Open Access

Curcumin ameliorates H2O2‑induced inflammatory response in chondrocytes by inducing autophagy activation

  • Authors:
    • Hai-Liang Qi
    • Zheng-Yi Chen
    • Yu-Huan Qin
    • Ya-Zhai Li
  • View Affiliations

  • Published online on: February 9, 2022     https://doi.org/10.3892/etm.2022.11198
  • Article Number: 272
  • Copyright: © Qi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Relapsing polychondritis (RP) is a clinical disease characterized by inflammation of cartilage tissue and chondrocytes. The principal curcuminoid curcumin is the most active component in turmeric and has been reported to have a chondroprotective effect, including anti‑inflammatory activity, which is vitally important for mitigating RP symptoms and prognosis. However, the mechanisms underlying these actions have remained to be fully elucidated. In the present study, the chondroprotective mechanisms of curcumin on hydrogen peroxide (H2O2)‑treated primary chondrocytes were examined in vitro. The viability of chondrocytes treated with H2O2 was significantly reduced in a dose‑ and time‑dependent manner. Cotreatment of curcumin with H2O2 significantly decreased growth inhibition. It was observed that curcumin inhibited the expression levels of the inflammatory mediators interleukin (IL)‑1β, IL‑6 and inducible nitric oxide synthase and induced autophagy activation. Curcumin increased the protein levels of the autophagy marker beclin‑1 and light chain 3‑II and decreased the expression levels of P62 in H2O2‑treated chondrocytes. The curcumin‑induced anti‑inflammatory effects were markedly abrogated by the autophagy inhibitor 3‑methyladenine. In conclusion, the present study suggested that curcumin regulates inflammatory factors by activating autophagy in chondrocytes. The protective role of curcumin in chondrocytes was demonstrated, suggesting that it should be explored for the prophylactic treatment of RP in the clinic in the future.
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April-2022
Volume 23 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Qi H, Chen Z, Qin Y and Li Y: Curcumin ameliorates H<sub>2</sub>O<sub>2</sub>‑induced inflammatory response in chondrocytes by inducing autophagy activation. Exp Ther Med 23: 272, 2022
APA
Qi, H., Chen, Z., Qin, Y., & Li, Y. (2022). Curcumin ameliorates H<sub>2</sub>O<sub>2</sub>‑induced inflammatory response in chondrocytes by inducing autophagy activation. Experimental and Therapeutic Medicine, 23, 272. https://doi.org/10.3892/etm.2022.11198
MLA
Qi, H., Chen, Z., Qin, Y., Li, Y."Curcumin ameliorates H<sub>2</sub>O<sub>2</sub>‑induced inflammatory response in chondrocytes by inducing autophagy activation". Experimental and Therapeutic Medicine 23.4 (2022): 272.
Chicago
Qi, H., Chen, Z., Qin, Y., Li, Y."Curcumin ameliorates H<sub>2</sub>O<sub>2</sub>‑induced inflammatory response in chondrocytes by inducing autophagy activation". Experimental and Therapeutic Medicine 23, no. 4 (2022): 272. https://doi.org/10.3892/etm.2022.11198