Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May-2021 Volume 21 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2021 Volume 21 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Effects of sevoflurane general anesthesia during early pregnancy on AIM2 expression in the hippocampus and parietal cortex of Sprague‑Dawley offspring rats

  • Authors:
    • Yulin Zhu
    • Chao Lv
    • Jingying Liu
    • Shujun Shang
    • Wei Jing
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Yantaishan Hospital, Yantai, Shandong 264000, P.R. China, Department of Anesthesiology, People's Hospital of Laixi, Laixi, Shandong 266600, P.R. China, Department of Obstetrics, Yantaishan Hospital, Yantai, Shandong 264000, P.R. China, Department of Anesthesiology, Taian City Central Hospital, Taishan, Taian, Shandong 271000, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 469
    |
    Published online on: March 8, 2021
       https://doi.org/10.3892/etm.2021.9900
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the effect of exposure to sevoflurane general anesthesia during early pregnancy on interferon‑inducible protein AIM2 (AIM2) expression in the hippocampus and parietal cortex of the offspring Sprague‑Dawley (SD) rats. A total of 18 SD rats at a gestational age of 5‑7 days were randomly divided into three groups: i) A control group (control); ii) 2‑h sevoflurane general anesthesia, group 1 (S1); and iii) 4‑h sevoflurane general anesthesia, group 2 (S2). The six offspring rats in each group were maintained for 30 days and assessed by Morris water maze testing. Brain specimens were collected from offspring rats 30 days after birth. Changes in the structural morphology of neurons in the hippocampus and parietal cortex were observed using hematoxylin and eosin staining. Nissl bodies in the hippocampus and parietal cortex were observed by Nissl staining. The expression of glial fibrillary acidic protein (GFAP), AIM2, CD45 and IL‑1β was detected by immunohistochemistry and the protein levels of CD45, IL‑1β, pro‑caspase‑1 and caspase‑1 p10 were detected by western blotting. Compared with the control group, offspring rats in the S1 and S2 groups exhibited poor long‑term learning and memory ability and experienced different degrees of damage to both the hippocampus and parietal cortex. The expression levels of GFAP, AIM2, CD45, IL‑1β, caspase‑1 and caspase‑1 p10 in the offspring of both the S1 and the S2 groups were significantly increased (P<0.05) compared with offspring of the control group. Moreover, compared with the offspring of the S1 group, hippocampal and parietal cortex injury in the offspring of the S2 group was further aggravated, and the expression of GFAP, AIM2, CD45, IL‑1β, pro‑caspase‑1 and cleaved‑caspase‑1 was significantly increased (P<0.05). In conclusion, sevoflurane general anesthesia in SD rat early pregnancy promoted the expression of AIM2 and the inflammatory response in the hippocampus and parietal cortex of offspring rats.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Brioni JD, Varughese S, Ahmed R and Bein B: A clinical review of inhalation anesthesia with sevoflurane: From early research to emerging topics. J Anesth. 31:764–778. 2017.PubMed/NCBI View Article : Google Scholar

2 

Choi ES, Shin JY, Oh AY, Park HP, Hwang JW, Lim YJ and Jeon YT: Sevoflurane versus propofol for interventional neuroradiology: A comparison of the maintenance and recovery profiles at comparable depths of anesthesia. Korean J Anesthesiol. 66:290–294. 2014.PubMed/NCBI View Article : Google Scholar

3 

O'Farrell RA, Foley AG, Buggy DJ and Gallagher HC: Neurotoxicity of inhalation anesthetics in the neonatal rat brain: Effects on behavior and neurodegeneration in the piriform cortex. Anesthesiol Res Pract. 2018(6376090)2018.PubMed/NCBI View Article : Google Scholar

4 

Ji MH, Wang XM, Sun XR, Zhang H, Ju LS, Qiu LL, Yng JJ, Jia M, Wu J and Yang J: Environmental ehrichment ameliorates neonatal sevoflurane exposure-induced cognitive and synaptic plasticity impairments. J Mol Neurosci. 57:358–365. 2015.PubMed/NCBI View Article : Google Scholar

5 

Wu J, Yu J, Xie P, Maimaitili Y, Wang J, Yang L, Ma H, Zhang X, Yang Y and Zheng H: Sevoflurane postconditioning protects the myocardium against ischemia/reperfusion injury via activation of the JAK2-STAT3 pathway. PeerJ. 5(e3196)2017.PubMed/NCBI View Article : Google Scholar

6 

Juhasz-Boss I, Solomayer E, Strik M and Raspe C: Abdominal surgery in pregnancy-an interdisciplinary challenge. Dtsch Arztebl Int. 111:465–472. 2014.PubMed/NCBI View Article : Google Scholar

7 

Olutoye OA, Baker BW, Belfort MA and Olutoye OO: Food and Drug Administration warning on anesthesia and brain development: Implications for obstetric and fetal surgery. Am J Obstet Gynecol. 218:98–102. 2018.PubMed/NCBI View Article : Google Scholar

8 

Malhotra A, Yosh E and Xiong M: Propofol's effects on the fetal brain for non-obstetric surgery. Brain Sci. 7(107)2017.PubMed/NCBI View Article : Google Scholar

9 

Walkden GJ, Pickering AE and Gill H: Assessing long-term neurodevelopmental outcome following general anesthesia in early childhood: Challenges and opportunities. Anesth Analg. 128:681–694. 2019.PubMed/NCBI View Article : Google Scholar

10 

Vutskits L and Xie Z: Lasting impact of general anaesthesia on the brain: Mechanisms and relevance. Nat Rev Neurosci. 17:705–717. 2016.PubMed/NCBI View Article : Google Scholar

11 

Jevtovic-Todorovic V: Exposure of developing brain to general anesthesia: What is the animal evidence? Anesthesiology. 128:832–839. 2018.PubMed/NCBI View Article : Google Scholar

12 

Bi C, Cai Q, Shan Y, Yang F, Sun S, Wu X and Liu H: Sevoflurane induces neurotoxicity in the developing rat hippocampus by upregulating connexin 43 via the JNK/c-Jun/AP-1 pathway. Biomed Pharmacother. 108:1469–1476. 2018.PubMed/NCBI View Article : Google Scholar

13 

Song R, Ling X, Peng M, Xue Z, Cang J and Fang F: Maternal sevoflurane exposure causes abnormal development of fetal prefrontal cortex and induces cognitive dysfunction in offspring. Stem Cells Int. 2017(6158468)2017.PubMed/NCBI View Article : Google Scholar

14 

National Institutes of Health (NIH) guidelines revised in 1996. https://nihrecord.nih.gov/.

15 

Huang H, Liu CM, Sun J, Jin WJ, Wu YQ and Chen J: Repeated 2% sevoflurane administration in 7-and 60-day-old rats: Neurotoxicity and neurocognitive dysfunction. Aneasthesist. 66:850–857. 2017.PubMed/NCBI View Article : Google Scholar

16 

Guo Z, Zhao F, Wang Y, Wang Y, Geng M, Zhang Y, Ma Q and Xu X: Sevoflurane Exerts an Anti-depressive Action by Blocking the HMGB1/TLR4 Pathway in Unpredictable Chronic Mild Stress Rats. J Mol Neurosci. 69:546–556. 2019.PubMed/NCBI View Article : Google Scholar

17 

Yu X, Zhang F and Shi J: Neonatal exposure to sevoflurane caused cognitive deficits by dysregulating SK2 channels and GluA2-lacking AMPA receptors in juvenile rat hippocampus. Neuropharmacology. 141:66–75. 2018.PubMed/NCBI View Article : Google Scholar

18 

Zheng SQ, An LX, Cheng X and Wang YJ: Sevoflurane causes neuronal apoptosis and adaptability changes of neonatal rats. Acta Anaesthesiol Scand. 57:1167–1174. 2013.PubMed/NCBI View Article : Google Scholar

19 

Zhang Y, Yang F, Gao Y, Shan Y, Dong Y and Liu H: Neuroglobin protects offspring rats from neuronal damage induced by sevoflurane exposure to pregnant rats by inhibiting endogenous apoptosis. Int J Dev Neurosci. 76:17–24. 2019.PubMed/NCBI View Article : Google Scholar

20 

Wu Z, Li X, Zhang Y, Tong D, Wang L and Zhao P: Effects of sevoflurane exposure during mid-pregnancy on learning and memory in offspring rats: Beneficial effects of maternal exercise. Front Cell Neurosci. 12(122)2018.PubMed/NCBI View Article : Google Scholar

21 

Fang F, Song R, Ling X, Peng M, Xue Z and Cang J: Multiple sevoflurane anesthesia in pregnant mice inhibits neurogenesis of fetal hippocampus via repressing transcription factor Pax6. Life Sci. 175:16–22. 2017.PubMed/NCBI View Article : Google Scholar

22 

Sharma HS, Muresanu DF, Nozari A, Castellani RJ, Dey PK, Wiklund L and Sharma A: Anesthetics influence concussive head injury induced blood-brain barrier breakdown, brain edema formation, cerebral blood flow, serotonin levels, brain pathology and functional outcome. Int Rev Neurobiol. 146:45–81. 2019.PubMed/NCBI View Article : Google Scholar

23 

Rocha TL, Dias-Junior CA, Possomato-Vieira JS, Goncalves-Rizzi VH, Nogueira FR, de Souza KM, Braz LG and Braz MG: Sevoflurane induces DNA damage whereas isoflurane leads to higher antioxidative status in anesthetized rats. Biomed Res Int. 2015(264971)2015.PubMed/NCBI View Article : Google Scholar

24 

Zhang MQ, Ji MH, Zhao QS, Jia M, Qiu LL, Yang JJ, Peng YG, Yang JJ and Martynyuk AE: Neurobehavioural abnormalities induced by repeated exposure of neonatal rats to sevoflurane can be aggravated by social isolation and enrichment deprivation initiated after exposure to the anaesthetic. Br J Anaesth. 115:752–760. 2015.PubMed/NCBI View Article : Google Scholar

25 

Guo SB, Liu LD, Wang C, Jiang Q, Dong YX and Tian Y: Repeated exposure to sevoflurane impairs the learning and memory of older male rats. Life Sci. 192:75–83. 2018.PubMed/NCBI View Article : Google Scholar

26 

Ge X, Li W, Huang S, Yin Z, Xu X, Chen F, Kong X, Wang H, Zhang J and Lei P: The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury. Brain Res. 1697:10–20. 2018.PubMed/NCBI View Article : Google Scholar

27 

Lam HYP, Chen TT, Chen CC, Yang TH, Cheng PC and Peng SY: Angiostrongylus cantonensis activates inflammasomes in meningoencephalitic BALB/c mice. Parasitol Int. 77(102119)2020.PubMed/NCBI View Article : Google Scholar

28 

Rheinländer A, Schraven B and Bommhardt U: CD45 in human physiology and clinical medicine. Immunol Lett. 196:22–32. 2018.PubMed/NCBI View Article : Google Scholar

29 

Hirotsu A, Iwata Y, Tatsumi K, Miyai Y, Matsuyama T and Tanaka T: Maternal exposure to volatile anesthetics induces IL-6 in fetal brains and affects neuronal development. Eur J Pharmacol. 863(172682)2019.PubMed/NCBI View Article : Google Scholar

30 

Gilsoul M, Grisar T, Delgado-Escueta AV, de Nijs L and Lakaye B: Subtle brain developmental abnormalities in the pathogenesis of Juvenile Myoclonic epilepsy. Front Cell Neurosci. 13(433)2019.PubMed/NCBI View Article : Google Scholar

31 

Perez-Zoghbi JF, Zhu W, Grafe MR and Brambrink AM: Dexmedetomidine-mediated neuroprotection against sevoflurane-induced neurotoxicity extends to several brain regions in neonatal rats. Br J Anaesth. 119:506–516. 2017.PubMed/NCBI View Article : Google Scholar

32 

Malik A and Kanneganti TD: Inflammasome activation and assembly at a glance. J Cell Sci. 30:3955–3963. 2017.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhu Y, Lv C, Liu J, Shang S and Jing W: Effects of sevoflurane general anesthesia during early pregnancy on AIM2 expression in the hippocampus and parietal cortex of Sprague‑Dawley offspring rats. Exp Ther Med 21: 469, 2021.
APA
Zhu, Y., Lv, C., Liu, J., Shang, S., & Jing, W. (2021). Effects of sevoflurane general anesthesia during early pregnancy on AIM2 expression in the hippocampus and parietal cortex of Sprague‑Dawley offspring rats. Experimental and Therapeutic Medicine, 21, 469. https://doi.org/10.3892/etm.2021.9900
MLA
Zhu, Y., Lv, C., Liu, J., Shang, S., Jing, W."Effects of sevoflurane general anesthesia during early pregnancy on AIM2 expression in the hippocampus and parietal cortex of Sprague‑Dawley offspring rats". Experimental and Therapeutic Medicine 21.5 (2021): 469.
Chicago
Zhu, Y., Lv, C., Liu, J., Shang, S., Jing, W."Effects of sevoflurane general anesthesia during early pregnancy on AIM2 expression in the hippocampus and parietal cortex of Sprague‑Dawley offspring rats". Experimental and Therapeutic Medicine 21, no. 5 (2021): 469. https://doi.org/10.3892/etm.2021.9900
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu Y, Lv C, Liu J, Shang S and Jing W: Effects of sevoflurane general anesthesia during early pregnancy on AIM2 expression in the hippocampus and parietal cortex of Sprague‑Dawley offspring rats. Exp Ther Med 21: 469, 2021.
APA
Zhu, Y., Lv, C., Liu, J., Shang, S., & Jing, W. (2021). Effects of sevoflurane general anesthesia during early pregnancy on AIM2 expression in the hippocampus and parietal cortex of Sprague‑Dawley offspring rats. Experimental and Therapeutic Medicine, 21, 469. https://doi.org/10.3892/etm.2021.9900
MLA
Zhu, Y., Lv, C., Liu, J., Shang, S., Jing, W."Effects of sevoflurane general anesthesia during early pregnancy on AIM2 expression in the hippocampus and parietal cortex of Sprague‑Dawley offspring rats". Experimental and Therapeutic Medicine 21.5 (2021): 469.
Chicago
Zhu, Y., Lv, C., Liu, J., Shang, S., Jing, W."Effects of sevoflurane general anesthesia during early pregnancy on AIM2 expression in the hippocampus and parietal cortex of Sprague‑Dawley offspring rats". Experimental and Therapeutic Medicine 21, no. 5 (2021): 469. https://doi.org/10.3892/etm.2021.9900
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team