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Pathological complete response following cisplatin or carboplatin‑based neoadjuvant chemotherapy for triple‑negative breast cancer: A systematic review and meta‑analysis

  • Authors:
    • Radu Vidra
    • Adina Nemes
    • Andreea Vidrean
    • Sebastian Pintea
    • Snejeana Tintari
    • Andrada Deac
    • Tudor Ciuleanu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, 400012 Cluj‑Napoca, Romania, Department of Oncology, ‘Prof. Dr. Ion Chiricuta’ Oncology Institute, 400015 Cluj‑Napoca, Romania, Department of Psychology, ‘Babeș‑Bolyai’ University, 400084 Cluj‑Napoca, Romania, Department of Oncology, ‘Prof. Dr. Octavian Fodor’ Regional Institute of Gastroenterology and Hepatology, 400162 Cluj‑Napoca, Romania
    Copyright: © Vidra et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 91
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    Published online on: November 26, 2021
       https://doi.org/10.3892/etm.2021.11014
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Abstract

The addition of platinum compounds to standard neoadjuvant chemotherapy (NACT) for triple‑negative breast cancer (TNBC) is highly controversial. Platinum agents, such as cisplatin and carboplatin, are DNA‑damaging agents which exhibit activity in breast cancer, particularly in the TNBC subgroup. In order to assess the efficacy of each most representative platinum agent (cisplatin and carboplatin) in patients with TNBC treated with NACT, the present study performed a systematic review and meta‑analysis of all available published studies on TNBC. A search of PubMed was performed to identify studies that investigated platinum‑based NACT in patients with TNBC. The primary endpoints were the pooled rate of the pathological complete response (pCR) between cisplatin vs. carboplatin‑based NACT. A total of 24 studies were selected (17 studies for carboplatin and 6 studies for cisplatin and 1 study with both carboplatin and cisplatin, with 20 prospective studies) for the analysis of 1,711 patients with TNBC. Overall, the pooled rate of pCR in patients treated with platinum‑based NACT was 48%. No significant differences were observed between the rates of pCR obtained under carboplatin vs cisplatin treatment. The carboplatin pCR rate was 0.470 [95% confidence interval (CI), 0.401‑0.539], while the cisplatin pCR rate was 0.473 (95% CI, 0.379‑0.568). The comparison between these two categories revealed no significant differences (P=0.959). In the whole, the present study demonstrates that neoadjuvant platinum‑based chemotherapy improves the pCR rate in patients with TNBC, regardless of the platinum agent used. Carboplatin may thus represent a viable option due to its more favorable toxicity profile.
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Vidra R, Nemes A, Vidrean A, Pintea S, Tintari S, Deac A and Ciuleanu T: Pathological complete response following cisplatin or carboplatin‑based neoadjuvant chemotherapy for triple‑negative breast cancer: A systematic review and meta‑analysis. Exp Ther Med 23: 91, 2022.
APA
Vidra, R., Nemes, A., Vidrean, A., Pintea, S., Tintari, S., Deac, A., & Ciuleanu, T. (2022). Pathological complete response following cisplatin or carboplatin‑based neoadjuvant chemotherapy for triple‑negative breast cancer: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 23, 91. https://doi.org/10.3892/etm.2021.11014
MLA
Vidra, R., Nemes, A., Vidrean, A., Pintea, S., Tintari, S., Deac, A., Ciuleanu, T."Pathological complete response following cisplatin or carboplatin‑based neoadjuvant chemotherapy for triple‑negative breast cancer: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 23.1 (2022): 91.
Chicago
Vidra, R., Nemes, A., Vidrean, A., Pintea, S., Tintari, S., Deac, A., Ciuleanu, T."Pathological complete response following cisplatin or carboplatin‑based neoadjuvant chemotherapy for triple‑negative breast cancer: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 23, no. 1 (2022): 91. https://doi.org/10.3892/etm.2021.11014
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Spandidos Publications style
Vidra R, Nemes A, Vidrean A, Pintea S, Tintari S, Deac A and Ciuleanu T: Pathological complete response following cisplatin or carboplatin‑based neoadjuvant chemotherapy for triple‑negative breast cancer: A systematic review and meta‑analysis. Exp Ther Med 23: 91, 2022.
APA
Vidra, R., Nemes, A., Vidrean, A., Pintea, S., Tintari, S., Deac, A., & Ciuleanu, T. (2022). Pathological complete response following cisplatin or carboplatin‑based neoadjuvant chemotherapy for triple‑negative breast cancer: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 23, 91. https://doi.org/10.3892/etm.2021.11014
MLA
Vidra, R., Nemes, A., Vidrean, A., Pintea, S., Tintari, S., Deac, A., Ciuleanu, T."Pathological complete response following cisplatin or carboplatin‑based neoadjuvant chemotherapy for triple‑negative breast cancer: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 23.1 (2022): 91.
Chicago
Vidra, R., Nemes, A., Vidrean, A., Pintea, S., Tintari, S., Deac, A., Ciuleanu, T."Pathological complete response following cisplatin or carboplatin‑based neoadjuvant chemotherapy for triple‑negative breast cancer: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 23, no. 1 (2022): 91. https://doi.org/10.3892/etm.2021.11014
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