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Role of adjunctive therapy with subantimicrobial doses of doxycycline in glycemic control (HbA1c) in patients with diabetes and endo‑periodontal lesions to prevent sinus complications

  • Authors:
    • Anamaria Zaharescu
    • Ioana Mârțu
    • Alexandru-Ionuț Luchian
    • Maria-Alexandra Mârțu
    • Irina-Georgeta Șufaru
    • Cristian Mârțu
    • Sorina-Mihaela Solomon
  • View Affiliations / Copyright

    Affiliations: Department of Periodontology, ‘Gr. T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Implantology, ‘Gr. T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of ENT, ‘Gr. T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania
    Copyright: © Zaharescu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 277
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    Published online on: January 25, 2021
       https://doi.org/10.3892/etm.2021.9708
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Abstract

The present study aimed to analyze local and regional changes in regards to odontogenic sinusitis in subjects with endo‑periodontal lesions and diabetes mellitus and to investigate the effect on the level of glycemic control (glycated hemoglobin) that could be generated by adjunctive therapy with subantimicrobial doses of doxycycline. This study was performed on 51 subjects with diabetes who were divided into two therapeutic groups: 31 patients with diabetes (the study group) who underwent conventional endo‑periodontal therapy and subantimicrobial doses of doxycycline and 20 patients with diabetes who followed only conventional endo‑periodontal therapy (the control group). Patients underwent endodontic and periodontal clinical examination, with retro‑dental‑alveolar radiographs and CBCT examinations. For each patient, glycated hemoglobin A1c (HbA1c) was determined. This evaluation was performed at the beginning of the study, as well as 3, 6 and 12 months after baseline. A significant percentage of patients, both in the study group and in the control group, showed radiological signs of odontogenic sinusitis, totaling 29 patients (56.86%). Periodontal parameters revealed lower levels in patients who underwent the regimen which consisted of subantimicrobial doses of doxycycline; these results were maintained over the study period. Moreover, we demonstrated significantly reduced glycated hemoglobin levels throughout the study (12 months) in the doxycycline‑treated group. This fact has far‑reaching effects in the sphere of loco‑regional complications as well, and the risk of odontogenic sinusitis can be significantly reduced.
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Copy and paste a formatted citation
Spandidos Publications style
Zaharescu A, Mârțu I, Luchian A, Mârțu M, Șufaru I, Mârțu C and Solomon S: Role of adjunctive therapy with subantimicrobial doses of doxycycline in glycemic control (HbA1c) in patients with diabetes and endo‑periodontal lesions to prevent sinus complications. Exp Ther Med 21: 277, 2021.
APA
Zaharescu, A., Mârțu, I., Luchian, A., Mârțu, M., Șufaru, I., Mârțu, C., & Solomon, S. (2021). Role of adjunctive therapy with subantimicrobial doses of doxycycline in glycemic control (HbA1c) in patients with diabetes and endo‑periodontal lesions to prevent sinus complications. Experimental and Therapeutic Medicine, 21, 277. https://doi.org/10.3892/etm.2021.9708
MLA
Zaharescu, A., Mârțu, I., Luchian, A., Mârțu, M., Șufaru, I., Mârțu, C., Solomon, S."Role of adjunctive therapy with subantimicrobial doses of doxycycline in glycemic control (HbA1c) in patients with diabetes and endo‑periodontal lesions to prevent sinus complications". Experimental and Therapeutic Medicine 21.3 (2021): 277.
Chicago
Zaharescu, A., Mârțu, I., Luchian, A., Mârțu, M., Șufaru, I., Mârțu, C., Solomon, S."Role of adjunctive therapy with subantimicrobial doses of doxycycline in glycemic control (HbA1c) in patients with diabetes and endo‑periodontal lesions to prevent sinus complications". Experimental and Therapeutic Medicine 21, no. 3 (2021): 277. https://doi.org/10.3892/etm.2021.9708
Copy and paste a formatted citation
x
Spandidos Publications style
Zaharescu A, Mârțu I, Luchian A, Mârțu M, Șufaru I, Mârțu C and Solomon S: Role of adjunctive therapy with subantimicrobial doses of doxycycline in glycemic control (HbA1c) in patients with diabetes and endo‑periodontal lesions to prevent sinus complications. Exp Ther Med 21: 277, 2021.
APA
Zaharescu, A., Mârțu, I., Luchian, A., Mârțu, M., Șufaru, I., Mârțu, C., & Solomon, S. (2021). Role of adjunctive therapy with subantimicrobial doses of doxycycline in glycemic control (HbA1c) in patients with diabetes and endo‑periodontal lesions to prevent sinus complications. Experimental and Therapeutic Medicine, 21, 277. https://doi.org/10.3892/etm.2021.9708
MLA
Zaharescu, A., Mârțu, I., Luchian, A., Mârțu, M., Șufaru, I., Mârțu, C., Solomon, S."Role of adjunctive therapy with subantimicrobial doses of doxycycline in glycemic control (HbA1c) in patients with diabetes and endo‑periodontal lesions to prevent sinus complications". Experimental and Therapeutic Medicine 21.3 (2021): 277.
Chicago
Zaharescu, A., Mârțu, I., Luchian, A., Mârțu, M., Șufaru, I., Mârțu, C., Solomon, S."Role of adjunctive therapy with subantimicrobial doses of doxycycline in glycemic control (HbA1c) in patients with diabetes and endo‑periodontal lesions to prevent sinus complications". Experimental and Therapeutic Medicine 21, no. 3 (2021): 277. https://doi.org/10.3892/etm.2021.9708
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