Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
March-2022 Volume 23 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2022 Volume 23 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

MicroRNA‑4722‑5p and microRNA‑615‑3p serve as potential biomarkers for Alzheimer's disease

  • Authors:
    • Yan Liu
    • Yuhao Xu
    • Ming Yu
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 241
    |
    Published online on: January 26, 2022
       https://doi.org/10.3892/etm.2022.11166
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the expression levels of microRNA(miR)‑4722‑5p and miR‑615‑3p in Alzheimer's disease (AD) and their diagnostic value. Blood samples were collected from 33 patients with AD and 33 healthy controls, and an β‑amyloid (Aβ)25‑35‑induced PC12 cell model was also established. The relative mRNA expression levels of miR‑4722‑5p and miR‑615‑3p were detected using reverse transcription‑quantitative PCR. The correlations between the mRNA expression levels of the two miRNAs and the mini‑mental state examination (MMSE) scores were analyzed, and the receiver operating characteristic curve was used to assess the diagnostic value of miR‑4722‑5p and miR‑615‑3p in AD. Functional enrichment analysis of the miRNA target genes was performed using The Database for Annotation, Visualization and Integrated Discovery database and the R language analysis package. The mRNA expression levels of miR‑4722‑5p and miR‑615‑3p were increased in patients with AD and the Aβ25‑35‑induced PC12 cell model. The mRNA expression levels of miR‑4722‑5p and miR‑615‑3p were negatively correlated with MMSE scores, and the combination of the two miRNAs for AD had an improved diagnostic value than that of each miRNA alone. The results of Gene Ontology (GO) enrichment analysis showed that the target genes of miR‑4722‑5p were found in the cytoplasm and cytosol, and were mainly involved in protein folding and cell division. The molecular functions included protein binding and GTPase activator activity. The results of Kyoto Encyclopedia of Genes and Genomes analysis showed that miR‑4722‑5p was associated with the regulation of dopaminergic synapses and mTOR signaling pathways. GO enrichment analysis also revealed that the target genes of miR‑615‑3p were located in the nucleus and cytoplasm, were involved in the regulation of transcription and protein phosphorylation, and were associated with protein binding, metal ion binding and transcription factor activity. The target genes of miR‑615‑3p played important roles in the regulation of the Ras and FoxO signaling pathways. In conclusion, miR‑4722‑5p and miR‑615‑3p may be potential biomarkers in the early diagnosis of AD.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Eratne D, Loi SM, Farrand S, Kelso W, Velakoulis D and Looi JC: Alzheimer's disease: Clinical update on epidemiology, pathophysiology and diagnosis. Australas Psychiatry. 26:347–357. 2018.PubMed/NCBI View Article : Google Scholar

2 

Di Resta C and Ferrari M: New molecular approaches to Alzheimer's disease. Clin Biochem. 72:81–86. 2019.PubMed/NCBI View Article : Google Scholar

3 

Takeda S: Progression of Alzheimer's disease, tau propagation, and its modifiable risk factors. Neurosci Res. 141:36–42. 2019.PubMed/NCBI View Article : Google Scholar

4 

Jiang L, Dong H, Cao H, Ji X, Luan S and Liu J: Exosomes in pathogenesis, diagnosis, and treatment of Alzheimer's Disease. Med Sci Monit. 25:3329–3335. 2019.PubMed/NCBI View Article : Google Scholar

5 

Tian X, Wang J, Dai J, Yang L, Zhang L, Shen S and Huang P: Hyperbaric oxygen and Ginkgo Biloba extract inhibit Aβ25-35-induced toxicity and oxidative stress in vivo: A potential role in Alzheimer's disease. Int J Neurosci. 122:563–569. 2012.PubMed/NCBI View Article : Google Scholar

6 

Karch CM, Cruchaga C and Goate AM: Alzheimer's disease genetics: from the bench to the clinic. Neuron. 83:11–26. 2014.PubMed/NCBI View Article : Google Scholar

7 

Pereira JB, Westman E and Hansson O: Association between cerebrospinal fluid and plasma neurodegeneration biomarkers with brain atrophy in Alzheimer's disease. Neurobiol Aging. 58:14–29. 2017.PubMed/NCBI View Article : Google Scholar

8 

Pradhan R, Yadav SK, Prem NN, Bhagel V, Pathak M, Shekhar S, Gaikwad S, Dwivedi SN, Bal CS, Dey AB and Dey S: Serum FOXO3A: A ray of hope for early diagnosis of Alzheimer's disease. Mech Ageing Dev. 190(111290)2020.PubMed/NCBI View Article : Google Scholar

9 

Goetzl EJ, Boxer A, Schwartz JB, Abner EL, Petersen RC, Miller BL and Kapogiannis D: Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease. Neurology. 85:40–47. 2015.PubMed/NCBI View Article : Google Scholar

10 

Abdullah M, Kimura N, Akatsu H, Hashizume Y, Ferdous T, Tachita T, Iida S, Zou K, Matsubara E and Michikawa M: Flotillin is a novel diagnostic blood marker of Alzheimer's Disease. J Alzheimers Dis. 72:1165–1176. 2019.PubMed/NCBI View Article : Google Scholar

11 

Briggs R, Kennelly SP and O'Neill D: Drug treatments in Alzheimer's disease. Clin Med (Lond). 16:247–253. 2016.PubMed/NCBI View Article : Google Scholar

12 

Sancesario GM and Bernardini S: Alzheimer's disease in the omics era. Clin Biochem. 59:9–16. 2018.PubMed/NCBI View Article : Google Scholar

13 

Serpente M, Fenoglio C, D'Anca M, Arcaro M, Sorrentino F, Visconte C, Arighi A, Fumagalli GG, Porretti L, Cattaneo A, et al: MiRNA profiling in plasma neural-derived small extracellular vesicles from patients with Alzheimer's Disease. Cells. 9(1443)2020.PubMed/NCBI View Article : Google Scholar

14 

Silvestro S, Bramanti P and Mazzon E: Role of miRNAs in Alzheimer's Disease and possible fields of application. Int J Mol Sci. 20(3979)2019.PubMed/NCBI View Article : Google Scholar

15 

Yang TT, Liu CG, Gao SC, Zhang Y and Wang PC: The serum exosome derived MicroRNA-135a, -193b, and -384 Were potential Alzheimer's Disease Biomarkers. Biomed Environ Sci. 31:87–96. 2018.PubMed/NCBI View Article : Google Scholar

16 

Lusardi TA, Phillips JI, Wiedrick JT, Harrington CA, Lind B, Lapidus JA, Quinn JF and Saugstad JA: MicroRNAs in human cerebrospinal fluid as biomarkers for Alzheimer's Disease. J Alzheimers Dis. 55:1223–1233. 2017.PubMed/NCBI View Article : Google Scholar

17 

Bai X, Tang Y, Yu M, Wu L, Liu F, Ni J, Wang Z, Wang J, Fei J, Wang W, et al: Downregulation of blood serum microRNA 29 family in patients with Parkinson's disease. Sci Rep. 7(5411)2017.PubMed/NCBI View Article : Google Scholar

18 

Dobrowolny G, Martone J, Lepore E, Casola I, Petrucci A, Inghilleri M, Morlando M, Colantoni A, Scicchitano BM, Calvo A, et al: A longitudinal study defined circulating microRNAs as reliable biomarkers for disease prognosis and progression in ALS human patients. Cell Death Discov. 7(4)2021.PubMed/NCBI View Article : Google Scholar

19 

Zhang M, Han W, Xu Y, Li D and Xue Q: Serum miR-128 Serves as a potential diagnostic biomarker for Alzheimer's Disease. Neuropsychiatr Dis Treat. 17:269–275. 2021.PubMed/NCBI View Article : Google Scholar

20 

Shi Z, Zhang K, Zhou H, Jiang L, Xie B, Wang R, Xia W, Yin Y, Gao Z, Cui D, et al: Increased miR-34c mediates synaptic deficits by targeting synaptotagmin 1 through ROS-JNK-p53 pathway in Alzheimer's Disease. Aging Cell. 19(e13125)2020.PubMed/NCBI View Article : Google Scholar

21 

Hou TY, Zhou Y, Zhu LS, Wang X, Pang P, Wang DQ, Liuyang ZY, Man H, Lu Y, Zhu LQ and Liu D: Correcting abnormalities in miR-124/PTPN1 signaling rescues tau pathology in Alzheimer's disease. J Neurochem. 154:441–457. 2020.PubMed/NCBI View Article : Google Scholar

22 

Han C, Guo L, Yang Y, Guan Q, Shen H, Sheng Y and Jiao Q: Mechanism of microRNA-22 in regulating neuroinflammation in Alzheimer's disease. Brain Behav. 10(e01627)2020.PubMed/NCBI View Article : Google Scholar

23 

He B, Chen W, Zeng J, Tong W and Zheng P: MicroRNA-326 decreases tau phosphorylation and neuron apoptosis through inhibition of the JNK signaling pathway by targeting VAV1 in Alzheimer's disease. J Cell Physiol. 235:480–493. 2020.PubMed/NCBI View Article : Google Scholar

24 

Soleimani Zakeri NS, Pashazadeh S and MotieGhader H: Gene biomarker discovery at different stages of Alzheimer using gene co-expression network approach. Sci Rep. 10(12210)2020.PubMed/NCBI View Article : Google Scholar

25 

McKhann G, Drachman D, Folstein M, Katzman R, Price D and Stadlan EM: Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of department of health and human services task force on Alzheimer's Disease. Neurology. 34:939–944. 1984.PubMed/NCBI View Article : Google Scholar

26 

Folstein MF, Folstein SE and McHugh PR: ‘Mini-mental state’. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 12:189–198. 1975.PubMed/NCBI View Article : Google Scholar

27 

Kahle-Wrobleski K, Andrews JS, Belger M, Ye W, Gauthier S, Rentz DM and Galasko D: Dependence levels as interim clinical milestones along the continuum of Alzheimer's Disease: 18-Month results from the GERAS Observational study. J Prev Alzheimers Dis. 4:72–80. 2017.PubMed/NCBI View Article : Google Scholar

28 

Zeng Q, Zou L, Qian L, Zhou F, Nie H, Yu S, Jiang J, Zhuang A, Wang C and Zhang H: Expression of microRNA-222 in serum of patients with Alzheimer's disease. Mol Med Rep. 16:5575–5579. 2017.PubMed/NCBI View Article : Google Scholar

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

30 

Hoo ZH, Candlish J and Teare D: What is an ROC curve? Emerg Med J. 34:357–359. 2017.PubMed/NCBI View Article : Google Scholar

31 

Gene Ontology Consortium. Gene ontology consortium: Going forward. Nucleic Acids Res. 43(Database issue):D1049–D1056. 2015.PubMed/NCBI View Article : Google Scholar

32 

Kanehisa M, Furumichi M, Tanabe M, Sato Y and Morishima K: KEGG: New perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 45:D353–D361. 2017.PubMed/NCBI View Article : Google Scholar

33 

Dos Santos Picanco LC, Ozela PF, de Fatima de Brito Brito M, Pinheiro AA, Padilha EC, Braga FS, de Paula da Silva CHT, Dos Santos CBR, Rosa JMC and da Silva Hage-Melim LI: Alzheimer's Disease: A review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment. Curr Med Chem. 25:3141–3159. 2018.PubMed/NCBI View Article : Google Scholar

34 

Van der Kant R, Goldstein LSB and Ossenkoppele R: Amyloid-β-independent regulators of tau pathology in Alzheimer disease. Nat Rev Neurosci. 21:21–35. 2020.PubMed/NCBI View Article : Google Scholar

35 

Wei S, Peng W, Mai Y, Li K, Wei W, Hu L, Zhu S, Zhou H, Jie W, Wei Z, et al: Outer membrane vesicles enhance tau phosphorylation and contribute to cognitive impairment. J Cell Physiol. 235:4843–4855. 2020.PubMed/NCBI View Article : Google Scholar

36 

Bello-Medina PC, González-Franco DA, Vargas-Rodríguez I and Díaz-Cintra S: Oxidative stress, the immune response, synaptic plasticity, and cognition in transgenic models of Alzheimer disease. Neurologia (Engl Ed) S0213-4853(19)30109-4, 2019 (Epub ahead of print).

37 

Yoo SM, Park J, Kim SH and Jung YK: Emerging perspectives on mitochondrial dysfunction and inflammation in Alzheimer's disease. BMB Rep. 53:35–46. 2020.PubMed/NCBI View Article : Google Scholar

38 

Devi L, Prabhu BM, Galati DF, Avadhani NG and Anandatheerthavarada HK: Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction. J Neurosci. 26:9057–9068. 2006.PubMed/NCBI View Article : Google Scholar

39 

Cheignon C, Tomas M, Bonnefont-Rousselot D, Faller P, Hureau C and Collin F: Oxidative stress and the amyloid beta peptide in Alzheimer's disease. Redox Biol. 14:450–464. 2018.PubMed/NCBI View Article : Google Scholar

40 

Šimić G, Babić Leko M, Wray S, Harrington C, Delalle I, Jovanov-Milošević N, Bažadona D, Buée L, de Silva R, Di Giovanni G, et al: Tau Protein Hyperphosphorylation and Aggregation in Alzheimer's Disease and other Tauopathies, and possible Neuroprotective Strategies. Biomolecules. 6(6)2016.PubMed/NCBI View Article : Google Scholar

41 

Leyns CEG, Ulrich JD, Finn MB, Stewart FR, Koscal LJ, Remolina Serrano J, Robinson GO, Anderson E, Colonna M and Holtzman DM: TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy. Proc Natl Acad Sci USA. 114:11524–11529. 2017.PubMed/NCBI View Article : Google Scholar

42 

Langbaum JB, Fleisher AS, Chen K, Ayutyanont N, Lopera F, Quiroz YT, Caselli RJ, Tariot PN and Reiman EM: Ushering in the study and treatment of preclinical Alzheimer disease. Nat Rev Neurol. 9:371–381. 2013.PubMed/NCBI View Article : Google Scholar

43 

Niemantsverdriet E, Ottoy J, Somers C, De Roeck E, Struyfs H, Soetewey F, Verhaeghe J, Van den Bossche T, Van Mossevelde S, Goeman J, et al: The cerebrospinal fluid Aβ1-42/Aβ1-40 ratio improves concordance with Amyloid-PET for diagnosing Alzheimer's Disease in a clinical setting. J Alzheimers Dis. 60:561–576. 2017.PubMed/NCBI View Article : Google Scholar

44 

Blennow K and Zetterberg H: Biomarkers for Alzheimer's disease: Current status and prospects for the future. J Intern Med. 284:643–663. 2018.PubMed/NCBI View Article : Google Scholar

45 

Cao F, Liu Z and Sun G: Diagnostic value of miR-193a-3p in Alzheimer's disease and miR-193a-3p attenuates amyloid-β induced neurotoxicity by targeting PTEN. Exp Gerontol. 130(110814)2020.PubMed/NCBI View Article : Google Scholar

46 

Jia LH and Liu YN: Downregulated serum miR-223 servers as biomarker in Alzheimer's disease. Cell Biochem Funct. 34:233–237. 2016.PubMed/NCBI View Article : Google Scholar

47 

Ravnskjaer K, Madiraju A and Montminy M: Role of the cAMP pathway in glucose and lipid metabolism. Handb Exp Pharmacol. 233:29–49. 2016.PubMed/NCBI View Article : Google Scholar

48 

Ricciarelli R and Fedele E: cAMP, cGMP and Amyloid β: Three ideal partners for memory formation. Trends Neurosci. 41:255–266. 2018.PubMed/NCBI View Article : Google Scholar

49 

Nassireslami E, Nikbin P, Payandemehr B, Amini E, Mohammadi M, Vakilzadeh G, Ghadiri T, Noorbakhsh F and Sharifzadeh M: A cAMP analog reverses contextual and tone memory deficits induced by a PKA inhibitor in Pavlovian fear conditioning. Pharmacol Biochem Behav. 105:177–182. 2013.PubMed/NCBI View Article : Google Scholar

50 

Myeku N, Clelland CL, Emrani S, Kukushkin NV, Yu WH, Goldberg AL and Duff KE: Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling. Nat Med. 22:46–53. 2016.PubMed/NCBI View Article : Google Scholar

51 

Heras-Sandoval D, Pérez-Rojas JM, Hernández-Damián J and Pedraza-Chaverri J: The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration. Cell Signal. 26:2694–2701. 2014.PubMed/NCBI View Article : Google Scholar

52 

Wang Y and Zhang H: Regulation of autophagy by mTOR signaling pathway. Adv Exp Med Biol. 1206:67–83. 2019.PubMed/NCBI View Article : Google Scholar

53 

Wang C, Yu JT, Miao D, Wu ZC, Tan MS and Tan L: Targeting the mTOR signaling network for Alzheimer's disease therapy. Mol Neurobiol. 49:120–135. 2014.PubMed/NCBI View Article : Google Scholar

54 

Hoss AG, Kartha VK, Dong X, Latourelle JC, Dumitriu A, Hadzi TC, Macdonald ME, Gusella JF, Akbarian S, Chen JF, et al: MicroRNAs located in the Hox gene clusters are implicated in huntington's disease pathogenesis. PLoS Genet. 10(e1004188)2014.PubMed/NCBI View Article : Google Scholar

55 

Miyamoto Y, Mauer AS, Kumar S, Mott JL and Malhi H: Mmu-miR-615-3p regulates lipoapoptosis by inhibiting C/EBP homologous protein. PLoS One. 9(e109637)2014.PubMed/NCBI View Article : Google Scholar

56 

Feng H, Gui Q, Wu G, Zhu W, Dong X, Shen M, Fu X, Shi G, Luo H, Yang X, et al: Long noncoding RNA Nespas inhibits apoptosis of epileptiform hippocampal neurons by inhibiting the PI3K/Akt/mTOR pathway. Exp Cell Res. 398(112384)2021.PubMed/NCBI View Article : Google Scholar

57 

Wang J, Liu L, Sun Y, Xue Y, Qu J, Pan S, Li H, Qu H, Wang J and Zhang J: MiR-615-3p promotes proliferation and migration and inhibits apoptosis through its potential target CELF2 in gastric cancer. Biomed Pharmacother. 101:406–413. 2018.PubMed/NCBI View Article : Google Scholar

58 

Maiese K: Forkhead transcription factors: New considerations for alzheimer's disease and dementia. J Transl Sci. 2:241–247. 2016.PubMed/NCBI View Article : Google Scholar

59 

Santo EE and Paik J: FOXO in neural cells and diseases of the nervous system. Curr Top Dev Biol. 127:105–118. 2018.PubMed/NCBI View Article : Google Scholar

60 

Maiese K: FoxO proteins in the nervous system. Anal Cell Pathol (Amst). 2015(569392)2015.PubMed/NCBI View Article : Google Scholar

61 

Maiese K: Forkhead transcription factors: Formulating a FOXO target for cognitive loss. Curr Neurovasc Res. 14:415–420. 2017.PubMed/NCBI View Article : Google Scholar

62 

Shi C, Zhu J, Leng S, Long D and Luo X: Mitochondrial FOXO3a is involved in amyloid β peptide-induced mitochondrial dysfunction. J Bioenerg Biomembr. 48:189–196. 2016.PubMed/NCBI View Article : Google Scholar

63 

Saleem S and Biswas SC: Tribbles pseudokinase 3 induces both apoptosis and autophagy in amyloid-β-induced neuronal death. J Biol Chem. 292:2571–2585. 2017.PubMed/NCBI View Article : Google Scholar

64 

Seshacharyulu P, Ponnusamy MP, Haridas D, Jain M, Ganti AK and Batra SK: Targeting the EGFR signaling pathway in cancer therapy. Expert Opin Ther Targets. 16:15–31. 2012.PubMed/NCBI View Article : Google Scholar

65 

Stupack J, Xiong XP, Jiang LL, Zhang T, Zhou L, Campos A, Ranscht B, Mobley W, Pasquale EB, Xu H and Huang TY: Soluble SORLA enhances neurite outgrowth and regeneration through activation of the EGF Receptor/ERK signaling axis. J Neurosci. 40:5908–5921. 2020.PubMed/NCBI View Article : Google Scholar

66 

Mansour HM, Fawzy HM, El-Khatib AS and Khattab MM: Potential repositioning of anti-cancer EGFR inhibitors in Alzheimer's Disease: Current perspectives and challenging prospects. Neuroscience. 469:191–196. 2021.PubMed/NCBI View Article : Google Scholar

67 

Liu F, Lv Q, Du WW, Li H, Yang X, Liu D, Deng Z, Ling W, Zhang Y and Yang BB: Specificity of miR-378a-5p targeting rodent fibronectin. Biochim Biophys Acta. 1833:3272–3285. 2013.PubMed/NCBI View Article : Google Scholar

68 

Kenny NJ, Sin YW, Hayward A, Paps J, Chu KH and Hui JH: The phylogenetic utility and functional constraint of microRNA flanking sequences. Proc Biol Sci. 282(20142983)2015.PubMed/NCBI View Article : Google Scholar

69 

Eun JW, Kim HS, Shen Q, Yang HD, Kim SY, Yoon JH, Park WS, Lee JY and Nam SW: MicroRNA-495-3p functions as a tumor suppressor by regulating multiple epigenetic modifiers in gastric carcinogenesis. J Pathol. 244:107–119. 2018.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Xu Y and Yu M: MicroRNA‑4722‑5p and microRNA‑615‑3p serve as potential biomarkers for Alzheimer's disease. Exp Ther Med 23: 241, 2022.
APA
Liu, Y., Xu, Y., & Yu, M. (2022). MicroRNA‑4722‑5p and microRNA‑615‑3p serve as potential biomarkers for Alzheimer's disease. Experimental and Therapeutic Medicine, 23, 241. https://doi.org/10.3892/etm.2022.11166
MLA
Liu, Y., Xu, Y., Yu, M."MicroRNA‑4722‑5p and microRNA‑615‑3p serve as potential biomarkers for Alzheimer's disease". Experimental and Therapeutic Medicine 23.3 (2022): 241.
Chicago
Liu, Y., Xu, Y., Yu, M."MicroRNA‑4722‑5p and microRNA‑615‑3p serve as potential biomarkers for Alzheimer's disease". Experimental and Therapeutic Medicine 23, no. 3 (2022): 241. https://doi.org/10.3892/etm.2022.11166
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Xu Y and Yu M: MicroRNA‑4722‑5p and microRNA‑615‑3p serve as potential biomarkers for Alzheimer's disease. Exp Ther Med 23: 241, 2022.
APA
Liu, Y., Xu, Y., & Yu, M. (2022). MicroRNA‑4722‑5p and microRNA‑615‑3p serve as potential biomarkers for Alzheimer's disease. Experimental and Therapeutic Medicine, 23, 241. https://doi.org/10.3892/etm.2022.11166
MLA
Liu, Y., Xu, Y., Yu, M."MicroRNA‑4722‑5p and microRNA‑615‑3p serve as potential biomarkers for Alzheimer's disease". Experimental and Therapeutic Medicine 23.3 (2022): 241.
Chicago
Liu, Y., Xu, Y., Yu, M."MicroRNA‑4722‑5p and microRNA‑615‑3p serve as potential biomarkers for Alzheimer's disease". Experimental and Therapeutic Medicine 23, no. 3 (2022): 241. https://doi.org/10.3892/etm.2022.11166
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team