Open Access

Role of heparinase in the gastrointestinal dysfunction of sepsis (Review)

  • Authors:
    • Ting-Ting Chen
    • Jia-Jun Lv
    • Ling Chen
    • Yu-Wei Gao
    • Li-Ping Liu
  • View Affiliations

  • Published online on: December 6, 2021     https://doi.org/10.3892/etm.2021.11042
  • Article Number: 119
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Heparinase (HPA) is a β‑D glucuronidase that belongs to the endoglycosidase enzyme family, and plays an important role in numerous pathological and physiological processes, including inflammation, angiogenesis and tumor metastasis. When the expression of HPA is abnormally high, the side chain of heparin sulfate proteoglycans degrades, destroying the cell barrier and leading to the occurrence and development of inflammation, with systemic inflammation occurring in severe cases. Sepsis is a major cause of mortality in critically ill patients. In sepsis, the gastrointestinal tract is the first and most frequently involved target organ, which often leads to gastrointestinal dysfunction. HPA overexpression has been determined to accelerate sepsis progression and gastrointestinal dysfunction; thus, it was hypothesized that HPA may play an important role and may serve as an index for the diagnosis of gastrointestinal dysfunction in sepsis. HPA inhibitors may therefore become applicable as targeted drugs for the treatment of gastrointestinal dysfunction in patients with sepsis. The present review mainly discussed the role of HPA in gastrointestinal dysfunction of sepsis.
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February-2022
Volume 23 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Chen T, Lv J, Chen L, Gao Y and Liu L: Role of heparinase in the gastrointestinal dysfunction of sepsis (Review). Exp Ther Med 23: 119, 2022
APA
Chen, T., Lv, J., Chen, L., Gao, Y., & Liu, L. (2022). Role of heparinase in the gastrointestinal dysfunction of sepsis (Review). Experimental and Therapeutic Medicine, 23, 119. https://doi.org/10.3892/etm.2021.11042
MLA
Chen, T., Lv, J., Chen, L., Gao, Y., Liu, L."Role of heparinase in the gastrointestinal dysfunction of sepsis (Review)". Experimental and Therapeutic Medicine 23.2 (2022): 119.
Chicago
Chen, T., Lv, J., Chen, L., Gao, Y., Liu, L."Role of heparinase in the gastrointestinal dysfunction of sepsis (Review)". Experimental and Therapeutic Medicine 23, no. 2 (2022): 119. https://doi.org/10.3892/etm.2021.11042