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Case Report Open Access

Paget's disease of bone and megaloblastic anemia in a 72‑year‑old patient: A case report and systematic literature review

  • Authors:
    • Violeta Diana Oprea
    • Violeta Claudia Bojincă
    • Andra-Rodica Bălănescu
    • Alin Laurențiu Tatu
    • Mihai Bojincă
    • Aurelia Romila
  • View Affiliations / Copyright

    Affiliations: Department of Geriatrics and Gerontology, ‘St. Apostle Andrei’ Clinical Emergency County Hospital, 800578 Galați, Romania, Department of Internal Medicine and Rheumatology, ‘Sf. Maria’ Clinical Hospital, 011172 Bucharest, Romania, Clinical‑Medical Department, Dermatology, Faculty of Medicine and Pharmacy, ‘Dunărea de Jos’ University of Galati, ReForm UDJ, 800216 Galați, Romania, Department of Internal Medicine, Faculty of Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania
    Copyright: © Oprea et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 269
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    Published online on: February 8, 2022
       https://doi.org/10.3892/etm.2022.11195
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Abstract

Paget's disease of bone (PDB) is characterized by abnormal osteoclastic bone resorption with disorganized bone neo‑formation, primarily affecting elderly (>55 years) patients. Although the majority of patients are asymptomatic, some patients may experience bone pain due to local periosteal involvement or osteoarthritic lesions in the spine; in addition, limb deformities may lead to secondary gait problems or degenerative joint changes. Anemia has an overall prevalence of 12‑17% in elderly adults (>65 years old), with macrocytic anemia being the less common type. Megaloblastic anemia is a macrocytic anemia characterized by the presence of large, immature, nucleated cells (megaloblasts) in the blood, with the most common cause being a deficiency of folate and/or vitamin B12. We herein report the rare case of a 72‑year‑old male patient exhibiting both these conditions, with the aim of discussing the possible association between the two and, most importantly, the clinical management of the patient in a real‑life setting over a period of 10 years. The patient was diagnosed based on clinical symptoms (bone pain), radiological imaging and specific laboratory tests, and received discontinuous courses of bisphosphonates and cyanocobalamin supplementation therapy, based mainly on aggravated symptomatology. A systematic literature review was also performed and revealed not only the scarcity of reports on similar cases, but also the mechanisms that may underlie the possible association of PDB with macrocytic anemia due to vitamin B12 deficiency in elderly patients.
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1 

Shaker JL: Paget's disease of bone: A review of epidemiology, pathophysiology and management. Ther Adv Musculoskelet Dis. 1:107–125. 2009.PubMed/NCBI View Article : Google Scholar

2 

Ralston SH, Corral-Gudino L, Cooper C, Francis RM, Fraser WD, Gennari L, Guañabens N, Javaid MK, Layfield R, O'Neill TW, et al: Diagnosis and management of Paget's disease of bone in adults: A clinical guideline. J Bone Miner Res. 34:579–604. 2019.PubMed/NCBI View Article : Google Scholar

3 

Appelman-Dijkstra NM and Papapoulos SE: Paget's disease of bone. Best Pract Res Clin Endocrinol Metab. 32:657–668. 2018.PubMed/NCBI View Article : Google Scholar

4 

Mohamed M, Thio J, Thomas RS and Phillips J: Pernicious anaemia. BMJ. 369(m1319)2020.PubMed/NCBI View Article : Google Scholar

5 

Aslinia F, Mazza JJ and Yale SH: Megaloblastic anemia and other causes of macrocytosis. Clin Med Res. 4:236–241. 2006.PubMed/NCBI View Article : Google Scholar

6 

Doyle T, Gunn J, Anderson G, Gill M and Cundy T: Paget's disease in New Zealand: Evidence for declining prevalence. Bone. 31:616–619. 2002.PubMed/NCBI View Article : Google Scholar

7 

Poór G, Donáth J, Fornet B and Cooper C: Epidemiology of Paget's disease in Europe: The prevalence is decreasing. J Bone Miner Res. 21:1545–1549. 2006.PubMed/NCBI View Article : Google Scholar

8 

Abdulla O, Naqvi MJ, Shamshuddin S, Bukhari M and Proctor R: Prevalence of Paget's disease of bone in Lancaster: Time for an update. Rheumatology (Oxford). 57:931–932. 2018.PubMed/NCBI View Article : Google Scholar

9 

Michou L and Orcel P: Has Paget's bone disease become rare? Joint Bone Spine. 86:538–541. 2019.PubMed/NCBI View Article : Google Scholar

10 

Singer FR: Paget's disease of bone-genetic and environmental factors. Nat Rev Endocrinol. 11:662–671. 2015.PubMed/NCBI View Article : Google Scholar

11 

Cook SJ and Wall C: Paget's disease of bone: A clinical update. Aust J Gen Pract. 50:23–29. 2021.PubMed/NCBI View Article : Google Scholar

12 

Paul Tuck S, Layfield R, Walker J, Mekkayil B and Francis R: Adult Paget's disease of bone: A review. Rheumatology (Oxford). 56:2050–2059. 2017.PubMed/NCBI View Article : Google Scholar

13 

Govindaraj M and Krishnan MU: Possible association of Paget's disease of bone and pernicious anaemia. Gerontol Clin (Basel). 12:94–98. 1970.PubMed/NCBI View Article : Google Scholar

14 

Mavrikakis ME, Athanassiades P, Baltopoulos G, Rassidakis A and Rokas S: Paget's bone disease, anaemia and vitiligo: A case report. Clin Exp Rheumatol. 4:57–59. 1986.PubMed/NCBI

15 

Beickert A and Heinicke HJ: Simultaneous occurrence of Biermer's disease and Paget's disease. Observations of 5 associated cases. 1 Of them with vitiligo. Dtsch Gesundheitsw. 26:579–583. 1971.PubMed/NCBI(In German).

16 

Borz-Baba C, Sachan Y, Sapers B and Georgescu L: A case of rheumatoid arthritis and Paget disease of bone. Am J Case Rep. 20:764–769. 2019.PubMed/NCBI View Article : Google Scholar

17 

Hadjipavlou AG, Gaitanis IN and Kontakis GM: Paget's disease of the bone and its management. J Bone Joint Surg Br. 84:160–169. 2002.PubMed/NCBI View Article : Google Scholar

18 

Menéndez-Bueyes LR and Soler Fernández MC: Paget's disease of bone: Approach to its historical origins. Reumatol Clin. 13:66–72. 2017.PubMed/NCBI View Article : Google Scholar : (In English, Spanish).

19 

Hughes AE, Shearman AM, Weber JL, Barr RJ, Wallace RG, Osterberg PH, Nevin NC and Mollan RA: Genetic linkage of familial expansile osteolysis to chromosome 18q. Hum Mol Genet. 3:359–361. 1994.PubMed/NCBI View Article : Google Scholar

20 

Niculet E, Chioncel V, Elisei AM, Miulescu M, Buzia OD, Nwabudike LC, Craescu M, Draganescu M, Bujoreanu F, Marinescu E, et al: Multifactorial expression of IL-6 with update on COVID-19 and the therapeutic strategies of its blockade (Review). Exp Ther Med. 21(263)2021.PubMed/NCBI View Article : Google Scholar

21 

Galson DL and Roodman GD: Pathobiology of Paget's disease of bone. J Bone Metab. 21:85–98. 2014.PubMed/NCBI View Article : Google Scholar

22 

Alonso N, Calero-Paniagua I and Del Pino-Montes J: Clinical and genetic advances in Paget's disease of bone: A review. Clin Rev Bone Miner Metab. 15:37–48. 2017.PubMed/NCBI View Article : Google Scholar

23 

Hoyland JA, Freemont AJ and Sharpe PT: Interleukin-6, IL-6 receptor, and IL-6 nuclear factor gene expression in Paget's disease. J Bone Miner Res. 9:75–80. 1994.PubMed/NCBI View Article : Google Scholar

24 

Van Wijngaarden JP, Doets EL, Szczecińska A, Souverein OW, Duffy ME, Dullemeijer C, Cavelaars AE, Pietruszka B, Van't Veer P, Brzozowska A, et al: Vitamin B12, folate, homocysteine, and bone health in adults and elderly people: A systematic review with meta-analyses. J Nutr Metab. 2013(486186)2013.PubMed/NCBI View Article : Google Scholar

25 

Drake MT, Clarke BL and Khosla S: Bisphosphonates: Mechanism of action and role in clinical practice. Mayo Clin Proc. 83:1032–1045. 2008.PubMed/NCBI View Article : Google Scholar

26 

Panuccio VA and Tripepi R: Paget's disease and secondary hyperparathyroidism: Is healing possible? Front Cell Dev Biol. 8(399)2020.PubMed/NCBI View Article : Google Scholar

27 

Malamud T and Rosenfeld I: Icteroedematous form of pernicious anemia in Paget's disease of the bone. Prensa Med Argent. 38:1164–1166. 1951.PubMed/NCBI(In Undetermined Language).

28 

Punzi L, Avossa M, De Zambiasi P, Volpe A, Cesaro G, Schiavon F and Todesco S: Paget's disease of bone associated with autoimmune thyroiditis and joint chondrocalcinosis. Rev Rhum Ed Fr. 61:354–356. 1994.PubMed/NCBI(In French).

29 

Chan PK, Lyu SY and Lu CC: Paget disease of bone in an elderly patient with chronic renal disease and weight loss: A case report. Medicine (Baltimore). 98(e17458)2019.PubMed/NCBI View Article : Google Scholar

30 

Bojincă V and Janta I: Rheumatic diseases and malignancies. Maedica (Bucur). 7:364–371. 2012.PubMed/NCBI

31 

Davies A, Pluot E and James S: Tumour and tumour-like conditions associated with Paget's disease of bone. In: Imaging of Bone Tumors and Tumor-Like Lesions. Davies A, Sundaram M and James S (eds). Springer, Berlin, Heidelberg, pp515-530, 2009.

32 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, et al: The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ. 372(n71)2021.PubMed/NCBI View Article : Google Scholar

33 

Somayaji BN: Malabsorption syndrome in Paget's disease of bone. Br Med J. 4:278–280. 1968.PubMed/NCBI View Article : Google Scholar

34 

Tatu AL and Ionescu MA: Multiple autoimmune syndrome type 3-thyroiditis, vitiligo and alopecia areata. Acta Endocrinol (Buchar). 13:124–125. 2017.PubMed/NCBI View Article : Google Scholar

35 

Mihăilă B, Dinică RM, Tatu AL and Buzia OD: New insights in vitiligo treatments using bioactive compounds from Piper nigrum. Exp Ther Med. 17:1039–1044. 2019.PubMed/NCBI View Article : Google Scholar

36 

Tatu AL and Nwabudike LC: Male genital lichen sclerosus-a permanent therapeutic challenge. J Am Acad Dermatol. 79 (Suppl 1)(AB185)2018.

37 

Vaes BL, Lute C, Blom HJ, Bravenboer N, de Vries TJ, Everts V, Dhonukshe-Rutten RA, Muller M, de Groot LC and Steegenga WT: Vitamin B(12) deficiency stimulates osteoclastogenesis via increased homocysteine and methylmalonic acid. Calcif Tissue Int. 84:413–422. 2009.PubMed/NCBI View Article : Google Scholar

38 

Toh BH: Pathophysiology and laboratory diagnosis of pernicious anemia. Immunol Res. 65:326–330. 2017.PubMed/NCBI View Article : Google Scholar

39 

Kharb S, Kumar S and Kundu ZS: Homocysteine, a biomarker of osteosarcoma. J Can Res Ther. 11:51–53. 2015.PubMed/NCBI View Article : Google Scholar

40 

Van Dommelen CKV and Klaassen CHL: Cyanocobalamin-dependent depression of the serum alkaline phosphatase level in patients with pernicious anemia. N Engl J Med. 271:541–544. 1964.PubMed/NCBI View Article : Google Scholar

41 

Hanna S, Lachover L and Rajarethinam RP: Vitamin B12 deficiency and depression in the elderly: Review and case report. Prim Care Companion J Clin Psychiatry. 11:269–270. 2009.PubMed/NCBI View Article : Google Scholar

42 

Wolters M, Ströhle A and Hahn A: Age-associated changes in the metabolism of vitamin B(12) and folic acid: Prevalence, aetiopathogenesis and pathophysiological consequences. Z Gerontol Geriatr. 37:109–135. 2004.PubMed/NCBI View Article : Google Scholar : (In German).

43 

Polyzos SA, Anastasilakis AD, Efstathiadou Z, Litsas I, Kita M, Panagiotou A, Papatheodorou A, Arsos G, Moralidis E, Barmpalios G, et al: Serum homocysteine, folate and vitamin B12 in patients with Paget's disease of bone: The effect of zoledronic acid. J Bone Miner Metab. 28:314–319. 2010.PubMed/NCBI View Article : Google Scholar

44 

Căruntu C, Zurac SA, Jugulete G and Boda D: Extramammary Paget's disease in an HIV-positive patient. Rom J Morphol Embryol. 58:1009–1015. 2017.PubMed/NCBI

45 

Rabjohns EM, Hurst K, Ghosh A, Cuellar MC, Rampersad RR and Tarrant TK: Paget's disease of bone: Osteoimmunology and osteoclast pathology. Curr Allergy Asthma Rep. 21(23)2021.PubMed/NCBI View Article : Google Scholar

46 

Roodman GD and Windle JJ: Paget disease of bone. J Clin Invest. 115:200–208. 2005.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Oprea VD, Bojincă VC, Bălănescu A, Tatu AL, Bojincă M and Romila A: Paget's disease of bone and megaloblastic anemia in a 72‑year‑old patient: A case report and systematic literature review. Exp Ther Med 23: 269, 2022.
APA
Oprea, V.D., Bojincă, V.C., Bălănescu, A., Tatu, A.L., Bojincă, M., & Romila, A. (2022). Paget's disease of bone and megaloblastic anemia in a 72‑year‑old patient: A case report and systematic literature review. Experimental and Therapeutic Medicine, 23, 269. https://doi.org/10.3892/etm.2022.11195
MLA
Oprea, V. D., Bojincă, V. C., Bălănescu, A., Tatu, A. L., Bojincă, M., Romila, A."Paget's disease of bone and megaloblastic anemia in a 72‑year‑old patient: A case report and systematic literature review". Experimental and Therapeutic Medicine 23.4 (2022): 269.
Chicago
Oprea, V. D., Bojincă, V. C., Bălănescu, A., Tatu, A. L., Bojincă, M., Romila, A."Paget's disease of bone and megaloblastic anemia in a 72‑year‑old patient: A case report and systematic literature review". Experimental and Therapeutic Medicine 23, no. 4 (2022): 269. https://doi.org/10.3892/etm.2022.11195
Copy and paste a formatted citation
x
Spandidos Publications style
Oprea VD, Bojincă VC, Bălănescu A, Tatu AL, Bojincă M and Romila A: Paget's disease of bone and megaloblastic anemia in a 72‑year‑old patient: A case report and systematic literature review. Exp Ther Med 23: 269, 2022.
APA
Oprea, V.D., Bojincă, V.C., Bălănescu, A., Tatu, A.L., Bojincă, M., & Romila, A. (2022). Paget's disease of bone and megaloblastic anemia in a 72‑year‑old patient: A case report and systematic literature review. Experimental and Therapeutic Medicine, 23, 269. https://doi.org/10.3892/etm.2022.11195
MLA
Oprea, V. D., Bojincă, V. C., Bălănescu, A., Tatu, A. L., Bojincă, M., Romila, A."Paget's disease of bone and megaloblastic anemia in a 72‑year‑old patient: A case report and systematic literature review". Experimental and Therapeutic Medicine 23.4 (2022): 269.
Chicago
Oprea, V. D., Bojincă, V. C., Bălănescu, A., Tatu, A. L., Bojincă, M., Romila, A."Paget's disease of bone and megaloblastic anemia in a 72‑year‑old patient: A case report and systematic literature review". Experimental and Therapeutic Medicine 23, no. 4 (2022): 269. https://doi.org/10.3892/etm.2022.11195
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