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Aggressive prolactinoma (Review)

  • Authors:
    • Ana Valea
    • Florica Sandru
    • Aida Petca
    • Mihai Cristian Dumitrascu
    • Mara Carsote
    • Razvan-Cosmin Petca
    • Adina Ghemigian
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, ‘I. Hatieganu’ University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania, Department of Dermatology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Obstetrics and Gynecology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Endocrinology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Urology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania
  • Article Number: 74
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    Published online on: November 24, 2021
       https://doi.org/10.3892/etm.2021.10997
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Abstract

Aggressive prolactinoma (APRL) is a subgroup of aggressive pituitary tumors (accounting for 10% of all hypophyseal neoplasia) which are defined by: invasion based on radiological and/or histological features, a higher proliferation profile when compared to typical adenomas and rapidly developing resistance to standard medication/protocols in addition to an increased risk of early recurrence. This is a narrative review focusing on APRL in terms of both presentation and management. Upon admission, the suggestive features may include increased serum prolactin with a large tumor diameter (mainly >4 cm), male sex, early age at diagnosis (<20 years), and genetic predisposition [multiple endocrine neoplasia type 1 (MEN1), aryl hydrocarbon receptor interacting protein (AIP), succinate dehydrogenase (SDHx) gene mutations]. Potential prognostic factors are indicated by assessment of E-cadherin, matrix metalloproteinase (MMP)-9, and vascular endothelial growth factor (VEGF) status. Furthermore, during management, APRL may be associated with dopamine agonist (DA) resistance (described in 10-20% of all prolactinomas), post-hypophysectomy relapse, mitotic count >2, Ki-67 proliferation index ≥3%, the need for radiotherapy, lack of response in terms of controlling prolactin levels and tumor growth despite multimodal therapy. However, none of these as an isolated element serves as a surrogate of APRL diagnosis. A fourth-line therapy is necessary with temozolomide, an oral alkylating chemotherapeutic agent, that may induce tumor reduction and serum prolactin reduction in 75% of cases but only 8% have a normalization of prolactin levels. Controversies surrounding the duration of therapy still exist; also regarding the fifth-line therapy, post-temozolomide intervention. Recent data suggest alternatives such as somatostatin analogues (pasireotide), checkpoint inhibitors (ipilimumab, nivolumab), tyrosine kinase inhibitors (TKIs) (lapatinib), and mTOR inhibitors (everolimus). APRL represents a complex condition that is still challenging, and multimodal therapy is essential.
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1 

Chatzellis E, Alexandraki KI, Androulakis II and Kaltsas G: Aggressive pituitary tumors. Neuroendocrinology. 101:87–104. 2015.PubMed/NCBI View Article : Google Scholar

2 

Iglesias P, Magallón R, Mitjavila M, Rodríguez Berrocal V, Pian H and Díez JJ: Multimodal therapy in aggressive pituitary tumors. Endocrinol Diabetes Nutr (Engl Ed). 67:469–485. 2020.PubMed/NCBI View Article : Google Scholar

3 

Ilie MD, Jouanneau E and Raverot G: Aggressive pituitary adenomas and carcinomas. Endocrinol Metab Clin North Am. 49:505–515. 2020.PubMed/NCBI View Article : Google Scholar

4 

Raverot G, Burman P, McCormack A, Heaney A, Petersenn S, Popovic V, Trouillas J and Dekkers OM: European Society of Endocrinology. European society of endocrinology clinical practice guidelines for the management of aggressive pituitary tumours and carcinomas. Eur J Endocrinol. 178:G1–G24. 2018.PubMed/NCBI View Article : Google Scholar

5 

Thakkar K, Sarathi V and Shah NS: Current Status of diagnosis and management for functioning pituitary tumors: Part I. Neurol India. 68 (Suppl 1):S13–S19. 2020.PubMed/NCBI View Article : Google Scholar

6 

Mehta GU and Lonser RR: Management of hormone-secreting pituitary adenomas. Neuro Oncol. 19:762–773. 2017.PubMed/NCBI View Article : Google Scholar

7 

Araujo-Castro M, Berrocal VR and Pascual-Corrales E: Pituitary tumors: Epidemiology and clinical presentation spectrum. Hormones (Athens). 19:145–155. 2020.PubMed/NCBI View Article : Google Scholar

8 

Poiana C, Chirita C, Carsote M, Hortopan D and Goldstein A: Galactocele and prolactinoma-a pathogenic association? Maturitas. 6:98–102. 2009.PubMed/NCBI View Article : Google Scholar

9 

Samperi I, Lithgow K and Karavitaki N: Hyperprolactinaemia. J Clin Med. 8(2203)2019.PubMed/NCBI View Article : Google Scholar

10 

Greenman Y: Prolactinomas and menopause: Any changes in management? Pituitary. 23:58–64. 2020.PubMed/NCBI View Article : Google Scholar

11 

Tirosh A and Shimon I: Management of macroprolactinomas. Clin Diabetes Endocrinol. 1(5)2015.PubMed/NCBI View Article : Google Scholar

12 

Iliesiu A, Ungureanu IA, Petca A, Constantin MM, Petca RC, Sandru F, Constantin T and Dumitrascu MC: Paraganglioma presenting as a mesenteric cystic mass: A case report. Exp Ther Med. 20:2489–2492. 2020.PubMed/NCBI View Article : Google Scholar

13 

Nassiri F, Cusimano MD, Scheithauer BW, Rotondo F, Fazio A, Syro LV, Kovacs K and Lloyd RV: Prolactinomas: Diagnosis and treatment. Expert Rev Endocrinol Metab. 7:233–241. 2012.PubMed/NCBI View Article : Google Scholar

14 

Van den Broek MF, van Nesselrooij BP, Verrijn Stuart AA, van Leeuwaarde RS and Valk GD: Clinical relevance of genetic analysis in patients with pituitary adenomas: A systematic review. Front Endocrinol (Lausanne). 10(837)2019.PubMed/NCBI View Article : Google Scholar

15 

Barry S and Korbonits M: Update on the genetics of pituitary tumors. Endocrinol Metab Clin North Am. 49:433–452. 2020.PubMed/NCBI View Article : Google Scholar

16 

Carty DM, Harte R, Drummond RS, Ward R, Magid K, Collier D, Owens M and Korbonits M: AIP variant causing familial prolactinoma. Pituitary. 24:48–52. 2021.PubMed/NCBI View Article : Google Scholar

17 

Daly AF, Cano DA, Venegas-Moreno E, Petrossians P, Dios E, Castermans E, Flores-Martínez A, Bours V, Beckers A and Soto-Moreno A: AIP and MEN1 mutations and AIP immunohistochemistry in pituitary adenomas in a tertiary referral center. Endocr Connect. 8:338–348. 2019.PubMed/NCBI View Article : Google Scholar

18 

Schernthaner-Reiter MH, Trivellin G and Stratakis CA: Interaction of AIP with protein kinase A (cAMP-dependent protein kinase). Hum Mol Genet. 27:2604–2613. 2018.PubMed/NCBI View Article : Google Scholar

19 

Cuny T, Barlier A, Feelders R, Weryha G, Hofland LJ, Ferone D and Gatto F: Medical therapies in pituitary adenomas: Current rationale for the use and future perspectives. Ann Endocrinol (Paris). 76:43–58. 2015.PubMed/NCBI View Article : Google Scholar

20 

Honegger J, Nasi-Kordhishti I, Aboutaha N and Giese S: Surgery for prolactinomas: A better choice? Pituitary. 23:45–51. 2020.PubMed/NCBI View Article : Google Scholar

21 

Kuo M, Maya MM, Bonert V and Melmed S: Prospective evaluation of incidental pituitary imaging findings in the Sella Turcica. J Endocr Soc. 5(bvaa186)2020.PubMed/NCBI View Article : Google Scholar

22 

Chanson P and Maiter D: The epidemiology, diagnosis and treatment of Prolactinomas: The old and the new. Best Pract Res Clin Endocrinol Metab. 33(101290)2019.PubMed/NCBI View Article : Google Scholar

23 

Lasolle H, Ilie MD and Raverot G: Aggressive prolactinomas: How to manage? Pituitary. 23:70–77. 2020.PubMed/NCBI View Article : Google Scholar

24 

Donoho DA and Laws ER Jr: The role of surgery in the management of prolactinomas. Neurosurg Clin N Am. 30:509–514. 2019.PubMed/NCBI View Article : Google Scholar

25 

Dai C, Liu X, Ma W and Wang R: The treatment of refractory pituitary adenomas. Front Endocrinol (Lausanne). 10(334)2019.PubMed/NCBI View Article : Google Scholar

26 

Hauser BM, Lau A, Gupta S, Bi WL and Dunn IF: The Epigenomics of pituitary adenoma. Front Endocrinol (Lausanne). 10(290)2019.PubMed/NCBI View Article : Google Scholar

27 

Trouillas J, Delgrange E, Wierinckx A, Vasiljevic A, Jouanneau E, Burman P and Raverot G: Clinical, pathological, and molecular factors of aggressiveness in lactotroph tumours. Neuroendocrinology. 109:70–76. 2019.PubMed/NCBI View Article : Google Scholar

28 

Vroonen L, Daly AF and Beckers A: Epidemiology and management challenges in prolactinomas. Neuroendocrinology. 109:20–27. 2019.PubMed/NCBI View Article : Google Scholar

29 

Yoo F, Chan C, Kuan EC, Bergsneider M and Wang MB: Comparison of male and female prolactinoma patients requiring surgical intervention. J Neurol Surg B Skull Base. 79:394–400. 2018.PubMed/NCBI View Article : Google Scholar

30 

Olarescu NC, Perez-Rivas LG, Gatto F, Cuny T, Tichomirowa MA, Tamagno G and Gahete MD: EYRC (ENEA Young Researcher Committee). Aggressive and malignant prolactinomas. Neuroendocrinology. 109:57–69. 2019.PubMed/NCBI View Article : Google Scholar

31 

Glezer A and Bronstein MD: Prolactinomas. Endocrinol Metab Clin North Am. 44:71–78. 2015.PubMed/NCBI View Article : Google Scholar

32 

Langlois F, McCartney S and Fleseriu M: Recent progress in the medical therapy of pituitary tumors. Endocrinol Metab (Seoul). 32:162–170. 2017.PubMed/NCBI View Article : Google Scholar

33 

Bettencourt-Silva R, Queirós J, Pereira J and Carvalho D: Giant prolactinoma, germline BRCA1 mutation, and depression: A case report. J Med Case Rep. 12(360)2018.PubMed/NCBI View Article : Google Scholar

34 

Huynh PP, Ishii LE and Ishii M: Prolactinomas. JAMA. 325(195)2021.PubMed/NCBI View Article : Google Scholar

35 

Giraldi EA and Ioachimescu AG: The role of dopamine agonists in pituitary adenomas. Endocrinol Metab Clin North Am. 49:453–474. 2020.PubMed/NCBI View Article : Google Scholar

36 

Shimon I: Giant prolactinomas. Neuroendocrinology. 109:51–56. 2019.PubMed/NCBI View Article : Google Scholar

37 

Sahakian N, Castinetti F, Dufour H, Graillon T, Romanet P, Barlier A, Brue T and Cuny T: Clinical management of difficult to treat macroprolactinomas. Expert Rev Endocrinol Metab. 14:179–192. 2019.PubMed/NCBI View Article : Google Scholar

38 

Vroonen L, Daly AF and Beckers A: Challenges and controversies in the treatment of prolactinomas. Expert Rev Endocrinol Metab. 9:593–604. 2014.PubMed/NCBI View Article : Google Scholar

39 

Salenave S, Ancelle D, Bahougne T, Raverot G, Kamenický P, Bouligand J, Guiochon-Mantel A, Linglart A, Souchon PF, Nicolino M, et al: Macroprolactinomas in children and adolescents: Factors associated with the response to treatment in 77 patients. J Clin Endocrinol Metab. 100:1177–1186. 2015.PubMed/NCBI View Article : Google Scholar

40 

Vermeulen E, D'Haens J, Stadnik T, Unuane D, Barbe K, Van Velthoven V and Gläsker S: Predictors of dopamine agonist resistance in prolactinoma patients. BMC Endocr Disord. 20(68)2020.PubMed/NCBI View Article : Google Scholar

41 

Maiter D: Management of dopamine agonist-resistant prolactinoma. Neuroendocrinology. 109:42–50. 2019.PubMed/NCBI View Article : Google Scholar

42 

Espinosa-Cárdenas E, Sánchez-García M, Ramírez-Rentería C, Mendoza-Zubieta V, Sosa-Eroza E and Mercado M: High biochemical recurrence rate after withdrawal of cabergoline in prolactinomas: Is it necessary to restart treatment? Endocrine. 70:143–149. 2020.PubMed/NCBI View Article : Google Scholar

43 

Vermeulen E, D'Haens J, Stadnik T, Unuane D, Barbe K, Van Velthoven V and Gläsker S: Predictors of dopamine agonist resistance in prolactinoma patients. BMC Endocr Disord. 20(68)2020.PubMed/NCBI View Article : Google Scholar

44 

Lu C, Liu Y, Lu Z and Huan C: Ki-67 and clinical correlations in patients with resistant prolactinomas. Ann Clin Lab Sci. 50:199–204. 2020.PubMed/NCBI

45 

Stiles CE, Steeds RP and Drake WM: Monitoring patients receiving dopamine agonist therapy for hyperprolactinaemia. Ann Endocrinol (Paris). 82:182–186. 2021.PubMed/NCBI View Article : Google Scholar

46 

Souteiro P, Belo S and Carvalho D: Dopamine agonists in prolactinomas: When to withdraw? Pituitary. 23:38–44. 2020.PubMed/NCBI View Article : Google Scholar

47 

Castinetti F: Radiation techniques in aggressive pituitary tumours and carcinomas. Rev Endocr Metab Disord. 21:287–292. 2020.PubMed/NCBI View Article : Google Scholar

48 

Pérez Pinzón J, González-Devia D, Kattah Calderón W, López Panqueva RDP and Jiménez Hakim E: Unusual course of an aggressive pituitary prolactinoma: Case report and review of the literature. Case Rep Neurol. 11:148–156. 2019.PubMed/NCBI View Article : Google Scholar

49 

Barkhoudarian G, Palejwala SK, Ogunbameru R, Wei H, Eisenberg A and Kelly DF: Early recognition and initiation of temozolomide chemotherapy for refractory, invasive pituitary macroprolactinoma with long-term sustained remission. World Neurosurg. 118:118–124. 2018.PubMed/NCBI View Article : Google Scholar

50 

Chen C, Yin S, Zhang S, Wang M, Hu Y, Zhou P and Jiang S: Treatment of aggressive prolactinoma with temozolomide: A case report and review of literature up to date. Medicine (Baltimore). 96(e8733)2017.PubMed/NCBI View Article : Google Scholar

51 

Lizzul L, Lombardi G, Barbot M, Ceccato F, Gardiman MP, Regazzo D, Bellu L, Mazza E, Losa M and Scaroni C: Long-course temozolomide in aggressive pituitary adenoma: Real-life experience in two tertiary care centers and review of the literature. Pituitary. 23:359–366. 2020.PubMed/NCBI View Article : Google Scholar

52 

Elbelt U, Schlaffer SM, Buchfelder M, Knappe UJ, Vila G, Micko A, Deutschbein T, Unger N, Lammert A, Topuzoglu-Müller T, et al: Efficacy of temozolomide therapy in patients with aggressive pituitary adenomas and carcinomas-a German survey. J Clin Endocrinol Metab. 105(dgz211)2020.PubMed/NCBI View Article : Google Scholar

53 

Almalki MH, Aljoaib NN, Alotaibi MJ, Aldabas BS, Wahedi TS, Ahmad MM and Alshahrani F: Temozolomide therapy for resistant prolactin-secreting pituitary adenomas and carcinomas: A systematic review. Hormones (Athens). 16:139–149. 2017.PubMed/NCBI View Article : Google Scholar

54 

Aydoğan Bİ, Ünlütürk U, Emral R and Güllü S: Course of aggressive somatotroph, corticotroph and mammotroph tumors under temozolomide; Report of three cases and review of the literature. Turk Neurosurg: May 7, 2017 (Epub ahead of print).

55 

Mele C, Mencarelli M, Caputo M, Mai S, Pagano L, Aimaretti G, Scacchi M, Falchetti A and Marzullo P: Phenotypes associated with MEN1 syndrome: A focus on genotype-phenotype correlations. Front Endocrinol (Lausanne). 11(591501)2020.PubMed/NCBI View Article : Google Scholar

56 

Miulescu R, Balaban DV, Sandru F and Jinga M: Cutaneous manifestations in pancreatic diseases-A review. J Clin Med. 9(2611)2020.PubMed/NCBI View Article : Google Scholar

57 

Ortiz LD, Syro LV, Scheithauer BW, Rotondo F, Uribe H, Fadul CE, Horvath E and Kovacs K: Temozolomide in aggressive pituitary adenomas and carcinomas. Clinics (Sao Paulo). 67 (Suppl 1):S119–S123. 2012.PubMed/NCBI View Article : Google Scholar

58 

Duhamel C, Ilie MD, Salle H, Nassouri AS, Gaillard S, Deluche E, Assaker R, Mortier L, Cortet C and Raverot G: Immunotherapy in corticotroph and lactotroph aggressive tumors and carcinomas: Two case reports and a review of the literature. J Pers Med. 10(88)2020.PubMed/NCBI View Article : Google Scholar

59 

Cooper O, Bonert VS, Rudnick J, Pressman BD, Lo J, Salvatori R, Yuen KCJ, Fleseriu M and Melmed S: EGFR/ErbB2-targeting lapatinib therapy for aggressive prolactinomas. J Clin Endocrinol Metab. 106:e917–e925. 2021.PubMed/NCBI View Article : Google Scholar

60 

Souteiro P and Karavitaki N: Dopamine agonist resistant prolactinomas: Any alternative medical treatment? Pituitary. 23:27–37. 2020.PubMed/NCBI View Article : Google Scholar

61 

Raverot G, Vasiljevic A, Jouanneau E and Lasolle H: Confirmation of a new therapeutic option for aggressive or dopamine agonist-resistant prolactin pituitary neuroendocrine tumors. Eur J Endocrinol. 181:C1–C3. 2019.PubMed/NCBI View Article : Google Scholar

62 

Gomes-Porras M, Cárdenas-Salas J and Álvarez-Escolá C: Somatostatin analogs in clinical practice: A review. Int J Mol Sci. 21(1682)2020.PubMed/NCBI View Article : Google Scholar

63 

Lv L, Jiang Y, Yin S, Hu Y, Chen C, Ma W, Jiang S and Zhou P: Mammosomatotroph and mixed somatotroph-lactotroph adenoma in acromegaly: A retrospective study with long-term follow-up. Endocrine. 66:310–318. 2019.PubMed/NCBI View Article : Google Scholar

64 

Coopmans EC, van Meyel SWF, Pieterman KJ, van Ipenburg JA, Hofland LJ, Donga E, Daly AF, Beckers A, van der Lely AJ and Neggers SJCMM: Excellent response to pasireotide therapy in an aggressive and dopamine-resistant prolactinoma. Eur J Endocrinol. 181:K21–K27. 2019.PubMed/NCBI View Article : Google Scholar

65 

Siddiqui M, Vora A, Ali S, Abramowitz J and Mirfakhraee S: Pasireotide: A novel treatment for tumor-induced hypoglycemia due to insulinoma and non-islet cell tumor hypoglycemia. J Endocr Soc. 5(bvaa171)2020.PubMed/NCBI View Article : Google Scholar

66 

Zhao N, Yang X, Li C, Ma J and Yin X: Efficacy and safety of pasireotide for Cushing's disease: A protocol for systematic review and meta-analysis. Medicine (Baltimore). 99(e23824)2020.PubMed/NCBI View Article : Google Scholar

67 

Lasolle H, Vasiljevic A, Borson-Chazot F and Raverot G: Pasireotide: A potential therapeutic alternative for resistant prolactinoma. Ann Endocrinol (Paris). 80:84–88. 2019.PubMed/NCBI View Article : Google Scholar

68 

Oki Y: Medical management of functioning pituitary adenoma: An update. Neurol Med Chir (Tokyo). 54:958–965. 2014.PubMed/NCBI View Article : Google Scholar

69 

Valea A, Ghervan C, Carsote M, Morar A, Iacob I, Tomesc F, Pop DD and Georgescu C: Effects of combination therapy: Somatostatin analogues and dopamine agonists on GH and IGF1 levels in acromegaly. Clujul Med. 88:310–313. 2015.PubMed/NCBI View Article : Google Scholar

70 

Valea A, Carsote M, Ghervan C and Georgescu C: Glycemic profile in patients with acromegaly treated with somatostatin analogue. J Med Life. 8:82–86. 2015.PubMed/NCBI

71 

Zhang D, Way JS, Zhang X, Sergey M, Bergsneider M, Wang MB, Yong WH and Heaney AP: Effect of everolimus in treatment of aggressive prolactin-secreting pituitary adenomas. J Clin Endocrinol Metab. 104:1929–1936. 2019.PubMed/NCBI View Article : Google Scholar

72 

Zhang J, Francois R, Iyer R, Seshadri M, Zajac-Kaye M and Hochwald SN: Current understanding of the molecular biology of pancreatic neuroendocrine tumors. J Natl Cancer Inst. 105:1005–1017. 2013.PubMed/NCBI View Article : Google Scholar

73 

Wolin EM: The expanding role of somatostatin analogs in the management of neuroendocrine tumors. Gastrointest Cancer Res. 5:161–168. 2012.PubMed/NCBI

74 

Chen R, Duan J, Li L, Ma Q, Sun Q, Ma J, Li C, Zhou X, Chen H, Jing Y, et al: mTOR promotes pituitary tumor development through activation of PTTG1. Oncogene. 36:979–988. 2017.PubMed/NCBI View Article : Google Scholar

75 

Gorshtein A, Rubinfeld H, Kendler E, Theodoropoulou M, Cerovac V, Stalla GK, Cohen ZR, Hadani M and Shimon I: Mammalian target of rapamycin inhibitors rapamycin and RAD001 (everolimus) induce anti-proliferative effects in GH-secreting pituitary tumor cells in vitro. Endocr Relat Cancer. 16:1017–1027. 2009.PubMed/NCBI View Article : Google Scholar

76 

Dai C, Zhang B, Liu X, Ma S, Yang Y, Yao Y, Feng M, Bao X, Li G, Wang J, et al: Inhibition of PI3K/AKT/mTOR pathway enhances temozolomide-induced cytotoxicity in pituitary adenoma cell lines in vitro and xenografted pituitary adenoma in female nude mice. Endocrinology. 154:1247–1259. 2013.PubMed/NCBI View Article : Google Scholar

77 

Whitelaw BC: How and when to use temozolomide to treat aggressive pituitary tumours. Endocr Relat Cancer. 26:R545–R552. 2019.PubMed/NCBI View Article : Google Scholar

78 

Schreck KC and Grossman SA: Role of temozolomide in the treatment of cancers involving the central nervous system. Oncology (Williston Park). 32:555–560. 2018.PubMed/NCBI

79 

Arora A and Somasundaram K: Glioblastoma vs temozolomide: Can the red queen race be won? Cancer Biol Ther. 20:1083–1090. 2019.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Valea A, Sandru F, Petca A, Dumitrascu MC, Carsote M, Petca R and Ghemigian A: Aggressive prolactinoma (Review). Exp Ther Med 23: 74, 2022.
APA
Valea, A., Sandru, F., Petca, A., Dumitrascu, M.C., Carsote, M., Petca, R., & Ghemigian, A. (2022). Aggressive prolactinoma (Review). Experimental and Therapeutic Medicine, 23, 74. https://doi.org/10.3892/etm.2021.10997
MLA
Valea, A., Sandru, F., Petca, A., Dumitrascu, M. C., Carsote, M., Petca, R., Ghemigian, A."Aggressive prolactinoma (Review)". Experimental and Therapeutic Medicine 23.1 (2022): 74.
Chicago
Valea, A., Sandru, F., Petca, A., Dumitrascu, M. C., Carsote, M., Petca, R., Ghemigian, A."Aggressive prolactinoma (Review)". Experimental and Therapeutic Medicine 23, no. 1 (2022): 74. https://doi.org/10.3892/etm.2021.10997
Copy and paste a formatted citation
x
Spandidos Publications style
Valea A, Sandru F, Petca A, Dumitrascu MC, Carsote M, Petca R and Ghemigian A: Aggressive prolactinoma (Review). Exp Ther Med 23: 74, 2022.
APA
Valea, A., Sandru, F., Petca, A., Dumitrascu, M.C., Carsote, M., Petca, R., & Ghemigian, A. (2022). Aggressive prolactinoma (Review). Experimental and Therapeutic Medicine, 23, 74. https://doi.org/10.3892/etm.2021.10997
MLA
Valea, A., Sandru, F., Petca, A., Dumitrascu, M. C., Carsote, M., Petca, R., Ghemigian, A."Aggressive prolactinoma (Review)". Experimental and Therapeutic Medicine 23.1 (2022): 74.
Chicago
Valea, A., Sandru, F., Petca, A., Dumitrascu, M. C., Carsote, M., Petca, R., Ghemigian, A."Aggressive prolactinoma (Review)". Experimental and Therapeutic Medicine 23, no. 1 (2022): 74. https://doi.org/10.3892/etm.2021.10997
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