Open Access

Circulating microRNAs in patients with aneurysmal dilatation of coronary arteries

  • Authors:
    • Sylwia Iwańczyk
    • Tomasz Lehmann
    • Artur Cieślewicz
    • Artur Radziemski
    • Katarzyna Malesza
    • Michał Wrotyński
    • Paweł P. Jagodziński
    • Marek Grygier
    • Maciej Lesiak
    • Aleksander Araszkiewicz
  • View Affiliations

  • Published online on: April 21, 2022     https://doi.org/10.3892/etm.2022.11331
  • Article Number: 404
  • Copyright: © Iwańczyk et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

To understand the mechanism underlying coronary artery abnormal dilatation (CAAD), the present study identified and compared the expression of circulating microRNAs (miRNAs) in three groups of patients. Group 1 included 20 patients with CAAD, Group 2 included 20 patients with angiographically confirmed coronary artery disease (CAD), and Group 3 included 20 patients with normal coronary arteries (control). miRNAs were isolated from plasma samples and were profiled using PCR arrays and miRCURY LNA Serum/Plasma Focus PCR Panels. The present study demonstrated that the plasma miRNA levels were significantly different in Group 1 compared with in Group 2 and Group 3 (fold change >2 and P<0.05). The comparison of Group 1 with Group 3 identified 21 significantly upregulated and two downregulated miRNAs in patients with CAAD compared with in the control group. Moreover, six upregulated and two downregulated miRNAs were identified in patients with CAD compared with in the controls. The third comparison revealed four upregulated and three downregulated miRNAs in Group 1, when compared with patients with CAD. In conclusion, the present study identified a specific signature of plasma miRNAs, which were upregulated and downregulated in patients with CAAD compared with in patients with CAD and control individuals.

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June-2022
Volume 23 Issue 6

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Spandidos Publications style
Iwańczyk S, Lehmann T, Cieślewicz A, Radziemski A, Malesza K, Wrotyński M, Jagodziński PP, Grygier M, Lesiak M, Araszkiewicz A, Araszkiewicz A, et al: Circulating microRNAs in patients with aneurysmal dilatation of coronary arteries. Exp Ther Med 23: 404, 2022
APA
Iwańczyk, S., Lehmann, T., Cieślewicz, A., Radziemski, A., Malesza, K., Wrotyński, M. ... Araszkiewicz, A. (2022). Circulating microRNAs in patients with aneurysmal dilatation of coronary arteries. Experimental and Therapeutic Medicine, 23, 404. https://doi.org/10.3892/etm.2022.11331
MLA
Iwańczyk, S., Lehmann, T., Cieślewicz, A., Radziemski, A., Malesza, K., Wrotyński, M., Jagodziński, P. P., Grygier, M., Lesiak, M., Araszkiewicz, A."Circulating microRNAs in patients with aneurysmal dilatation of coronary arteries". Experimental and Therapeutic Medicine 23.6 (2022): 404.
Chicago
Iwańczyk, S., Lehmann, T., Cieślewicz, A., Radziemski, A., Malesza, K., Wrotyński, M., Jagodziński, P. P., Grygier, M., Lesiak, M., Araszkiewicz, A."Circulating microRNAs in patients with aneurysmal dilatation of coronary arteries". Experimental and Therapeutic Medicine 23, no. 6 (2022): 404. https://doi.org/10.3892/etm.2022.11331