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Article

Laminar shear stress upregulates the expression of PPARs in vascular endothelial cells under high free fatty acid‑induced stress

  • Authors:
    • Yu-Lin Wang
    • Chen-Te Chen
    • Che-Se Tung
    • Min-Chien Tsai
  • View Affiliations / Copyright

    Affiliations: Center of General Education, Southern Taiwan University of Science and Technology, Tainan 710, Taiwan, R.O.C., Department of Emergency Medicine, Cheng Hsin General Hospital, Taipei 112, Taiwan, R.O.C., Department of Medical Research and Education, Cheng Hsin General Hospital, Taipei 112, Taiwan, R.O.C., Department of Physiology and Biophysics, Graduate Institute of Physiology, National Defense Medical Center, Taipei 114, Taiwan, R.O.C.
  • Article Number: 438
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    Published online on: February 26, 2021
       https://doi.org/10.3892/etm.2021.9855
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Abstract

Shear stress has been reported to result in various metabolic effects in endothelial cells (ECs), which in turn contribute to the regulation of their vascular functions. Peroxisome proliferator‑activated receptors (PPARs) have been reported to regulate lipid metabolism and have been implicated in metabolic disorders. The present study assessed the effects of laminar shear stress on the expression of PPARs in ECs in the presence of high concentrations of free fatty acids (FFAs). Human aortic ECs (HAECs) were treated with a high concentrations of palmitic acid (PA) and exposed to high shear stress (HSS) or low shear stress (LSS). Western blotting and ELISA were performed to quantify protein expression and assess prostacyclin production. The results revealed that long‑term application of HSS to PA‑treated HAECs induced PPAR‑α, ‑δ and -γ protein expression. Additionally, LSS induced higher levels of PPAR‑α protein expression in PA‑treated HAECs compared with those after HSS. HAECs exposed to HSS also released prostacyclin (PGI2). However, HAECs treated with high concentrations of PA also produced high levels of PGI2 in the perfusion media in response to HSS compared with the static PA group. HSS also reduced the static PA‑induced expression of intercellular adhesion molecule‑1 and monocyte chemoattractant protein‑1. The results demonstrated that HAECs increases the expression of all three peroxisome proliferator‑activated receptor isoforms in response to shear metabolic stress at high FFA concentrations. The present study may provide preliminary insights into the potential roles of PPARs as an effective treatment method against metabolic disturbances that can result in EC dysfunction.
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1 

Morigi M, Zoja C, Figliuzzi M, Foppolo M, Micheletti G, Bontempelli M, Saronni M, Remuzzi G and Remuzzi A: Fluid shear stress modulates surface expression of adhesion molecules by endothelial cells. Blood. 85:1696–1703. 1995.PubMed/NCBI

2 

Surapisitchat J, Hoefen RJ, Pi X, Yoshizumi M, Yan C and Berk BC: Fluid shear stress inhibits TNF-alpha activation of JNK but not ERK1/2 or p38 in human umbilical vein endothelial cells: Inhibitory crosstalk among MAPK family members. Proc Natl Acad Sci USA. 98:6476–6481. 2001.PubMed/NCBI View Article : Google Scholar

3 

Mun GI, An SM, Park H, Jo H and Boo YC: Laminar shear stress inhibits lipid peroxidation induced by high glucose plus arachidonic acid in endothelial cells. Am J Physiol Heart Circ Physiol. 295:H1966–H1973. 2008.PubMed/NCBI View Article : Google Scholar

4 

Boden G: Free fatty acids, insulin resistance, and type 2 diabetes mellitus. Proc Assoc Am Physicians. 111:241–248. 1999.PubMed/NCBI View Article : Google Scholar

5 

Liu L, Li Y, Guan C, Li K, Wang C, Feng R and Sun C: Free fatty acid metabolic profile and biomarkers of isolated post-challenge diabetes and type 2 diabetes mellitus based on GC-MS and multivariate statistical analysis. J Chromatogr B Analyt Technol Biomed Life Sci. 878:2817–2825. 2010.PubMed/NCBI View Article : Google Scholar

6 

Yi LZ, He J, Liang YZ, Yuan DL and Chau FT: Plasma fatty acid metabolic profiling and biomarkers of type 2 diabetes mellitus based on GC/MS and PLS-LDA. FEBS Lett. 580:6837–6845. 2006.PubMed/NCBI View Article : Google Scholar

7 

Ghosh A, Gao L, Thakur A, Siu PM and Lai CWK: Role of free fatty acids in endothelial dysfunction. J Biomed Sci. 24(50)2017.PubMed/NCBI View Article : Google Scholar

8 

Pankow JS, Duncan BB, Schmidt MI, Ballantyne CM, Couper DJ, Hoogeveen RC and Golden SH: Atherosclerosis Risk in Communities Study. Fasting plasma free fatty acids and risk of type 2 diabetes: The atherosclerosis risk in communities study. Diabetes Care. 27:77–82. 2004.PubMed/NCBI View Article : Google Scholar

9 

Inoguchi T, Li P, Umeda F, Yu HY, Kakimoto M, Imamura M, Aoki T, Etoh T, Hashimoto T, Naruse M, et al: High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes. 49:1939–1945. 2000.PubMed/NCBI View Article : Google Scholar

10 

Su J, Tian H, Liu R and Liang J: Inhibitive effects of glucose and free fatty acids on proliferation of human vascular endothelial cells in vitro. Chin Med J (Engl). 115:1486–1490. 2002.PubMed/NCBI

11 

Trombetta A, Togliatto G, Rosso A, Dentelli P, Olgasi C, Cotogni P and Brizzi MF: Increase of palmitic acid concentration impairs endothelial progenitor cell and bone marrow-derived progenitor cell bioavailability: Role of the STAT5/PPARγ transcriptional complex. Diabetes. 62:1245–1257. 2013.PubMed/NCBI View Article : Google Scholar

12 

Song X, Yang B, Qiu F, Jia M and Fu G: High glucose and free fatty acids induce endothelial progenitor cell senescence via PGC-1α/SIRT1 signaling pathway. Cell Biol Int. 41:1146–1159. 2017.PubMed/NCBI View Article : Google Scholar

13 

Legrand-Poels S, Esser N, L'homme L, Scheen A, Paquot N and Piette J: Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes. Biochem Pharmacol. 92:131–141. 2014.PubMed/NCBI View Article : Google Scholar

14 

Qi Y, Du X, Yao X and Zhao Y: Vildagliptin inhibits high free fatty acid (FFA)-induced NLRP3 inflammasome activation in endothelial cells. Artif Cells Nanomed Biotechnol. 47:1067–1074. 2019.PubMed/NCBI View Article : Google Scholar

15 

Wang L, Chen Y, Li X and Zhang Y, Gulbins E and Zhang Y: Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated Nlrp3 inflammasome activation. Oncotarget. 7:73229–73241. 2016.PubMed/NCBI View Article : Google Scholar

16 

Evans RM, Barish GD and Wang YX: PPARs and the complex journey to obesity. Nat Med. 10:355–361. 2004.PubMed/NCBI View Article : Google Scholar

17 

Chinetti G, Fruchart JC and Staels B: Peroxisome proliferator-activated receptors (PPARs): Nuclear receptors at the crossroads between lipid metabolism and inflammation. Inflamm Res. 49:497–505. 2000.PubMed/NCBI View Article : Google Scholar

18 

Marx N, Duez H, Fruchart JC and Staels B: Peroxisome proliferator-activated receptors and atherogenesis: Regulators of gene expression in vascular cells. Circ Res. 94:1168–1178. 2004.PubMed/NCBI View Article : Google Scholar

19 

Tsai MC, Chen L, Zhou J, Tang Z, Hsu TF, Wang Y, Shih YT, Peng HH, Wang N, Guan Y, et al: Shear stress induces synthetic-to-contractile phenotypic modulation in smooth muscle cells via peroxisome proliferator-activated receptor alpha/delta activations by prostacyclin released by sheared endothelial cells. Circ Res. 105:471–480. 2009.PubMed/NCBI View Article : Google Scholar

20 

Liu Y, Zhu Y, Rannou F, Lee TS, Formentin K, Zeng L, Yuan X, Wang N, Chien S, Forman BM and Shyy JY: Laminar flow activates peroxisome proliferator-activated receptor-gamma in vascular endothelial cells. Circulation. 110:1128–1133. 2004.PubMed/NCBI View Article : Google Scholar

21 

Ge X, Pan P, Jing J, Hu X, Chen L, Qiu X, Ma R, Jueraitetibaike K, Huang X and Yao B: Rosiglitazone ameliorates palmitic acid-induced cytotoxicity in TM4 Sertoli cells. Reprod Biol Endocrinol. 16(98)2018.PubMed/NCBI View Article : Google Scholar

22 

Zhang Z, Xie X, Yao Q, Liu J, Tian Y, Yang C, Xiao L and Wang N: PPARδ agonist prevents endothelial dysfunction via induction of dihydrofolate reductase gene and activation of tetrahydrobiopterin salvage pathway. Br J Pharmacol. 176:2945–2961. 2019.PubMed/NCBI View Article : Google Scholar

23 

Chiu JJ, Lee PL, Chen CN, Lee CI, Chang SF, Chen LJ, Lien SC, Ko YC, Usami S and Chien S: Shear stress increases ICAM-1 and decreases VCAM-1 and E-selectin expressions induced by tumor necrosis factor-(alpha) in endothelial cells. Arterioscler Thromb Vasc Biol. 24:73–79. 2004.PubMed/NCBI View Article : Google Scholar

24 

Chiu JJ, Chen LJ, Chang SF, Lee PL, Lee CI, Tsai MC, Lee DY, Hsieh HP, Usami S and Chien S: Shear stress inhibits smooth muscle cell-induced inflammatory gene expression in endothelial cells: Role of NF-kappaB. Arterioscler Thromb Vasc Biol. 25:963–969. 2005.PubMed/NCBI View Article : Google Scholar

25 

Chiu JJ, Chen LJ, Lee CI, Lee PL, Lee DY, Tsai MC, Lin CW, Usami S and Chien S: Mechanisms of induction of endothelial cell E-selectin expression by smooth muscle cells and its inhibition by shear stress. Blood. 110:519–528. 2007.PubMed/NCBI View Article : Google Scholar

26 

Chang SF, Chang CA, Lee DY, Lee PL, Yeh YM, Yeh CR, Cheng CK, Chien S and Chiu JJ: Tumor cell cycle arrest induced by shear stress: Roles of integrins and Smad. Proc Natl Acad Sci USA. 105:3927–3932. 2008.PubMed/NCBI View Article : Google Scholar

27 

Chiu JJ and Chien S: Effects of disturbed flow on vascular endothelium: Pathophysiological basis and clinical perspectives. Physiol Rev. 91:327–387. 2011.PubMed/NCBI View Article : Google Scholar

28 

Vessby B: Dietary fat, fatty acid composition in plasma and the metabolic syndrome. Curr Opin Lipidol. 14:15–19. 2003.PubMed/NCBI View Article : Google Scholar

29 

Guerci B, Böhme P, Kearney-Schwartz A, Zannad F and Drouin P: Endothelial dysfunction and type 2 diabetes. Part 2: Altered endothelial function and the effects of treatments in type 2 diabetes mellitus. Diabetes Metab. 4:436–447. 2001.PubMed/NCBI

30 

Ndisang JF: Cross-talk between heme oxygenase and peroxisome proliferator-activated receptors in the regulation of physiological functions. Front Biosci (Landmark Ed). 19:916–935. 2014.PubMed/NCBI View Article : Google Scholar

31 

Taba Y, Sasaguri T, Miyagi M, Abumiya T, Miwa Y, Ikeda T and Mitsumata M: Fluid shear stress induces lipocalin-type prostaglandin D(2) synthase expression in vascular endothelial cells. Circ Res. 86:967–973. 2000.PubMed/NCBI View Article : Google Scholar

32 

Ye G, Gao H, Wang Z, Lin Y, Liao X, Zhang H, Chi Y, Zhu H and Dong S: PPARα and PPARγ activation attenuates total free fatty acid and triglyceride accumulation in macrophages via the inhibition of Fatp1 expression. Cell Death Dis. 10(39)2019.PubMed/NCBI View Article : Google Scholar

33 

Moraes LA, Piqueras L and Bishop-Bailey D: Peroxisome proliferator-activated receptors and inflammation. Pharmacol Ther. 110:371–385. 2006.PubMed/NCBI View Article : Google Scholar

34 

Doroudi R, Gan LM, Selin Sjögren L and Jern S: Effects of shear stress on eicosanoid gene expression and metabolite production in vascular endothelium as studied in a novel biomechanical perfusion model. Biochem Biophys Res Commun. 269:257–264. 2000.PubMed/NCBI View Article : Google Scholar

35 

Frangos JA, Eskin SG, McIntire LV and Ives CL: Flow effects on prostacyclin production by cultured human endothelial cells. Science. 227:1477–1479. 1985.PubMed/NCBI View Article : Google Scholar

36 

Vane J and Corin RE: Prostacyclin: A vascular mediator. Eur J Vasc Endovasc Surg. 26:571–578. 2003.PubMed/NCBI View Article : Google Scholar

37 

Rolland PH, Jouve R, Pellegrin E, Mercier C and Serradimigni A: Alteration in prostacyclin and prostaglandin E2 production. Correlation with changes in human aortic atherosclerotic disease. Arteriosclerosis. 4:70–78. 1984.PubMed/NCBI View Article : Google Scholar

38 

Shimokawa H: Primary endothelial dysfunction: Atherosclerosis. J Mol Cell Cardiol. 31:23–37. 1999.PubMed/NCBI View Article : Google Scholar

39 

Di Francesco L, Totani L, Dovizio M, Piccoli A, Di Francesco A, Salvatore T, Pandolfi A, Evangelista V, Dercho RA, Seta F and Patrignani P: Induction of prostacyclin by steady laminar shear stress suppresses tumor necrosis factor-alpha biosynthesis via heme oxygenase-1 in human endothelial cells. Circ Res. 104:506–513. 2009.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Chen C, Tung C and Tsai M: Laminar shear stress upregulates the expression of PPARs in vascular endothelial cells under high free fatty acid‑induced stress. Exp Ther Med 21: 438, 2021.
APA
Wang, Y., Chen, C., Tung, C., & Tsai, M. (2021). Laminar shear stress upregulates the expression of PPARs in vascular endothelial cells under high free fatty acid‑induced stress. Experimental and Therapeutic Medicine, 21, 438. https://doi.org/10.3892/etm.2021.9855
MLA
Wang, Y., Chen, C., Tung, C., Tsai, M."Laminar shear stress upregulates the expression of PPARs in vascular endothelial cells under high free fatty acid‑induced stress". Experimental and Therapeutic Medicine 21.5 (2021): 438.
Chicago
Wang, Y., Chen, C., Tung, C., Tsai, M."Laminar shear stress upregulates the expression of PPARs in vascular endothelial cells under high free fatty acid‑induced stress". Experimental and Therapeutic Medicine 21, no. 5 (2021): 438. https://doi.org/10.3892/etm.2021.9855
Copy and paste a formatted citation
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Spandidos Publications style
Wang Y, Chen C, Tung C and Tsai M: Laminar shear stress upregulates the expression of PPARs in vascular endothelial cells under high free fatty acid‑induced stress. Exp Ther Med 21: 438, 2021.
APA
Wang, Y., Chen, C., Tung, C., & Tsai, M. (2021). Laminar shear stress upregulates the expression of PPARs in vascular endothelial cells under high free fatty acid‑induced stress. Experimental and Therapeutic Medicine, 21, 438. https://doi.org/10.3892/etm.2021.9855
MLA
Wang, Y., Chen, C., Tung, C., Tsai, M."Laminar shear stress upregulates the expression of PPARs in vascular endothelial cells under high free fatty acid‑induced stress". Experimental and Therapeutic Medicine 21.5 (2021): 438.
Chicago
Wang, Y., Chen, C., Tung, C., Tsai, M."Laminar shear stress upregulates the expression of PPARs in vascular endothelial cells under high free fatty acid‑induced stress". Experimental and Therapeutic Medicine 21, no. 5 (2021): 438. https://doi.org/10.3892/etm.2021.9855
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