Clinicopathological correlation of transient acantholytic dermatosis: A case report

Brihan,Ilarie; Fekete,Gyula László; Turda,Constanta; Tica,Ovidiu; Venter,Alina Cristiana; Ianosi,Simona; Neagoe,Carmen-Daniela; Branisteanu,Daciana Elena

doi:10.3892/etm.2021.11096

February-2022 Volume 23 Issue 2

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February-2022 Volume 23 Issue 2

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Case Report Open Access

Clinicopathological correlation of transient acantholytic dermatosis: A case report

Authors:
- Ilarie Brihan
- Gyula László Fekete
- Constanta Turda
- Ovidiu Tica
- Alina Cristiana Venter
- Simona Ianosi
- Carmen-Daniela Neagoe
- Daciana Elena Branisteanu
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Affiliations: Dermatology Department, Dermatology Clinic, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania, Dermatology Department, Dermatology Clinic, ‘George Emil Palade’ University of Medicine, Pharmacy, Science and Technology, 540530 Targu Mureș, Romania, Department of Psycho‑Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania, Department of Morphological Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania, Department of Dermatology, University of Medicine and Pharmacy, 200349 Craiova, Romania, Department of Internal Medicine, University of Medicine and Pharmacy, 200349 Craiova, Romania, Department of Dermatology, University of Medicine and Pharmacy ‘Grigore T. Popa’, 700115 Iasi, Romania

Copyright: © Brihan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 173
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Published online on: December 28, 2021

https://doi.org/10.3892/etm.2021.11096
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Abstract

Transient acantholytic dermatosis (TAD) is a benign, non‑familial, non‑immune mediated acantholytic disorder of unknown etiology. The presence of polymorphous, unorganized, pruritic lesions on the trunk, associated with focal acantholysis and dyskeratosis, resembles a wide variety of dermatoses. The etiology of TAD (also known as Grover's disease) is unknown, and the success of treatment relies on the correct identification of the disease; however, some cases are refractory to all forms of therapy. For accurate diagnosis, a comprehensive literature review is required. Here, the case of a 55‑year‑old male with TAD displaying a Darier‑like histopathological pattern was reported. The patient was successfully treated with retinoids and acitretin (Neotigason), as well as dapsone, an anti‑inflammatory agent, as maintenance therapy. The presence of more than two histological findings, limited to small foci and clinical information, can diagnose Darier disease. The exact pathogenesis has not been elucidated, thus further studies of the pathogenesis of TAD are required.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clinicopathological correlation of transient acantholytic dermatosis: A case report

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