Serum metabonomics as a diagnostic approach for cancer‑related fatigue

  • Authors:
    • Haiming Wang
    • Tong Zhao
    • Can Lv
    • Zhan Zhang
    • Fanfu Fang
    • Bai Li
  • View Affiliations

  • Published online on: February 2, 2022     https://doi.org/10.3892/etm.2022.11181
  • Article Number: 256
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Abstract

In the present study, differences in metabolic pat­hways between patients with and without cancer‑related fatigue (CRF) were examined to identify metabolic serum biomarkers of CRF. In this preliminary study, metabolic profiling was applied to analyze the serum samples from 14 patients with CRF and 11 non‑CRF individuals (non‑fatigue cancer survivors) by ultra‑performance liquid chromatography coupled with mass spectrometry. Orthogonal partial least‑squares discriminant analysis was adopted to evaluate the differences between the CRF and non‑CRF groups. The CRF group was characterized by increases in phosphatidylethanolamine (PE; 18:0/0:0), LysoPE (0:0/20:4 and 0:0/16:0), lysophosphatidylcholine (LysoPC; 20:4, 22:4 and 16:0) and LysoPC/PC, phosphatidylserine (21:0/0:0), glycerophosphocholine and N‑docosahexaenoyl γ‑aminobutyric acid. Furthermore, decreases in anandamide, uric acid, dihydrouracil, LysoPE (0:0/22:5), 2,5,7,8‑tetramethyl‑2(2'‑carboxyethyl)‑6‑hydroxychroman, 19(R)‑hydroxy‑prostaglandin F1α, N‑(3α,12α‑dihydroxy‑5β‑ cholan‑24‑oyl)‑glycine, ketoleucine, indoxyl sulfate, α‑N‑phenylacetyl‑L‑glutamine and 1‑linoleoyl‑glycerophosphocholine were detected. These data indicate a possible disturbance in the metabolism of phospholipids and adjustments in the endocannabinoid system. The metabonomic approach may be helpful to determine the pathophysiological mechanisms of CRF and the identification of potential biomarkers for the accurate diagnosis of CRF. All clinical data were obtained from the ‘Research on the efficacy of traditional Chinese medicine comprehensive intervention in cancer‑related fatigue’ (TCM‑CRF) project. Medical Ethical Approval for TCM‑CRF was approved by the Chinese Ethics Committee of Registering Clinical Trials. The approval number for the TCM‑CRF study was ChiECRCT‑2013038, and the TCM‑CRF study was completed.
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April-2022
Volume 23 Issue 4

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Spandidos Publications style
Wang H, Zhao T, Lv C, Zhang Z, Fang F and Li B: Serum metabonomics as a diagnostic approach for cancer‑related fatigue. Exp Ther Med 23: 256, 2022
APA
Wang, H., Zhao, T., Lv, C., Zhang, Z., Fang, F., & Li, B. (2022). Serum metabonomics as a diagnostic approach for cancer‑related fatigue. Experimental and Therapeutic Medicine, 23, 256. https://doi.org/10.3892/etm.2022.11181
MLA
Wang, H., Zhao, T., Lv, C., Zhang, Z., Fang, F., Li, B."Serum metabonomics as a diagnostic approach for cancer‑related fatigue". Experimental and Therapeutic Medicine 23.4 (2022): 256.
Chicago
Wang, H., Zhao, T., Lv, C., Zhang, Z., Fang, F., Li, B."Serum metabonomics as a diagnostic approach for cancer‑related fatigue". Experimental and Therapeutic Medicine 23, no. 4 (2022): 256. https://doi.org/10.3892/etm.2022.11181