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Role of hsa_circ_0066966 in proliferation and migration of hepatitis B virus‑related liver cancer cells

  • Authors:
    • Yinghua Yuan
    • Xiaojin Yang
    • Desheng Xie
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Diseases, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, P.R. China
    Copyright: © Yuan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 87
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    Published online on: November 25, 2021
       https://doi.org/10.3892/etm.2021.11010
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Abstract

A large proportion of liver cancer cases is caused by hepatitis B virus (HBV) infection. In recent years, an increasing number of reports have indicated that circular RNAs (circRNAs) exert regulatory effects in cancer development, whereas the role of circRNAs in HBV‑positive liver cancer requires further investigation. In the present study, abnormally expressed circRNAs were identified in HBV‑positive liver cancer cells through microarray analysis. A total of 1,493 differentially expressed circRNAs [absolute fold‑change (FC) ≥2] in HBV‑positive liver cancer cells were detected, of which 171 were upregulated and 1,322 were downregulated. Subsequently, Gene Ontology enrichment analysis indicated that the genes of dysregulated circRNAs were mainly involved in regulating Sertoli cell differentiation and development, as well as telomeric DNA binding. Kyoto Encyclopedia of Genes and Genomes pathway analysis revealed that most of these genes were enriched in cancer‑related signaling pathways, including the MAPK and Hippo signaling pathways. Next, the expression levels of the top‑10 dysregulated circRNAs were verified in HBV‑positive liver cancer cells through reverse transcription‑quantitative PCR. Among them, hsa_circ_0066966 had the highest absolute Log2FC value and was abnormally increased in HBV‑positive liver cancer cells. Functional experiments further verified that knockdown of hsa_circ_0066966 had a significant inhibitory effect on the proliferation and migration of HBV‑positive liver cancer cells. By contrast, overexpression of hsa_circ_0066966 in HBV‑negative liver cancer cells resulted in the opposite effect. In conclusion, in the present study, comprehensive circRNA profiling in HBV‑positive liver cancer cells indicated that hsa_circ_0066966 may regulate the progression of HBV‑positive liver cancer.
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1 

de Mattos AZ, Debes JD, Boonstra A, Yang JD, Balderramo DC, Sartori GDP and de Mattos AA: Current impact of viral hepatitis on liver cancer development: The challenge remains. World J Gastroenterol. 27:3556–3567. 2021.PubMed/NCBI View Article : Google Scholar

2 

Bravi F, Bosetti C, Tavani A, Gallus S and La Vecchia C: Coffee reduces risk for hepatocellular carcinoma: An updated meta-analysis. Clin Gastroenterol Hepatol. 11:1413–1421.e1. 2013.PubMed/NCBI View Article : Google Scholar

3 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011.PubMed/NCBI View Article : Google Scholar

4 

El-Serag HB and Rudolph KL: Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis. Gastroenterology. 132:2557–2576. 2007.PubMed/NCBI View Article : Google Scholar

5 

Tangkijvanich P, Mahachai V, Komolmit P, Fongsarun J, Theamboonlers A and Poovorawan Y: Hepatitis B virus genotypes and hepatocellular carcinoma in Thailand. World J Gastroenterol. 11:2238–2243. 2005.PubMed/NCBI View Article : Google Scholar

6 

Du Y, Su T, Ding Y and Cao G: Effects of antiviral therapy on the recurrence of hepatocellular carcinoma after curative resection or liver transplantation. Hepat Mon. 12(e6031)2012.PubMed/NCBI View Article : Google Scholar

7 

Meng S, Zhou H, Feng Z, Xu Z, Tang Y, Li P and Wu M: CircRNA: Functions and properties of a novel potential biomarker for cancer. Mol Cancer. 16(94)2017.PubMed/NCBI View Article : Google Scholar

8 

He YX, Ju H, Li N, Jiang YF, Zhao WJ, Song TT and Ren WH: Association between hsa_circ_0006156 expression and incidence of gastric cancer. Eur Rev Med Pharmacol Sci. 24:3030–3036. 2020.PubMed/NCBI View Article : Google Scholar

9 

Chen KH, Pan JF, Chen ZX, Pan D, Gao T, Huang M and Huang JN: Effects of hsa_circ_0000711 expression level on proliferation and apoptosis of hepatoma cells. Eur Rev Med Pharmacol Sci. 24:4161–4171. 2020.PubMed/NCBI View Article : Google Scholar

10 

Wu C, Deng L, Zhuo H, Chen X, Tan Z, Han S, Tang J, Qian X and Yao A: Circulating circRNA predicting the occurrence of hepatocellular carcinoma in patients with HBV infection. J Cell Mol Med. 24:10216–10222. 2020.PubMed/NCBI View Article : Google Scholar

11 

Wang S, Cui S, Zhao W, Qian Z, Liu H, Chen Y, Lv F and Ding HG: Screening and bioinformatics analysis of circular RNA expression profiles in hepatitis B-related hepatocellular carcinoma. Cancer Biomark. 22:631–640. 2018.PubMed/NCBI View Article : Google Scholar

12 

Cortes-Lopez M and Miura P: Emerging functions of circular RNAs. Yale J Biol Med. 89:527–537. 2016.PubMed/NCBI

13 

Barbagallo D, Caponnetto A, Brex D, Mirabella F, Barbagallo C, Lauretta G, Morrone A, Certo F, Broggi G, Caltabiano R, et al: CircSMARCA5 regulates VEGFA mRNA splicing and angiogenesis in glioblastoma multiforme through the binding of SRSF1. Cancers (Basel). 11(194)2019.PubMed/NCBI View Article : Google Scholar

14 

Chen G, Liu T, Yu B, Wang B and Peng Q: CircRNA-UBE2G1 regulates LPS-induced osteoarthritis through miR-373/HIF-1a axis. Cell Cycle. 19:1696–1705. 2020.PubMed/NCBI View Article : Google Scholar

15 

Lu Y, Tan L and Wang X: Circular HDAC9/microRNA-138/Sirtuin-1 pathway mediates synaptic and amyloid precursor protein processing deficits in Alzheimer's disease. Neurosci Bull. 35:877–888. 2019.PubMed/NCBI View Article : Google Scholar

16 

Gu H, Cheng X, Xu J, Zhou K, Bian C, Chen G and Yin X: Circular RNA circFAT1(e2) promotes osteosarcoma progression and metastasis by sponging miR-181b and Regulating HK2 Expression. Biomed Res Int. 2020(3589871)2020.PubMed/NCBI View Article : Google Scholar

17 

Pasquinelli AE: MicroRNAs and their targets: Recognition, regulation and an emerging reciprocal relationship. Nat Rev Genet. 13:271–282. 2012.PubMed/NCBI View Article : Google Scholar

18 

Enright AJ, John B, Gaul U, Tuschl T, Sander C and Marks DS: MicroRNA targets in Drosophila. Genome Biol. 5(R1)2003.PubMed/NCBI View Article : Google Scholar

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

20 

Zhao G and Dai GJ: Hsa_circRNA_000166 Promotes cell proliferation, migration and invasion by regulating miR-330-5p/ELK1 in colon cancer. Onco Targets Ther. 13:5529–5539. 2020.PubMed/NCBI View Article : Google Scholar

21 

Li Y, Shi P, Zheng T, Ying Z and Jiang D: Circular RNA hsa_circ_0131242 promotes triple-negative breast cancer progression by sponging hsa-miR-2682. Onco Targets Ther. 13:4791–4798. 2020.PubMed/NCBI View Article : Google Scholar

22 

Lin J, Liao S, Li E, Liu Z, Zheng R, Wu X and Zeng W: circCYFIP2 acts as a sponge of miR-1205 and affects the expression of its target gene E2F1 to regulate gastric cancer metastasis. Mol Ther Nucleic Acids. 21:121–132. 2020.PubMed/NCBI View Article : Google Scholar

23 

Mao Y, Lv M, Cao W, Liu X, Cui J, Wang Y, Wang Y, Nie G, Liu X and Wang H: Circular RNA 000554 represses epithelial-mesenchymal transition in breast cancer by regulating microRNA-182/ZFP36 axis. FASEB J:. 34:11405–11420. 2020.PubMed/NCBI View Article : Google Scholar

24 

Shang A, Gu C, Wang W, Wang X, Sun J, Zeng B, Chen C, Chang W, Ping Y, Ji P, et al: Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p/miR-506-3p- TGF-β1 axis. Mol Cancer. 19(117)2020.PubMed/NCBI View Article : Google Scholar

25 

Zhang M, Luo H and Hui L: MiR-3619-5p hampers proliferation and cisplatin resistance in cutaneous squamous-cell carcinoma via KPNA4. Biochem Biophys Res Commun. 513:419–425. 2019.PubMed/NCBI View Article : Google Scholar

26 

Zhang Q, Miao S, Han X, Li C, Zhang M, Cui K, Xiong T, Chen Z, Wang C and Xu H: MicroRNA-3619-5p suppresses bladder carcinoma progression by directly targeting beta-catenin and CDK2 and activating p21. Cell Death Dis. 9(960)2018.PubMed/NCBI View Article : Google Scholar

27 

Tan A, Li Q and Chen L: CircZFR promotes hepatocellular carcinoma progression through regulating miR-3619-5p/CTNNB1 axis and activating Wnt/β-catenin pathway. Arch Biochem Biophys. 661:196–202. 2019.PubMed/NCBI View Article : Google Scholar

28 

Zhan M, He K, Xiao J, Liu F, Wang H, Xia Z, Duan X, Huang R, Li Y, He X, et al: LncRNA HOXA11-AS promotes hepatocellular carcinoma progression by repressing miR-214-3p. J Cell Mol Med. 22:3758–3767. 2018.PubMed/NCBI View Article : Google Scholar

29 

Lin T, Dai Y, Guo X, Chen W, Zhao J, Cao L and Wu Z: Silencing of hsa_circ_0008450 represses hepatocellular carcinoma progression through regulation of microRNA-214-3p/EZH2 Axis. Cancer Manag Res. 11:9133–9143. 2019.PubMed/NCBI View Article : Google Scholar

30 

Pan H, Tang L, Jiang H, Li X, Wang R, Gao J and Li Q: Enhanced expression of circ_0000267 in hepatocellular carcinoma indicates poor prognosis and facilitates cell progression by sponging miR-646. J Cell Biochem: Feb 5, 2019 (Epub ahead of print).

31 

Huang JL, Ren TY, Cao SW, Zheng SH, Hu XM, Hu YW, Lin L, Chen J, Zheng L and Wang Q: HBx-related long non-coding RNA DBH-AS1 promotes cell proliferation and survival by activating MAPK signaling in hepatocellular carcinoma. Oncotarget. 6:33791–33804. 2015.PubMed/NCBI View Article : Google Scholar

32 

Zhao X, Qin W, Jiang Y, Yang Z, Yuan B, Dai R, Shen H, Chen Y, Fu J and Wang H: ACADL plays a tumor-suppressor role by targeting Hippo/YAP signaling in hepatocellular carcinoma. NPJ Precis Oncol. 4(7)2020.PubMed/NCBI View Article : Google Scholar

33 

Shi Y, Fang N, Li Y, Guo Z, Jiang W, He Y, Ma Z and Chen Y: Circular RNA LPAR3 sponges microRNA-198 to facilitate esophageal cancer migration, invasion, and metastasis. Cancer Sci. 111:2824–2836. 2020.PubMed/NCBI View Article : Google Scholar

34 

Wang X, Chen Y, Liu W, Liu T and Sun D: Hsa_circ_0128846 promotes tumorigenesis of colorectal cancer by sponging hsa-miR-1184 and releasing AJUBA and inactivating Hippo/YAP signalling. J Cell Mol Med. 24:9908–9924. 2020.PubMed/NCBI View Article : Google Scholar

35 

Choi JH, Kim MJ, Park YK, Im JY, Kwon SM, Kim HC, Woo HG and Wang HJ: Mutations acquired by hepatocellular carcinoma recurrence give rise to an aggressive phenotype. Oncotarget. 8:22903–22916. 2017.PubMed/NCBI View Article : Google Scholar

36 

Cao Y, Tao Q, Kao X and Zhu X: Hsa-circRNA-103809 promotes hepatocellular carcinoma development via MicroRNA-1270/PLAG1 like zinc finger 2 axis. Dig Dis Sci. 66:1524–1532. 2021.PubMed/NCBI View Article : Google Scholar

37 

Liu W, Yin C and Liu Y: Circular RNA circ_0091579 promotes hepatocellular carcinoma proliferation, migration, invasion, and glycolysis through miR-490-5p/CASC3 Axis. Cancer Biother Radiopharm: Jul 14, 2020 (Epub ahead of print).

38 

Guerrieri F, Belloni L, D'Andrea D, Pediconi N, Le Pera L, Testoni B, Scisciani C, Floriot O, Zoulim F, Tramontano A and Levrero M: Genome-wide identification of direct HBx genomic targets. BMC Genomics. 18(184)2017.PubMed/NCBI View Article : Google Scholar

39 

Levrero M and Zucman-Rossi J: Mechanisms of HBV-induced hepatocellular carcinoma. J Hepatol. 64 (Suppl 1):S84–S101. 2016.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Yuan Y, Yang X and Xie D: Role of hsa_circ_0066966 in proliferation and migration of hepatitis B virus‑related liver cancer cells. Exp Ther Med 23: 87, 2022.
APA
Yuan, Y., Yang, X., & Xie, D. (2022). Role of hsa_circ_0066966 in proliferation and migration of hepatitis B virus‑related liver cancer cells. Experimental and Therapeutic Medicine, 23, 87. https://doi.org/10.3892/etm.2021.11010
MLA
Yuan, Y., Yang, X., Xie, D."Role of hsa_circ_0066966 in proliferation and migration of hepatitis B virus‑related liver cancer cells". Experimental and Therapeutic Medicine 23.1 (2022): 87.
Chicago
Yuan, Y., Yang, X., Xie, D."Role of hsa_circ_0066966 in proliferation and migration of hepatitis B virus‑related liver cancer cells". Experimental and Therapeutic Medicine 23, no. 1 (2022): 87. https://doi.org/10.3892/etm.2021.11010
Copy and paste a formatted citation
x
Spandidos Publications style
Yuan Y, Yang X and Xie D: Role of hsa_circ_0066966 in proliferation and migration of hepatitis B virus‑related liver cancer cells. Exp Ther Med 23: 87, 2022.
APA
Yuan, Y., Yang, X., & Xie, D. (2022). Role of hsa_circ_0066966 in proliferation and migration of hepatitis B virus‑related liver cancer cells. Experimental and Therapeutic Medicine, 23, 87. https://doi.org/10.3892/etm.2021.11010
MLA
Yuan, Y., Yang, X., Xie, D."Role of hsa_circ_0066966 in proliferation and migration of hepatitis B virus‑related liver cancer cells". Experimental and Therapeutic Medicine 23.1 (2022): 87.
Chicago
Yuan, Y., Yang, X., Xie, D."Role of hsa_circ_0066966 in proliferation and migration of hepatitis B virus‑related liver cancer cells". Experimental and Therapeutic Medicine 23, no. 1 (2022): 87. https://doi.org/10.3892/etm.2021.11010
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