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Article

First clinical experience with CDK4/6 inhibitors in breast cancer therapy

  • Authors:
    • Ionut Marcel Cobec
    • Lavinia Moleriu
    • Aurica Elisabeta Moatar
    • Andreas Rempen
  • View Affiliations / Copyright

    Affiliations: Clinic of Obstetrics and Gynecology, Diakonie‑Klinikum Schwäbisch Hall, D‑74523 Schwäbisch Hall, Germany, Department of Medical Informatics and Biostatistics, ‘Victor Babeș’ University of Medicine and Pharmacy, Timișoara, 300041 Timișoara, Romania, Clinic of Internal Medicine, Hohenloher Krankenhaus Öhringen, D‑74613 Öhringen, Germany
  • Article Number: 522
    |
    Published online on: March 22, 2021
       https://doi.org/10.3892/etm.2021.9954
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Abstract

For hormone receptor‑positive, HER2‑negative breast cancer patients with metastatic or advanced disease, therapy with CDK4/6 inhibitors in addition to aromatase inhibitors (AIs) or to the estrogen receptor (ER) downregulator fulvestrant has resulted in an additional therapy option and a longer progression‑free survival. In the Gynecologic‑Oncology Clinic, Diakonie‑Klinikum Schwäbisch Hall, we followed and registered our initial clinical experience with CDK4/6 inhibitors, following the side effects and tumor response over two years since they were officially approved for general use in Germany. Differences were observed when palbociclib or ribociclib was used in combination with letrozole or anastrozole or fulvestrant. The dynamic side effects and tumor response under therapy with palbociclib or ribociclib were found to be comparable with the main reported data in the official drug information. The CDK4/6 inhibitors have an important and promising role in the therapy of breast cancer patients. Patient age and therapy duration do not influence the use of palbociclib or ribociclib, although it may be important which AI is used in combination with palbociclib.
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Copy and paste a formatted citation
Spandidos Publications style
Cobec IM, Moleriu L, Moatar AE and Rempen A: First clinical experience with CDK4/6 inhibitors in breast cancer therapy. Exp Ther Med 21: 522, 2021.
APA
Cobec, I.M., Moleriu, L., Moatar, A.E., & Rempen, A. (2021). First clinical experience with CDK4/6 inhibitors in breast cancer therapy. Experimental and Therapeutic Medicine, 21, 522. https://doi.org/10.3892/etm.2021.9954
MLA
Cobec, I. M., Moleriu, L., Moatar, A. E., Rempen, A."First clinical experience with CDK4/6 inhibitors in breast cancer therapy". Experimental and Therapeutic Medicine 21.5 (2021): 522.
Chicago
Cobec, I. M., Moleriu, L., Moatar, A. E., Rempen, A."First clinical experience with CDK4/6 inhibitors in breast cancer therapy". Experimental and Therapeutic Medicine 21, no. 5 (2021): 522. https://doi.org/10.3892/etm.2021.9954
Copy and paste a formatted citation
x
Spandidos Publications style
Cobec IM, Moleriu L, Moatar AE and Rempen A: First clinical experience with CDK4/6 inhibitors in breast cancer therapy. Exp Ther Med 21: 522, 2021.
APA
Cobec, I.M., Moleriu, L., Moatar, A.E., & Rempen, A. (2021). First clinical experience with CDK4/6 inhibitors in breast cancer therapy. Experimental and Therapeutic Medicine, 21, 522. https://doi.org/10.3892/etm.2021.9954
MLA
Cobec, I. M., Moleriu, L., Moatar, A. E., Rempen, A."First clinical experience with CDK4/6 inhibitors in breast cancer therapy". Experimental and Therapeutic Medicine 21.5 (2021): 522.
Chicago
Cobec, I. M., Moleriu, L., Moatar, A. E., Rempen, A."First clinical experience with CDK4/6 inhibitors in breast cancer therapy". Experimental and Therapeutic Medicine 21, no. 5 (2021): 522. https://doi.org/10.3892/etm.2021.9954
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