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Article

Lectin‑type oxidized LDL receptor 1 modulates matrix metalloproteinase 2 production in peri‑implantitis

  • Authors:
    • Qian Zhang
    • Tao Xu
    • Na Bai
    • Fei Tan
    • Hongmei Zhao
    • Jie Liu
  • View Affiliations / Copyright

    Affiliations: Department of Prosthodontics, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China, School of Stomatology of Qingdao University, Qingdao, Shandong 266000, P.R. China
  • Article Number: 171
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    Published online on: December 27, 2021
       https://doi.org/10.3892/etm.2021.11094
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Abstract

Peri‑implantitis is a disease in which inflammatory lesions that affect the surrounding soft and hard tissues develop. Matrix metalloproteinase 2 (MMP2) is hypothesized to be involved in this destructive process. However, the regulatory mechanism of action of MMP2 in the peripheral tissues of the implant are not fully understood. To determine the expression of MMP2 in peri‑implantitis, peri‑implant crevicular fluid (PICF) was collected from patients with peri‑implantitis. The healthy volunteers' peripheral blood human macrophages infected with Porphyromonas gingivalis (P. gingivalis) were used as a cell model to explore the regulatory mechanism of MMP2 regarding dental implants. Western blotting, reverse transcription‑­quantitative PCR and immunofluorescence staining were used to measure the expression of MMP2 in the present study. MMP2 expression was increased in the PICF of the patients with peri‑implantitis and in human macrophages infected with P. gingivalis. Lectin‑type oxidized LDL receptor 1 (LOX‑1) mediated the expression of MMP2 in human macrophages upon infection of P. gingivalis, whereas dendritic cell‑associated c‑type lectin‑1 did not appear to be involved in this regulatory process. However, JNK and ERK1/2 were involved in P. gingivalis induced MMP2 expression. The results of this study showed that MMP2 was involved in peri‑implantitis. MMP2 was upregulated by LOX‑1 in a JNK and ERKk1/2 signaling dependent manner in the cell model. The LOX‑1/MMP2 signaling pathway may thus be a potential target for management of peri‑implantitis.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Q, Xu T, Bai N, Tan F, Zhao H and Liu J: Lectin‑type oxidized LDL receptor 1 modulates matrix metalloproteinase 2 production in peri‑implantitis. Exp Ther Med 23: 171, 2022.
APA
Zhang, Q., Xu, T., Bai, N., Tan, F., Zhao, H., & Liu, J. (2022). Lectin‑type oxidized LDL receptor 1 modulates matrix metalloproteinase 2 production in peri‑implantitis. Experimental and Therapeutic Medicine, 23, 171. https://doi.org/10.3892/etm.2021.11094
MLA
Zhang, Q., Xu, T., Bai, N., Tan, F., Zhao, H., Liu, J."Lectin‑type oxidized LDL receptor 1 modulates matrix metalloproteinase 2 production in peri‑implantitis". Experimental and Therapeutic Medicine 23.2 (2022): 171.
Chicago
Zhang, Q., Xu, T., Bai, N., Tan, F., Zhao, H., Liu, J."Lectin‑type oxidized LDL receptor 1 modulates matrix metalloproteinase 2 production in peri‑implantitis". Experimental and Therapeutic Medicine 23, no. 2 (2022): 171. https://doi.org/10.3892/etm.2021.11094
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Q, Xu T, Bai N, Tan F, Zhao H and Liu J: Lectin‑type oxidized LDL receptor 1 modulates matrix metalloproteinase 2 production in peri‑implantitis. Exp Ther Med 23: 171, 2022.
APA
Zhang, Q., Xu, T., Bai, N., Tan, F., Zhao, H., & Liu, J. (2022). Lectin‑type oxidized LDL receptor 1 modulates matrix metalloproteinase 2 production in peri‑implantitis. Experimental and Therapeutic Medicine, 23, 171. https://doi.org/10.3892/etm.2021.11094
MLA
Zhang, Q., Xu, T., Bai, N., Tan, F., Zhao, H., Liu, J."Lectin‑type oxidized LDL receptor 1 modulates matrix metalloproteinase 2 production in peri‑implantitis". Experimental and Therapeutic Medicine 23.2 (2022): 171.
Chicago
Zhang, Q., Xu, T., Bai, N., Tan, F., Zhao, H., Liu, J."Lectin‑type oxidized LDL receptor 1 modulates matrix metalloproteinase 2 production in peri‑implantitis". Experimental and Therapeutic Medicine 23, no. 2 (2022): 171. https://doi.org/10.3892/etm.2021.11094
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