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Aberrant blood cell division cycle 42 expression and its correlation with disease severity, inflammation and mortality risk in patients with acute pancreatitis

  • Authors:
    • Jun Yang
    • Xiaoqian Li
    • Xuefeng Yang
    • Hongjiang Wei
    • Lipu Deng
    • Nian Fu
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421000, P.R. China, Department of Gastroenterology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421000, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 458
    |
    Published online on: May 20, 2022
       https://doi.org/10.3892/etm.2022.11385
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Abstract

Cell division cycle 42 (CDC42) can inhibit inflammation by regulating the activity of macrophage and T cells, which contributes to the pathophysiology of acute pancreatitis (AP). Therefore, CDC42 may have application as a potential biomarker for AP. The present study aimed to explore this possibility. Peripheral blood mononuclear cells (PBMCs) were collected from 149 patients with AP and 50 healthy controls (HCs). Subsequently, CDC42 expression in the PBMCs was measured using RT‑qPCR; C‑reactive protein (CRP), TNF‑α and IL‑6 in the serum of patients with AP were measured using ELISA. Meanwhile, Mann‑Whitney U test, Kruskal‑Wallis test, and Spearman's rank correlation test were performed on the data. The CDC42 expression levels were lower in patients with AP compared with those in HCs (P<0.001). CDC42 expression was declined in patients with moderate‑severe AP (MSAP) vs. patients with mild AP (MAP) (P=0.029), and in patients with severe AP (SAP) vs. patients with MAP (P=0.004). CDC42 expression correlated negatively with the Ranson's score (P<0.001), APACEH II score (P=0.011) and SOFA score (P<0.001) in patients with AP. CDC42 expression also correlated negatively with CRP (P<0.001) and TNF‑α (P=0.004) levels but not with IL‑6 levels (P=0.177). Furthermore, CDC42 expression was lower in deceased patients with AP vs. AP survivors (P<0.001) and in deceased patients with SAP vs. SAP survivors (P=0.026). CDC42 had good potential in predicting mortality from AP, with AUC of 0.829 and a 95% CI of 0.731‑0.927, and it also had certain potential in predicting mortality from SAP and MSAP, with AUC (95% CI) of 0.794 (0.616‑0.973) and 0.757 (0.558‑0.956), respectively. In conclusion, data from the present study suggest that lower CDC42 expression levels correlate with higher disease susceptibility, disease severity, inflammation, and mortality risk in patients with AP.
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Copy and paste a formatted citation
Spandidos Publications style
Yang J, Li X, Yang X, Wei H, Deng L and Fu N: Aberrant blood cell division cycle 42 expression and its correlation with disease severity, inflammation and mortality risk in patients with acute pancreatitis. Exp Ther Med 24: 458, 2022.
APA
Yang, J., Li, X., Yang, X., Wei, H., Deng, L., & Fu, N. (2022). Aberrant blood cell division cycle 42 expression and its correlation with disease severity, inflammation and mortality risk in patients with acute pancreatitis. Experimental and Therapeutic Medicine, 24, 458. https://doi.org/10.3892/etm.2022.11385
MLA
Yang, J., Li, X., Yang, X., Wei, H., Deng, L., Fu, N."Aberrant blood cell division cycle 42 expression and its correlation with disease severity, inflammation and mortality risk in patients with acute pancreatitis". Experimental and Therapeutic Medicine 24.1 (2022): 458.
Chicago
Yang, J., Li, X., Yang, X., Wei, H., Deng, L., Fu, N."Aberrant blood cell division cycle 42 expression and its correlation with disease severity, inflammation and mortality risk in patients with acute pancreatitis". Experimental and Therapeutic Medicine 24, no. 1 (2022): 458. https://doi.org/10.3892/etm.2022.11385
Copy and paste a formatted citation
x
Spandidos Publications style
Yang J, Li X, Yang X, Wei H, Deng L and Fu N: Aberrant blood cell division cycle 42 expression and its correlation with disease severity, inflammation and mortality risk in patients with acute pancreatitis. Exp Ther Med 24: 458, 2022.
APA
Yang, J., Li, X., Yang, X., Wei, H., Deng, L., & Fu, N. (2022). Aberrant blood cell division cycle 42 expression and its correlation with disease severity, inflammation and mortality risk in patients with acute pancreatitis. Experimental and Therapeutic Medicine, 24, 458. https://doi.org/10.3892/etm.2022.11385
MLA
Yang, J., Li, X., Yang, X., Wei, H., Deng, L., Fu, N."Aberrant blood cell division cycle 42 expression and its correlation with disease severity, inflammation and mortality risk in patients with acute pancreatitis". Experimental and Therapeutic Medicine 24.1 (2022): 458.
Chicago
Yang, J., Li, X., Yang, X., Wei, H., Deng, L., Fu, N."Aberrant blood cell division cycle 42 expression and its correlation with disease severity, inflammation and mortality risk in patients with acute pancreatitis". Experimental and Therapeutic Medicine 24, no. 1 (2022): 458. https://doi.org/10.3892/etm.2022.11385
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