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Effects of exercise on the expression of long non‑coding RNAs in the bone of mice with osteoporosis

  • Authors:
    • Jianmin Guo
    • Yu Yuan
    • Lingli Zhang
    • Miao Wang
    • Xiaoyang Tong
    • Lifei Liu
    • Miao Zhang
    • Hui Li
    • Xi Chen
    • Jun Zou
  • View Affiliations / Copyright

    Affiliations: School of Kinesiology, Shanghai University of Sport, Shanghai 200438, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 70
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    Published online on: November 23, 2021
       https://doi.org/10.3892/etm.2021.10993
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Abstract

Physical activity or exercise are known to promote bone formation and decrease bone resorption to maintain skeletal and bone health both in animal models and in humans with osteoporosis. Previous studies have indicated that long non‑coding RNAs (lncRNAs) are able to regulate bone metabolism. Therefore, the present study aimed to evaluate whether lncRNAs responded to exercise by regulating the balance of bone metabolism in order to prevent osteoporosis. To meet this end, ovariectomized mice were used in the present study to establish an osteoporosis model. The exercise treatment groups were subjected to 9 weeks of treadmill running exercise in 4 weeks of the operation was performed Femurs were collected to measure bone mineral density, bone mass, bone formation and resorption. The expression levels of lncRNAs were subsequently measured using microarray and gene function analyses. The pairwise comparison results [ovariectomy (OVX) vs. OVX + exercise (EX); OVX vs. SHAM; SHAM vs. SHAM + EX; OVX + EX vs. SHAM + EX] of the gene microarray analysis revealed that the expression of 2,424 lncRNAs (1718 upregulated and 706 downregulated) were significantly altered in the mouse femurs following treadmill running. Gene Ontology (GO) analysis, incorporating the GO annotations ‘biological processes’, ‘molecular function’ and ‘cellular components’, of osteoporosis revealed that the VEGF, mTOR and NF‑κB signaling pathways were potential targets of the lncRNAs. Moreover, it was possible to predict the target microRNAs (miRNAs) of six lncRNAs (LOC105246953, LOC102637959, NONMMUT014677, NONMMUT027251, ri|D130079K21|PX00187K16|1491 and NONMMUT006626), which suggested that the underlying mechanism by which lncRNAs respond to exercise involved bone regulation via lncRNA‑miRNA sponge adsorption. Overall, these results suggested that the treadmill running exercise did regulate lncRNA expression in the bone, and that this was involved in the prevention of osteoporosis.
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1 

Bliuc D, Alarkawi D, Nguyen TV, Eisman JA and Center JR: Risk of subsequent fractures and mortality in elderly women and men with fragility fractures with and without osteoporotic bone density: The Dubbo Osteoporosis Epidemiology Study. J Bone Miner Res. 30:637–646. 2015.PubMed/NCBI View Article : Google Scholar

2 

Moreira LD, Oliveira ML, Lirani-Galvão AP, Marin-Mio RV, Santos RN and Lazaretti-Castro M: Physical exercise and osteoporosis: Effects of different types of exercises on bone and physical function of postmenopausal women. Arq Bras Endocrinol Metabol. 58:514–522. 2014.PubMed/NCBI View Article : Google Scholar

3 

Ma D, Wu L and He Z: Effects of walking on the preservation of bone mineral density in perimenopausal and postmenopausal women: A systematic review and meta-analysis. Menopause. 20:1216–1226. 2013.PubMed/NCBI View Article : Google Scholar

4 

Hamilton CJ, Swan VJ and Jamal SA: The effects of exercise and physical activity participation on bone mass and geometry in postmenopausal women: A systematic review of pQCT studies. Osteoporos Int. 21:11–23. 2010.PubMed/NCBI View Article : Google Scholar

5 

Weaver CM, Gordon CM, Janz KF, Kalkwarf HJ, Lappe JM, Lewis R, O'Karma M, Wallace TC and Zemel BS: The National Osteoporosis Foundation's position statement on peak bone mass development and lifestyle factors: A systematic review and implementation recommendations. Osteoporos Int. 27:1281–1386. 2016.PubMed/NCBI View Article : Google Scholar

6 

Yuan Y, Chen X, Zhang L, Wu J, Guo J, Zou D, Chen B, Sun Z, Shen C and Zou J: The roles of exercise in bone remodeling and in prevention and treatment of osteoporosis. Prog Biophys Mol Biol. 122:122–130. 2016.PubMed/NCBI View Article : Google Scholar

7 

Chen X, Li L, Guo J, Zhang L, Yuan Y, Chen B, Sun Z, Xu J and Zou J: Treadmill running exercise prevents senile osteoporosis and upregulates the Wnt signaling pathway in SAMP6 mice. Oncotarget. 7:71072–71086. 2016.PubMed/NCBI View Article : Google Scholar

8 

Li L, Chen X, Lv S, Dong M, Zhang L, Tu J, Yang J, Zhang L, Song Y, Xu L, et al: Influence of exercise on bone remodeling-related hormones and cytokines in ovariectomized rats: A model of postmenopausal osteoporosis. PLoS One. 9(e112845)2014.PubMed/NCBI View Article : Google Scholar

9 

Brosnan CA and Voinnet O: The long and the short of noncoding RNAs. Curr Opin Cell Biol. 21:416–425. 2009.PubMed/NCBI View Article : Google Scholar

10 

Krol J, Krol I, Alvarez CP, Fiscella M, Hierlemann A, Roska B and Filipowicz W: A network comprising short and long noncoding RNAs and RNA helicase controls mouse retina architecture. Nat Commun. 6(7305)2015.PubMed/NCBI View Article : Google Scholar

11 

Wu QY, Li X, Miao ZN, Ye JX, Wang B, Zhang F, Xu RS, Jiang DL, Zhao MD and Yuan FL: Long non-coding RNAs: A new regulatory code for osteoporosis. Front Endocrinol (Lausanne). 9(587)2018.PubMed/NCBI View Article : Google Scholar

12 

Gong YY, Peng MY, Yin DQ and Yang YF: Long non-coding RNA H19 promotes the osteogenic differentiation of rat ectomesenchymal stem cells via Wnt/β-catenin signaling pathway. Eur Rev Med Pharmacol Sci. 22:8805–8813. 2018.PubMed/NCBI View Article : Google Scholar

13 

Liao J, Xiao H, Dai G, He T and Huang W: Recombinant adenovirus (AdEasy system) mediated exogenous expression of long non-coding RNA H19 (lncRNA H19) biphasic regulating osteogenic differentiation of mesenchymal stem cells (MSCs). Am J Transl Res. 12:1700–1713. 2020.PubMed/NCBI

14 

Zhang J, Tao Z and Wang Y: Long non-coding RNA DANCR regulates the proliferation and osteogenic differentiation of human bone-derived marrow mesenchymal stem cells via the p38 MAPK pathway. Int J Mol Med. 41:213–219. 2018.PubMed/NCBI View Article : Google Scholar

15 

Jin C, Jia L, Huang Y, Zheng Y, Du N, Liu Y and Zhou Y: Inhibition of lncRNA MIR31HG Promotes Osteogenic Differentiation of Human Adipose-Derived Stem Cells. Stem Cells. 34:2707–2720. 2016.PubMed/NCBI View Article : Google Scholar

16 

Xiaoling G, Shuaibin L and Kailu L: MicroRNA-19b-3p promotes cell proliferation and osteogenic differentiation of BMSCs by interacting with lncRNA H19. BMC Med Genet. 21(11)2020.PubMed/NCBI View Article : Google Scholar

17 

Gao X, Ge J, Li W, Zhou W and Xu L: LncRNA KCNQ1OT1 ameliorates particle-induced osteolysis through inducing macrophage polarization by inhibiting miR-21a-5p. Biol Chem. 399:375–386. 2018.PubMed/NCBI View Article : Google Scholar

18 

Bu Y, Zheng D, Wang L and Liu J: LncRNA TSIX promotes osteoblast apoptosis in particle-induced osteolysis by down-regulating miR-30a-5p. Connect Tissue Res. 59:534–541. 2018.PubMed/NCBI View Article : Google Scholar

19 

Percie Du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, et al: The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. BMJ Open Sci. 4(e100115)2020.PubMed/NCBI View Article : Google Scholar

20 

Inada M, Matsumoto C and Miyaura C: Animal models for bone and joint disease. Ovariectomized and orchidectomized animals. Clin Calcium. 21:164–170. 2011.PubMed/NCBI(In Japanese).

21 

Høydal MA, Wisløff U, Kemi OJ and Ellingsen O: Running speed and maximal oxygen uptake in rats and mice: Practical implications for exercise training. Eur J Cardiovasc Prev Rehabil. 14:753–760. 2007.PubMed/NCBI View Article : Google Scholar

22 

Deckard C, Walker A and Hill BJF: Using three-point bending to evaluate tibia bone strength in ovariectomized young mice. J Biol Phys. 43:139–148. 2017.PubMed/NCBI View Article : Google Scholar

23 

Zhang L, Chen X, Wu J, Yuan Y, Guo J, Biswas S, Li B and Zou J: The effects of different intensities of exercise and active vitamin D on mouse bone mass and bone strength. J Bone Miner Metab. 35:265–277. 2017.PubMed/NCBI View Article : Google Scholar

24 

Zhang M, Ishikawa S, Inagawa T, Ikemoto H, Guo S, Sunagawa M and Hisamitsu T: Influence of mechanical force on bone matrix proteins in ovariectomised mice and osteoblast-like MC3T3-E1 Cells. In Vivo. 31:87–95. 2017.PubMed/NCBI View Article : Google Scholar

25 

Bu S, Chen Y, Wang S, Zhang F and Ji G: Treadmill training regulates β-catenin signaling through phosphorylation of GSK-3β in lumbar vertebrae of ovariectomized rats. Eur J Appl Physiol. 112:3295–3304. 2012.PubMed/NCBI View Article : Google Scholar

26 

Liu M, Zhong C, He RX and Chen LF: Icariin associated with exercise therapy is an effective treatment for postmenopausal osteoporosis. Chin Med J (Engl). 125:1784–1789. 2012.PubMed/NCBI

27 

Shang G, Wang Y, Xu Y, Zhang S, Sun X, Guan H, Zhao X, Wang Y, Li Y and Zhao G: Long non-coding RNA TCONS_00041960 enhances osteogenesis and inhibits adipogenesis of rat bone marrow mesenchymal stem cell by targeting miR-204-5p and miR-125a-3p. J Cell Physiol. 233:6041–6051. 2018.PubMed/NCBI View Article : Google Scholar

28 

Wu J, Zhao J, Sun L, Pan Y, Wang H and Zhang WB: Long non-coding RNA H19 mediates mechanical tension-induced osteogenesis of bone marrow mesenchymal stem cells via FAK by sponging miR-138. Bone. 108:62–70. 2018.PubMed/NCBI View Article : Google Scholar

29 

Yang Y, Yujiao W, Fang W, Linhui Y, Ziqi G, Zhichen W, Zirui W and Shengwang W: The roles of miRNA, lncRNA and circRNA in the development of osteoporosis. Biol Res. 53(40)2020.PubMed/NCBI View Article : Google Scholar

30 

Huang G, Kang Y, Huang Z and Zhang Z, Meng F, Chen W, Fu M, Liao W and Zhang Z: Identification and characterization of long non-coding RNAs in osteogenic differentiation of human adipose-derived stem cells. Cell Physiol Biochem. 42:1037–1050. 2017.PubMed/NCBI View Article : Google Scholar

31 

Hao L, Fu J, Tian Y and Wu J: Systematic analysis of lncRNAs, miRNAs and mRNAs for the identification of biomarkers for osteoporosis in the mandible of ovariectomized mice. Int J Mol Med. 40:689–702. 2017.PubMed/NCBI View Article : Google Scholar

32 

Li B, Liu J, Zhao J, Ma JX, Jia HB, Zhang Y, Xing GS and Ma XL: LncRNA-H19 modulates Wnt/β-catenin signaling by targeting Dkk4 in hindlimb unloaded rat. Orthop Surg. 9:319–327. 2017.PubMed/NCBI View Article : Google Scholar

33 

Wei CW, Luo T, Zou SS and Wu AS: The role of long noncoding RNAs in central nervous system and neurodegenerative diseases. Front Behav Neurosci. 12(175)2018.PubMed/NCBI View Article : Google Scholar

34 

Zhao N, Zeng L, Liu Y, Han D, Liu H, Xu J, Jiang Y, Li C, Cai T, Feng H, et al: DLX3 promotes bone marrow mesenchymal stem cell proliferation through H19/miR-675 axis. Clin Sci (Lond). 131:2721–2735. 2017.PubMed/NCBI View Article : Google Scholar

35 

Li W, Zhu HM, Xu HD, Zhang B and Huang SM: CRNDE impacts the proliferation of osteoclast by estrogen deficiency in postmenopausal osteoporosis. Eur Rev Med Pharmacol Sci. 22:5815–5821. 2018.PubMed/NCBI View Article : Google Scholar

36 

Wang Q, Li Y and Zhang Y, Ma L, Lin L, Meng J, Jiang L, Wang L, Zhou P and Zhang Y: LncRNA MEG3 inhibited osteogenic differentiation of bone marrow mesenchymal stem cells from postmenopausal osteoporosis by targeting miR-133a-3p. Biomed Pharmacother. 89:1178–1186. 2017.PubMed/NCBI View Article : Google Scholar

37 

Cauley JA: Estrogen and bone health in men and women. Steroids. 99:11–15. 2015.PubMed/NCBI View Article : Google Scholar

38 

Wapinski O and Chang HY: Long noncoding RNAs and human disease. Trends Cell Biol. 21:354–361. 2011.PubMed/NCBI View Article : Google Scholar

39 

Linder M, Hecking M, Glitzner E, Zwerina K, Holcmann M, Bakiri L, Ruocco MG, Tuckermann J, Schett G, Wagner EF, et al: EGFR controls bone development by negatively regulating mTOR-signaling during osteoblast differentiation. Cell Death Differ. 25:1094–1106. 2018.PubMed/NCBI View Article : Google Scholar

40 

Ruocco MG, Maeda S, Park JM, Lawrence T, Hsu LC, Cao Y, Schett G, Wagner EF and Karin M: I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. J Exp Med. 201:1677–1687. 2005.PubMed/NCBI View Article : Google Scholar

41 

Franzoso G, Carlson L, Xing L, Poljak L, Shores EW, Brown KD, Leonardi A, Tran T, Boyce BF and Siebenlist U: Requirement for NF-kappaB in osteoclast and B-cell development. Genes Dev. 11:3482–3496. 1997.PubMed/NCBI View Article : Google Scholar

42 

Youssef A and Han VKM: Regulation of osteogenic differentiation of placental-derived mesenchymal stem cells by insulin-like growth factors and low oxygen tension. Stem Cells Int. 2017(4576327)2017.PubMed/NCBI View Article : Google Scholar

43 

Kang H, Yan Y, Jia P, Yang K, Guo C, Chen H, Qi J, Qian N, Xu X, Wang F, et al: Desferrioxamine reduces ultrahigh-molecular-weight polyethylene-induced osteolysis by restraining inflammatory osteoclastogenesis via heme oxygenase-1. Cell Death Dis. 7(e2435)2016.PubMed/NCBI View Article : Google Scholar

44 

Mayr-Wohlfart U, Waltenberger J, Hausser H, Kessler S, Günther KP, Dehio C, Puhl W and Brenner RE: Vascular endothelial growth factor stimulates chemotactic migration of primary human osteoblasts. Bone. 30:472–477. 2002.PubMed/NCBI View Article : Google Scholar

45 

HaDuong JH, Blavier L, Baniwal SK, Frenkel B, Malvar J, Punj V, Sposto R and DeClerck YA: Interaction between bone marrow stromal cells and neuroblastoma cells leads to a VEGFA-mediated osteoblastogenesis. Int J Cancer. 137:797–809. 2015.PubMed/NCBI View Article : Google Scholar

46 

Xia T, Liao Q, Jiang X, Shao Y, Xiao B, Xi Y and Guo J: Long noncoding RNA associated-competing endogenous RNAs in gastric cancer. Sci Rep. 4(6088)2014.PubMed/NCBI View Article : Google Scholar

47 

Grünhagen J, Bhushan R, Degenkolbe E, Jäger M, Knaus P, Mundlos S, Robinson PN and Ott CE: MiR-497~195 cluster microRNAs regulate osteoblast differentiation by targeting BMP signaling. J Bone Miner Res. 30:796–808. 2015.PubMed/NCBI View Article : Google Scholar

48 

Gan K, Dong GH, Wang N and Zhu JF: miR-221-3p and miR-222-3p downregulation promoted osteogenic differentiation of bone marrow mesenchyme stem cells through IGF-1/ERK pathway under high glucose condition. Diabetes Res Clin Pract. 167(108121)2020.PubMed/NCBI View Article : Google Scholar

49 

Cui Q, Xing J, Yu M, Wang Y, Xu J, Gu Y, Nan X, Ma W, Liu H and Zhao H: Mmu-miR-185 depletion promotes osteogenic differentiation and suppresses bone loss in osteoporosis through the Bgn-mediated BMP/Smad pathway. Cell Death Dis. 10(172)2019.PubMed/NCBI View Article : Google Scholar

50 

Wu Z, Zhang Y, Yang Z, Zhu Y, Xie Y, Zhou F and Cai L: Elevation of miR-302b prevents multiple myeloma cell growth and bone destruction by blocking DKK1 secretion. Cancer Cell Int. 21(187)2021.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Guo J, Yuan Y, Zhang L, Wang M, Tong X, Liu L, Zhang M, Li H, Chen X, Zou J, Zou J, et al: Effects of exercise on the expression of long non‑coding RNAs in the bone of mice with osteoporosis. Exp Ther Med 23: 70, 2022.
APA
Guo, J., Yuan, Y., Zhang, L., Wang, M., Tong, X., Liu, L. ... Zou, J. (2022). Effects of exercise on the expression of long non‑coding RNAs in the bone of mice with osteoporosis. Experimental and Therapeutic Medicine, 23, 70. https://doi.org/10.3892/etm.2021.10993
MLA
Guo, J., Yuan, Y., Zhang, L., Wang, M., Tong, X., Liu, L., Zhang, M., Li, H., Chen, X., Zou, J."Effects of exercise on the expression of long non‑coding RNAs in the bone of mice with osteoporosis". Experimental and Therapeutic Medicine 23.1 (2022): 70.
Chicago
Guo, J., Yuan, Y., Zhang, L., Wang, M., Tong, X., Liu, L., Zhang, M., Li, H., Chen, X., Zou, J."Effects of exercise on the expression of long non‑coding RNAs in the bone of mice with osteoporosis". Experimental and Therapeutic Medicine 23, no. 1 (2022): 70. https://doi.org/10.3892/etm.2021.10993
Copy and paste a formatted citation
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Spandidos Publications style
Guo J, Yuan Y, Zhang L, Wang M, Tong X, Liu L, Zhang M, Li H, Chen X, Zou J, Zou J, et al: Effects of exercise on the expression of long non‑coding RNAs in the bone of mice with osteoporosis. Exp Ther Med 23: 70, 2022.
APA
Guo, J., Yuan, Y., Zhang, L., Wang, M., Tong, X., Liu, L. ... Zou, J. (2022). Effects of exercise on the expression of long non‑coding RNAs in the bone of mice with osteoporosis. Experimental and Therapeutic Medicine, 23, 70. https://doi.org/10.3892/etm.2021.10993
MLA
Guo, J., Yuan, Y., Zhang, L., Wang, M., Tong, X., Liu, L., Zhang, M., Li, H., Chen, X., Zou, J."Effects of exercise on the expression of long non‑coding RNAs in the bone of mice with osteoporosis". Experimental and Therapeutic Medicine 23.1 (2022): 70.
Chicago
Guo, J., Yuan, Y., Zhang, L., Wang, M., Tong, X., Liu, L., Zhang, M., Li, H., Chen, X., Zou, J."Effects of exercise on the expression of long non‑coding RNAs in the bone of mice with osteoporosis". Experimental and Therapeutic Medicine 23, no. 1 (2022): 70. https://doi.org/10.3892/etm.2021.10993
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