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Glycogen‑rich clear cell carcinoma of the breast with solid papillary pattern: Two cases with heterogeneous clinicopathological features

  • Authors:
    • Tiberiu-Augustin Georgescu
    • Octavian Munteanu
    • Antonia-Carmen Lisievici
    • Tiberiu Tebeică
    • Dragoș Crețoiu
    • Oana Toader
    • Nicolae Suciu
    • Roxana Elena Bohîlțea
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, ‘Alessandrescu‑Rusescu’ National Institute for Mother and Child Health, 020395 Bucharest, Romania, Department of Obstetrics and Gynecology, Emergency University Hospital of Bucharest, 050098 Bucharest, Romania, Discipline of Pathology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Pathology, Dr Leventer Centre, 011216 Bucharest, Romania, Department of Genetics, ‘Alessandrescu‑Rusescu’ National Institute for Mother and Child Health, 020395 Bucharest, Romania, Department of Obstetrics and Gynecology, ‘Alessandrescu‑Rusescu’ National Institute for Mother and Child Health, 020395 Bucharest, Romania
    Copyright: © Georgescu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 524
    |
    Published online on: March 22, 2021
       https://doi.org/10.3892/etm.2021.9956
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Abstract

Invasive breast cancer is a heterogeneous disease, both in its histopathological classification and clinical course. Glycogen‑rich clear cell carcinoma of the breast is an extremely rare subtype of invasive breast carcinoma, accounting for up to 3% of all breast carcinomas. The tumor is composed of polygonal cells with abundant clear cytoplasm containing glycogen and has a very controversial prognosis. Solid papillary pattern is an uncommon morphological variant of breast carcinoma which is associated with indolent behavior in the absence of an invasive component. To date, there are only three cases of glycogen‑rich clear cell carcinoma with solid papillary pattern reported in the English literature. In this article, we present two cases of glycogen‑rich clear cell carcinoma of the breast, encountered in our daily clinical practice over a period of 5 years (2015‑2020) and perform a brief review of currently published literature. Unlike most cases of glycogen‑rich clear cell carcinoma documented to date, follow‑up of our case featuring solid papillary pattern revealed extremely favorable clinical outcome, suggesting a better prognosis for tumors with this morphology.
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Copy and paste a formatted citation
Spandidos Publications style
Georgescu T, Munteanu O, Lisievici A, Tebeică T, Crețoiu D, Toader O, Suciu N and Bohîlțea RE: Glycogen‑rich clear cell carcinoma of the breast with solid papillary pattern: Two cases with heterogeneous clinicopathological features. Exp Ther Med 21: 524, 2021.
APA
Georgescu, T., Munteanu, O., Lisievici, A., Tebeică, T., Crețoiu, D., Toader, O. ... Bohîlțea, R.E. (2021). Glycogen‑rich clear cell carcinoma of the breast with solid papillary pattern: Two cases with heterogeneous clinicopathological features. Experimental and Therapeutic Medicine, 21, 524. https://doi.org/10.3892/etm.2021.9956
MLA
Georgescu, T., Munteanu, O., Lisievici, A., Tebeică, T., Crețoiu, D., Toader, O., Suciu, N., Bohîlțea, R. E."Glycogen‑rich clear cell carcinoma of the breast with solid papillary pattern: Two cases with heterogeneous clinicopathological features". Experimental and Therapeutic Medicine 21.5 (2021): 524.
Chicago
Georgescu, T., Munteanu, O., Lisievici, A., Tebeică, T., Crețoiu, D., Toader, O., Suciu, N., Bohîlțea, R. E."Glycogen‑rich clear cell carcinoma of the breast with solid papillary pattern: Two cases with heterogeneous clinicopathological features". Experimental and Therapeutic Medicine 21, no. 5 (2021): 524. https://doi.org/10.3892/etm.2021.9956
Copy and paste a formatted citation
x
Spandidos Publications style
Georgescu T, Munteanu O, Lisievici A, Tebeică T, Crețoiu D, Toader O, Suciu N and Bohîlțea RE: Glycogen‑rich clear cell carcinoma of the breast with solid papillary pattern: Two cases with heterogeneous clinicopathological features. Exp Ther Med 21: 524, 2021.
APA
Georgescu, T., Munteanu, O., Lisievici, A., Tebeică, T., Crețoiu, D., Toader, O. ... Bohîlțea, R.E. (2021). Glycogen‑rich clear cell carcinoma of the breast with solid papillary pattern: Two cases with heterogeneous clinicopathological features. Experimental and Therapeutic Medicine, 21, 524. https://doi.org/10.3892/etm.2021.9956
MLA
Georgescu, T., Munteanu, O., Lisievici, A., Tebeică, T., Crețoiu, D., Toader, O., Suciu, N., Bohîlțea, R. E."Glycogen‑rich clear cell carcinoma of the breast with solid papillary pattern: Two cases with heterogeneous clinicopathological features". Experimental and Therapeutic Medicine 21.5 (2021): 524.
Chicago
Georgescu, T., Munteanu, O., Lisievici, A., Tebeică, T., Crețoiu, D., Toader, O., Suciu, N., Bohîlțea, R. E."Glycogen‑rich clear cell carcinoma of the breast with solid papillary pattern: Two cases with heterogeneous clinicopathological features". Experimental and Therapeutic Medicine 21, no. 5 (2021): 524. https://doi.org/10.3892/etm.2021.9956
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