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Emergency department point‑of‑care biomarkers and day 90 functional outcome in spontaneous intracerebral hemorrhage: A single‑center pilot study

  • Authors:
    • Eugenia-Maria Mureșan
    • Adela Golea
    • Ștefan Cristian Vesa
    • Manuela Lenghel
    • Csaba Csutak
    • Lăcrămioara Perju‑Dumbravă
  • View Affiliations / Copyright

    Affiliations: Department of Neurosciences, Faculty of Medicine, ‘Iuliu Hațieganu’ University of Medicine and Pharmacy, 400012 Cluj‑Napoca, Romania, Department of Surgery, Emergency Medicine Discipline, ‘Iuliu Hațieganu’ University of Medicine and Pharmacy, 400006 Cluj‑Napoca, Romania, Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, ‘Iuliu Haţieganu’ University of Medicine and Pharmacy, 400349 Cluj‑Napoca, Romania, Department of Surgical Specialties, Radiology Discipline, ‘Iuliu Hațieganu’, University of Medicine and Pharmacy, 400162 Cluj‑Napoca, Romania
    Copyright: © Mureșan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 200
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    Published online on: January 5, 2022
       https://doi.org/10.3892/etm.2022.11123
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Abstract

Spontaneous intracerebral hemorrhage (sICH) results in high morbidity and mortality rates, thus identifying strategies for timely prognosis and treatment is important. The present study aimed to analyze the relationship between emergency department point‑of‑care (POC) blood biomarkers and day 90 functional outcome (FO) in patients with acute (<8 h) sICH. On‑site POC determinations, including complete blood count, glucose, cardiac troponin I, D‑dimer and C‑reactive protein, and derived inflammatory indexes were performed for a cohort of 35 patients. The primary endpoint was a favorable day 90 FO (modified Rankin Score ≤3). Secondary endpoints included early neurological worsening (ENW), day 7/discharge neurological impairment, day 90 independence assessment (Barthel Index <60), hematoma enlargement and perihematomal edema (PHE) growth. A favorable three‑month FO was reported in 16 (46%) participants. Older age, previous history of ischemic stroke and initial imagistic parameters, including intraventricular hemorrhage, enlarged contralateral ventricle and cerebral atrophy, significantly predicted an unfavorable FO. The admission D‑dimer similarly predicted day 90 FO and the independence status, along with ENW and a more severe day 7/discharge neurological status. The D‑dimer also correlated with the initial neurological status and PHE. PHE growth correlated with granulocytes, systemic immune‑inflammation index and glycemia. The results suggested that a lower admission D‑dimer could indicate an improved day 90 FO of patients with sICH, while also anticipating the development of PHE growth and ENW.
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Copy and paste a formatted citation
Spandidos Publications style
Mureșan E, Golea A, Vesa ȘC, Lenghel M, Csutak C and Perju‑Dumbravă L: Emergency department point‑of‑care biomarkers and day 90 functional outcome in spontaneous intracerebral hemorrhage: A single‑center pilot study. Exp Ther Med 23: 200, 2022.
APA
Mureșan, E., Golea, A., Vesa, Ș.C., Lenghel, M., Csutak, C., & Perju‑Dumbravă, L. (2022). Emergency department point‑of‑care biomarkers and day 90 functional outcome in spontaneous intracerebral hemorrhage: A single‑center pilot study. Experimental and Therapeutic Medicine, 23, 200. https://doi.org/10.3892/etm.2022.11123
MLA
Mureșan, E., Golea, A., Vesa, Ș. C., Lenghel, M., Csutak, C., Perju‑Dumbravă, L."Emergency department point‑of‑care biomarkers and day 90 functional outcome in spontaneous intracerebral hemorrhage: A single‑center pilot study". Experimental and Therapeutic Medicine 23.3 (2022): 200.
Chicago
Mureșan, E., Golea, A., Vesa, Ș. C., Lenghel, M., Csutak, C., Perju‑Dumbravă, L."Emergency department point‑of‑care biomarkers and day 90 functional outcome in spontaneous intracerebral hemorrhage: A single‑center pilot study". Experimental and Therapeutic Medicine 23, no. 3 (2022): 200. https://doi.org/10.3892/etm.2022.11123
Copy and paste a formatted citation
x
Spandidos Publications style
Mureșan E, Golea A, Vesa ȘC, Lenghel M, Csutak C and Perju‑Dumbravă L: Emergency department point‑of‑care biomarkers and day 90 functional outcome in spontaneous intracerebral hemorrhage: A single‑center pilot study. Exp Ther Med 23: 200, 2022.
APA
Mureșan, E., Golea, A., Vesa, Ș.C., Lenghel, M., Csutak, C., & Perju‑Dumbravă, L. (2022). Emergency department point‑of‑care biomarkers and day 90 functional outcome in spontaneous intracerebral hemorrhage: A single‑center pilot study. Experimental and Therapeutic Medicine, 23, 200. https://doi.org/10.3892/etm.2022.11123
MLA
Mureșan, E., Golea, A., Vesa, Ș. C., Lenghel, M., Csutak, C., Perju‑Dumbravă, L."Emergency department point‑of‑care biomarkers and day 90 functional outcome in spontaneous intracerebral hemorrhage: A single‑center pilot study". Experimental and Therapeutic Medicine 23.3 (2022): 200.
Chicago
Mureșan, E., Golea, A., Vesa, Ș. C., Lenghel, M., Csutak, C., Perju‑Dumbravă, L."Emergency department point‑of‑care biomarkers and day 90 functional outcome in spontaneous intracerebral hemorrhage: A single‑center pilot study". Experimental and Therapeutic Medicine 23, no. 3 (2022): 200. https://doi.org/10.3892/etm.2022.11123
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