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Lidocaine suppresses the malignant behavior of gastric cancer cells via the c‑Met/c‑Src pathway

  • Authors:
    • Wei Zeng
    • Ze Ting Xing
    • Mei Yun Tan
    • Yan Wen Wu
    • Chun Yuan Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Affiliated Boai Hospital of Zhongshan, Southern Medical University, Zhongshan, Guangdong 528403, P.R. China
    Copyright: © Zeng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 424
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    Published online on: February 25, 2021
       https://doi.org/10.3892/etm.2021.9868
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Abstract

The present study was designed to investigate the role and mechanism of action behind the action of lidocaine in gastric cancer cells. Lidocaine was tested for its potential role in affecting the viability of cells using Cell Counting Kit‑8 (CCK‑8) assays. It was found that there was a decreased MKN45 cell viability upon lidocaine treatment in a dose‑dependent manner. Phosphorylated c‑Met, phosphorylated c‑Src, c‑Met and c‑Src levels were detected using western blotting following lidocaine or hepatocyte growth factor (HGF) intervention. It was found that the phosphorylation levels of c‑Met and c‑Src were markedly reduced by lidocaine treatment, with this effect being further relieved by the addition of HGF. Subsequently, whether lidocaine repressed the malignant biological properties of gastric cancer cells through the c‑Met/c‑Src axis was further investigated through the detection of epithelial‑mesenchymal transition markers (N‑caderin and vimentin), wound healing and transwell assay analysis. In addition, cell apoptosis and the levels of apoptosis‑related proteins were determined using TUNEL and western blot assays, respectively. The results demonstrated that the malignant behavior of cells were notably repressed upon lidocaine treatment, but the addition of HGF markedly reversed these effects, indicating that the effects of lidocaine on supressing the malignant behaviour of cells could be mediated through the c‑Met/c‑Src axis. Subsequently, whether lidocaine affected the sensitivity of cells to cisplatin or 5‑FU was analyzed using a CCK‑8 assay. Enhanced sensitivity of cells to cisplatin or 5‑FU was observed when treated in combination with lidocaine. The present study concluded that the involvement of the c‑Met/c‑Src pathway in the biological behaviour of MKN45 cells was mediated by lidocaine. Therefore, lidocaine may have the potential to suppress the malignant behaviour and proliferation of gastric cancer cells.
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1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015.PubMed/NCBI View Article : Google Scholar

2 

Casamayor M, Morlock R, Maeda H and Ajani J: . Targeted literature review of the global burden of gastric cancer. Ecancermedicalscience. 12(883)2018.PubMed/NCBI View Article : Google Scholar

3 

Sui H, Lou A, Li Z and Yang J: . Lidocaine inhibits growth, migration and invasion of gastric carcinoma cells by up-regulation of miR-145. BMC Cancer. 19(233)2019.PubMed/NCBI View Article : Google Scholar

4 

Yang W, Cai J, Zhang H, Wang G and Jiang W: . Effects of lidocaine and ropivacaine on gastric cancer cells through down-regulation of ERK1/2 phosphorylation in vitro. Anticancer Res. 38:6729–6735. 2018.PubMed/NCBI View Article : Google Scholar

5 

Ye L, Zhang Y, Chen YJ and Liu Q: Anti-tumor effects of lidocaine on human gastric cancer cells in vitro. Bratisl Lek Listy. 120:212–217. 2019.PubMed/NCBI View Article : Google Scholar

6 

Piegeler T, Votta-Velis EG, Bakhshi FR, Mao M, Carnegie G, Bonini MG, Schwartz DE, Borgeat A, Beck-Schimmer B and Minshall RD: Endothelial barrier protection by local anesthetics: Ropivacaine and lidocaine block tumor necrosis factor-α-induced endothelial cell src activation. Anesthesiology. 120:1414–1428. 2014.PubMed/NCBI View Article : Google Scholar

7 

Piegeler T, Votta-Velis EG, Liu G, Place AT, Schwartz DE, Beck-Schimmer B, Minshall RD and Borgeat A: Antimetastatic potential of amide-linked local anesthetics: Inhibition of lung adenocarcinoma cell migration and inflammatory src signaling independent of sodium channel blockade. Anesthesiology. 117:548–559. 2012.PubMed/NCBI View Article : Google Scholar

8 

Wall TP, Crowley PD, Sherwin A, Foley AG and Buggy DJ: Effects of lidocaine and src inhibition on metastasis in a murine model of breast cancer surgery. Cancers (Basel). 11(1414)2019.PubMed/NCBI View Article : Google Scholar

9 

Matsumoto K, Umitsu M, De Silva DM, Roy A and Bottaro DP: Hepatocyte growth factor/MET in cancer progression and biomarker discovery. Cancer Sci. 108:296–307. 2017.PubMed/NCBI View Article : Google Scholar

10 

Han SU, Lee HY, Lee JH, Kim WH, Nam H, Kim H, Cho YK, Kim MW and Lee KU: Modulation of E-cadherin by hepatocyte growth factor induces aggressiveness of gastric carcinoma. Ann Surg. 242:676–683. 2005.PubMed/NCBI View Article : Google Scholar

11 

Lee KH, Choi EY, Hyun MS, Jang BI, Kim TN, Kim SW, Song SK, Kim JH and Kim JR: Hepatocyte growth factor/c-met signaling in regulating urokinase plasminogen activator in human stomach cancer: A potential therapeutic target for human stomach cancer. Korean J Intern Med. 21:20–27. 2006.PubMed/NCBI View Article : Google Scholar

12 

Park WS, Oh RR, Kim YS, Park JY, Shin MS, Lee HK, Lee SH, Yoo NJ and Lee JY: Absence of mutations in the kinase domain of the met gene and frequent expression of met and HGF/SF protein in primary gastric carcinomas. APMIS. 108:195–200. 2000.PubMed/NCBI View Article : Google Scholar

13 

Okamoto W, Okamoto I, Yoshida T, Okamoto K, Takezawa K, Hatashita E, Yamada Y, Kuwata K, Arao T, Yanagihara K, et al: Identification of c-src as a potential therapeutic target for gastric cancer and of MET activation as a cause of resistance to c-src inhibition. Mol Cancer Ther. 9:1188–1197. 2010.PubMed/NCBI View Article : Google Scholar

14 

Kuniyasu H, Yasui W, Kitadai Y, Yokozaki H, Ito H and Tahara E: Frequent amplification of the c-met gene in scirrhous type stomach cancer. Biochem Biophys Res Commun. 189:227–232. 1992.PubMed/NCBI View Article : Google Scholar

15 

Nessling M, Solinas-Toldo S, Wilgenbus KK, Borchard F and Lichter P: Mapping of chromosomal imbalances in gastric adenocarcinoma revealed amplified protooncogenes MYCN, MET, WNT2, and ERBB2. Genes Chromosomes Cancer. 23:307–316. 1998.PubMed/NCBI View Article : Google Scholar

16 

Sakakura C, Mori T, Sakabe T, Ariyama Y, Shinomiya T, Date K, Hagiwara A, Yamaguchi T, Takahashi T, Nakamura Y, et al: Gains, losses, and amplifications of genomic materials in primary gastric cancers analyzed by comparative genomic hybridization. Genes Chromosomes Cancer. 24:299–305. 1999.PubMed/NCBI View Article : Google Scholar

17 

Irby RB and Yeatman TJ: Role of src expression and activation in human cancer. Oncogene. 19:5636–5642. 2000.PubMed/NCBI View Article : Google Scholar

18 

Kim LC, Song L and Haura EB: Src kinases as therapeutic targets for cancer. Nat Rev Clin Oncol. 6:587–595. 2009.PubMed/NCBI View Article : Google Scholar

19 

Anestis A, Zoi I and Karamouzis MV: Current advances of targeting HGF/c-Met pathway in gastric cancer. Ann Transl Med. 6(247)2018.PubMed/NCBI View Article : Google Scholar

20 

Moosavi F, Giovannetti E, Saso L and Firuzi O: HGF/MET pathway aberrations as diagnostic, prognostic, and predictive biomarkers in human cancers. Crit Rev Clin Lab Sci. 56:533–566. 2019.PubMed/NCBI View Article : Google Scholar

21 

Summy JM and Gallick GE: Src family kinases in tumor progression and metastasis. Cancer Metastasis Rev. 22:337–358. 2003.PubMed/NCBI View Article : Google Scholar

22 

Yan H, Sun Y, Wu Q, Wu Z, Hu M, Sun Y, Liu Y, Ma Z, Liu S, Xiao W, et al: PELP1 suppression inhibits gastric cancer through downregulation of c-Src-PI3K-ERK pathway. Front Oncol. 9(1423)2019.PubMed/NCBI View Article : Google Scholar

23 

Kim HJ, Kang SK, Kwon WS, Kim TS, Jeong I, Jeung HC, Kragh M, Horak ID, Chung HC and Rha SY: Forty-nine gastric cancer cell lines with integrative genomic profiling for development of c-MET inhibitor. Int J Cancer. 143:151–159. 2018.PubMed/NCBI View Article : Google Scholar

24 

Huang KH, Sung IC, Fang WL, Chi CW, Yeh TS, Lee HC, Yin PH, Li AF, Wu CW, Shyr YM and Yang MH: Correlation between HGF/c-Met and notch1 signaling pathways in human gastric cancer cells. Oncol Rep. 40:294–302. 2018.PubMed/NCBI View Article : Google Scholar

25 

Oh HA, Lee G, Kang HJ, Kim YG, Bae SH, Lee JL, Lee KH, Hyun MS and Kim DS: Overexpression of c-met protein in gastric cancer and role of uPAR as a therapeutic target. Cancer Res Treat. 35:9–15. 2003.PubMed/NCBI View Article : Google Scholar

26 

Chen C, Tang X, Liu Y, Zhu J and Liu J: Induction/reversal of drug resistance in gastric cancer by non-coding RNAs (Review). Int J Oncol. 54:1511–1524. 2019.PubMed/NCBI View Article : Google Scholar

27 

Kiriyama S, Oda I, Nishimoto F, Mashimo Y, Ikehara H and Gotoda T: Pilot study to assess the safety of local lidocaine injections during endoscopic submucosal dissection for early gastric cancer. Gastric Cancer. 12:142–147. 2009.PubMed/NCBI View Article : Google Scholar

28 

Kim TH, Kang H, Choi YS, Park JM, Chi KC, Shin HY and Hong JH: Pre- and intraoperative lidocaine injection for preemptive analgesics in laparoscopic gastrectomy: A prospective, randomized, double-blind, placebo-controlled study. J Laparoendosc Adv Surg Tech A. 23:663–668. 2013.PubMed/NCBI View Article : Google Scholar

29 

Yao L, Zhang D, Zhao X, Sun B, Liu Y, Gu Q, Zhang Y, Zhao X, Che N, Zheng Y, et al: Dickkopf-1-Promoted vasculogenic mimicry in non-small cell lung cancer is associated with EMT and development of a cancer stem-like cell phenotype. J Cell Mol Med. 20:1673–1685. 2016.PubMed/NCBI View Article : Google Scholar

30 

Acloque H, Adams MS, Fishwick K, Bronner-Fraser M and Nieto MA: Epithelial-mesenchymal transitions: The importance of changing cell state in development and disease. J Clin Invest. 119:1438–1449. 2009.PubMed/NCBI View Article : Google Scholar

31 

Toiyama Y, Yasuda H, Saigusa S, Matushita K, Fujikawa H, Tanaka K, Mohri Y, Inoue Y, Goel A and Kusunoki M: Co-Expression of hepatocyte growth factor and c-met predicts peritoneal dissemination established by autocrine hepatocyte growth factor/c-met signaling in gastric cancer. Int J Cancer. 130:2912–2921. 2012.PubMed/NCBI View Article : Google Scholar

32 

Lee JC, Koh SA, Lee KH and Kim JR: BAG3 contributes to HGF-mediated cell proliferation, migration, and invasion via the egr1 pathway in gastric cancer. Tumori. 105:63–75. 2019.PubMed/NCBI View Article : Google Scholar

33 

Koh SA and Lee KH: HGF-Mediated S100A11 overexpression enhances proliferation and invasion of gastric cancer. Am J Transl Res. 10:3385–3394. 2018.PubMed/NCBI

34 

Konturek PC, Konturek SJ, Sulekova Z, Meixner H, Bielanski W, Starzynska T, Karczewska E, Marlicz K, Stachura J and Hahn EG: Expression of hepatocyte growth factor, transforming growth factor alpha, apoptosis related proteins bax and bcl-2, and gastrin in human gastric cancer. Aliment Pharmacol Ther. 15:989–999. 2001.PubMed/NCBI View Article : Google Scholar

35 

Kamiya Y, Ohta K and Kaneko Y: Lidocaine-induced apoptosis and necrosis in U937 cells depending on its dosage. Biomed Res. 26:231–239. 2005.PubMed/NCBI View Article : Google Scholar

36 

Qu X, Yang L, Shi Q, Wang X, Wang D and Wu G: Lidocaine inhibits proliferation and induces apoptosis in colorectal cancer cells by upregulating mir-520a-3p and targeting EGFR. Pathol Res Pract. 214:1974–1979. 2018.PubMed/NCBI View Article : Google Scholar

37 

Zhu J and Han S: Lidocaine inhibits cervical cancer cell proliferation and induces cell apoptosis by modulating the lncRNA-MEG3/miR-421/BTG1 pathway. Am J Transl Res. 11:5404–5416. 2019.PubMed/NCBI

38 

Arnold L, Enders J and Thomas SM: Activated HGF-c-met axis in head and neck cancer. Cancers (Basel). 9(169)2017.PubMed/NCBI View Article : Google Scholar

39 

Rucki AA, Xiao Q, Muth S, Chen J, Che X, Kleponis J, Sharma R, Anders RA, Jaffee EM and Zheng L: Dual inhibition of hedgehog and c-met pathways for pancreatic cancer treatment. Mol Cancer Ther. 16:2399–2409. 2017.PubMed/NCBI View Article : Google Scholar

40 

Leonetti E, Gesualdi L, Scheri KC, Dinicola S, Fattore L, Masiello MG, Cucina A, Mancini R, Bizzarri M, Ricci G and Catizone A: C-Src recruitment is involved in c-MET-mediated malignant behaviour of NT2D1 non-seminoma cells. Int J Mol Sci. 20(320)2019.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zeng W, Xing ZT, Tan MY, Wu YW and Zhang CY: Lidocaine suppresses the malignant behavior of gastric cancer cells via the c‑Met/c‑Src pathway. Exp Ther Med 21: 424, 2021.
APA
Zeng, W., Xing, Z.T., Tan, M.Y., Wu, Y.W., & Zhang, C.Y. (2021). Lidocaine suppresses the malignant behavior of gastric cancer cells via the c‑Met/c‑Src pathway. Experimental and Therapeutic Medicine, 21, 424. https://doi.org/10.3892/etm.2021.9868
MLA
Zeng, W., Xing, Z. T., Tan, M. Y., Wu, Y. W., Zhang, C. Y."Lidocaine suppresses the malignant behavior of gastric cancer cells via the c‑Met/c‑Src pathway". Experimental and Therapeutic Medicine 21.5 (2021): 424.
Chicago
Zeng, W., Xing, Z. T., Tan, M. Y., Wu, Y. W., Zhang, C. Y."Lidocaine suppresses the malignant behavior of gastric cancer cells via the c‑Met/c‑Src pathway". Experimental and Therapeutic Medicine 21, no. 5 (2021): 424. https://doi.org/10.3892/etm.2021.9868
Copy and paste a formatted citation
x
Spandidos Publications style
Zeng W, Xing ZT, Tan MY, Wu YW and Zhang CY: Lidocaine suppresses the malignant behavior of gastric cancer cells via the c‑Met/c‑Src pathway. Exp Ther Med 21: 424, 2021.
APA
Zeng, W., Xing, Z.T., Tan, M.Y., Wu, Y.W., & Zhang, C.Y. (2021). Lidocaine suppresses the malignant behavior of gastric cancer cells via the c‑Met/c‑Src pathway. Experimental and Therapeutic Medicine, 21, 424. https://doi.org/10.3892/etm.2021.9868
MLA
Zeng, W., Xing, Z. T., Tan, M. Y., Wu, Y. W., Zhang, C. Y."Lidocaine suppresses the malignant behavior of gastric cancer cells via the c‑Met/c‑Src pathway". Experimental and Therapeutic Medicine 21.5 (2021): 424.
Chicago
Zeng, W., Xing, Z. T., Tan, M. Y., Wu, Y. W., Zhang, C. Y."Lidocaine suppresses the malignant behavior of gastric cancer cells via the c‑Met/c‑Src pathway". Experimental and Therapeutic Medicine 21, no. 5 (2021): 424. https://doi.org/10.3892/etm.2021.9868
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