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Review

Effects of melatonin on protecting against lung injury (Review)

  • Authors:
    • Weiwei Wang
    • Ju Gao
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Clinical Medical College of Yangzhou University, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China
  • Article Number: 228
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    Published online on: January 20, 2021
       https://doi.org/10.3892/etm.2021.9659
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Abstract

Melatonin (MT; N‑acetyl‑5‑methoxy‑tryptamine), which has multiple effects and roles, is secreted from the pineal gland at night according to the daily rhythm. In addition to circadian regulation, MT has anti‑inflammatory, antioxidant and anticancer functions. Recent studies postulated that MT serves a critical role in apoptosis, anti‑ischemic reperfusion injury and anti‑proliferative effects on various cells. The current review reported on the underlying mechanism behind the protective effect of MT on lung diseases, such as acute lung injury, acute respiratory distress syndrome, chronic obstructive pulmonary disease, lung ischemia‑reperfusion injury, sepsis‑induced lung injury and ventilator‑induced lung injury. MT is considered an adjuvant with therapeutic drugs for preventing inflammation and is responsible for regulating patient sleep cycles in the intensive care unit. The current review described the anti‑inflammatory and antioxidant efficiency of MT with a focus on the molecular mechanisms of action in various lung injuries.
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1 

Harhay MO and King CH: Global burden of disease in young people aged 10-24 years. Lancet. 379:27–28; author reply 28. 2012.PubMed/NCBI View Article : Google Scholar

2 

Habtemariam S, Daglia M, Sureda A, Selamoglu Z, Gulhan MF and Nabavi SM: Melatonin and Respiratory Diseases: A Review. Curr Top Med Chem. 17:467–488. 2017.PubMed/NCBI View Article : Google Scholar

3 

Rudan I, Tomaskovic L, Boschi-Pinto C and Campbell H: WHO Child Health Epidemiology Reference Group. Global estimate of the incidence of clinical pneumonia among children under five years of age. Bull World Health Organ. 82:895–903. 2004.PubMed/NCBI

4 

Rosenberg SR, Kalhan R and Mannino DM: Epidemiology of Chronic Obstructive Pulmonary Disease: Prevalence, Morbidity, Mortality, and Risk Factors. Semin Respir Crit Care Med. 36:457–469. 2015.PubMed/NCBI View Article : Google Scholar

5 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018.PubMed/NCBI View Article : Google Scholar

6 

Pedreira PR, García-Prieto E, Parra D, Astudillo A, Diaz E, Taboada F and Albaiceta GM: Effects of melatonin in an experimental model of ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 295:L820–L827. 2008.PubMed/NCBI View Article : Google Scholar

7 

Lerner AB, Case JD, Takahashi Y, Lee TH and Mori W: Isolation of melatonin, the pineal gland factor that lightens melanocytes 1. J Am Chem Soc. 80(2587)1958.

8 

Lapin V and Ebels I: Effects of some low molecular weight sheep pineal fractions and melatonin on different tumors in rats and mice. Oncology. 33:110–113. 1976.PubMed/NCBI View Article : Google Scholar

9 

Beñaldo FA, Llanos AJ, Araya-Quijada C, Rojas A, Gonzalez-Candia A, Herrera EA, Ebensperger G, Cabello G, Valenzuela GJ and Serón-Ferré M: Effects of Melatonin on the Defense to Acute Hypoxia in Newborn Lambs. Front Endocrinol (Lausanne). 10(433)2019.PubMed/NCBI View Article : Google Scholar

10 

Alvarez-Artime A, Cernuda-Cernuda R, Francisco-Artime-Naveda Cepas V, Gonzalez-Menendez P, Fernadez-Vega S, Quiros-Gonzalez I, Sainz RM and Mayo JC: Melatonin-Induced Cytoskeleton Reorganization Leads to Inhibition of Melanoma Cancer Cell Proliferation. Int J Mol Sci. 21(E548)2020.PubMed/NCBI View Article : Google Scholar

11 

Andersson TPM, Filippini D, Suska A, Johansson TL, Svensson SPS and Lundström I: Frog melanophores cultured on fluorescent microbeads: Biomimic-based biosensing. Biosens Bioelectron. 21:111–120. 2005.PubMed/NCBI View Article : Google Scholar

12 

Plaimee P, Weerapreeyakul N, Thumanu K, Tanthanuch W and Barusrux S: Melatonin induces apoptosis through biomolecular changes, in SK-LU-1 human lung adenocarcinoma cells. Cell Prolif. 47:564–577. 2014.PubMed/NCBI View Article : Google Scholar

13 

Karimfar MH, Rostami S, Haghani K, Bakhtiyari S and Noori-Zadeh A: Melatonin alleviates bleomycin-induced pulmonary fibrosis in mice. J Biol Regul Homeost Agents. 29:327–334. 2015.PubMed/NCBI

14 

Zisapel N: New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation. Br J Pharmacol. 175:3190–3199. 2018.PubMed/NCBI View Article : Google Scholar

15 

Genovese T, Di Paola R, Mazzon E, Muià C, Caputi AP and Cuzzocrea S: Melatonin limits lung injury in bleomycin treated mice. J Pineal Res. 39:105–112. 2005.PubMed/NCBI View Article : Google Scholar

16 

Trivedi AK, Mishra I and Kumar V: Temporal expression of genes coding for aryl-alkamine-N-acetyltransferase and melatonin receptors in circadian clock tissues: Circadian rhythm dependent role of melatonin in seasonal responses. Physiol Behav. 207:167–178. 2019.PubMed/NCBI View Article : Google Scholar

17 

Kurhaluk N and Tkachenko H: Melatonin and alcohol-related disorders. Chronobiol Int. 37:781–803. 2020.PubMed/NCBI View Article : Google Scholar

18 

Sanchez-Hidalgo M, de la Lastra CA, Carrascosa-Salmoral MP, Naranjo MC, Gomez-Corvera A, Caballero B and Guerrero JM: Age-related changes in melatonin synthesis in rat extrapineal tissues. Exp Gerontol. 44:328–334. 2009.PubMed/NCBI View Article : Google Scholar

19 

Erren TC and Reiter RJ: Melatonin: A universal time messenger. Neuro Endocrinol Lett. 36:187–192. 2015.PubMed/NCBI

20 

Bonmati-Carrion MA, Arguelles-Prieto R, Martinez-Madrid MJ, Reiter R, Hardeland R, Rol MA and Madrid JA: Protecting the melatonin rhythm through circadian healthy light exposure. Int J Mol Sci. 15:23448–23500. 2014.PubMed/NCBI View Article : Google Scholar

21 

Lewis SR, Pritchard MW, Schofield-Robinson OJ, Alderson P and Smith AF: Melatonin for the promotion of sleep in adults in the intensive care unit. Cochrane Database Syst Rev. 5(CD012455)2018.PubMed/NCBI View Article : Google Scholar

22 

Mo Y, Scheer CE and Abdallah GT: Emerging Role of Melatonin and Melatonin Receptor Agonists in Sleep and Delirium in Intensive Care Unit Patients. J Intensive Care Med. 31:451–455. 2016.PubMed/NCBI View Article : Google Scholar

23 

Gobbi G and Comai S: Differential Function of Melatonin MT1 and MT2Receptors in REM and NREM Sleep. Front Endocrinol (Lausanne). 10(87)2019.PubMed/NCBI View Article : Google Scholar

24 

Comai S, Lopez-Canul M, De Gregorio D, Posner A, Ettaoussi M, Guarnieri FC and Gobbi G: Melatonin MT1 receptor as a novel target in neuropsychopharmacology: MT1 ligands, pathophysiological and therapeutic implications, and perspectives. Pharmacol Res. 144:343–356. 2019.PubMed/NCBI View Article : Google Scholar

25 

Owino S, Buonfiglio DDC, Tchio C and Tosini G: Melatonin Signaling a Key Regulator of Glucose Homeostasis and Energy Metabolism. Front Endocrinol (Lausanne). 10(488)2019.PubMed/NCBI View Article : Google Scholar

26 

Hu JJ, Xiao LF, Song LL, Ge WB, Duan HW and Jiang Y: The expression of melatonin receptors MT1 and MT2 is regulated by E2 in sheep oviduct. Gen Comp Endocrinol. 286(113135)2020.PubMed/NCBI View Article : Google Scholar

27 

Jablonska K, Nowinska K, Piotrowska A, Partynska A, Katnik E, Pawelczyk K, Glatzel-Plucinska N, Podhorska-Okolow M and Dziegiel P: Prognostic Impact of Melatonin Receptors MT1 and MT2 in Non-Small Cell Lung Cancer (NSCLC). Cancers (Basel). 11(E1001)2019.PubMed/NCBI View Article : Google Scholar

28 

Xu L, Su Y, Zhao Y, Sheng X, Tong R, Ying X, Gao L, Ji Q, Gao Y, Yan Y, et al: Melatonin differentially regulates pathological and physiological cardiac hypertrophy: Crucial role of circadian nuclear receptor RORα signaling. J Pineal Res. 67(e12579)2019.PubMed/NCBI View Article : Google Scholar

29 

Ding S, Lin N, Sheng X, Zhao Y, Su Y, Xu L, Tong R, Yan Y, Fu Y, He J, et al: Melatonin stabilizes rupture-prone vulnerable plaques via regulating macrophage polarization in a nuclear circadian receptor RORα-dependent manner. J Pineal Res. 67(e12581)2019.PubMed/NCBI View Article : Google Scholar

30 

Puig Á, Rancan L, Paredes SD, Carrasco A, Escames G, Vara E and Tresguerres JAF: Melatonin decreases the expression of inflammation and apoptosis markers in the lung of a senescence-accelerated mice model. Exp Gerontol. 75:1–7. 2016.PubMed/NCBI View Article : Google Scholar

31 

Peng Z, Zhang W, Qiao J and He B: Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD. Int Immunopharmacol. 62:23–28. 2018.PubMed/NCBI View Article : Google Scholar

32 

Chen J, Qian C, Duan H, Cao S, Yu X, Li J, Gu C, Yan F, Wang L and Chen G: Melatonin attenuates neurogenic pulmonary edema via the regulation of inflammation and apoptosis after subarachnoid hemorrhage in rats. J Pineal Res. 59:469–477. 2015.PubMed/NCBI View Article : Google Scholar

33 

Shin I-S, Shin N-R, Park J-W, Jeon C-M, Hong J-M, Kwon O-K, Kim J-S, Lee I-C, Kim J-C, Oh S-R, et al: Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling. J Pineal Res. 58:50–60. 2015.PubMed/NCBI View Article : Google Scholar

34 

Hardeland R: Melatonin and inflammation-Story of a double-edged blade. J Pineal Res. 65(e12525)2018.PubMed/NCBI View Article : Google Scholar

35 

Zhang Y, Li X, Grailer JJ, Wang N, Wang M, Yao J, Zhong R, Gao GF, Ward PA, Tan D-X, et al: Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome. J Pineal Res. 60:405–414. 2016.PubMed/NCBI View Article : Google Scholar

36 

Aguilar SA, Arias PV, Canquil I, Ebensperger G, Llanos AJ, Reyes RV, González-Candia A and Herrera EA: Melatonin modulates the expression of pulmonary prostanoids. Rev Med Chil. 147:281–288. 2019.PubMed/NCBI View Article : Google Scholar : (In Spanish).

37 

Wu X, Ji H, Wang Y, Gu C, Gu W, Hu L and Zhu L: Melatonin Alleviates Radiation-Induced Lung Injury via Regulation of miR-30e/NLRP3 Axis. Oxid Med Cell Longev. 2019(4087298)2019.PubMed/NCBI View Article : Google Scholar

38 

Pourhanifeh MH, Sharifi M, Reiter RJ, Davoodabadi A and Asemi Z: Melatonin and non-small cell lung cancer: New insights into signaling pathways. Cancer Cell Int. 19(131)2019.PubMed/NCBI View Article : Google Scholar

39 

Panmanee J, Nopparat C, Chavanich N, Shukla M, Mukda S, Song W, Vincent B and Govitrapong P: Melatonin regulates the transcription of βAPP-cleaving secretases mediated through melatonin receptors in human neuroblastoma SH-SY5Y cells. J Pineal Res. 59:308–320. 2015.PubMed/NCBI View Article : Google Scholar

40 

Hardeland R: Aging, Melatonin, and the Pro- and Anti-Inflammatory Networks. Int J Mol Sci. 20(E1223)2019.PubMed/NCBI View Article : Google Scholar

41 

Wang M-L, Wei C-H, Wang W-D, Wang J-S, Zhang J and Wang J-J: Melatonin attenuates lung ischaemia-reperfusion injury via inhibition of oxidative stress and inflammation. Interact Cardiovasc Thorac Surg. 26:761–767. 2018.PubMed/NCBI View Article : Google Scholar

42 

Sánchez A, Calpena AC and Clares B: Evaluating the Oxidative Stress in Inflammation: Role of Melatonin. Int J Mol Sci. 16:16981–17004. 2015.PubMed/NCBI View Article : Google Scholar

43 

Carrascal L, Nunez-Abades P, Ayala A and Cano M: Role of Melatonin in the Inflammatory Process and its Therapeutic Potential. Curr Pharm Des. 24:1563–1588. 2018.PubMed/NCBI View Article : Google Scholar

44 

Mańka S and Majewska E: Immunoregulatory action of melatonin. The mechanism of action and the effect on inflammatory cells. Postepy Hig Med Dosw. 70:1059–1067. 2016.PubMed/NCBI View Article : Google Scholar

45 

Dong Y-J, Ding C-H, Zhang Z, Gu W-W and Ma Y-L: Protective effects of melatonin in acute lung injury rats caused by LPS. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 26:481–484. 2010.PubMed/NCBI(In Chinese).

46 

Chiu M-H, Su C-L, Chen C-F, Chen K-H, Wang D and Wang J-J: Protective effect of melatonin on liver ischemia-reperfusion induced pulmonary microvascular injury in rats. Transplant Proc. 44:962–965. 2012.PubMed/NCBI View Article : Google Scholar

47 

Reiter RJ, Rosales-Corral S, Tan DX, Jou MJ, Galano A and Xu B: Melatonin as a mitochondria-targeted antioxidant: One of evolution's best ideas. Cell Mol Life Sci. 74:3863–3881. 2017.PubMed/NCBI View Article : Google Scholar

48 

Bhattacharya S, Patel KK, Dehari D, Agrawal AK and Singh S: Melatonin and its ubiquitous anticancer effects. Mol Cell Biochem. 462:133–155. 2019.PubMed/NCBI View Article : Google Scholar

49 

Tan D-X, Reiter RJ, Manchester LC, Yan MT, El-Sawi M, Sainz RM, Mayo JC, Kohen R, Allegra M and Hardeland R: Chemical and physical properties and potential mechanisms: Melatonin as a broad spectrum antioxidant and free radical scavenger. Curr Top Med Chem. 2:181–197. 2002.PubMed/NCBI View Article : Google Scholar

50 

Poeggeler B, Thuermann S, Dose A, Schoenke M, Burkhardt S and Hardeland R: Melatonin's unique radical scavenging properties - roles of its functional substituents as revealed by a comparison with its structural analogs. J Pineal Res. 33:20–30. 2002.PubMed/NCBI View Article : Google Scholar

51 

Zheng X, Zhou J, Tan D-X, Wang N, Wang L, Shan D and Kong J: Melatonin Improves Waterlogging Tolerance of Malus baccata (Linn.) Borkh. Seedlings by Maintaining Aerobic Respiration, Photosynthesis and ROS Migration. Front Plant Sci. 8(483)2017.PubMed/NCBI View Article : Google Scholar

52 

Yildiz A, Vardi N, Karaaslan MG, Ates B, Taslidere E and Esrefoglu M: The protective effect of melatonin in lungs of newborn rats exposed to maternal nicotine. Biotech Histochem. 93:442–452. 2018.PubMed/NCBI View Article : Google Scholar

53 

Reiter RJ, Mayo JC, Tan D-X, Sainz RM, Alatorre-Jimenez M and Qin L: Melatonin as an antioxidant: Under promises but over delivers. J Pineal Res. 61:253–278. 2016.PubMed/NCBI View Article : Google Scholar

54 

Charão MF, Goethel G, Brucker N, Paese K, Eifler-Lima VL, Pohlmann AR, Guterres SS and Garcia SC: Melatonin-loaded lipid-core nanocapsules protect against lipid peroxidation caused by paraquat through increased SOD expression in Caenorhabditis elegans. BMC Pharmacol Toxicol. 20 (Suppl 1)(80)2019.PubMed/NCBI View Article : Google Scholar

55 

Radovic M, Ristic L, Krtinic D, Rancic M, Nickovic V, Vujnovic Zivkovic ZN, Zivkovic JB, Mirkovic MV, Toskic DR and Sokolovic D: Melatonin treatment prevents carbon tetrachloride-induced acute lung injury in rats by mitigating tissue antioxidant capacity and inflammatory response. Bratisl Lek Listy. 120:527–531. 2019.PubMed/NCBI View Article : Google Scholar

56 

Chen W, Chen X, Chen AC, Shi Q, Pan G, Pei M, Yang H, Liu T and He F: Melatonin restores the osteoporosis-impaired osteogenic potential of bone marrow mesenchymal stem cells by preserving SIRT1-mediated intracellular antioxidant properties. Free Radic Biol Med. 146:92–106. 2020.PubMed/NCBI View Article : Google Scholar

57 

de Matos Cavalcante AG, de Bruin PFC, de Bruin VMS, Nunes DM, Pereira EDB, Cavalcante MM and Andrade GM: Melatonin reduces lung oxidative stress in patients with chronic obstructive pulmonary disease: A randomized, double-blind, placebo-controlled study. J Pineal Res. 53:238–244. 2012.PubMed/NCBI View Article : Google Scholar

58 

Chen D, Zhang T and Lee TH: Cellular Mechanisms of Melatonin: Insight from Neurodegenerative Diseases. Biomolecules. 10(E1158)2020.PubMed/NCBI View Article : Google Scholar

59 

Ostadmohammadi V, Soleimani A, Bahmani F, Aghadavod E, Ramezani R, Reiter RJ, Mansournia MA, Banikazemi Z, Soleimani M, Zaroudi M, et al: The Effects of Melatonin Supplementation on Parameters of Mental Health, Glycemic Control, Markers of Cardiometabolic Risk, and Oxidative Stress in Diabetic Hemodialysis Patients: A Randomized, Double-Blind, Placebo-Controlled Trial. J Ren Nutr. 30:242–250. 2020.PubMed/NCBI View Article : Google Scholar

60 

Carlomagno G, Minini M, Tilotta M and Unfer V: From Implantation to Birth: Insight into Molecular Melatonin Functions. Int J Mol Sci. 19(E2802)2018.PubMed/NCBI View Article : Google Scholar

61 

Tan D-X, Hardeland R, Manchester LC, Galano A and Reiter RJ: Cyclic-3-hydroxymelatonin (C3HOM), a potent antioxidant, scavenges free radicals and suppresses oxidative reactions. Curr Med Chem. 21:1557–1565. 2014.PubMed/NCBI View Article : Google Scholar

62 

Fang Y, Zhang J, Li Y, Guo X, Li J, Zhong R and Zhang X: Melatonin-induced demethylation of antioxidant genes increases antioxidant capacity through RORα in cumulus cells of prepubertal lambs. Free Radic Biol Med. 131:173–183. 2019.PubMed/NCBI View Article : Google Scholar

63 

Esteban MÁ, Cuesta A, Chaves-Pozo E and Meseguer J: Influence of melatonin on the immune system of fish: A review. Int J Mol Sci. 14:7979–7999. 2013.PubMed/NCBI View Article : Google Scholar

64 

Carrillo-Vico A, Guerrero JM, Lardone PJ and Reiter RJ: A review of the multiple actions of melatonin on the immune system. Endocrine. 27:189–200. 2005.PubMed/NCBI View Article : Google Scholar

65 

Lee J, Byun H, Madhurakkat Perikamana SK, Lee S and Shin H: Current Advances in Immunomodulatory Biomaterials for Bone Regeneration. Adv Healthc Mater. 8(e1801106)2019.PubMed/NCBI View Article : Google Scholar : Zhang R, Wang X, Ni L, Di X, Ma B, Niu S, Liu C and Reiter RJ: COVID-19: Melatonin as a potential adjuvant treatment. Life Sci 250: 117583, 2020.

66 

Channappanavar R and Perlman S: Pathogenic human coronavirus infections: Causes and consequences of cytokine storm and immunopathology. Semin Immunopathol. 39:529–539. 2017.PubMed/NCBI View Article : Google Scholar

67 

Haldar C and Ahmad R: Photoimmunomodulation and melatonin. J Photochem Photobiol B. 98:107–117. 2010.PubMed/NCBI View Article : Google Scholar

68 

Wu X, Ji H, Wang Y, Gu C, Gu W, Hu L and Zhu L: Melatonin Alleviates Radiation-Induced Lung Injury via Regulation of miR-30e/NLRP3 Axis. Oxid Med Cell Longev. 2019(4087298)2019.PubMed/NCBI View Article : Google Scholar

69 

Miller SC, Pandi-Perumal SR, Esquifino AI, Cardinali DP and Maestroni GJM: The role of melatonin in immuno-enhancement: Potential application in cancer. Int J Exp Pathol. 87:81–87. 2006.PubMed/NCBI View Article : Google Scholar

70 

Butt Y, Kurdowska A and Allen TC: Acute Lung Injury: A Clinical and Molecular Review. Arch Pathol Lab Med. 140:345–350. 2016.PubMed/NCBI View Article : Google Scholar

71 

Morales-Ortíz J, Deal V, Reyes F, Maldonado-Martínez G, Ledesma N, Staback F, Croft C, Pacheco A, Ortiz-Zuazaga H, Yost CC, et al: Platelet-derived TLT-1 is a prognostic indicator in ALI/ARDS and prevents tissue damage in the lungs in a mouse model. Blood. 132:2495–2505. 2018.PubMed/NCBI View Article : Google Scholar

72 

Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, Gattinoni L, van Haren F, Larsson A, McAuley DF, et al: LUNG SAFE Investigators; ESICM Trials Group: Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries. JAMA. 315:788–800. 2016.PubMed/NCBI View Article : Google Scholar

73 

Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, Stern EJ and Hudson LD: Incidence and outcomes of acute lung injury. N Engl J Med. 353:1685–1693. 2005.PubMed/NCBI View Article : Google Scholar

74 

Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L and Slutsky AS: ARDS Definition Task Force. Acute respiratory distress syndrome: The Berlin Definition. JAMA. 307:2526–2533. 2012.PubMed/NCBI View Article : Google Scholar

75 

Ozdinc S, Oz G, Ozdemir C, Kilic I, Karakaya Z, Bal A, Koken T and Solak O: Melatonin: Is it an effective antioxidant for pulmonary contusion? J Surg Res. 204:445–451. 2016.PubMed/NCBI View Article : Google Scholar

76 

Zhang Z, Gao L, Ding C-H, Ma W-Z, Gu W-W and Ma Y-L: Protective function of melatonin to acute lung injury and its mechanisms in rats caused by oleic acid. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 27:480–483. 2011.PubMed/NCBI(In Chinese).

77 

Taslidere E, Esrefoglu M, Elbe H, Cetin A and Ates B: Protective effects of melatonin and quercetin on experimental lung injury induced by carbon tetrachloride in rats. Exp Lung Res. 40:59–65. 2014.PubMed/NCBI View Article : Google Scholar

78 

Wu WS, Chou MT, Chao CM, Chang CK, Lin MT and Chang CP: Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats. Acta Pharmacol Sin. 33:775–782. 2012.PubMed/NCBI View Article : Google Scholar

79 

Huai J-P, Sun X-C, Chen M-J, Jin Y, Ye X-H, Wu J-S and Huang Z-M: Melatonin attenuates acute pancreatitis-associated lung injury in rats by modulating interleukin 22. World J Gastroenterol. 18:5122–5128. 2012.PubMed/NCBI View Article : Google Scholar

80 

Zhang XH, Qi HX, Xu DS, Pang XC, Wang CY and Yu WJ: Expression of proteinase-activated receptor-2 and transient receptor potential A1 in vagal afferent nerve of rat after lung schemia-reperfusion injury. J Biol Regul Homeost Agents. 33:1405–1413. 2019.PubMed/NCBI View Article : Google Scholar

81 

Fındık O, Yılmaz MY, Yazır Y, Rençber SF, Sarıhan KK and Kunt AT: Investigation of the protective effect of enoxaparin and ticagrelor pretreatment against ischemia-reperfusion injury in rat lung tissue. Rev Assoc Med Bras (1992). 65:1193–1200. 2019.PubMed/NCBI View Article : Google Scholar

82 

Esteban-Zubero E, García-Gil FA, López-Pingarrón L, Alatorre-Jiménez MA, Iñigo-Gil P, Tan D-X, García JJ and Reiter RJ: Potential benefits of melatonin in organ transplantation: A review. J Endocrinol. 229:R129–R146. 2016.PubMed/NCBI View Article : Google Scholar

83 

Banaei S, Ahmadiasl N and Alihemmati A: Comparison of the Protective Effects of Erythropoietin and Melatonin on Renal Ischemia-Reperfusion Injury. Trauma Mon. 21(e23005)2016.PubMed/NCBI View Article : Google Scholar

84 

Takhtfooladi H, Takhtfooladi M, Moayer F and Mobarakeh S: Melatonin attenuates lung injury in a hind limb ischemia-reperfusion rat model. Rev Port Pneumol. 21:30–35. 2015.PubMed/NCBI View Article : Google Scholar

85 

Lambrecht BN and Hammad H: The airway epithelium in asthma. Nat Med. 18:684–692. 2012.PubMed/NCBI View Article : Google Scholar

86 

Ryzhov S, Goldstein AE, Matafonov A, Zeng D, Biaggioni I and Feoktistov I: Adenosine-activated mast cells induce IgE synthesis by B lymphocytes: An A2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma. J Immunol. 172:7726–7733. 2004.PubMed/NCBI View Article : Google Scholar

87 

Steurer-Stey C: Asthmamanagement: Uberblick und neue Aspekte. Praxis (Bern 1994). 96:1951–1957. 2007.PubMed/NCBI View Article : Google Scholar : (In German).

88 

Woodruff Pg, Modrek B, Choy DF, Jia g, Abbas AR, Ellwanger A, Koth LL, Arron JR and Fahy JV: T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma. Am J Respir Crit Care Med. 180:388–395. 2009.PubMed/NCBI View Article : Google Scholar

89 

Brown V and Ennis M: T Cell Cytokine Production in Childhood Asthma. CRMR. 1:1–6. 2005.

90 

Huang W-C, Liu C-Y, Shen S-C, Chen L-C, Yeh K-W, Liu S-H and Liou C-J: Protective Effects of Licochalcone A Improve Airway Hyper-Responsiveness and Oxidative Stress in a Mouse Model of Asthma. Cells. 8(E617)2019.PubMed/NCBI View Article : Google Scholar

91 

Cobham VE, Hickling A, Kimball H, Thomas HJ, Scott JG and Middeldorp CM: Systematic Review: Anxiety in Children and Adolescents With Chronic Medical Conditions. J Am Acad Child Adolesc Psychiatry 59:. 59:595–618. 2019.PubMed/NCBI View Article : Google Scholar

92 

To T, Stanojevic S, Moores G, Gershon AS, Bateman ED, Cruz AA and Boulet L-P: Global asthma prevalence in adults: Findings from the cross-sectional world health survey. BMC Public Health. 12(204)2012.PubMed/NCBI View Article : Google Scholar

93 

Wang YT, Chen SL and Xu SY: Effect of melatonin on the expression of nuclear factor-kappa B and airway inflammation in asthmatic rats. Zhonghua Er Ke Za Zhi. 42:94–97. 2004.PubMed/NCBI(In Chinese).

94 

Wu H-M, Shen Q-Y, Fang L, Zhang S-H, Shen P-T, Liu Y-J and Liu R-Y: JNK-TLR9 signal pathway mediates allergic airway inflammation through suppressing melatonin biosynthesis. J Pineal Res. 60:415–423. 2016.PubMed/NCBI View Article : Google Scholar

95 

Shin I-S, Park J-W, Shin N-R, Jeon C-M, Kwon O-K, Kim J-S, Kim J-C, Oh S-R and Ahn K-S: Melatonin reduces airway inflammation in ovalbumin-induced asthma. Immunobiology. 219:901–908. 2014.PubMed/NCBI View Article : Google Scholar

96 

Shin I-S, Park J-W, Shin N-R, Jeon C-M, Kwon O-K, Lee M-Y, Kim H-S, Kim J-C, Oh S-R and Ahn K-S: Melatonin inhibits MUC5AC production via suppression of MAPK signaling in human airway epithelial cells. J Pineal Res. 56:398–407. 2014.PubMed/NCBI View Article : Google Scholar

97 

American Thoracic Society. Standardization of Spirometry, 1994 Update. Am J Respir Crit Care Med. 152:1107–1136. 1995.PubMed/NCBI View Article : Google Scholar

98 

Campos FL, da Silva-Júnior FP, de Bruin VM and de Bruin PF: Melatonin improves sleep in asthma: A randomized, double-blind, placebo-controlled study. Am J Respir Crit Care Med. 170:947–951. 2004.PubMed/NCBI View Article : Google Scholar

99 

Li Q, Qu HJ, Lv D, Yeh M-K, Sun S, Li L and Liao Y: Drug-related problems among hospitalized patients with COPD in mainland China. Int J Clin Pharm. 41:1507–1515. 2019.PubMed/NCBI View Article : Google Scholar

100 

Kc R, Shukla SD, Gautam SS, Hansbro PM and O'Toole RF: The role of environmental exposure to non-cigarette smoke in lung disease. Clin Transl Med. 7(39)2018.PubMed/NCBI View Article : Google Scholar

101 

Brandsma CA, Van den Berge M, Hackett TL, Brusselle G and Timens W: Recent advances in chronic obstructive pulmonary disease pathogenesis: From disease mechanisms to precision medicine. J Pathol. 250:624–635. 2020.PubMed/NCBI View Article : Google Scholar

102 

He B, Zhang W, Qiao J, Peng Z and Chai X: Melatonin protects against COPD by attenuating apoptosis and endoplasmic reticulum stress via upregulating SIRT1 expression in rats. Can J Physiol Pharmacol. 97:386–391. 2019.PubMed/NCBI View Article : Google Scholar

103 

Shin N-R, Ko J-W, Kim J-C, Park G, Kim S-H, Kim M-S, Kim J-S and Shin I-S: Role of melatonin as an SIRT1 enhancer in chronic obstructive pulmonary disease induced by cigarette smoke. J Cell Mol Med. 24:1151–1156. 2020.PubMed/NCBI View Article : Google Scholar

104 

Cherpanath TGV, Smeding L, Hirsch A, Lagrand WK, Schultz MJ and Groeneveld ABJ: Low tidal volume ventilation ameliorates left ventricular dysfunction in mechanically ventilated rats following LPS-induced lung injury. BMC Anesthesiol. 15(140)2015.PubMed/NCBI View Article : Google Scholar

105 

Pandita A, Murki S, Oleti TP, Tandur B, Kiran S, Narkhede S and Prajapati A: Effect of Nasal Continuous Positive Airway Pressure on Infants With Meconium Aspiration Syndrome: A Randomized Clinical Trial. JAMA Pediatr. 172:161–165. 2018.PubMed/NCBI View Article : Google Scholar

106 

Sutherasan Y, Vargas M and Pelosi P: Protective mechanical ventilation in the non-injured lung: Review and meta-analysis. Crit Care. 18(211)2014.PubMed/NCBI View Article : Google Scholar

107 

Ball L, Hemmes SNT, Serpa Neto A, Bluth T, Canet J, Hiesmayr M, Hollmann MW, Mills GH, Vidal Melo MF, Putensen C, et al: LAS VEGAS investigators; PROVE Network; Clinical Trial Network of the European Society of Anaesthesiology: Intraoperative ventilation settings and their associations with postoperative pulmonary complications in obese patients. Br J Anaesth. 121:899–908. 2018.PubMed/NCBI View Article : Google Scholar

108 

Yu Q, Wang D, Wen X, Tang X, Qi D, He J, Zhao Y, Deng W and Zhu T: Adipose-derived exosomes protect the pulmonary endothelial barrier in ventilator-induced lung injury by inhibiting the TRPV4/Ca2+ signaling pathway. Am J Physiol Lung Cell Mol Physiol. 318:L723–L741. 2020.PubMed/NCBI View Article : Google Scholar

109 

van der Zee P and Gommers D: Recruitment Maneuvers and Higher PEEP, the So-Called Open Lung Concept, in Patients with ARDS. Crit Care. 23(73)2019.PubMed/NCBI View Article : Google Scholar

110 

Alkasalias T, Alexeyenko A, Hennig K, Danielsson F, Lebbink RJ, Fielden M, Turunen SP, Lehti K, Kashuba V, Madapura HS, et al: RhoA knockout fibroblasts lose tumor-inhibitory capacity in vitro and promote tumor growth in vivo. Proc Natl Acad Sci USA. 114:E1413–E1421. 2017.PubMed/NCBI View Article : Google Scholar

111 

Sripathi SR, Prigge CL, Elledge B, He W, Offor J, Gutsaeva DR and Jahng WJ: Melatonin Modulates Prohibitin and Cytoskeleton in the Retinal Pigment Epithelium. Int J Sci Eng Res. 8:502–506. 2017.PubMed/NCBI View Article : Google Scholar

112 

Gu C, Liu M, Zhao T, Wang D and Wang Y: Protective role of p120-catenin in maintaining the integrity of adherens and tight junctions in ventilator-induced lung injury. Respir Res. 16(58)2015.PubMed/NCBI View Article : Google Scholar

113 

Ito K, Colley T and Mercado N: Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease. Int J Chron Obstruct Pulmon Dis. 7:641–652. 2012.PubMed/NCBI View Article : Google Scholar

114 

Giamarellos-Bourboulis EJ, Netea MG, Rovina N, Akinosoglou K, Antoniadou A, Antonakos N, Damoraki G, Gkavogianni T, Adami M-E, Katsaounou P, et al: Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure. Cell Host Microbe. 27:992–1000.e3. 2020.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wang W and Gao J: Effects of melatonin on protecting against lung injury (Review). Exp Ther Med 21: 228, 2021.
APA
Wang, W., & Gao, J. (2021). Effects of melatonin on protecting against lung injury (Review). Experimental and Therapeutic Medicine, 21, 228. https://doi.org/10.3892/etm.2021.9659
MLA
Wang, W., Gao, J."Effects of melatonin on protecting against lung injury (Review)". Experimental and Therapeutic Medicine 21.3 (2021): 228.
Chicago
Wang, W., Gao, J."Effects of melatonin on protecting against lung injury (Review)". Experimental and Therapeutic Medicine 21, no. 3 (2021): 228. https://doi.org/10.3892/etm.2021.9659
Copy and paste a formatted citation
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Spandidos Publications style
Wang W and Gao J: Effects of melatonin on protecting against lung injury (Review). Exp Ther Med 21: 228, 2021.
APA
Wang, W., & Gao, J. (2021). Effects of melatonin on protecting against lung injury (Review). Experimental and Therapeutic Medicine, 21, 228. https://doi.org/10.3892/etm.2021.9659
MLA
Wang, W., Gao, J."Effects of melatonin on protecting against lung injury (Review)". Experimental and Therapeutic Medicine 21.3 (2021): 228.
Chicago
Wang, W., Gao, J."Effects of melatonin on protecting against lung injury (Review)". Experimental and Therapeutic Medicine 21, no. 3 (2021): 228. https://doi.org/10.3892/etm.2021.9659
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