Cardiovascular risk estimation in young patients with ankylosing spondylitis: A new model based on a prospective study in Constanta County, Romania

  • Authors:
    • Mihaela Ionescu
    • Paris Ionescu
    • Adrian Paul Suceveanu
    • Anca Pantea Stoian
    • Ion Motofei
    • Valeriu Ardeleanu
    • Irinel-Raluca Parepa
  • View Affiliations

  • Published online on: March 22, 2021     https://doi.org/10.3892/etm.2021.9961
  • Article Number: 529
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Cardiovascular (CV) risk assessment charts are useful in establishing a patient therapeutic plan, but the most commonly used charts have essential limitations when applied to special populations. Our aim was to determine whether the Systematic Coronary Risk Evaluation (SCORE) chart underestimates the CV risk in young patients with ankylosing spondylitis (AS) and to promote the necessity of new risk assessment models. We conducted a prospective study in Constanta County, Romania including 70 consecutive patients ≤50 years of age, previously diagnosed with AS, without a history of established CV disease, diabetes mellitus and chronic kidney disease. We estimated the CV risk using SCORE based on total cholesterol, applied for a high‑risk population, such as the Romanian population. Estimation of CV risk was also conducted with the relative risk (RR) chart, considering the following variables: smoking, systolic blood pressure and total cholesterol. The majority of patients (n=46, 65.71%) had low risk according to the SCORE chart and only 24 (34.28%) were found to have moderate CV risk; none of them with high or very high CV risk. Ten patients (21.74%) of the 46 who were considered to have a low risk based on the SCORE system presented with carotid plaques. Twelve patients (50%) of the remaining 24 with moderate CV risk were found to have carotid plaques. According to 2016 ‘European Society of Cardiology’ (ESC) guidelines, 22 of all 70 patients were at high/very high CV risk due to the presence of carotid plaques. Comparing the RR chart with carotid plaque detection, only 4 out of 30 (13.3%) patients with RR=1 had carotid plaques; the frequency was higher in those with RR>1. Our results attested that the SCORE system underestimates the risk in patients with carotid plaques. Carotid ultrasound provided a more heightened sensitivity of the RR chart. C‑reactive protein (CRP) >3 mg/dl is associated with RR>1, making this chart a better CV risk predictive system in this particular category of patients.
View Figures
View References

Related Articles

Journal Cover

May-2021
Volume 21 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ionescu M, Ionescu P, Suceveanu AP, Stoian AP, Motofei I, Ardeleanu V and Parepa I: Cardiovascular risk estimation in young patients with ankylosing spondylitis: A new model based on a prospective study in Constanta County, Romania. Exp Ther Med 21: 529, 2021
APA
Ionescu, M., Ionescu, P., Suceveanu, A.P., Stoian, A.P., Motofei, I., Ardeleanu, V., & Parepa, I. (2021). Cardiovascular risk estimation in young patients with ankylosing spondylitis: A new model based on a prospective study in Constanta County, Romania. Experimental and Therapeutic Medicine, 21, 529. https://doi.org/10.3892/etm.2021.9961
MLA
Ionescu, M., Ionescu, P., Suceveanu, A. P., Stoian, A. P., Motofei, I., Ardeleanu, V., Parepa, I."Cardiovascular risk estimation in young patients with ankylosing spondylitis: A new model based on a prospective study in Constanta County, Romania". Experimental and Therapeutic Medicine 21.5 (2021): 529.
Chicago
Ionescu, M., Ionescu, P., Suceveanu, A. P., Stoian, A. P., Motofei, I., Ardeleanu, V., Parepa, I."Cardiovascular risk estimation in young patients with ankylosing spondylitis: A new model based on a prospective study in Constanta County, Romania". Experimental and Therapeutic Medicine 21, no. 5 (2021): 529. https://doi.org/10.3892/etm.2021.9961