Clinicopathological correlation of transient acantholytic dermatosis: A case report

Brihan,Ilarie; Fekete,Gyula László; Turda,Constanta; Tica,Ovidiu; Venter,Alina Cristiana; Ianosi,Simona; Neagoe,Carmen-Daniela; Branisteanu,Daciana Elena

doi:10.3892/etm.2021.11096

Clinicopathological correlation of transient acantholytic dermatosis: A case report

Authors:
- Ilarie Brihan
- Gyula László Fekete
- Constanta Turda
- Ovidiu Tica
- Alina Cristiana Venter
- Simona Ianosi
- Carmen-Daniela Neagoe
- Daciana Elena Branisteanu
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Affiliations: Dermatology Department, Dermatology Clinic, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania, Dermatology Department, Dermatology Clinic, ‘George Emil Palade’ University of Medicine, Pharmacy, Science and Technology, 540530 Targu Mureș, Romania, Department of Psycho‑Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania, Department of Morphological Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania, Department of Dermatology, University of Medicine and Pharmacy, 200349 Craiova, Romania, Department of Internal Medicine, University of Medicine and Pharmacy, 200349 Craiova, Romania, Department of Dermatology, University of Medicine and Pharmacy ‘Grigore T. Popa’, 700115 Iasi, Romania
Published online on: December 28, 2021 https://doi.org/10.3892/etm.2021.11096
Article Number: 173
Copyright: © Brihan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Transient acantholytic dermatosis (TAD) is a benign, non‑familial, non‑immune mediated acantholytic disorder of unknown etiology. The presence of polymorphous, unorganized, pruritic lesions on the trunk, associated with focal acantholysis and dyskeratosis, resembles a wide variety of dermatoses. The etiology of TAD (also known as Grover's disease) is unknown, and the success of treatment relies on the correct identification of the disease; however, some cases are refractory to all forms of therapy. For accurate diagnosis, a comprehensive literature review is required. Here, the case of a 55‑year‑old male with TAD displaying a Darier‑like histopathological pattern was reported. The patient was successfully treated with retinoids and acitretin (Neotigason), as well as dapsone, an anti‑inflammatory agent, as maintenance therapy. The presence of more than two histological findings, limited to small foci and clinical information, can diagnose Darier disease. The exact pathogenesis has not been elucidated, thus further studies of the pathogenesis of TAD are required.

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