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Increased thalamo‑cortical functional connectivity in patients with diabetic painful neuropathy: A resting‑state functional MRI study

  • Authors:
    • Xiaomei Liu
    • Xianghong Xu
    • Cunnan Mao
    • Peng Zhang
    • Qing Zhang
    • Lanlan Jiang
    • Yuyin Yang
    • Jianhua Ma
    • Lei Ye
    • Kok-Onn Lee
    • Jindan Wu
    • Zhijian Yao
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210010, P.R. China, Department of Endocrinology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China, Department of Psychiatry, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore 169609, Singapore, Department of Medicine, National University of Singapore, Singapore 119074, Singapore
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 509
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    Published online on: March 19, 2021
       https://doi.org/10.3892/etm.2021.9940
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Abstract

Functional changes in the brain of patients with painful diabetic neuropathy (PDN) have remained largely elusive. The aim of the present study was to explore changes in thalamo‑cortical functional connectivity (FC) of patients with PDN using resting‑state functional MRI. A total of 20 patients with type 2 diabetes mellitus (T2DM) with non‑painful diabetic neuropathy (Group NDN), 19 patients with T2DM with PDN (Group‑PDN) and 13 age‑, sex‑ and education‑matched healthy controls were recruited. The differences in thalamo‑cortical FC among the three groups were compared. Patients in Group PDN had increased FC in the left thalamus, the right angular gyrus and the occipital gyrus as compared to those in Group NDN. Furthermore, patients in Group PDN had increased FC in the right thalamus and angular gyrus as compared to those in Group NDN. In conclusion, the present results suggested that the thalamo‑cortical FC is increased in patients with T2DM and PDN. Furthermore, the increased FC in the thalamic‑parietal‑occipital connectivity may be a central pathophysiological mechanism for PDN. The study was retrospectively registered at ClinicalTrials.gov on 3 October 2018 (identifier no. NCT03700502).
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Copy and paste a formatted citation
Spandidos Publications style
Liu X, Xu X, Mao C, Zhang P, Zhang Q, Jiang L, Yang Y, Ma J, Ye L, Lee K, Lee K, et al: Increased thalamo‑cortical functional connectivity in patients with diabetic painful neuropathy: A resting‑state functional MRI study. Exp Ther Med 21: 509, 2021.
APA
Liu, X., Xu, X., Mao, C., Zhang, P., Zhang, Q., Jiang, L. ... Yao, Z. (2021). Increased thalamo‑cortical functional connectivity in patients with diabetic painful neuropathy: A resting‑state functional MRI study. Experimental and Therapeutic Medicine, 21, 509. https://doi.org/10.3892/etm.2021.9940
MLA
Liu, X., Xu, X., Mao, C., Zhang, P., Zhang, Q., Jiang, L., Yang, Y., Ma, J., Ye, L., Lee, K., Wu, J., Yao, Z."Increased thalamo‑cortical functional connectivity in patients with diabetic painful neuropathy: A resting‑state functional MRI study". Experimental and Therapeutic Medicine 21.5 (2021): 509.
Chicago
Liu, X., Xu, X., Mao, C., Zhang, P., Zhang, Q., Jiang, L., Yang, Y., Ma, J., Ye, L., Lee, K., Wu, J., Yao, Z."Increased thalamo‑cortical functional connectivity in patients with diabetic painful neuropathy: A resting‑state functional MRI study". Experimental and Therapeutic Medicine 21, no. 5 (2021): 509. https://doi.org/10.3892/etm.2021.9940
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X, Xu X, Mao C, Zhang P, Zhang Q, Jiang L, Yang Y, Ma J, Ye L, Lee K, Lee K, et al: Increased thalamo‑cortical functional connectivity in patients with diabetic painful neuropathy: A resting‑state functional MRI study. Exp Ther Med 21: 509, 2021.
APA
Liu, X., Xu, X., Mao, C., Zhang, P., Zhang, Q., Jiang, L. ... Yao, Z. (2021). Increased thalamo‑cortical functional connectivity in patients with diabetic painful neuropathy: A resting‑state functional MRI study. Experimental and Therapeutic Medicine, 21, 509. https://doi.org/10.3892/etm.2021.9940
MLA
Liu, X., Xu, X., Mao, C., Zhang, P., Zhang, Q., Jiang, L., Yang, Y., Ma, J., Ye, L., Lee, K., Wu, J., Yao, Z."Increased thalamo‑cortical functional connectivity in patients with diabetic painful neuropathy: A resting‑state functional MRI study". Experimental and Therapeutic Medicine 21.5 (2021): 509.
Chicago
Liu, X., Xu, X., Mao, C., Zhang, P., Zhang, Q., Jiang, L., Yang, Y., Ma, J., Ye, L., Lee, K., Wu, J., Yao, Z."Increased thalamo‑cortical functional connectivity in patients with diabetic painful neuropathy: A resting‑state functional MRI study". Experimental and Therapeutic Medicine 21, no. 5 (2021): 509. https://doi.org/10.3892/etm.2021.9940
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