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Case Report Open Access

Malignant mixed Müllerian tumor of the fallopian tube: Case report and literature review

  • Authors:
    • Alexandra Lavinia Cozlea
    • Mihai Gheorghe
    • Szilard Leo Kiss
    • Anas Fandi
    • Mihai Stanca
    • Simona Mocan
    • Mihai Emil Căpîlna
    • Nicolae Bacalbașa
    • Andreea Anamaria Moldovan
  • View Affiliations / Copyright

    Affiliations: First Obstetrics and Gynecology Clinic, ‘George Emil Palade’ University of Medicine, Pharmacy, Science, and Technology, 540136 Târgu Mureș, Romania, Department of Pathology, ‘George Emil Palade’ University of Medicine, Pharmacy, Science, and Technology, 540136 Târgu Mureș, Romania, Department of Obstetrics and Gynecology, ‘Carol Davila’ University of Medicine and Pharmacy, 020022 Bucharest, Romania, Department of Infectious Diseases, Brașov County Emergency Hospital, 500326 Brașov, Romania
    Copyright: © Cozlea et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 177
    |
    Published online on: December 28, 2021
       https://doi.org/10.3892/etm.2021.11100
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Abstract

Carcinosarcoma, also known as malignant mixed Müllerian tumor (MMMT), includes both malignant epithelial and mesenchymal elements. While the endometrium is the most frequent known site for carcinosarcomas, their development in the fallopian tube is rare condition, only accounting for 0.1 to 0.5% among all gynecological malignancies. Fallopian tube MMMT is associated with an aggressive progression. A total of 94 previous case reports were reviewed and divided, after applying the exclusion criteria, into 2 groups: No evidence of disease (NED) Group including 33 patients reported to be without any residual disease at the end of the follow‑up period; death of disease (DOD) Group including 51 patients who died due to the progression of fallopian carcinosarcoma or its complications. The gathered data were statistically analyzed together with a case from our clinical experience: a 65‑year‑old postmenopausal patient with a final histological diagnosis of fallopian carcinosarcoma staged FIGO IC2, synchronous with a serous endometrial intraepithelial carcinoma. Patient age between 41 and 60 years, symptoms at presentation and computed tomography (CT)/magnetic resonance imaging (MRI) tumor evidence are prognostic factors (P<0.05). Omentectomy [odds ratio (OR)=0.3545] and pelvic lymphadenectomy (OR=0.3732) were found to be significant factors for survival (P<0.05). Fimbrial localization of the tumor is a negative prognosis factor (OR=4.263), as well as the heterologous type of tumor (OR=2.880). Chemotherapy was found to improve survival (OR=0.2679) while radiotherapy had no influence on patient prognosis. Reporting these rare cases could be essential for obtaining more precise information regarding the treatment and prognosis of patients with MMMT of the fallopian tube, in order to improve patient survival and quality of life.
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Copy and paste a formatted citation
Spandidos Publications style
Cozlea AL, Gheorghe M, Kiss SL, Fandi A, Stanca M, Mocan S, Căpîlna ME, Bacalbașa N and Moldovan AA: Malignant mixed Müllerian tumor of the fallopian tube: Case report and literature review. Exp Ther Med 23: 177, 2022.
APA
Cozlea, A.L., Gheorghe, M., Kiss, S.L., Fandi, A., Stanca, M., Mocan, S. ... Moldovan, A.A. (2022). Malignant mixed Müllerian tumor of the fallopian tube: Case report and literature review. Experimental and Therapeutic Medicine, 23, 177. https://doi.org/10.3892/etm.2021.11100
MLA
Cozlea, A. L., Gheorghe, M., Kiss, S. L., Fandi, A., Stanca, M., Mocan, S., Căpîlna, M. E., Bacalbașa, N., Moldovan, A. A."Malignant mixed Müllerian tumor of the fallopian tube: Case report and literature review". Experimental and Therapeutic Medicine 23.2 (2022): 177.
Chicago
Cozlea, A. L., Gheorghe, M., Kiss, S. L., Fandi, A., Stanca, M., Mocan, S., Căpîlna, M. E., Bacalbașa, N., Moldovan, A. A."Malignant mixed Müllerian tumor of the fallopian tube: Case report and literature review". Experimental and Therapeutic Medicine 23, no. 2 (2022): 177. https://doi.org/10.3892/etm.2021.11100
Copy and paste a formatted citation
x
Spandidos Publications style
Cozlea AL, Gheorghe M, Kiss SL, Fandi A, Stanca M, Mocan S, Căpîlna ME, Bacalbașa N and Moldovan AA: Malignant mixed Müllerian tumor of the fallopian tube: Case report and literature review. Exp Ther Med 23: 177, 2022.
APA
Cozlea, A.L., Gheorghe, M., Kiss, S.L., Fandi, A., Stanca, M., Mocan, S. ... Moldovan, A.A. (2022). Malignant mixed Müllerian tumor of the fallopian tube: Case report and literature review. Experimental and Therapeutic Medicine, 23, 177. https://doi.org/10.3892/etm.2021.11100
MLA
Cozlea, A. L., Gheorghe, M., Kiss, S. L., Fandi, A., Stanca, M., Mocan, S., Căpîlna, M. E., Bacalbașa, N., Moldovan, A. A."Malignant mixed Müllerian tumor of the fallopian tube: Case report and literature review". Experimental and Therapeutic Medicine 23.2 (2022): 177.
Chicago
Cozlea, A. L., Gheorghe, M., Kiss, S. L., Fandi, A., Stanca, M., Mocan, S., Căpîlna, M. E., Bacalbașa, N., Moldovan, A. A."Malignant mixed Müllerian tumor of the fallopian tube: Case report and literature review". Experimental and Therapeutic Medicine 23, no. 2 (2022): 177. https://doi.org/10.3892/etm.2021.11100
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