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Case Report Open Access

Cutaneous adverse reactions in a lung cancer patient treated with pembrolizumab: A case report

  • Authors:
    • Carmen Bobeica
    • Laura Rebegea
    • Gabriel Murariu
    • Michaela Dobre
    • Aurel Nechita
    • Alin Laurentiu Tatu
    • Elena Niculet
    • Lucretia Anghel
    • Silvia Fotea
    • Mihaela Craescu
  • View Affiliations / Copyright

    Affiliations: Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, ‘Dunarea de Jos’ University, 800010 Galati, Romania, Clinical Medical Department, Faculty of Medicine and Pharmacy, ‘Dunarea de Jos’ University, 800010 Galati, Romania, Department of Chemistry, Physics and Environment, Faculty of Sciences and Environment, ‘Dunarea de Jos’ University, 800201 Galati, Romania, Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, ‘Dunarea de Jos’ University, 800010 Galati, Romania, Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, ‘Dunarea de Jos’ University of Galati, 800010 Galati, Romania
    Copyright: © Bobeica et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 15
    |
    Published online on: October 29, 2021
       https://doi.org/10.3892/etm.2021.10937
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Abstract

Lung cancer is the main cause of oncological death in the US and worldwide, constituting a significant public health problem. The incidence of lung cancer is on the increase. In the present study, the diagnostic process was carried out and treatment options were considered to determine the therapeutic response of a patient diagnosed with lung cancer. The case of an early stage lung cancer patient who benefited from surgical treatment was presented. The pathology report stated the complete diagnosis to be pleomorphic lung cancer with an adenocarcinoma component, pT2aN0M0, with focal positivity for thyroid transcription factor 1 (TTF1), without epidermal growth factor receptor (EGFR) mutations and ALK recombinations, having an initial clinical stage of IB and programmed death ligand‑1 (PD‑L1) positivity with a tumor proportion score of over 70%. The patient underwent radiotherapy treatment and was administered osteoclast inhibitors and immunotherapy, with no favorable therapeutic effect and with the presence of secondary cutaneous adverse effects to pembrolizumab. As a main cause of death, lung cancer registers a low general survival rate even in patients with targeted therapies or immunotherapy. By better identifying the patients at risk, one can establish a more efficient personalized treatment; the future objective of scientific studies is the follow‑up of adverse effects of new therapies.
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1 

Craescu M, Rebegea L, Ivan I, Dumitru M, Serban C and Firescu D: Therapeutic challenges in a case of trachea neuroendocrine tumor. Acta Med Mediterr. 35:1493–1496. 2019.

2 

Fekete GL, Cotoi OS and Fekete JE: Multiple nodular cutaneous metastases as the first clinical sign of signet ring cell gastric carcinoma: Case report. Acta Dermatovenerol Croat. 20:34–37. 2012.PubMed/NCBI

3 

Riihimäki M, Hemminki A, Fallah M, Thomsen H, Sundquist K, Sundquist J and Hemminki K: Metastatic sites and survival in lung cancer. Lung Cancer. 86:78–84. 2014.PubMed/NCBI View Article : Google Scholar

4 

National Comprehensive Cancer Network (NCCN): NCCN Clinical Practice Guidelines in Oncology (NCCN guidelines): Non-small cell lung cancer. Version 5.2019 - June 7, 2019. NCCN, Plymouth Meeting, PA, 2019. https://www.nccn.org/guidelines/category_1#si. Accessed July 30, 2019.

5 

Nomori H, Watanabe K, Ohtusuka T, Naruke T, Suemasu K and Uno K: The size of metastatic foci and lymph nodes yielding false-negative and false-positive lymph node staging with positron emission tomography in patients with lung cancer. J Thorac Cardiovasc Surg. 127:1087–1092. 2004.PubMed/NCBI View Article : Google Scholar

6 

Niculet E, Chioncel V, Elisei AM, Miulescu M, Buzia OD, Nwabudike LC, Craescu M, Draganescu M, Bujoreanu F, Marinescu E, et al: Multifactorial expression of IL-6 with update on COVID-19 and the therapeutic strategies of its blockade (Review). Exp Ther Med. 21(263)2021.PubMed/NCBI View Article : Google Scholar

7 

Dela Cruz CS, Tanoue LT and Matthay RA: Lung cancer: Epidemiology, etiology and prevention. Clin Chest Med. 32:605–644. 2011.PubMed/NCBI View Article : Google Scholar

8 

Zhou H, Wu A, Fu W, Lv Z and Zhang Z: Significance of semaphorin-3A and MMP-14 protein expression in non-small cell lung cancer. Oncol Lett. 7:1395–1400. 2014.PubMed/NCBI View Article : Google Scholar

9 

Gheorghe I, Tatu AL, Lupu I, Thamer O, Cotar AI, Pircalabioru GG, Popa M, Cristea VC, Lazar V and Chifiriuc MC: Molecular characterization of virulence and resistance features in Staphylococcus aureus clinical strains isolated from cutaneous lesions in patients with drug adverse reactions. Rom Biotech Lett. 22:12321–12327. 2017.

10 

Hwang SJE and Fernández-Peñas P: Adverse reactions to biologics: Melanoma (Ipilimumab, Nivolumab, Pembrolizumab). Curr Probl Dermatol. 53:82–92. 2018.PubMed/NCBI View Article : Google Scholar

11 

Lee M and Seetharamu N: An atypical presentation of lichen planus-like reaction from pembrolizumab. Case Rep Dermatol Med. 2019(4065437)2019.PubMed/NCBI View Article : Google Scholar

12 

Nwabudike LC and Tatu AL: Reply to Gambichler T et al: Altered epigenetic pathways and cell cycle dysregulation in healthy appearing skin of patients with koebnerized squamous cell carcinomas following skin surgery. J Eur Acad Dermatol Venereol. 33:e3–e4. 2019.PubMed/NCBI View Article : Google Scholar

13 

Flaten HK and Monte AA: The pharmacogenomic and metabolomic predictors of ACE inhibitor and angiotensin II receptor blocker effectiveness and safety. Cardiovasc Drugs Ther. 31:471–482. 2017.PubMed/NCBI View Article : Google Scholar

14 

Johnson JA: Advancing management of hypertension through pharmacogenomics. Ann Med. 44 (Suppl 1):S17–S22. 2012.PubMed/NCBI View Article : Google Scholar

15 

Tatu AL, Elisei AM, Chioncel V, Miulescu M and Nwabudike LC: Immunologic adverse reactions of β-blockers and the skin (Review). Exp Ther Med. 18:955–959. 2019.PubMed/NCBI View Article : Google Scholar

16 

Nwabudike LC, Elisei AM, Buzia OD, Miulescu M and Tatu AL: Statins. A review on structural perspectives, adverse reactions and relations with non-melanoma skin cancer. Rev Chim (Bucharest). 69:2557–2562. 2018.

17 

Tatu AL, Ciobotaru OR, Miulescu M, Buzia OD, Elisei AM, Mardare N, Diaconu C, Robu S and Nwabudike LC: Hydrochlorothiazide: Chemical structure, therapeutic, phototoxic and carcinogenetic effects in dermatology. Rev Chim (Bucharest). 69:2110–2114. 2018.

18 

Dobre M, Georgescu C, Stefanescu V, Cuciureanu M, Nechita A and Arbune M: Homeostatic changes during anticonvulsant medication in children. Farmacia. 63:402–406. 2015.

19 

Jáuregui-Garrido B and Jáuregui-Lobera I: Interactions between antihypertensive drugs and food. Nutr Hosp. 27:1866–1875. 2012.PubMed/NCBI View Article : Google Scholar

20 

Fidler-Benaoudia MM, Torre LA, Bray F, Ferlay J and Jemal A: Lung cancer incidence in young women vs. young men: A systematic analysis in 40 countries. Int J Cancer. 147:811–819. 2020.PubMed/NCBI View Article : Google Scholar

21 

Özmen S and Ceylan O: Trends in lung cancer incidence within the last 10 years: An Eastern Anatolian single center experience. J Surg Med. 4:112–115. 2020.

22 

Blandino G and Di Agostino S: New therapeutic strategies to treat human cancers expressing mutant p53 proteins. J Exp Clin Cancer Res. 37(30)2018.PubMed/NCBI View Article : Google Scholar

23 

NSCLC Meta-analyses Collaborative Group. Arriagada R, Auperin A, Burdett S, Higgins JP, Johnson DH, Le Chevalier T, Le Pechoux C, Parmar MK, Pignon JP, et al: Adjuvant chemotherapy, with or without postoperative radiotherapy, in operable non-small-cell lung cancer: Two meta-analyses of individual patient data. Lancet. 375:1267–1277. 2010.PubMed/NCBI View Article : Google Scholar

24 

Sui H, Ma N, Wang Y, Li H, Liu X, Su Y and Yang J: Anti-PD-1/PD-L1 therapy for non-small-cell lung cancer: Toward personalized medicine and combination strategies. J Immunol Res. 2018(6984948)2018.PubMed/NCBI View Article : Google Scholar

25 

Biton J, Mansuet-Lupo A, Pécuchet N, Alifano M, Ouakrim H, Arrondeau J, Boudou-Rouquette P, Goldwasser F, Leroy K, Goc J, et al: TP53, STK11, and EGFR mutations predict tumor immune profile and the response to anti-PD-1 in lung adenocarcinoma. Clin Cancer Res. 24:5710–5723. 2018.PubMed/NCBI View Article : Google Scholar

26 

Wu CH and Hwang MJ: Risk stratification for lung adenocarcinoma on EGFR and TP53 mutation status, chemotherapy, and PD-L1 immunotherapy. Cancer Med. 8:5850–5861. 2019.PubMed/NCBI View Article : Google Scholar

27 

Sanlorenzo M, Vujic I, Daud A, Algazi A, Gubens M, Luna SA, Lin K, Quaglino P, Rappersberger K and Ortiz-Urda S: Pembrolizumab cutaneous adverse events and their association with disease progression. JAMA Dermatol. 151:1206–1212. 2015.PubMed/NCBI View Article : Google Scholar

28 

Simonsen AB, Kaae J, Ellebaek E, Svane IM and Zachariae C: Cutaneous adverse reactions to anti-PD-1 treatment-a systematic review. J Am Acad Dermatol. 83:1415–1424. 2020.PubMed/NCBI View Article : Google Scholar

29 

Garon EB, Rizvi NA, Hui R, Leighl N, Balmanoukian AS, Eder JP, Patnaik A, Aggarwal C, Gubens M, Horn L, et al: Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med. 372:2018–2028. 2015.PubMed/NCBI View Article : Google Scholar

30 

Fekete GL, Boda D, Căruntu C and Fekete L: Paraneoplastic pityriasis rubra pilaris in association with prostate carcinoma: A case report and literature review. Exp Ther Med. 18:5052–5055. 2019.PubMed/NCBI View Article : Google Scholar

31 

Coleman E, Panse G, Haldas J, Gettinger SN and Leventhal JS: Pityriasis rubra pilaris-like erythroderma in the setting of pembrolizumab therapy responsive to acitretin. JAAD Case Rep. 4:669–671. 2018.PubMed/NCBI View Article : Google Scholar

32 

Creţu A, Dimitriu A, Brănişteanu D and Brinişteanu DE: Erythema multiforme-etiopathogenic, clinical and therapeutic aspects. Rev Med Chir Soc Med Nat Iasi. 119:55–61. 2015.PubMed/NCBI

33 

Joshi N (ed): Pembrolizumab/rivaroxaban interaction. In: Reactions Weekly. Vol 1704. Springer Nature Switzerland AG, Cham, p304, 2018.

34 

Bobeică C, Tatu AL, Crăescu M and Solovăstru L: Dynamics of digital ulcers in systemic sclerosis. Exp Ther Med. 20:61–67. 2020.PubMed/NCBI View Article : Google Scholar

35 

Bobeica C, Niculet E, Craescu M, Onisor C, Bujoreanu F, Draganescu ML, Halip IA and Gheuca-Solovastru L: Epidemiological profile of systemic sclerosis in the southeast region of Romania. Exp Ther Med. 21(77)2021.PubMed/NCBI View Article : Google Scholar

36 

Niculet E, Bobeica C and Tatu AL: Glucocorticoid-induced skin atrophy: The old and the new. Clin Cosmet Investig Dermatol. 13:1041–1050. 2020.PubMed/NCBI View Article : Google Scholar

37 

Haanen J, Ernstoff M, Wang Y, Menzies A, Puzanov I, Grivas P, Larkin J, Peters S, Thompson J and Obeid M: Rechallenge patients with immune checkpoint inhibitors following severe immune-related adverse events: Review of the literature and suggested prophylactic strategy. J Immunother Cancer. 8(e000604)2020.PubMed/NCBI View Article : Google Scholar

38 

Winer A, Bodor JN and Borghaei H: Identifying and managing the adverse effects of immune checkpoint blockade. J Thorac Dis. 10 (Suppl 3):S480–S489. 2018.PubMed/NCBI View Article : Google Scholar

39 

Bhatlapenumarthi V, Patwari A and Harb AJ: Immune-related adverse events and immune checkpoint inhibitor tolerance on rechallenge in patients with irAEs: A single-center experience. J Cancer Res Clin Oncol. 147:2789–2800. 2021.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Bobeica C, Rebegea L, Murariu G, Dobre M, Nechita A, Tatu AL, Niculet E, Anghel L, Fotea S, Craescu M, Craescu M, et al: Cutaneous adverse reactions in a lung cancer patient treated with pembrolizumab: A case report. Exp Ther Med 23: 15, 2022.
APA
Bobeica, C., Rebegea, L., Murariu, G., Dobre, M., Nechita, A., Tatu, A.L. ... Craescu, M. (2022). Cutaneous adverse reactions in a lung cancer patient treated with pembrolizumab: A case report. Experimental and Therapeutic Medicine, 23, 15. https://doi.org/10.3892/etm.2021.10937
MLA
Bobeica, C., Rebegea, L., Murariu, G., Dobre, M., Nechita, A., Tatu, A. L., Niculet, E., Anghel, L., Fotea, S., Craescu, M."Cutaneous adverse reactions in a lung cancer patient treated with pembrolizumab: A case report". Experimental and Therapeutic Medicine 23.1 (2022): 15.
Chicago
Bobeica, C., Rebegea, L., Murariu, G., Dobre, M., Nechita, A., Tatu, A. L., Niculet, E., Anghel, L., Fotea, S., Craescu, M."Cutaneous adverse reactions in a lung cancer patient treated with pembrolizumab: A case report". Experimental and Therapeutic Medicine 23, no. 1 (2022): 15. https://doi.org/10.3892/etm.2021.10937
Copy and paste a formatted citation
x
Spandidos Publications style
Bobeica C, Rebegea L, Murariu G, Dobre M, Nechita A, Tatu AL, Niculet E, Anghel L, Fotea S, Craescu M, Craescu M, et al: Cutaneous adverse reactions in a lung cancer patient treated with pembrolizumab: A case report. Exp Ther Med 23: 15, 2022.
APA
Bobeica, C., Rebegea, L., Murariu, G., Dobre, M., Nechita, A., Tatu, A.L. ... Craescu, M. (2022). Cutaneous adverse reactions in a lung cancer patient treated with pembrolizumab: A case report. Experimental and Therapeutic Medicine, 23, 15. https://doi.org/10.3892/etm.2021.10937
MLA
Bobeica, C., Rebegea, L., Murariu, G., Dobre, M., Nechita, A., Tatu, A. L., Niculet, E., Anghel, L., Fotea, S., Craescu, M."Cutaneous adverse reactions in a lung cancer patient treated with pembrolizumab: A case report". Experimental and Therapeutic Medicine 23.1 (2022): 15.
Chicago
Bobeica, C., Rebegea, L., Murariu, G., Dobre, M., Nechita, A., Tatu, A. L., Niculet, E., Anghel, L., Fotea, S., Craescu, M."Cutaneous adverse reactions in a lung cancer patient treated with pembrolizumab: A case report". Experimental and Therapeutic Medicine 23, no. 1 (2022): 15. https://doi.org/10.3892/etm.2021.10937
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