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Case Report

Congenital dyserythropoietic anemia and drug‑induced liver injury present as bland cholestasis: A case report

  • Authors:
    • Yue Han
    • Yan Zhuang
    • Weiliang Tang
    • Lu Chen
    • Yejing Chen
    • Qiming Gong
    • Xinxin Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Diseases, Research Laboratory of Clinical Virology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China, Department of Infectious Diseases, Qionghai People's Hospital, Hainan 571400, P.R. China
  • Article Number: 456
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    Published online on: March 2, 2021
       https://doi.org/10.3892/etm.2021.9887
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Abstract

Anemias and drug‑induced liver injury(DILI) are separate disorders, which are difficult to diagnose. The clinical effects of DILI vary among individuals. However, the outcome determinants remain to be fully established. To the best of our knowledge, the role of anemia in DILI has yet to be reported. The present study reported on the case of one Chinese patient (male; age, 21 years) who experienced obvious drug‑induced cholestasis. Of note, the hepatocyte injury was minimal compared with that in previously reported cases treated with the same drug. In addition, the patient suffered from mild hemolytic anemia with no obvious cause. A genetic pedigree analysis revealed compound heterozygous mutations in the congenital anemia‑associated gene codanin 1, including the novel rare p.R1067H mutation. Treatment with ursodeoxycholic acid alone sufficed and the outcome was good. Therefore, whilst chronic hemolysis predisposed the liver to cholestasis, it could have shielded the liver from further injuries, since bilirubin, a by‑product of hemolysis, is a known antioxidant. The results of the present study indicated that genetic screening may be used for the diagnosis of liver injury concurring with undiagnosed anemia.
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1 

Gambale A, Iolascon A, Andolfo I and Russo R: Diagnosis and management of congenital dyserythropoietic anemias. Expert Rev Hematol. 9:283–296. 2016.PubMed/NCBI View Article : Google Scholar

2 

Russo R, Andolfo I, Manna F, Gambale A, Marra R, Rosato BE, Caforio P, Pinto V, Pignataro P, Radhakrishnan K, et al: Multi-gene panel testing improves diagnosis and management of patients with hereditary anemias. Am J Hematol. 93:672–682. 2018.PubMed/NCBI View Article : Google Scholar

3 

Bolton-Maggs PH, Stevens RF, Dodd NJ, Lamont G, Tittensor P and King MJ: General Haematology Task Force of the British Committee for Standards in Haematology. Guidelines for the diagnosis and management of hereditary spherocytosis. Br J Haematol. 126:455–474. 2004.PubMed/NCBI View Article : Google Scholar

4 

European Association for the Study of the Liver. Electronic address: simpleeasloffice@easloffice.eu; Clinical Practice Guideline Panel: Chair; Panel members and EASL Governing Board representative. EASL clinical practice guidelines: Drug-induced liver injury. J Hepatol. 70:1222–1261. 2019.PubMed/NCBI View Article : Google Scholar

5 

Lucena MI, Sanabria J, García-Cortes M, Stephens C and Andrade RJ: Drug-induced liver injury in older people. Lancet Gastroenterol Hepatol. 5:862–874. 2020.PubMed/NCBI View Article : Google Scholar

6 

Danan G and Teschke R: RUCAM in drug and herb induced liver injury: The update. Int J Mol Sci. 14(17)2015.PubMed/NCBI View Article : Google Scholar

7 

Russmann S, Jetter A and Kullak-Ublick GA: Pharmacogenetics of drug-induced liver injury. Hepatology. 52:748–761. 2010.PubMed/NCBI View Article : Google Scholar

8 

Garcia-Cortes M, Robles-Diaz M, Stephens C, Ortega-Alonso A, Lucena MI and Andrade RJ: Drug induced liver injury: An update. Arch Toxicol. 94:3381–3407. 2020.PubMed/NCBI View Article : Google Scholar

9 

Nadir A, Agrawal S, King PD and Marshall JB: Acute hepatitis associated with the use of a Chinese herbal product, ma-huang. Am J Gastroenterol. 91:1436–1438. 1996.PubMed/NCBI

10 

1000 Genomes Project Consortium. Auton A, Brooks LD, Durbin RM, Garrison EP, Kang HM, Korbel JO, Marchini JL, McCarthy S, McVean GA and Abecasis GR: A global reference for human genetic variation. Nature. 526:68–74. 2015.PubMed/NCBI View Article : Google Scholar

11 

Iezzoni JC: Diagnostic histochemistry in hepatic pathology. Semin Diagn Pathol. 35:381–389. 2018.PubMed/NCBI View Article : Google Scholar

12 

Singh C, Bishop P and Willson R: Extreme hyperbilirubinemia associated with the use of anabolic steroids, health/nutritional supplements, and ethanol: Response to ursodeoxycholic acid treatment. Am J Gastroenterol. 91:783–785. 1996.PubMed/NCBI

13 

Brown RS Jr, Kumar KS, Russo MW, Kinkhabwala M, Rudow DL, Harren P, Lobritto S and Emond JC: Model for end-stage liver disease and Child-Turcotte-Pugh score as predictors of pretransplantation disease severity, posttransplantation outcome, and resource utilization in United Network for Organ Sharing status 2A patients. Liver Transpl. 8:278–284. 2002.PubMed/NCBI View Article : Google Scholar

14 

Heimpel H, Schwarz K, Ebnöther M, Goede JS, Heydrich D, Kamp T, Plaumann L, Rath B, Roessler J, Schildknecht O, et al: Congenital dyserythropoietic anemia type I (CDA I): Molecular genetics, clinical appearance, and prognosis based on long-term observation. Blood. 107:334–340. 2006.PubMed/NCBI View Article : Google Scholar

15 

Shalev H, Kapleushnik Y, Haeskelzon L, Degani O, Kransnov T, Sphilberg O, Moser A, Yaniv I and Tamary H: Clinical and laboratory manifestations of congenital dyserythropoietic anemia type I in young adults. Eur J Haematol. 68:170–174. 2002.PubMed/NCBI View Article : Google Scholar

16 

LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. [Internet]. National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda (MD), 2012.

17 

Zaninoni A, Fermo E, Vercellati C, Marcello AP, Barcellini W and Bianchi P: Congenital hemolytic anemias: Is there a role for the immune system? Front Immunol. 11(1309)2020.PubMed/NCBI View Article : Google Scholar

18 

Roy NBA and Babbs C: The pathogenesis, diagnosis and management of congenital dyserythropoietic anaemia type I. Br J Haematol. 185:436–449. 2019.PubMed/NCBI View Article : Google Scholar

19 

Borgio JF, Al-Madan MS and AbdulAzeez S: Mutation near the binding interfaces at alpha-hemoglobin stabilizing protein is highly pathogenic. Am J Transl Res. 8:4224–4232. 2016.PubMed/NCBI

20 

AbdulAzeez S and Borgio JF: In-silico computing of the most deleterious nsSNPs in HBA1 Gene. PLoS One. 11(e0147702)2016.PubMed/NCBI View Article : Google Scholar

21 

Abdulazeez S, Sultana S, Almandil NB, Almohazey D, Bency BJ and Borgio JF: The rs61742690 (S783N) single nucleotide polymorphism is a suitable target for disrupting BCL11A-mediated foetal-to-adult globin switching. PLoS One. 14(e0212492)2019.PubMed/NCBI View Article : Google Scholar

22 

Fujiwara R, Haag M, Schaeffeler E, Nies AT, Zanger UM and Schwab M: Systemic regulation of bilirubin homeostasis: Potential benefits of hyperbilirubinemia. Hepatology. 67:1609–1619. 2018.PubMed/NCBI View Article : Google Scholar

23 

Vitek L, Bellarosa C and Tiribelli C: Induction of mild hyperbilirubinemia: Hype or real therapeutic opportunity? Clin Pharmacol Ther. 106:568–575. 2019.PubMed/NCBI View Article : Google Scholar

24 

Boon AC, Hawkins CL, Coombes JS, Wagner KH and Bulmer AC: Bilirubin scavenges chloramines and inhibits myeloperoxidase-induced protein/lipid oxidation in physiologically relevant hyperbilirubinemic serum. Free Radic Biol Med. 86:259–268. 2015.PubMed/NCBI View Article : Google Scholar

25 

Bulmer AC, Bakrania B, Du Toit EF, Boon AC, Clark PJ, Powell LW, Wagner KH and Headrick JP: Bilirubin acts as a multipotent guardian of cardiovascular integrity: More than just a radical idea. Am J Physiol Heart Circ Physiol. 315:H429–H447. 2018.PubMed/NCBI View Article : Google Scholar

26 

Vitek L and Tiribelli C: Bilirubin, intestinal integrity, the microbiome, and inflammation. N Engl J Med. 383:684–686. 2020.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Han Y, Zhuang Y, Tang W, Chen L, Chen Y, Gong Q and Zhang X: Congenital dyserythropoietic anemia and drug‑induced liver injury present as bland cholestasis: A case report. Exp Ther Med 21: 456, 2021.
APA
Han, Y., Zhuang, Y., Tang, W., Chen, L., Chen, Y., Gong, Q., & Zhang, X. (2021). Congenital dyserythropoietic anemia and drug‑induced liver injury present as bland cholestasis: A case report. Experimental and Therapeutic Medicine, 21, 456. https://doi.org/10.3892/etm.2021.9887
MLA
Han, Y., Zhuang, Y., Tang, W., Chen, L., Chen, Y., Gong, Q., Zhang, X."Congenital dyserythropoietic anemia and drug‑induced liver injury present as bland cholestasis: A case report". Experimental and Therapeutic Medicine 21.5 (2021): 456.
Chicago
Han, Y., Zhuang, Y., Tang, W., Chen, L., Chen, Y., Gong, Q., Zhang, X."Congenital dyserythropoietic anemia and drug‑induced liver injury present as bland cholestasis: A case report". Experimental and Therapeutic Medicine 21, no. 5 (2021): 456. https://doi.org/10.3892/etm.2021.9887
Copy and paste a formatted citation
x
Spandidos Publications style
Han Y, Zhuang Y, Tang W, Chen L, Chen Y, Gong Q and Zhang X: Congenital dyserythropoietic anemia and drug‑induced liver injury present as bland cholestasis: A case report. Exp Ther Med 21: 456, 2021.
APA
Han, Y., Zhuang, Y., Tang, W., Chen, L., Chen, Y., Gong, Q., & Zhang, X. (2021). Congenital dyserythropoietic anemia and drug‑induced liver injury present as bland cholestasis: A case report. Experimental and Therapeutic Medicine, 21, 456. https://doi.org/10.3892/etm.2021.9887
MLA
Han, Y., Zhuang, Y., Tang, W., Chen, L., Chen, Y., Gong, Q., Zhang, X."Congenital dyserythropoietic anemia and drug‑induced liver injury present as bland cholestasis: A case report". Experimental and Therapeutic Medicine 21.5 (2021): 456.
Chicago
Han, Y., Zhuang, Y., Tang, W., Chen, L., Chen, Y., Gong, Q., Zhang, X."Congenital dyserythropoietic anemia and drug‑induced liver injury present as bland cholestasis: A case report". Experimental and Therapeutic Medicine 21, no. 5 (2021): 456. https://doi.org/10.3892/etm.2021.9887
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