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Understanding orthopedic infections through a different perspective: Microcalorimetry growth curves

  • Authors:
    • Mihnea Popa
    • Adrian Cursaru
    • Vlad Popa
    • Alexandru Munteanu
    • Bogdan Șerban
    • Bogdan Crețu
    • Sergiu Iordache
    • Catalin Gabriel Smarandache
    • Carmen Orban
    • Cătălin Cîrstoiu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics and Traumatology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, ‘Ilie Murgulescu’ Institute of Physical Chemistry, 060021 Bucharest, Romania, Department of Medical Microbiology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of General Surgery, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Anaesthesia and Intensive Care, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania
  • Article Number: 263
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    Published online on: February 4, 2022
       https://doi.org/10.3892/etm.2022.11189
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Abstract

Infectious disease is a serious healthcare problem in orthopedics, as well as other surgical specialties. Accurate and prompt diagnosis, as well as proper care, is critical, as infection of a surgical wound, particularly in the case of arthroplasties or the use of orthopedic implants, can have a catastrophic effect in most cases, necessitating the removal of foreign material. Lyophilized bacteria samples were obtained from Cantacuzino National Institute of Research and Development for Microbiology and Immunology and investigated microcalorimetrically. Isothermal microcalorimetry measures the temperature generated by the multiplication of microorganisms; using an adapted program, it describes the growth curve in real‑time according to the received electrical signal. The thermograms of Escherichia coli and Klebsiella pneumonie were analyzed, and similarities were observed for both the time required for the bacteria to grow and the heat flow generated by their growth. Bacterial microcalorimetry has a variety of benefits, and should be regarded as a means of rapid and accurate diagnosis. Sensitivity is a valuable attribute for a diagnostic technique; when only a few microorganisms are present, microcalorimetric signs of bacterial multiplication can be observed. Microcalorimetry has potential as a simple diagnostic tool in a variety of infections, but further research is needed to ensure that it is used correctly. A thorough investigation (including kinetic analysis) of a reproducible thermal signal of bacterial growth could lead to the creation of new methods for quickly identifying bacteria.
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1 

Soon K and Acton C: Pain-induced stress: A barrier to wound healing. Wounds UK. 2:92–101. 2006.

2 

Preoteasa CT, Preoteasa E, Popa M, Pircalabrioru Gradisteanu G, Grigore R and Arutescu L: In vitro characterization of microbial biofilm on soft materials used in overdentures retained by mini implants. Rom Biotechnol Lett. 24:10–19. 2019.

3 

Varnum C, Pedersen AB, Rolfson O, Rogmark C, Furnes O, Hallan G, Mäkelä K, de Steiger R, Porter M and Overgaard S: Impact of hip arthroplasty registers on orthopaedic practice and perspectives for the future. EFORT Open Rev. 4:368–376. 2019.PubMed/NCBI View Article : Google Scholar

4 

Conen A, Fux CA, Vajkoczy P and Trampuz A: Management of infections associated with neurosurgical implanted devices. Expert Rev Anti Infect Ther. 15:241–255. 2017.PubMed/NCBI View Article : Google Scholar

5 

Hexter AT, Hislop SM, Blunn GW and Liddle AD: The effect of bearing surface on risk of periprosthetic joint infection in total hip arthroplasty: A systematic review and meta-analysis. Bone Joint J. 100-B:134–142. 2018.PubMed/NCBI View Article : Google Scholar

6 

Jiang B, Liang S, Peng ZR, Cong H, Levy M, Cheng Q, Wang T and Remais JV: Transport and public health in China: The road to a healthy future. Lancet. 390:1781–1791. 2017.PubMed/NCBI View Article : Google Scholar

7 

Katz NP, Paillard FC and Ekman E: Determining the clinical importance of treatment benefits for interventions for painful orthopedic conditions. J Orthop Surg Res. 10(24)2015.PubMed/NCBI View Article : Google Scholar

8 

Shao J, Chang H, Zhu Y, Chen W, Zheng Z, Zhang H and Zhang Y: Incidence and risk factors for surgical site infection after open reduction and internal fixation of tibial plateau fracture: A systematic review and meta-analysis. Int J Surg. 41:176–182. 2017.PubMed/NCBI View Article : Google Scholar

9 

Richards MJ, Edwards JR, Culver DH and Gaynes RP: Nosocomial infections in medical intensive care units in the United States. National nosocomial infections surveillance system. Crit Care Med. 27:887–892. 1999.PubMed/NCBI View Article : Google Scholar

10 

Gheorghe A, Moran G, Duffy H, Roberts T, Pinkney T and Calvert M: Health utility values associated with surgical site infection: A systematic review. Value Health. 18:1126–1137. 2015.PubMed/NCBI View Article : Google Scholar

11 

Triantafyllopoulos G, Stundner O, Memtsoudis S and Poultsides LA: Patient, surgery, and hospital related risk factors for surgical site infections following total hip arthroplasty. ScientificWorldJournal. 2015(979560)2015.PubMed/NCBI View Article : Google Scholar

12 

Gallo J, Holinka M and Moucha CS: Antibacterial surface treatment for orthopaedic implants. Int J Mol Sci. 15:13849–13880. 2014.PubMed/NCBI View Article : Google Scholar

13 

Trampuz A, Salzmann S, Antheaume J and Daniels AU: Microcalorimetry: A novel method for detection of microbial contamination in platelet products. Transfusion. 47:1643–1650. 2007.PubMed/NCBI View Article : Google Scholar

14 

De Vries FEE, Wallert ED, Solomkin JS, Allegranzi B, Egger M, Dellinger EP and Boermeester MA: A systematic review and meta-analysis including GRADE qualification of the risk of surgical site infections after prophylactic negative pressure wound therapy compared with conventional dressings in clean and contaminated surgery. Medicine (Baltimore). 95(e4673)2016.PubMed/NCBI View Article : Google Scholar

15 

Mattiassich G, Ortmaier R, Rittenschober F and Hochreiter J: Diagnostic parameters in periprosthetic infections: The current state of the literature. Eur J Orthop Surg Traumatol. 28:1573–1580. 2018.PubMed/NCBI View Article : Google Scholar

16 

Graves N, Wloch C, Wilson J, Barnett A, Sutton A, Cooper N, Merollini K, McCreanor V, Cheng Q, Burn E, et al: A cost-effectiveness modelling study of strategies to reduce risk of infection following primary hip replacement based on a systematic review. Health Technol Assess. 20:1–144. 2016.PubMed/NCBI View Article : Google Scholar

17 

Popa M, Cîrstoiu M, Cîrstoiu C, et al: Algic syndrome in osteoarticular infectious pathology; detection and rapid treatment of the causative agent using microcalorimetry. Filodiritto Editore-Proceedings, pp589-594, 2018.

18 

Braissant O, Wirz D, Göpfert B and Daniels AU: Biomedical use of isothermal microcalorimeters. Sensors (Basel). 10:9369–9383. 2010.PubMed/NCBI View Article : Google Scholar

19 

Zaharia DC, Iancu C, Steriade AT, Muntean AA, Balint O, Popa VT, Popa MI and Bogdan MA: MicroDSC study of staphylococcus epidermidis growth. BMC Microbiol. 10(322)2010.PubMed/NCBI View Article : Google Scholar

20 

Popa MG, Muntean A, Popa VT, Dragomirescu CC, Eremia I, Nica S, Popa MI and Cîrstoiu C: Microcalorimetric growth evaluation of Candida albicans in different conditions. Rom Biotechnol Lett. 25:2140–2147. 2020.

21 

Uçkay I, Hoffmeyer P, Lew D and Pitted D: Prevention of surgical site infections in orthopaedic surgery and bone trauma: State-of-the-art update. J Hosp Infect. 84:5–12. 2013.PubMed/NCBI View Article : Google Scholar

22 

Schwarz EM, Parvizi J, Gehrke T, Aiyer A, Battenberg A, Brown SA, Callaghan JJ, Citak M, Egol K, Garrigues GE, et al: 2018 International consensus meeting on musculoskeletal infection: Research priorities from the general assembly questions. J Orthop Res. 37:997–1006. 2019.PubMed/NCBI View Article : Google Scholar

23 

Rak M, KavčIč M, Trebše R and CőR A: Detection of bacteria with molecular methods in prosthetic joint infection: Sonication fluid better than periprosthetic tissue. Acta Orthop. 87:339–345. 2016.PubMed/NCBI View Article : Google Scholar

24 

Scherping SC Jr and Aaron AD: Orthopedic Infections. In: Essentials of Orthopedic Surgery. Wiesel SW and Delahay JN (ed) 3rd edition. Springer, pp84-105, 2007.

25 

Bori G, McNally MA and Athanasou N: Histopathology in periprosthetic joint infection: When will the morphomolecular diagnosis be a reality? Biomed Res Int. 2018(141270)2018.PubMed/NCBI View Article : Google Scholar

26 

Cursaru A, Cretu B, Serban B, Lupu AG, Iacobescu G, Popa M, Cursaru R and Cirstoiu C: Mechanical safety study and antibiotic-loaded polymethylmethacrylate spacers threshold, manufactured intraoperatively in orthopaedic surgery. Mater Plast. 57:317–324. 2021.

27 

Higuera-Guisset J, Rodríguez-Viejo J, Chacón M, Muñoz FJ, Vigués N and Mas J: Calorimetry of microbial growth using a thermopile based microreactor. Thermochim Acta. 427:187–191. 2005.

28 

Calvet EJP: Calorimeter. In. Edited by Patent US, vol. 3059471, G01N25/48 ed. United States: Calvet, Edouard J.P., 1962. https://patents.google.com/patent/US3059471A/en.

29 

Calvet E and Prat H: Recent Progress in Microcalorimetry. Macmillan, New York, NY, 1963.

30 

Chen HL, Yao J, Wang L, Wang F, Bramanti E, Maskow T and Zaray G: Evaluation of solvent tolerance of microorganisms by microcalorimetry. Chemosphere. 74:1407–1411. 2009.PubMed/NCBI View Article : Google Scholar

31 

Zaharia DC, Muntean A, Popa MG, Steriade AT, Balint O, Micut R, Iftene C, Tofolean I, Popa VT, Baicus C, et al: Comparative analysis of Staphylococcus aureus and Escherichia coli microcalorimetric growth. BMC Microbiol. 13(171)2013.PubMed/NCBI View Article : Google Scholar

32 

Wadsö L: Isothermal microcalorimetry. Current problems and prospects. J Therm Anal Calorim. 64:75–84. 2001.

33 

Wadsö I: Isothermal microcalorimetry in applied biology. Thermochim Acta. 394:305–311. 2002.

34 

Braissant O, Keiser J, Meister I, Bachmann A, Wirz D, Göpfert B, Bonkat G and Wadsö I: Isothermal microcalorimetry accurately detects bacteria, tumorous microtissues, and parasitic worms in a label-free well-plate assay. Biotechnol J. 10:460–468. 2015.PubMed/NCBI View Article : Google Scholar

35 

Borriello SP, Murray PR and Funke G (eds): Topley and Wilson's Microbiology and Microbial Infections. Bacteriology. Vol. 1. 10th edition. Hodder Arnold, London, 2005.

36 

Madigan MT: Brock Biology of Microorganisms. Benjamin Cummings, San Francisco, CA, 2012.

37 

Kong W, Wang J, Xing X, Jin C, Xiao X, Zhao Y, Zhang P, Zang Q and Li Z: Screening for novel antibacterial agents based on the activities of compounds on metabolism of Escherichia coli: A microcalorimetric study. J Hazard Mater. 185:346–352. 2011.PubMed/NCBI View Article : Google Scholar

38 

R Core Team: R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria, 2013. http://www.R-project.org/.

39 

RStudio Team: RStudio: Integrated development for R. RStudio, PBC, Boston, MA, 2020. http://www.rstudio.com/.

40 

Popa MI, Cursaru A, Popa TV, Muntean AA, Bogdan S, Crețu B, Iordache S and Cirstoiu C: Study of bacterial proliferation using a method that shows bacterial growth depending on the heat released-microcalorimetry. Proc Rom Acad Series B. 23:197–203. 2021.

41 

Popa MIG, Cursaru A, Serban B, Cretu B, Muntean AA, Popa TV, Chifiriuc MC and Cirstoiu C: Microcalorimetry-versatile method of describing bacterial growth. Appl Sci. 11(9740)2021.

42 

Braissant O, Wirz D, Gopfert B and Daniels AU: Use of isothermal microcalorimetry to monitor microbial activities. FEMS Microbiol Lett. 303:1–8. 2010.PubMed/NCBI View Article : Google Scholar

43 

Popa M, Popa V, Şerban B, Nedelcu R, Creţu B, Cursaru A and Cîrstoiu C: Utility of microcalorimetru in describing the growth curve of Candida albicans at different temperatures-identitying the optimal growth temperature. Rom J Orthop Surg Traumatol. 2:69–74. 2019.

44 

Knight R, Spoors LM, Costa ML and Dutton SJ: Wound healing in surgery for trauma (WHIST): Statistical analysis plan for a randomised controlled trial comparing standard wound management with negative pressure wound therapy. Trials. 20(186)2019.PubMed/NCBI View Article : Google Scholar

45 

Matthew L, Achten J, Knight J, Bruce J, Dutton SJ, Madan J, Dritsaki M, Parsons N, Fernandez M, Grant R, et al: Effect of incisional negative pressure wound therapy vs. standard wound dressing on deep surgical site infection after surgery for lower limb fractures associated with major trauma: The WHIST randomized clinical trial. JAMA. 323:519–526. 2020.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Popa M, Cursaru A, Popa V, Munteanu A, Șerban B, Crețu B, Iordache S, Smarandache CG, Orban C, Cîrstoiu C, Cîrstoiu C, et al: Understanding orthopedic infections through a different perspective: Microcalorimetry growth curves. Exp Ther Med 23: 263, 2022.
APA
Popa, M., Cursaru, A., Popa, V., Munteanu, A., Șerban, B., Crețu, B. ... Cîrstoiu, C. (2022). Understanding orthopedic infections through a different perspective: Microcalorimetry growth curves. Experimental and Therapeutic Medicine, 23, 263. https://doi.org/10.3892/etm.2022.11189
MLA
Popa, M., Cursaru, A., Popa, V., Munteanu, A., Șerban, B., Crețu, B., Iordache, S., Smarandache, C. G., Orban, C., Cîrstoiu, C."Understanding orthopedic infections through a different perspective: Microcalorimetry growth curves". Experimental and Therapeutic Medicine 23.4 (2022): 263.
Chicago
Popa, M., Cursaru, A., Popa, V., Munteanu, A., Șerban, B., Crețu, B., Iordache, S., Smarandache, C. G., Orban, C., Cîrstoiu, C."Understanding orthopedic infections through a different perspective: Microcalorimetry growth curves". Experimental and Therapeutic Medicine 23, no. 4 (2022): 263. https://doi.org/10.3892/etm.2022.11189
Copy and paste a formatted citation
x
Spandidos Publications style
Popa M, Cursaru A, Popa V, Munteanu A, Șerban B, Crețu B, Iordache S, Smarandache CG, Orban C, Cîrstoiu C, Cîrstoiu C, et al: Understanding orthopedic infections through a different perspective: Microcalorimetry growth curves. Exp Ther Med 23: 263, 2022.
APA
Popa, M., Cursaru, A., Popa, V., Munteanu, A., Șerban, B., Crețu, B. ... Cîrstoiu, C. (2022). Understanding orthopedic infections through a different perspective: Microcalorimetry growth curves. Experimental and Therapeutic Medicine, 23, 263. https://doi.org/10.3892/etm.2022.11189
MLA
Popa, M., Cursaru, A., Popa, V., Munteanu, A., Șerban, B., Crețu, B., Iordache, S., Smarandache, C. G., Orban, C., Cîrstoiu, C."Understanding orthopedic infections through a different perspective: Microcalorimetry growth curves". Experimental and Therapeutic Medicine 23.4 (2022): 263.
Chicago
Popa, M., Cursaru, A., Popa, V., Munteanu, A., Șerban, B., Crețu, B., Iordache, S., Smarandache, C. G., Orban, C., Cîrstoiu, C."Understanding orthopedic infections through a different perspective: Microcalorimetry growth curves". Experimental and Therapeutic Medicine 23, no. 4 (2022): 263. https://doi.org/10.3892/etm.2022.11189
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