Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May-2021 Volume 21 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2021 Volume 21 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

MicroRNAs as crucial mediators in the pharmacological activities of triptolide (Review)

  • Authors:
    • Kun Zhou
    • Yinxia Chang
    • Bo Han
    • Rui Li
    • Yanming Wei
  • View Affiliations / Copyright

    Affiliations: Shanxi Institute of Energy, Taiyuan, Shanxi 030600, P.R. China, College of Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong, Shanxi 030619, P.R. China, College of Basic Medicine, Shanxi University of Chinese Medicine, Jinzhong, Shanxi 030619, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 499
    |
    Published online on: March 17, 2021
       https://doi.org/10.3892/etm.2021.9930
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Triptolide is the main bioactive constituent isolated from the Chinese herb Tripterygium wilfordii Hook F., which possesses a variety of pharmacological properties. MicroRNAs (miRNAs/miRs) are short non‑coding RNAs that regulate gene expression post‑transcriptionally. miRNAs are implicated in several intracellular processes, whereby their dysregulation contributes to pathogenesis of various diseases. Thus, miRNAs have great potential as biomarkers and therapeutic targets for diseases, and are implicated in drug treatment. Previous studies have reported that specific miRNAs are targeted, and their expression levels can be altered following exposure to triptolide. Thus, miRNAs are emerging as crucial mediators in the pharmacological activities of triptolide. The present review summarizes current literature on miRNAs as target molecules in the pharmacological activities of triptolide, including antitumor, anti‑inflammatory, immunosuppressive, renal protective, cardioprotective, antiangiogenesis activities and multiorgan toxicity effects. In addition, the diverse signaling pathways involved are discussed to provide a comprehensive understanding of the underlying molecular mechanisms of triptolide in the regulation of target miRNAs.
View Figures

Figure 1

View References

1 

Auyeung KK, Han QB and Ko JK: Astragalus membranaceus: A review of its protection against inflammation and gastrointestinal cancers. Am J Chin Med. 44:1–22. 2016.PubMed/NCBI View Article : Google Scholar

2 

Wang Z, Xia Q, Liu X, Liu W, Huang W, Mei X, Luo J, Shan M, Lin R, Zou D and Ma Z: Phytochemistry, pharmacology, quality control and future research of Forsythia suspensa (Thunb.) Vahl: A review. J Ethnopharmacol. 210:318–339. 2018.PubMed/NCBI View Article : Google Scholar

3 

Shi JF, Luo YY, Li JX, Luo RF, Chen L, Li J, Zhang JM and Fu CM: Research progress on anti-tumor effects and mechanisms of triptolide and its combined application. China J Chin Mater Med. 44:3391–3398. 2019.PubMed/NCBI View Article : Google Scholar

4 

Noel P, Von Hoff DD, Saluja AK, Velagapudi M, Borazanci E and Han M: Triptolide and its derivatives as cancer therapies. Trends Pharmacol Sci. 40:327–341. 2019.PubMed/NCBI View Article : Google Scholar

5 

Yan P and Sun X: Triptolide: A new star for treating human malignancies. J Cancer Res Ther. 14 (Suppl):S271–S275. 2018.PubMed/NCBI View Article : Google Scholar

6 

Huang G, Yuan K, Zhu Q, Zhang S, Lu Q, Zhu M, Sheng H, Yu R, Luo G and Xu A: Triptolide inhibits the inflammatory activities of neutrophils to ameliorate chronic arthritis. Mol Immunol. 101:210–220. 2018.PubMed/NCBI View Article : Google Scholar

7 

Huang SH, Lin GJ, Chu CH, Yu JC, Chen TW, Chen YW, Chien MW, Chu CC and Sytwu HK: Triptolide ameliorates autoimmune diabetes and prolongs islet graft survival in nonobese diabetic mice. Pancreas. 42:442–451. 2013.PubMed/NCBI View Article : Google Scholar

8 

Zheng CX, Chen ZH, Zeng CH, Qin WS, Li LS and Liu ZH: Triptolide protects podocytes from puromycin aminonucleoside induced injury in vivo and in vitro. Kidney Int. 74:596–612. 2008.PubMed/NCBI View Article : Google Scholar

9 

Yu H, Shi L, Zhao S, Sun Y, Gao Y, Sun Y and Qi G: Triptolide attenuates myocardial ischemia/reperfusion injuries in rats by inducing the activation of Nrf2/HO-1 defense pathway. Cardiovasc Toxicol. 16:325–335. 2016.PubMed/NCBI View Article : Google Scholar

10 

Xi C, Peng S, Wu Z, Zhou Q and Zhou J: Toxicity of triptolide and the molecular mechanisms involved. Biomed Pharmacother. 90:531–541. 2017.PubMed/NCBI View Article : Google Scholar

11 

Chen SR, Dai Y, Zhao J, Lin L and Wang Y and Wang Y: A mechanistic overview of triptolide and celestrol, natural products from Tripterygium wilfordii Hook F. Front Pharmacol. 9(104)2018.PubMed/NCBI View Article : Google Scholar

12 

Yuan K, Li X, Lu Q, Zhu Q, Jiang H, Wang T, Huang G and Xu A: Application and mechanisms of triptolide in the treatment of inflammatory diseases-a review. Front Pharmacol. 10(1469)2019.PubMed/NCBI View Article : Google Scholar

13 

Wei YM, Wang YH, Xue HQ, Luan ZH, Liu BW and Ren JH: Triptolide, A potential autophagy modulator. Chin J Integr Med. 25:233–240. 2019.PubMed/NCBI View Article : Google Scholar

14 

Jin W, Wang J, Liu CP, Wang HW and Xu RM: Structural basis for pri-miRNA recognition by Drosha. Mol Cell. 78:423–433. 2020.PubMed/NCBI View Article : Google Scholar

15 

Olejniczak M, Kotowska-Zimmer A and Krzyzosiak W: Stress-induced changes in miRNA biogenesis and functioning. Cell Mol Life Sci. 75:177–191. 2018.PubMed/NCBI View Article : Google Scholar

16 

Dexheimer PJ and Cochella L: MicroRNAs: From mechanism to organism. Front Cell Dev Biol. 8(409)2020.PubMed/NCBI View Article : Google Scholar

17 

Rupaimoole R and Slack FJ: MicroRNA therapeutics: Towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov. 16:203–222. 2017.PubMed/NCBI View Article : Google Scholar

18 

Liu Q, Wang W, Li F, Yu D, Xu C and Hu H: Triptolide inhibits breast cancer cell metastasis through inducing the expression of miR-146a, a negative regulator of Rho GTPase. Oncol Res. 27:1043–1050. 2019.PubMed/NCBI View Article : Google Scholar

19 

Peng A, Huang X, Liu R, Wang X and Zhuang J: Triptolide inhibits the inflammatory response of monocytes from rheumatoid arthritis patients by regulating miR-155. Chin J Cell Mol Immunol. 30:635–638. 2014.PubMed/NCBI

20 

Feng Y, Zheng C, Zhang Y, Xing C, Cai W, Li R, Chen J and Duan Y: Triptolide inhibits preformed fibril-induced microglial activation by targeting the microRNA155-5p/SHIP1 pathway. Oxid Med Cell Longev. 2019(6527638)2019.PubMed/NCBI View Article : Google Scholar

21 

Zhao X, Tang X, Yan Q, Song H, Li Z, Wang D, Chen H and Sun L: Triptolide ameliorates lupus via the induction of miR-125a-5p mediating Treg upregulation. Int Immunopharmacol. 71:14–21. 2019.PubMed/NCBI View Article : Google Scholar

22 

Yang Q, Sun M, Chen Y, Lu Y, Ye Y, Song H, Xu X, Shi S and Wang J: Triptolide protects podocytes from TGF-β-induced injury by preventing miR-30 downregulation. Am J Transl Res. 9:5150–5159. 2017.PubMed/NCBI

23 

Wang SR, Chen X, Ling S, Ni RZ, Guo H and Xu JW: MicroRNA expression, targeting, release dynamics and early-warning biomarkers in acute cardiotoxicity induced by triptolide in rats. Biomed Pharmacother. 111:1467–1477. 2019.PubMed/NCBI View Article : Google Scholar

24 

Li SG, Shi QW, Yuan LY, Qin LP, Wang Y, Miao YQ, Chen Z, Ling CQ and Qin WX: C-Myc-dependent repression of two oncogenic miRNA clusters contributes to triptolide-induced cell death in hepatocellular carcinoma cells. J Exp Clin Cancer Res. 37(51)2018.PubMed/NCBI View Article : Google Scholar

25 

Reno TA, Kim JY and Raz DJ: Triptolide inhibits lung cancer cell migration, invasion, and metastasis. Ann Thorac Surg. 100:1817–1825. 2015.PubMed/NCBI View Article : Google Scholar

26 

Kalla R, Ventham NT, Kennedy NA, Quintana JF, Nimmo ER, Buck AH and Satsangi J: MicroRNAs: New players in IBD. Gut. 64:504–517. 2015.PubMed/NCBI View Article : Google Scholar

27 

Michlewski G and Caceres JF: Post-transcriptional control of miRNA biogenesis. RNA. 25:1–16. 2019.PubMed/NCBI View Article : Google Scholar

28 

Saliminejad K, Khorram Khorshid HR, Soleymani Fard S and Ghaffari SH: An overview of microRNAs: Biology, functions, therapeutics, and analysis methods. J Cell Physiol. 234:5451–5465. 2019.PubMed/NCBI View Article : Google Scholar

29 

Vishnoi A and Rani S: miRNA biogenesis and regulation of diseases: An overview. Methods Mol Biol. 1509:1–10. 2017.PubMed/NCBI View Article : Google Scholar

30 

Yates LA, Norbury CJ and Gilbert RJ: The long and short of microRNA. Cell. 153:516–519. 2013.PubMed/NCBI View Article : Google Scholar

31 

Turner MJ and Slack FJ: Transcriptional control of microRNA expression in C elegans: Promoting better understanding. RNA Biol. 6:49–53. 2009.PubMed/NCBI View Article : Google Scholar

32 

Kedde M, Strasser MJ, Boldajipour B, Oude Vrielink JA, Slanchev K, le Sage C, Nagel R, Voorhoeve PM, van Duijse J, Orom UA, et al: RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. Cell. 131:1273–1286. 2007.PubMed/NCBI View Article : Google Scholar

33 

Krol J, Loedige I and Filipowicz W: The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet. 11:597–610. 2010.PubMed/NCBI View Article : Google Scholar

34 

Qi Y and Li J: Triptolide inhibits the growth and migration of colon carcinoma cells by down-regulation of miR-191. Exp Mol Pathol. 107:23–31. 2019.PubMed/NCBI View Article : Google Scholar

35 

Wu CW, Wang SG, Lin ML and Chen SS: Downregulation of miR-144 by triptolide enhanced p85α-PTEN complex formation causing S phase arrest of human nasopharyngeal carcinoma cells. Eur J Pharmacol. 855:137–148. 2019.PubMed/NCBI View Article : Google Scholar

36 

Chen M, Wang JM, Wang D, Wu R and Hou HW: Triptolide inhibits migration and proliferation of fibroblasts from ileocolonic anastomosis of patients with Crohn's disease via regulating the miR161/HSP70 pathway. Mol Med Rep. 19:4841–4851. 2019.PubMed/NCBI View Article : Google Scholar

37 

Qian K, Zhang L and Shi K: Triptolide prevents osteoarthritis via inhibiting hsa-miR-20b. Inflammopharmacology. 27:109–119. 2019.PubMed/NCBI View Article : Google Scholar

38 

Xue M, Cheng Y, Han F, Chang Y, Yang Y, Li X and Chen L, Lu Y, Sun B and Chen L: Triptolide attenuates renal tubular epithelial-mesenchymal transition via the miR-188-5p-mediated PI3K/AKT pathway in diabetic kidney disease. Int J Biol Sci. 14:1545–1557. 2018.PubMed/NCBI View Article : Google Scholar

39 

Han F, Wang S, Chang Y, Li C, Yang J, Han Z, Chang B, Sun B and Chen L: Triptolide prevents extracellular matrix accumulation in experimental diabetic kidney disease by targeting microRNA-137/Notch1 pathway. J Cell Physiol. 233:2225–2237. 2018.PubMed/NCBI View Article : Google Scholar

40 

Cao Y, Guo Y, Wang Y, Cao Y, Zong R, Huang C and Liu J: Drug-containing serum of Xinfeng capsules protect against H9C2 from death by enhancing miRNA-21 and inhibiting toll-like receptor 4/phosphorylated p-38 (p-p38)/p-p65 signaling pathway and proinflammatory cytokines expression. J Tradit Chin Med. 38:359–365. 2018.PubMed/NCBI

41 

Cao YX, Huang D, Liu J, Zong RK, Wan L, Huang CB, Zhang WD and Wang Y: A novel chinese medicine, xinfeng capsule, modulates proinflammatory cytokines via regulating the toll-like receptor 4 (TLR4)/Mitogen-activated protein kinase (MAPK)/Nuclear Kappa B (NF-κB) signaling pathway in an adjuvant arthritis rat model. Med Sci Monit. 25:6767–6774. 2019.PubMed/NCBI View Article : Google Scholar

42 

Xu X, Tian L and Zhang Z: Triptolide inhibits angiogenesis in microvascular endothelial cells through regulation of miR-92a. J Physiol Biochem. 75:573–583. 2019.PubMed/NCBI View Article : Google Scholar

43 

Liang H, Zhang S and Li Z: Ginsenoside Rg3 protects mouse leydig cells against triptolide by downregulation of miR-26a. Drug Des Devel Ther. 13:2057–2066. 2019.PubMed/NCBI View Article : Google Scholar

44 

Mamoori A, Gopalan V and Lam AK: Role of miR-193a in cancer: Complexity and factors control the patterns of its expression. Curr Cancer Drug Targets. 18:618–628. 2018.PubMed/NCBI View Article : Google Scholar

45 

Svoronos AA, Engelman DM and Slack FJ: OncomiR or tumor suppressor? The duplicity of microRNAs in cancer. Cancer Res. 76:3666–3670. 2016.PubMed/NCBI View Article : Google Scholar

46 

Meng HT, Zhu L, Ni WM, You LS, Jin J and Qian WB: Triptolide inhibits the proliferation of cells from lymphocytic leukemic cell lines in association with downregulation of NF-kappaB activity and miR-16-1*. Acta Pharmacol Sin. 32:503–511. 2011.PubMed/NCBI View Article : Google Scholar

47 

Xiang W, Yang CY and Bai L: Mcl-1 inhibiton in cancer treatment. Onco Targets Ther. 11:7301–7314. 2018.PubMed/NCBI View Article : Google Scholar

48 

Chen Z, Sangwan V, Banerjee S, Mackenzie T, Dudeja V, Li X, Wang H, Vickers SM and Saluja AK: miR-204 mediated loss of Myeloid cell leukemia-1 results in pancreatic cancer cell death. Mol Cancer. 12(105)2013.PubMed/NCBI View Article : Google Scholar

49 

Roufayel R and Kadry S: Molecular chaperone HSP70 and key regulators of apoptosis - a review. Curr Mol Med. 19:315–325. 2019.PubMed/NCBI View Article : Google Scholar

50 

MacKenzie TN, Mujumdar N, Banerjee S, Sangwan V, Sarver A, Vickers S, Subramanian S and Saluja AK: Triptolide induces the expression of miR-142-3p: A negative regulator of heat shock protein 70 and pancreatic cancer cell proliferation. Mol Cancer Ther. 12:1266–1275. 2013.PubMed/NCBI View Article : Google Scholar

51 

Hang S, Wang X and Li H: Triptolide inhibits viability and migration while promotes apoptosis in nephroblastoma cells by regulation of miR-193b-3p. Exp Mol Pathol. 108:80–88. 2019.PubMed/NCBI View Article : Google Scholar

52 

Zhang H, Li H, Liu Z, Ge A, Guo E, Liu S and Chen Z: Triptolide inhibits the proliferation and migration of medulloblastoma Daoy cells by upregulation of microRNA-138. J Cell Biochem. 119:9866–9877. 2018.PubMed/NCBI View Article : Google Scholar

53 

Yao C, Li H and Zhang W: Triptolide inhibits benign prostatic epithelium viability and migration and induces apoptosis via upregulation of microRNA-218. Int J Immunopathol Pharmacol. 32(2058738418812349)2018.PubMed/NCBI View Article : Google Scholar

54 

Liu Q, Wang W, Yang X, Zhao D, Li F and Wang H: miRNA-146a inhibits cell migration and invasion by targeting RhoA in breast cancer. Oncol Rep. 36:189–196. 2016.PubMed/NCBI View Article : Google Scholar

55 

Hu H, Tang J, Liu C and Cen Y: miR-23b promotes the migration of keratinocytes through downregulating TIMP3. J Surg Res. 254:102–109. 2020.PubMed/NCBI View Article : Google Scholar

56 

Wang J, Zhou F, Yin L, Zhao L, Zhang Y and Wang J: MicroRNA-199b targets the regulation of ZEB1 expression to inhibit cell proliferation, migration and invasion in non-small cell lung cancer. Mol Med Rep. 16:5007–5014. 2017.PubMed/NCBI View Article : Google Scholar

57 

Charles S, Raj V, Arokiaraj J and Mala K: Caveolin1/protein arginine methyltransferase1/sirtuin1 axis as a potential target against endothelial dysfunction. Pharmacol Res. 119:1–11. 2017.PubMed/NCBI View Article : Google Scholar

58 

Philips BJ, Kumar A, Burki S, Ryan JP, Noda K and D'Cunha J: Triptolide-induced apoptosis in non-small cell lung cancer via a novel miR204-5p/Caveolin-1/Akt-mediated pathway. Oncotarget. 11:2793–2806. 2020.PubMed/NCBI View Article : Google Scholar

59 

Cao Y: Adipocyte and lipid metabolism in cancer drug resistance. J Clin Invest. 129:3006–3017. 2019.PubMed/NCBI View Article : Google Scholar

60 

Gomes BC, Rueff J and Rodrigues AS: MicroRNAs and cancer drug resistance. Methods Mol Biol. 1395:137–162. 2016.PubMed/NCBI View Article : Google Scholar

61 

Pfeffer SR, Yang CH and Preffer LM: The role of miR-21 in cancer. Drug Dev Res. 76:270–277. 2015.PubMed/NCBI View Article : Google Scholar

62 

Li X, Zang A, Jia Y, Zhang J, Fan W, Feng J, Duan M, Zhang L, Huo R, Jiao J and Zhu X: Triptolide reduces proliferation and enhances apoptosis of human non-small cell lung cancer cells through PTEN by targeting miR-21. Mol Med Rep. 13:2763–2768. 2016.PubMed/NCBI View Article : Google Scholar

63 

Li H, Hui L, Xu W, Shen H, Chen Q, Long L and Zhu X: Triptolide modulates the sensitivity of K562/A02 cells to adriamycin by regulating miR-21 expression. Pharm Biol. 50:1233–1240. 2012.PubMed/NCBI View Article : Google Scholar

64 

Wang R, Ma X, Su S and Liu Y: Triptolide antagonized the cisplatin resistance in human ovarian cancer cell line A2780/CP70 via hsa-mir-6751. Future Med Chem. 10:1947–1955. 2018.PubMed/NCBI View Article : Google Scholar

65 

Huang X, Yang M and Jin J: Triptolide enhances the sensitivity of multiple myeloma cells to dexamethasone via microRNAs. Leuk Lymphoma. 53:1188–1195. 2012.PubMed/NCBI View Article : Google Scholar

66 

Jiang C, Fang X, Zhang H, Wang X, Li M, Jiang W, Tian F, Zhu L and Bian Z: Triptolide inhibits the growth of osteosarcoma by regulating microRNA-181a via targeting PTEN gene in vivo and vitro. Tumour Biol. 39(1010428317697556)2017.PubMed/NCBI View Article : Google Scholar

67 

Jiang J, Song X, Yang J, Lei K, Ni Y, Zhou F and Sun L: Triptolide inhibits proliferation and migration of human neuroblastoma SH-SY5Y cells by upregulating MicroRNA-181a. Oncol Res. 26:1235–1243. 2018.PubMed/NCBI View Article : Google Scholar

68 

O'Connell RM, Rao DS and Baltimore D: microRNA regulation of inflammatory responses. Annu Rev Immunol. 30:295–312. 2012.PubMed/NCBI View Article : Google Scholar

69 

Mahesh G and Biswas R: miRNA-155: A master regulator of inflammation. J Interferon Cytokine Res. 39:321–330. 2019.PubMed/NCBI View Article : Google Scholar

70 

Matta R, Wang X, Ge H, Ray W, Nelin LD and Liu Y: Triptolide induces anti-inflammatory cellular responses. Am J Transl Res. 1:267–282. 2009.PubMed/NCBI

71 

Tang H, Mao J, Ye X, Zhang F, Kerr WG, Zheng T and Zhu Z: SHIP-1, a target of miR-155, regulates endothelial cell responses in lung fibrosis. FASEB J. 34:2011–2023. 2020.PubMed/NCBI View Article : Google Scholar

72 

Wu R, Li Y, Guo Z, Gong J, Zhu W, Li N and Li J: Triptolide ameliorates ileocolonic anastomosis inflammation in IL-10 deficient mice by mechanism involving suppression of miR-155/SHIP-1 signaling pathway. Mol Immunol. 56:340–346. 2013.PubMed/NCBI View Article : Google Scholar

73 

Hou HW, Wang JM, Wang D, Wu R and Ji ZL: Triptolide exerts protective effects against fibrosis following ileocolonic anastomosis by mechanisms involving the miR-16-1/HSP70 pathway in IL-10-deficient mice. Int J Mol Med. 40:337–346. 2017.PubMed/NCBI View Article : Google Scholar

74 

Lee GR: The balance of Th17 versus Treg cells in autoimmunity. Int J Mol Sci. 19(730)2018.PubMed/NCBI View Article : Google Scholar

75 

Li XY, Wang SS, Han Z, Han F, Chang YP, Yang Y, Xue M, Sun B and Chen LM: Triptolide restores autophagy to alleviate diabetic renal fibrosis through the miR-141-3p/PTEN/Akt/mTOR pathway. Mol Ther Nucleic Acids. 9:48–56. 2017.PubMed/NCBI View Article : Google Scholar

76 

Jiang CB, Wei MG, Tu Y, Zhu H, Li CQ, Jing WM and Sun W: Triptolide attenuates podocyte injury by regulating expression of miRNA-344b-3p and miRNA-30b-3p in rats with adriamycin-induced nephropathy. Evid Based Complement Alternat Med. 2015(107814)2015.PubMed/NCBI View Article : Google Scholar

77 

Ignarski M, Islam R and Muller RU: Long non-coding RNAs in kidney disease. Int J Mol Sci. 20(3276)2019.PubMed/NCBI View Article : Google Scholar

78 

Bonauer A, Carmona G, Iwasaki M, Mione M, Koyanagi M, Fischer A, Burchfield J, Fox H, Doebele C, Ohtani K, et al: MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science. 324:1710–1713. 2009.PubMed/NCBI View Article : Google Scholar

79 

Zhang L, Zhou M, Qin G, Weintraub NL and Tang Y: miR-92a regulates viability and angiogenesis of endothelial cells under oxidative stress. Biochem Biophys Res Commun. 446:952–958. 2014.PubMed/NCBI View Article : Google Scholar

80 

Marrone AK, Beland FA and Pogribny IP: The role for microRNAs in drug toxicity and in safety assessment. Expert Opin Drug Metab Toxicol. 11:601–611. 2015.PubMed/NCBI View Article : Google Scholar

81 

Ichihara S, Li P, Mise N, Suzuki Y, Izuoka K, Nakajima T, Gonzalez F and Ichihara G: Ablation of aryl hydrocarbon receptor promotes angiotensin II-induced cardiac fibrosis through enhanced c-Jun/HIF-1α signaling. Arch Toxicol. 93:1543–1553. 2019.PubMed/NCBI View Article : Google Scholar

82 

Nam HS, Hwang KS, Jeong YM, Ryu JI, Choi TY, Bae MA, Son WC, You KH, Son HY and Kim CH: Expression of miRNA-122 induced by liver toxicants in Zebrafish. Biomed Res Int. 2016(1473578)2016.PubMed/NCBI View Article : Google Scholar

83 

Vliegenthart ADB, Wei C, Buckley C, Berends C, de Potter CMJ, Schneemann S, Del Pozo J, Tucker C, Mullins JJ, Webb DJ and Dear JW: Characterization of triptolide-induced hepatotoxicity by imaging and transcriptomics in a novel Zebrafish model. Toxicol Sci. 159:380–391. 2017.PubMed/NCBI View Article : Google Scholar

84 

Cheng B, Zhu Q, Lin W and Wang L: MicroRNA-122 inhibits epithelial-mesenchymal transition of hepatic stellate cells induced by the TGF-β1/Smad signaling pathway. Exp Ther Med. 17:284–290. 2019.PubMed/NCBI View Article : Google Scholar

85 

Yuan Y, Tong L and Wu S: microRNA and NF-kappa B. Adv Exp Med Biol. 887:157–170. 2015.PubMed/NCBI View Article : Google Scholar

86 

Ichikawa D, Komatsu S, Konishi H and Otsuji E: Circulating microRNA in digestive tract cancers. Gastroenterology. 1421074–1078. (e1071)2012.PubMed/NCBI View Article : Google Scholar

87 

Titov DV, Gilman B, He QL, Bhat S, Low WK, Dang Y, Smeaton M, Demain AL, Miller PS, Kugel JF, et al: XPB, a subunit of TFIIH, is a target of the natural product triptolide. Nat Chem Biol. 7:182–188. 2011.PubMed/NCBI View Article : Google Scholar

88 

Chauhan AK, Li P, Sun Y, Wani G, Zhu Q and Wani AA: Spironolactone-induced XPB degradtion requires TFIIH integrity and ubiquitin-selective segregase VCP/p97. Cell Cycle. 20:81–95. 2021.PubMed/NCBI View Article : Google Scholar

89 

He QL, Titov DV, Li J, Tan M, Ye Z, Zhao Y, Romo D and Liu JO: Covalent modification of a cysteine residue in the XPB subunit of the general transcription factor TFIIH through single epoxide cleavage of the transcription inhibitor triptolide. Angew Chem Int Ed Engl. 54:1859–1863. 2015.PubMed/NCBI View Article : Google Scholar

90 

Manzo SG, Zhou ZL, Wang YQ, Marinello J, He JX, Li YC, Ding J, Capranico G and Miao ZH: Natural product triptolide mediates cancer cell death by triggering CDK7-dependent degradation of RNA polymerase II. Cancer Res. 72:5363–5373. 2012.PubMed/NCBI View Article : Google Scholar

91 

Abascal-Palacios G, Ramsay EP, Beuron F, Morris E and Vannini A: Structural basis of RNA polymerase III transcription initiation. Nature. 553:301–306. 2018.PubMed/NCBI View Article : Google Scholar

92 

Liang X, Xie R, Su J, Ye B, Wei S, Liang Z, Bai R, Chen Z, Li Z and Gao X: Inhibition of RNA polymerase III transcription by Triptolide attenuates colorectal tumorigenesis. J Exp Clin Cancer Res. 38(217)2019.PubMed/NCBI View Article : Google Scholar

93 

Yamagishi M and Uchimaru K: Targeting EZH2 in cancer therapy. Curr Opin Oncol. 29:375–381. 2017.PubMed/NCBI View Article : Google Scholar

94 

Ihira K, Dong P, Xiong Y, Watari H, Konno Y, Hanley SJ, Noguchi M, Hirata N, Suizu F, Yamada T, et al: EZH2 inhibition suppresses endometrial cancer progression via miR-361/Twist axis. Oncotarget. 8:13509–13520. 2017.PubMed/NCBI View Article : Google Scholar

95 

Tamgue O, Chai CS, Hao L, Zambe JC, Huang WW, Zhang B, Lei M and Wei YM: Triptolide inhibits histone methyltransferase EZH2 and modulates the expression of its target genes in prostate cancer cells. Asian Pac J Cancer Prev. 14:5663–5669. 2013.PubMed/NCBI View Article : Google Scholar

96 

Akkoc Y and Gozuacik D: MicroRNAs as major regulators of the autophagy pathway. Biochim Biophys Acta Mol Cell Res 1867: Kappa B, 2020.

97 

Gibbings D, Mostowy S, Jay F, Schwab Y, Cossart P and Voinnet O: Selective autophagy degrades DICER and AGO2 and regulates miRNA activity. Nat Cell Biol. 14:1314–1321. 2012.PubMed/NCBI View Article : Google Scholar

98 

Peng K, Li X, Wu C, Wang Y, Yu J, Zhang J, Gao Q, Zhang W, Zhang Q, Fan Y, et al: Derivation of haploid trophoblast stem cells via conversion in vitro. iScience. 11:508–518. 2019.PubMed/NCBI View Article : Google Scholar

99 

Wang H, Zhang W, Yu J, Wu C, Gao Q, Li X, Li Y, Zhang J, Tian Y, Tan T, et al: Genetic screening and multipotency in rhesus monkey haploid neural progenitor cells. Development. 145(dev160531)2018.PubMed/NCBI View Article : Google Scholar

100 

Huang Y, Zhu N, Chen T, Chen W, Kong J, Zheng W and Ruan J: Triptolide suppressed the microglia activation to improve spinal cord injury through miR-96/IKKβ/NF-κB pathway. Spine (Phila Pa 1976). 44:E707–E714. 2019.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhou K, Chang Y, Han B, Li R and Wei Y: MicroRNAs as crucial mediators in the pharmacological activities of triptolide (Review). Exp Ther Med 21: 499, 2021.
APA
Zhou, K., Chang, Y., Han, B., Li, R., & Wei, Y. (2021). MicroRNAs as crucial mediators in the pharmacological activities of triptolide (Review). Experimental and Therapeutic Medicine, 21, 499. https://doi.org/10.3892/etm.2021.9930
MLA
Zhou, K., Chang, Y., Han, B., Li, R., Wei, Y."MicroRNAs as crucial mediators in the pharmacological activities of triptolide (Review)". Experimental and Therapeutic Medicine 21.5 (2021): 499.
Chicago
Zhou, K., Chang, Y., Han, B., Li, R., Wei, Y."MicroRNAs as crucial mediators in the pharmacological activities of triptolide (Review)". Experimental and Therapeutic Medicine 21, no. 5 (2021): 499. https://doi.org/10.3892/etm.2021.9930
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou K, Chang Y, Han B, Li R and Wei Y: MicroRNAs as crucial mediators in the pharmacological activities of triptolide (Review). Exp Ther Med 21: 499, 2021.
APA
Zhou, K., Chang, Y., Han, B., Li, R., & Wei, Y. (2021). MicroRNAs as crucial mediators in the pharmacological activities of triptolide (Review). Experimental and Therapeutic Medicine, 21, 499. https://doi.org/10.3892/etm.2021.9930
MLA
Zhou, K., Chang, Y., Han, B., Li, R., Wei, Y."MicroRNAs as crucial mediators in the pharmacological activities of triptolide (Review)". Experimental and Therapeutic Medicine 21.5 (2021): 499.
Chicago
Zhou, K., Chang, Y., Han, B., Li, R., Wei, Y."MicroRNAs as crucial mediators in the pharmacological activities of triptolide (Review)". Experimental and Therapeutic Medicine 21, no. 5 (2021): 499. https://doi.org/10.3892/etm.2021.9930
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team