Open Access

Update on the etiopathogenesis of psoriasis (Review)

  • Authors:
    • Daciana Elena Branisteanu
    • Catalina Cojocaru
    • Roxana Diaconu
    • Elena Andrese Porumb
    • Anisia Iuliana Alexa
    • Alin Codrut Nicolescu
    • Ilarie Brihan
    • Camelia Margareta Bogdanici
    • George Branisteanu
    • Andreea Dimitriu
    • Mihail Zemba
    • Nicoleta Anton
    • Mihaela Paula Toader
    • Adrian Grechin
    • Daniel Constantin Branisteanu
  • View Affiliations

  • Published online on: January 5, 2022     https://doi.org/10.3892/etm.2022.11124
  • Article Number: 201
  • Copyright: © Branisteanu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Psoriasis is one of the most common immune-mediated chronic inflammatory skin disorders, involving hyperproliferative keratinocytes and infiltration of T cells, dendritic cells, macrophages, and neutrophils. Multiple factors appear to play important roles in the pathogenesis of psoriasis. These environmental (e.g., infectious agents and trauma), genetic, and immunologic factors are reviewed in this article. Although the pathogenesis of psoriasis remains to be established, data suggesting immune cell dysregulation in the skin are available. The involvement of the immune system, particularly T cells, in the etiopathogenesis of psoriasis is discussed in this review, indicating a potential justification for innovative treatment intervention. Besides describing pathogenic T cells, the aim of the review was to assess the function of newly identified antimicrobial peptides (AMPs), interleukin (IL)‑23, IL‑17, and tissue resident memory cells (TRMs), and their role in psoriasis. Furthermore, new insights were presented regarding TRMs, a recently identified subset of memory T cells, and the role they play in the local memory of disease, making them a potential new therapeutic target in psoriasis. Finally, current developments in T‑cell research and cytokine‑targeted therapy for psoriasis treatment are reviewed.
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March-2022
Volume 23 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Branisteanu DE, Cojocaru C, Diaconu R, Porumb EA, Alexa AI, Nicolescu AC, Brihan I, Bogdanici CM, Branisteanu G, Dimitriu A, Dimitriu A, et al: Update on the etiopathogenesis of psoriasis (Review). Exp Ther Med 23: 201, 2022
APA
Branisteanu, D.E., Cojocaru, C., Diaconu, R., Porumb, E.A., Alexa, A.I., Nicolescu, A.C. ... Branisteanu, D.C. (2022). Update on the etiopathogenesis of psoriasis (Review). Experimental and Therapeutic Medicine, 23, 201. https://doi.org/10.3892/etm.2022.11124
MLA
Branisteanu, D. E., Cojocaru, C., Diaconu, R., Porumb, E. A., Alexa, A. I., Nicolescu, A. C., Brihan, I., Bogdanici, C. M., Branisteanu, G., Dimitriu, A., Zemba, M., Anton, N., Toader, M. P., Grechin, A., Branisteanu, D. C."Update on the etiopathogenesis of psoriasis (Review)". Experimental and Therapeutic Medicine 23.3 (2022): 201.
Chicago
Branisteanu, D. E., Cojocaru, C., Diaconu, R., Porumb, E. A., Alexa, A. I., Nicolescu, A. C., Brihan, I., Bogdanici, C. M., Branisteanu, G., Dimitriu, A., Zemba, M., Anton, N., Toader, M. P., Grechin, A., Branisteanu, D. C."Update on the etiopathogenesis of psoriasis (Review)". Experimental and Therapeutic Medicine 23, no. 3 (2022): 201. https://doi.org/10.3892/etm.2022.11124