB: Ependymomas overexpress chemoresistance and DNA repair-related proteins. Oncotarget. 9:7822–7831. 2017.PubMed/NCBI View Article : Google Scholar

9 

Liu P, Verhaar AP and Peppelenbosch MP: Signaling Size: Ankyrin and SOCS Box-Containing ASB E3 Ligases in Action. Trends Biochem Sci. 44:64–74. 2019.PubMed/NCBI View Article : Google Scholar

10 

Kruglikov IL and Scherer PE: Caveolin as a Universal Target in Dermatology. Int J Mol Sci. 21(80)2019.PubMed/NCBI View Article : Google Scholar

11 

Son A, Kang N, Oh SY, Kim KW, Muallem S, Yang YM and Shin DM: Homer2 and Homer3 modulate RANKL-induced NFATc1 signaling in osteoclastogenesis and bone metabolism. J Endocrinol. 242:241–249. 2019.PubMed/NCBI View Article : Google Scholar

12 

Ciminski K, Pulvermüller J, Adam J and Schwemmle M: Human MxA is a potent interspecies barrier for the novel bat-derived influenza A-like virus H18N11. Emerg Microbes Infect. 8:556–563. 2019.PubMed/NCBI View Article : Google Scholar

13 

Nguyen LK, Kholodenko BN and von Kriegsheim A: Rac1 and RhoA: Networks, loops and bistability. Small GTPases. 9:316–321. 2018.PubMed/NCBI View Article : Google Scholar

14 

Redondo PC, Harper AG, Salido GM, Pariente JA, Sage SO and Rosado JA: A role for SNAP-25 but not VAMPs in store-mediated Ca2+ entry in human platelets. J Physiol. 558:99–109. 2004.PubMed/NCBI View Article : Google Scholar

15 

Antigny F, Konig S, Bernheim L and Frieden M: Inositol 1,4,5 trisphosphate receptor 1 is a key player of human myoblast differentiation. Cell Calcium. 56:513–521. 2014.PubMed/NCBI View Article : Google Scholar

16 

Dhar M, Wayman GA, Zhu M, Lambert TJ, Davare MA and Appleyard SM: Leptin-induced spine formation requires TrpC channels and the CaM kinase cascade in the hippocampus. J Neurosci. 34:10022–10033. 2014.PubMed/NCBI View Article : Google Scholar

17 

Marom M, Birnbaumer L and Atlas D: Membrane depolarization combined with Gq-activated G-protein-coupled receptors induce transient receptor potential channel 1 (TRPC1)- dependent potentiation of catecholamine release. Neuroscience. 189:132–145. 2011.PubMed/NCBI View Article : Google Scholar

18 

Tu CL, Chang W and Bikle DD: Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytes. J Invest Dermatol. 124:187–197. 2005.PubMed/NCBI View Article : Google Scholar

19 

Singh BB, Liu X, Tang J, Zhu MX and Ambudkar IS: Calmodulin regulates Ca(2+)-dependent feedback inhibition of store-operated Ca(2+) influx by interaction with a site in the C terminus of TrpC1. Mol Cell. 9:739–750. 2002.PubMed/NCBI View Article : Google Scholar

20 

Selli C, Erac Y and Tosun M: Simultaneous measurement of cytosolic and mitochondrial calcium levels: Observations in TRPC1-silenced hepatocellular carcinoma cells. J Pharmacol Toxicol Methods. 72:29–34. 2015.PubMed/NCBI View Article : Google Scholar

21 

Dyrda A, Koenig S and Frieden M: STIM1 long and STIM1 gate differently TRPC1 during store-operated calcium entry. Cell Calcium. 86(102134)2020.PubMed/NCBI View Article : Google Scholar

22 

Kwan HY, Shen B, Ma X, Kwok YC, Huang Y, Man YB, Yu S and Yao X: TRPC1 associates with BK(Ca) channel to form a signal complex in vascular smooth muscle cells. Circ Res. 104:670–678. 2009.PubMed/NCBI View Article : Google Scholar

23 

Kochukov MY, Balasubramanian A, Noel RC and Marrelli SP: Role of TRPC1 and TRPC3 channels in contraction and relaxation of mouse thoracic aorta. J Vasc Res. 50:11–20. 2013.PubMed/NCBI View Article : Google Scholar

24 

ÁvilaMedina J: CalderónSánchez E, GonzálezRodríguez P, Monje-Quiroga F, Rosado JA, Castellano A, Ordóñez A and Smani T: Orai1 and TRPC1 colocalize with CaV1.2 channels to form a signal complex in vascular smooth muscle cells. J Biol Chem. 291:21148–21159. 2016.PubMed/NCBI View Article : Google Scholar

25 

Nascimento Da Conceicao V, Sun Y, Zboril EK, De la Chapa JJ and Singh BB: Loss of Ca2+ entry via Orai-TRPC1 induces ER stress, initiating immune activation in macrophages. J Cell Sci. 133(jcs237610)2019.PubMed/NCBI View Article : Google Scholar : doi.org/10.1242/jcs.237610.

26 

Packard RR and Libby P: Inflammation in atherosclerosis: From vascular biology to biomarker discovery and risk prediction. Clin Chem. 54:24–38. 2008.PubMed/NCBI View Article : Google Scholar

27 

Andrés-Manzano MJ, Andrés V and Dorado B: Oil Red O and Hematoxylin and Eosin Staining for Quantification of Atherosclerosis Burden in Mouse Aorta and Aortic Root. Methods Mol Biol. 1339:85–99. 2015.PubMed/NCBI View Article : Google Scholar

28 

Wang LF, Gu L, Huang MX, Zhou WB, Li H and Zhang BZ: Effects of spironolactone towards rabbit atrial remodeling with rapid pacing. Pak J Pharm Sci. 29:151–156. 2016.PubMed/NCBI

29 

Cochain C and Zernecke A: Macrophages and immune cells in atherosclerosis: Recent advances and novel concepts. Basic Res Cardiol. 110(34)2015.PubMed/NCBI View Article : Google Scholar

30 

Davignon J, Cohn JS, Mabile L and Bernier L: Apolipoprotein E and atherosclerosis: Insight from animal and human studies. Clin Chim Acta. 286:115–143. 1999.PubMed/NCBI View Article : Google Scholar

31 

Libby P, Lichtman AH and Hansson GK: Immune effector mechanisms implicated in atherosclerosis: From mice to humans. Immunity. 38:1092–1104. 2013.PubMed/NCBI View Article : Google Scholar

32 

Tousoulis D, Psarros C, Demosthenous M, Patel R, Antoniades C and Stefanadis C: Innate and adaptive inflammation as a therapeutic target in vascular disease: The emerging role of statins. J Am Coll Cardiol. 63:2491–2502. 2014.PubMed/NCBI View Article : Google Scholar

33 

Tangvoraphonkchai K and Davenport A: Magnesium and Cardiovascular Disease. Adv Chronic Kidney Dis. 25:251–260. 2018.PubMed/NCBI View Article : Google Scholar

34 

Nesin V and Tsiokas L: TRPC1. In: Mammalian Transient Receptor Potential (TRP) Cation Channels. Handbook of Experimental Pharmacology. Nilius B and Flockerzi V (eds). Vol 222. Springer, Berlin, Heidelberg, pp15-51, 2014.

35 

Latorre R, Castillo K, Carrasquel-Ursulaez W, Sepulveda RV, Gonzalez-Nilo F, Gonzalez C and Alvarez O: Molecular Determinants of BK Channel Functional Diversity and Functioning. Physiol Rev. 97:39–87. 2017.PubMed/NCBI View Article : Google Scholar

36 

Tang X, Qian LL, Wang RX, Yao Y, Dang SP, Wu Y, Wang W, Ji Y, Sun MQ, Xia DY, et al: Regulation of coronary arterial large conductance Ca2+-activated K+ channel protein expression and function by n-3 polyunsaturated fatty acids in diabetic rats. J Vasc Res. 54:329–343. 2017.PubMed/NCBI View Article : Google Scholar

37 

Tykocki NR, Boerman EM and Jackson WF: Smooth muscle ion channels and regulation of vascular tone in resistance arteries and arterioles. Compr Physiol. 7:485–581. 2017.PubMed/NCBI View Article : Google Scholar

38 

Schmidt K, Dubrovska G, Nielsen G, Fesüs G, Uhrenholt TR, Hansen PB, Gudermann T, Dietrich A, Gollasch M, de Wit C, et al: Amplification of EDHF-type vasodilatations in TRPC1-deficient mice. Br J Pharmacol. 161:1722–1733. 2010.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang L, Ling D, Huang M, Tao L, Tong Q, Hou Y, Li H, Chen Z, Zhang B, Lu H, Lu H, et al: Influence of atherosclerosis on the molecular expression of the TRPC1/BK signal complex in the aortic smooth muscles of mice. Exp Ther Med 23: 4, 2022.
APA
Wang, L., Ling, D., Huang, M., Tao, L., Tong, Q., Hou, Y. ... Zhang, X. (2022). Influence of atherosclerosis on the molecular expression of the TRPC1/BK signal complex in the aortic smooth muscles of mice. Experimental and Therapeutic Medicine, 23, 4. https://doi.org/10.3892/etm.2021.10926
MLA
Wang, L., Ling, D., Huang, M., Tao, L., Tong, Q., Hou, Y., Li, H., Chen, Z., Zhang, B., Lu, H., Wang, Y., Zhang, X."Influence of atherosclerosis on the molecular expression of the TRPC1/BK signal complex in the aortic smooth muscles of mice". Experimental and Therapeutic Medicine 23.1 (2022): 4.
Chicago
Wang, L., Ling, D., Huang, M., Tao, L., Tong, Q., Hou, Y., Li, H., Chen, Z., Zhang, B., Lu, H., Wang, Y., Zhang, X."Influence of atherosclerosis on the molecular expression of the TRPC1/BK signal complex in the aortic smooth muscles of mice". Experimental and Therapeutic Medicine 23, no. 1 (2022): 4. https://doi.org/10.3892/etm.2021.10926
Copy and paste a formatted citation
x
Spandidos Publications style
Wang L, Ling D, Huang M, Tao L, Tong Q, Hou Y, Li H, Chen Z, Zhang B, Lu H, Lu H, et al: Influence of atherosclerosis on the molecular expression of the TRPC1/BK signal complex in the aortic smooth muscles of mice. Exp Ther Med 23: 4, 2022.
APA
Wang, L., Ling, D., Huang, M., Tao, L., Tong, Q., Hou, Y. ... Zhang, X. (2022). Influence of atherosclerosis on the molecular expression of the TRPC1/BK signal complex in the aortic smooth muscles of mice. Experimental and Therapeutic Medicine, 23, 4. https://doi.org/10.3892/etm.2021.10926
MLA
Wang, L., Ling, D., Huang, M., Tao, L., Tong, Q., Hou, Y., Li, H., Chen, Z., Zhang, B., Lu, H., Wang, Y., Zhang, X."Influence of atherosclerosis on the molecular expression of the TRPC1/BK signal complex in the aortic smooth muscles of mice". Experimental and Therapeutic Medicine 23.1 (2022): 4.
Chicago
Wang, L., Ling, D., Huang, M., Tao, L., Tong, Q., Hou, Y., Li, H., Chen, Z., Zhang, B., Lu, H., Wang, Y., Zhang, X."Influence of atherosclerosis on the molecular expression of the TRPC1/BK signal complex in the aortic smooth muscles of mice". Experimental and Therapeutic Medicine 23, no. 1 (2022): 4. https://doi.org/10.3892/etm.2021.10926
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team