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Protein tyrosine phosphatase receptor‑type O expression as a prognostic marker in patients with acute coronary syndrome undergoing percutaneous coronary intervention: A prospective study

  • Authors:
    • Minghui Hao
    • Ming Guo
    • Rui Yan
  • View Affiliations

  • Published online on: February 26, 2021     https://doi.org/10.3892/etm.2021.9852
  • Article Number: 435
  • Copyright: © Hao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Optimal clinical indicators are crucial for evaluating the prognosis of patients with acute coronary syndrome (ACS). In the present study, the potential prognostic value of protein tyrosine phosphatase receptor‑type O (PTPRO) expression in the peripheral blood mononuclear cells of patients with ACS undergoing percutaneous coronary intervention (PCI) was investigated. Patients diagnosed with ACS were prospectively recruited, and PTPRO expression in mononuclear cells separated from peripheral blood was assessed by western blotting. The prognosis was judged by the occurrence of major adverse cardiovascular events. Cox regression analyses were performed to assess the association between PTPRO expression and prognosis. In the enrolled 185 patients with ACS, PTPRO expression was lower after PCI compared with that before PCI (P<0.05). Although the pre‑PCI PTPRO expression did not differ significantly between the good and poor prognosis groups, PTPRO expression after PCI was significantly lower in the good prognosis group compared with the poor prognosis group (P<0.05). The area under the receiver operating characteristic curve for the prognostic value of post‑PCI PTPRO expression was significantly greater than that for pre‑PCI PTPRO expression (P<0.05). Cox regression analysis identified high post‑PCI PTPRO expression as an independent risk factor for poor prognosis in patients with ACS (P<0.05), and further analysis indicated that the post‑PCI PTPRO expression level was associated with the prognosis of patients with ACS (P<0.05). PTPRO expression in peripheral blood mononuclear cells after PCI is associated with the prognosis of patients with ACS, with high PTPRO expression indicating a high risk of poor prognosis in patients with ACS.
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May-2021
Volume 21 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Hao M, Guo M and Yan R: Protein tyrosine phosphatase receptor‑type O expression as a prognostic marker in patients with acute coronary syndrome undergoing percutaneous coronary intervention: A prospective study. Exp Ther Med 21: 435, 2021.
APA
Hao, M., Guo, M., & Yan, R. (2021). Protein tyrosine phosphatase receptor‑type O expression as a prognostic marker in patients with acute coronary syndrome undergoing percutaneous coronary intervention: A prospective study. Experimental and Therapeutic Medicine, 21, 435. https://doi.org/10.3892/etm.2021.9852
MLA
Hao, M., Guo, M., Yan, R."Protein tyrosine phosphatase receptor‑type O expression as a prognostic marker in patients with acute coronary syndrome undergoing percutaneous coronary intervention: A prospective study". Experimental and Therapeutic Medicine 21.5 (2021): 435.
Chicago
Hao, M., Guo, M., Yan, R."Protein tyrosine phosphatase receptor‑type O expression as a prognostic marker in patients with acute coronary syndrome undergoing percutaneous coronary intervention: A prospective study". Experimental and Therapeutic Medicine 21, no. 5 (2021): 435. https://doi.org/10.3892/etm.2021.9852