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Article

SARS‑CoV‑2 infection and diabetes mellitus: A North Eastern Romanian experience

  • Authors:
    • Carmen Manciuc
    • Dragos Nemescu
    • Andrei Vata
    • Georgiana Alexandra Lacatusu
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Diseases, University of Medicine and Pharmacy ‘Grigore T. Popa’, 700115 Iasi, Romania, Department of Obstetrics and Gynecology, University of Medicine and Pharmacy ‘Grigore T. Popa’, 700115 Iasi, Romania, Department of Infectious Diseases, ‘Sf. Parascheva’ Clinical Hospital of Infectious Diseases, 700116 Iasi, Romania
  • Article Number: 279
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    Published online on: January 25, 2021
       https://doi.org/10.3892/etm.2021.9710
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Abstract

As it spread globally, the new SARS‑CoV‑2 virus was first confirmed in Romania in February 2020, inevitably infecting individuals with diabetes mellitus (DM) along the way. Diabetes is known to affect the response of the body to pathogens and, according to studies conducted in the last 3 months, it appears that diabetic patients are at a higher risk for developing severe forms of the disease and multiple complications. We performed a retrospective study in order to assess the patients with SARS‑CoV‑2 infection and DM admitted to ‘Sf. Parascheva’ Clinical Hospital of Infectious Diseases from March 4th until June 30th, 2020. Of the total 1,080 patients admitted during this period, 85 patients (7.87%) had underlying DM, mostly type 2 (82 cases, 96.46%); the mean age of these patients was 62, and 42 were men (49.41%). Chest CTs revealed indicative SARS‑CoV‑2 images for all patients and their treatment included individually tailored administration of hydroxychloroquine/lopinavir + ritonavir/enoxaparin sodium/tocilizumab/antibiotherapy according to the then national and international guidelines. In total, 70 patients (82.35%) were cured and 15 succumbed to MODS and/or associated neoplasia, bringing the fatality rate to 17.64%. Although advanced age and DM have been associated with aggravated forms of SARS‑CoV‑2 infection, over 80% of the patients included in the present study were cured. Nonetheless, diabetes appears to be a significant predictor of morbidity and mortality in the SARS‑CoV‑2 infection.
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Copy and paste a formatted citation
Spandidos Publications style
Manciuc C, Nemescu D, Vata A and Lacatusu GA: SARS‑CoV‑2 infection and diabetes mellitus: A North Eastern Romanian experience. Exp Ther Med 21: 279, 2021.
APA
Manciuc, C., Nemescu, D., Vata, A., & Lacatusu, G.A. (2021). SARS‑CoV‑2 infection and diabetes mellitus: A North Eastern Romanian experience. Experimental and Therapeutic Medicine, 21, 279. https://doi.org/10.3892/etm.2021.9710
MLA
Manciuc, C., Nemescu, D., Vata, A., Lacatusu, G. A."SARS‑CoV‑2 infection and diabetes mellitus: A North Eastern Romanian experience". Experimental and Therapeutic Medicine 21.3 (2021): 279.
Chicago
Manciuc, C., Nemescu, D., Vata, A., Lacatusu, G. A."SARS‑CoV‑2 infection and diabetes mellitus: A North Eastern Romanian experience". Experimental and Therapeutic Medicine 21, no. 3 (2021): 279. https://doi.org/10.3892/etm.2021.9710
Copy and paste a formatted citation
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Spandidos Publications style
Manciuc C, Nemescu D, Vata A and Lacatusu GA: SARS‑CoV‑2 infection and diabetes mellitus: A North Eastern Romanian experience. Exp Ther Med 21: 279, 2021.
APA
Manciuc, C., Nemescu, D., Vata, A., & Lacatusu, G.A. (2021). SARS‑CoV‑2 infection and diabetes mellitus: A North Eastern Romanian experience. Experimental and Therapeutic Medicine, 21, 279. https://doi.org/10.3892/etm.2021.9710
MLA
Manciuc, C., Nemescu, D., Vata, A., Lacatusu, G. A."SARS‑CoV‑2 infection and diabetes mellitus: A North Eastern Romanian experience". Experimental and Therapeutic Medicine 21.3 (2021): 279.
Chicago
Manciuc, C., Nemescu, D., Vata, A., Lacatusu, G. A."SARS‑CoV‑2 infection and diabetes mellitus: A North Eastern Romanian experience". Experimental and Therapeutic Medicine 21, no. 3 (2021): 279. https://doi.org/10.3892/etm.2021.9710
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