Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
March-2021 Volume 21 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2021 Volume 21 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Shuxuetong injection simultaneously ameliorates dexamethasone‑driven vascular calcification and osteoporosis

  • Authors:
    • Zhe Xu
    • Xiaoguang Liu
    • Yanqing Li
    • Hongliang Gao
    • Tao He
    • Chunlei Zhang
    • Wei Hao
    • Xu Teng
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Hebei Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang, Hebei 050011, P.R. China, Department of Gynecology, Hebei Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang, Hebei 050011, P.R. China, Department of Physiology, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 197
    |
    Published online on: January 8, 2021
       https://doi.org/10.3892/etm.2021.9630
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Osteoporosis (OP) and vascular calcification (VC) share a number of common risk factors, pathophysiological mechanisms and etiology, which are known as bone‑vascular axis. The present study aimed to investigate the effects of Shuxuetong (SXT) injection on VC and osteoporosis. A rat model of VC and osteoporosis was induced by dexamethasone (DEX; 1 mg/kg/day for 4 weeks, intramuscularly). Simultaneously, 0.6 ml/kg/day SXT was intraperitoneally injected. Compared with control rats, DEX induced significantly more VC and OP, as determined by increased calcium deposition and alkaline phosphatase activity in the aorta, disturbed structure, decreased levels of cortical bone thickness and trabecular bone area, and increased apoptosis in the bone. SXT injection ameliorated DEX‑induced VC and osteoporosis; furthermore, the osteoblastic differentiation of vascular smooth muscle cells and the activation of endoplasmic reticulum stress in the DEX group was also prevented by SXT injection. Compared with control rats, protein expression levels of sclerostin, a crucial crosslink of the bone‑vascular axis, were significantly increased in the aorta and bone of rats with DEX, which was also attenuated by SXT injection. Thus, the present study suggested that SXT injection could ameliorate both VC and OP, and may be mediated by the regulation of sclerostin. The present study may provide the basis a novel strategy for the prevention and treatment of VC and OP, which emerge as side‑effects of glucocorticoids.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Towler DA: Arteriosclerosis, bone biology, and calciotropic hormone signaling: Learning the ABCs of disease in the bone-vascular axis. J Am Soc Nephrol. 26:243–245. 2015.PubMed/NCBI View Article : Google Scholar

2 

Vassalle C and Mazzone A: Bone loss and vascular calcification: A bi-directional interplay? Vascul Pharmacol. 86:77–86. 2016.PubMed/NCBI View Article : Google Scholar

3 

Tap L, Kirkham FA, Mattace-Raso F, Joly L, Rajkumar C and Benetos A: Unraveling the links underlying arterial stiffness, bone demineralization, and muscle loss. Hypertension. 76:629–639. 2020.PubMed/NCBI View Article : Google Scholar

4 

Stafford RS, Drieling RL and Hersh AL: National trends in osteoporosis visits and osteoporosis treatment, 1988-2003. Arch Intern Med. 164:1525–1530. 2004.PubMed/NCBI View Article : Google Scholar

5 

Viaene L, Behets GJ, Heye S, Claes K, Monbaliu D, Pirenne J, D'Haese PC and Evenepoel P: Inflammation and the bone-vascular axis in end-stage renal disease. Osteoporos Int. 27:489–497. 2016.PubMed/NCBI View Article : Google Scholar

6 

Zoppellaro G, Faggin E, Puato M, Pauletto P and Rattazzi M: Fibroblast growth factor 23 and the bone-vascular axis: Lessons learned from animal studies. Am J Kidney Dis. 59:135–144. 2012.PubMed/NCBI View Article : Google Scholar

7 

Kim JM, Lee WS and Kim J: Therapeutic strategy for atherosclerosis based on bone-vascular axis hypothesis. Pharmacol Ther. 206(107436)2020.PubMed/NCBI View Article : Google Scholar

8 

Brandenburg VM, D'Haese P, Deck A, Mekahli D, Meijers B, Neven E and Evenepoel P: From skeletal to cardiovascular disease in 12 steps-the evolution of sclerostin as a major player in CKD-MBD. Pediatr Nephrol. 31:195–206. 2016.PubMed/NCBI View Article : Google Scholar

9 

Fadini GP, Rattazzi M, Matsumoto T, Asahara T and Khosla S: Emerging role of circulating calcifying cells in the bone-vascular axis. Circulation. 125:2772–2781. 2012.PubMed/NCBI View Article : Google Scholar

10 

Pieralice S, Vigevano F, Del Toro R, Napoli N and Maddaloni E: Lifestyle management of diabetes: Implications for the bone-vascular axis. Curr Diab Rep. 18(84)2018.PubMed/NCBI View Article : Google Scholar

11 

D'Onofrio L, Maddaloni E and Buzzetti R: Osteocalcin and sclerostin: Background characters or main actors in cardiovascular disease? Diabetes Metab Res Rev. 36(e3217)2020.PubMed/NCBI View Article : Google Scholar

12 

Figurek A, Rroji M and Spasovski G: Sclerostin: A new biomarker of CKD-MBD. Int Urol Nephrol. 52:107–113. 2020.PubMed/NCBI View Article : Google Scholar

13 

De Maré A, Maudsley S, Azmi A, Hendrickx JO, Opdebeeck B, Neven E, D'Haese PC and Verhulst A: Sclerostin as regulatory molecule in vascular media calcification and the Bone-Vascular Axis. Toxins (Basel). 11(428)2019.PubMed/NCBI View Article : Google Scholar

14 

Leto G, D'Onofrio L, Lucantoni F, Zampetti S, Campagna G, Foffi C, Moretti C, Carlone A, Palermo A, Leopizzi M, et al: Sclerostin is expressed in the atherosclerotic plaques of patients who undergoing carotid endarterectomy. Diabetes Metab Res Rev. 35(e3069)2019.PubMed/NCBI View Article : Google Scholar

15 

Morales-Santana S, García-Fontana B, García-Martín A, Rozas-Moreno P, García-Salcedo JA, Reyes-García R and Muñoz-Torres M: Atherosclerotic disease in type 2 diabetes is associated with an increase in sclerostin levels. Diabetes Care. 36:1667–1674. 2013.PubMed/NCBI View Article : Google Scholar

16 

Saag KG, Petersen J, Brandi ML, Karaplis AC, Lorentzon M, Thomas T, Maddox J, Fan M, Meisner PD and Grauer A: Romosozumab or alendronate for fracture prevention in women with osteoporosis. N Engl J Med. 377:1417–1427. 2017.PubMed/NCBI View Article : Google Scholar

17 

Cai L, Huang W and Lin D: Effects of traditional Chinese medicine Shuxuetong injection on random skin flap survival in rats. ScientificWorldJournal. 2014(816545)2014.PubMed/NCBI View Article : Google Scholar

18 

Jin X, Shen G, Gao F, Zheng X, Xu X, Shen F, Li G, Gong J, Wen L, Yang X and Bie X: Traditional Chinese drug ShuXueTong facilitates angiogenesis during wound healing following traumatic brain injury. J Ethnopharmacol. 117:473–477. 2008.PubMed/NCBI View Article : Google Scholar

19 

Liu X, Qing Wang, Cui Y, Li X and Yang H: In-depth transcriptomic and proteomic analyses of the hippocampus and cortex in a rat model after cerebral ischemic injury and repair by Shuxuetong (SXT) injection. J Ethnopharmacol. 249(112362)2020.PubMed/NCBI View Article : Google Scholar

20 

Sun ZY, Wang FJ, Guo H, Chen L, Chai LJ, Li RL, Hu LM, Wang H and Wang SX: Shuxuetong injection protects cerebral microvascular endothelial cells against oxygen-glucose deprivation reperfusion. Neural Regen Res. 14:783–793. 2019.PubMed/NCBI View Article : Google Scholar

21 

Zhang X, Xiao B and Hu CL: Study in the mechanism of Shuxuetong injection on antithrombosis and thrombolysis. Zhongguo Zhong Yao Za Zhi. 30:1950–1952. 2005.PubMed/NCBI

22 

Chen X, Ding X, Liu L, Zhao L, Jiang Z and Wang X: Effect of Shuxuetong injection on reducing expression of vascular adhesion molecules in cerebral ischemia and reperfusion rats. J New Chin Med. 45:128–130. 2013.

23 

Wei J, Chen B, Tian Z, Luo K and Deng W: Effect of Shuxuetong injection on VEGF expression of hind-limb ischemic vascular disorder in diabetic rats. Zhong Xi Yi Jie He Xin Nao Xue Guan Bing Za Zhi. 7:1048–1049. 2009.(In Chinese).

24 

Zhang Y, Zhou S and Wang B: Effect of Shuxuetong injection on ET-1, sICAM-1, TNF-α and P-selection in diabetes mellitus with coronary artery disease. Zhong Xi Yi Jie He Xin Nao Xue Guan Bing Za Zhi. 6:1271–1272. 2008.(In Chinese).

25 

Xi L, Song Y, Wu W, Qu Z, Wen J, Liao B, Tao R, Ge J and Fang D: Investigation of bone matrix composition, architecture and mechanical properties reflect structure-function relationship of cortical bone in glucocorticoid induced osteoporosis. Bone. 136(115334)2020.PubMed/NCBI View Article : Google Scholar

26 

Ren H, Liang D, Jiang X, Tang J, Cui J, Wei Q, Zhang S, Yao Z, Shen G and Lin S: Variance of spinal osteoporosis induced by dexamethasone and methylprednisolone and its associated mechanism. Steroids. 102:65–75. 2015.PubMed/NCBI View Article : Google Scholar

27 

Mori K, Shioi A, Jono S, Nishizawa Y and Morii H: Dexamethasone enhances In vitro vascular calcification by promoting osteoblastic differentiation of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 19:2112–2118. 1999.PubMed/NCBI View Article : Google Scholar

28 

Kirton JP, Wilkinson FL, Canfield AE and Alexander MY: Dexamethasone downregulates calcification-inhibitor molecules and accelerates osteogenic differentiation of vascular pericytes: Implications for vascular calcification. Circ Res. 98:1264–1272. 2006.PubMed/NCBI View Article : Google Scholar

29 

Tao SC, Yuan T, Rui BY, Zhu ZZ, Guo SC and Zhang CQ: Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis of the femoral head via the Akt/Bad/Bcl-2 signal pathway. Theranostics. 7:733–750. 2017.PubMed/NCBI View Article : Google Scholar

30 

China Animal Management Rule, documentation No. 55,. 2001, the Ministry of Health of P.R. China.

31 

The National Institutes of Health Guide for the Care and Use of Laboratory Animals, NIH Publications no. 8023, revised 1978.

32 

Duan X, Zhou Y, Teng X, Tang C and Qi Y: Endoplasmic reticulum stress-mediated apoptosis is activated in vascular calcification. Biochem Biophys Res Commun. 387:694–699. 2009.PubMed/NCBI View Article : Google Scholar

33 

Feng K, Tan J and Chen Y: Treatment of lower extremity diabetic atherosclerotic obliterans with Shuxuetong injection. Zhongguo Zhong Xi Yi Jie He Za Zhi. 29:255–257. 2009.PubMed/NCBI(In Chinese).

34 

Duan XH, Chang JR, Zhang J, Zhang BH, Li YL, Teng X, Zhu Y, Du J, Tang CS and Qi YF: Activating transcription factor 4 is involved in endoplasmic reticulum stress-mediated apoptosis contributing to vascular calcification. Apoptosis. 18:1132–1144. 2013.PubMed/NCBI View Article : Google Scholar

35 

Chang JR, Duan XH, Zhang BH, Teng X, Zhou YB, Liu Y, Yu YR, Zhu Y, Tang CS and Qi YF: Intermedin1-53 attenuates vascular smooth muscle cell calcification by inhibiting endoplasmic reticulum stress via cyclic adenosine monophosphate/protein kinase A pathway. Exp Biol Med (Maywood). 238:1136–1146. 2013.PubMed/NCBI View Article : Google Scholar

36 

Yang R, Teng X, Li H, Xue HM, Guo Q, Xiao L and Wu YM: Hydrogen sulfide improves vascular calcification in rats by inhibiting endoplasmic reticulum stress. Oxid Med Cell Longev. 2016(9095242)2016.PubMed/NCBI View Article : Google Scholar

37 

Hao W, Yang R, Yang Y, Jin S, Li Y, Yuan F, Guo Q, Xiao L, Wang X, Wang F, et al: Stellate ganglion block ameliorates vascular calcification by inhibiting endoplasmic reticulum stress. Life Sci. 193:1–8. 2018.PubMed/NCBI View Article : Google Scholar

38 

Teng X, Song J, Zhang G, Cai Y, Yuan F, Du J, Tang C and Qi Y: Inhibition of endoplasmic reticulum stress by intermedin(1-53) protects against myocardial injury through a PI3 kinase-Akt signaling pathway. J Mol Med (Berl). 89:1195–1205. 2011.PubMed/NCBI View Article : Google Scholar

39 

Tian T, Zhao Y, Nakajima S, Huang T, Yao J, Paton AW, Paton JC and Kitamura M: Cytoprotective roles of ERK and Akt in endoplasmic reticulum stress triggered by subtilase cytotoxin. Biochem Biophys Res Commun. 410:852–858. 2011.PubMed/NCBI View Article : Google Scholar

40 

Liu H, Li X, Qin F and Huang K: Selenium suppresses oxidative-stress-enhanced vascular smooth muscle cell calcification by inhibiting the activation of the PI3K/AKT and ERK signaling pathways and endoplasmic reticulum stress. J Biol Inorg Chem. 19:375–388. 2014.PubMed/NCBI View Article : Google Scholar

41 

Rathi A, Ishaq M, Najmi AK and Akhtar M: Trigonelline demonstrated ameliorative effects in dexamethasone induced osteoporotic rats. Drug Res (Stuttg). 70:257–264. 2020.PubMed/NCBI View Article : Google Scholar

42 

Qin Z, Li S, Zhang X, Liu G, Gu M, Zhang N, Liu J, Ji Z, Li K, Han Y and Zhai H: Combination therapy of wuweizi (Schisandrae Chinensis Fructus) and dexamethasone alleviated dexamethasone-induced glucocorticoid osteoporosis in rats with idiopathic pulmonary fibrosis. Biomed Res Int. 2020(6301697)2020.PubMed/NCBI View Article : Google Scholar

43 

Fu L, Wu W, Sun X and Zhang P: Glucocorticoids enhanced osteoclast autophagy through the PI3K/Akt/mTOR signaling pathway. Calcif Tissue Int. 107:60–71. 2020.PubMed/NCBI View Article : Google Scholar

44 

Pietrzyk B, Smertka M and Chudek J: Sclerostin: Intracellular mechanisms of action and its role in the pathogenesis of skeletal and vascular disorders. Adv Clin Exp Med. 26:1283–1291. 2017.PubMed/NCBI View Article : Google Scholar

45 

Asadipooya K and Weinstock A: Cardiovascular outcomes of romosozumab and protective role of alendronate. Arterioscler Thromb Vasc Biol. 39:1343–1350. 2019.PubMed/NCBI View Article : Google Scholar

46 

Alazmi M and Motwalli O: In silico virtual screening, characterization, docking and molecular dynamics studies of crucial SARS-CoV-2 proteins. J Biomol Struct Dyn: Aug 7, 2020 (Epub ahead of print). doi: 10.1080/07391102.2020.1803965.

47 

Khosla S: Bone diseases: Romosozumab-on track or derailed? Nat Rev Endocrinol. 13:697–698. 2017.PubMed/NCBI View Article : Google Scholar

48 

Fontalis A, Kenanidis E, Kotronias RA, Papachristou A, Anagnostis P, Potoupnis M and Tsiridis E: Current and emerging osteoporosis pharmacotherapy for women: State of the art therapies for preventing bone loss. Expert Opin Pharmacother. 20:1123–1134. 2019.PubMed/NCBI View Article : Google Scholar

49 

Chen Z, Pan X, Sheng Z, Yan G, Chen L and Ma G: Baicalin suppresses the proliferation and migration of Ox-LDL-VSMCs in atherosclerosis through upregulating miR-126-5p. Biol Pharm Bull. 42:1517–1523. 2019.PubMed/NCBI View Article : Google Scholar

50 

Lu X, He W, Yang W, Li J, Han W, Liu Q, Zhang T, Jiang J, Qin A and Qian Y: Dual effects of baicalin on osteoclast differentiation and bone resorption. J Cell Mol Med. 22:5029–5039. 2018.PubMed/NCBI View Article : Google Scholar

51 

Turk JR, Deaton AM, Yin J, Stolina M, Felx M, Boyd G, Bienvenu JG, Varela A, Guillot M, Holdsworth G, et al: Nonclinical cardiovascular safety evaluation of romosozumab, an inhibitor of sclerostin for the treatment of osteoporosis in postmenopausal women at high risk of fracture. Regul Toxicol Pharmacol. 115(104697)2020.PubMed/NCBI View Article : Google Scholar

52 

Ding L, Jia C, Zhang Y, Wang W, Zhu W, Chen Y and Zhang T: Baicalin relaxes vascular smooth muscle and lowers blood pressure in spontaneously hypertensive rats. Biomed Pharmacother. 111:325–330. 2019.PubMed/NCBI View Article : Google Scholar

53 

Liu Y, Jia L, Min D, Xu Y, Zhu J and Sun Z: Baicalin inhibits proliferation and promotes apoptosis of vascular smooth muscle cells by regulating the MEG3/p53 pathway following treatment with ox-LDL. Int J Mol Med. 43:901–913. 2019.PubMed/NCBI View Article : Google Scholar

54 

Lv P, Zhang F, Yin YJ, Wang YC, Gao M, Xie XL, Zhao LL, Dong LH, Lin YL, Shu YN, et al: SM22α inhibits lamellipodium formation and migration via Ras-Arp2/3 signaling in synthetic VSMCs. Am J Physiol Cell Physiol. 311:C758–C767. 2016.PubMed/NCBI View Article : Google Scholar

55 

Dong LH, Wen JK, Miao SB, Jia Z, Hu HJ, Sun RH, Wu Y and Han M: Baicalin inhibits PDGF-BB-stimulated vascular smooth muscle cell proliferation through suppressing PDGFRβ-ERK signaling and increase in p27 accumulation and prevents injury-induced neointimal hyperplasia. Cell Res. 20:1252–1262. 2010.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xu Z, Liu X, Li Y, Gao H, He T, Zhang C, Hao W and Teng X: Shuxuetong injection simultaneously ameliorates dexamethasone‑driven vascular calcification and osteoporosis. Exp Ther Med 21: 197, 2021.
APA
Xu, Z., Liu, X., Li, Y., Gao, H., He, T., Zhang, C. ... Teng, X. (2021). Shuxuetong injection simultaneously ameliorates dexamethasone‑driven vascular calcification and osteoporosis. Experimental and Therapeutic Medicine, 21, 197. https://doi.org/10.3892/etm.2021.9630
MLA
Xu, Z., Liu, X., Li, Y., Gao, H., He, T., Zhang, C., Hao, W., Teng, X."Shuxuetong injection simultaneously ameliorates dexamethasone‑driven vascular calcification and osteoporosis". Experimental and Therapeutic Medicine 21.3 (2021): 197.
Chicago
Xu, Z., Liu, X., Li, Y., Gao, H., He, T., Zhang, C., Hao, W., Teng, X."Shuxuetong injection simultaneously ameliorates dexamethasone‑driven vascular calcification and osteoporosis". Experimental and Therapeutic Medicine 21, no. 3 (2021): 197. https://doi.org/10.3892/etm.2021.9630
Copy and paste a formatted citation
x
Spandidos Publications style
Xu Z, Liu X, Li Y, Gao H, He T, Zhang C, Hao W and Teng X: Shuxuetong injection simultaneously ameliorates dexamethasone‑driven vascular calcification and osteoporosis. Exp Ther Med 21: 197, 2021.
APA
Xu, Z., Liu, X., Li, Y., Gao, H., He, T., Zhang, C. ... Teng, X. (2021). Shuxuetong injection simultaneously ameliorates dexamethasone‑driven vascular calcification and osteoporosis. Experimental and Therapeutic Medicine, 21, 197. https://doi.org/10.3892/etm.2021.9630
MLA
Xu, Z., Liu, X., Li, Y., Gao, H., He, T., Zhang, C., Hao, W., Teng, X."Shuxuetong injection simultaneously ameliorates dexamethasone‑driven vascular calcification and osteoporosis". Experimental and Therapeutic Medicine 21.3 (2021): 197.
Chicago
Xu, Z., Liu, X., Li, Y., Gao, H., He, T., Zhang, C., Hao, W., Teng, X."Shuxuetong injection simultaneously ameliorates dexamethasone‑driven vascular calcification and osteoporosis". Experimental and Therapeutic Medicine 21, no. 3 (2021): 197. https://doi.org/10.3892/etm.2021.9630
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team