Open Access

Emerging roles of oxidative stress in the pathogenesis of pseudoexfoliation syndrome (Review)

  • Authors:
    • Stylianos Mastronikolis
    • Marina Pagkalou
    • Panagiotis Plotas
    • Konstantinos Kagkelaris
    • Constantinos D. Georgakopoulos
  • View Affiliations

  • Published online on: July 28, 2022     https://doi.org/10.3892/etm.2022.11539
  • Article Number: 602
  • Copyright: © Mastronikolis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pseudoexfoliation syndrome (PEXS) is a systemic disease caused by defects in the extracellular matrix (ECM) remodelling process leading to the chronic deposition of extracellular, fibrillary, white flaky pseudoexfoliation material (PEXM) throughout the body. Specifically, PEXM deposits on the lens capsule cause open‑angle glaucoma, cataracts and blindness in patients with PEXS. Several gene single nucleotide polymorphisms are linked to the development of PEXS in humans, including lysyl oxidase‑like 1 gene, clusterin and fibulin‑5. The exact reason for the PEXM generation and its resulting pathogenesis is not well understood. However, defective ECM remodelling and oxidative stress (OS) have been hypothesized as significant events leading to the PEXM. Specifically, the link between OS and PEXS has been well studied, although the investigation is still ongoing. The present review explored recent advances in various aspects of PEXS and the involvement of OS in the eye for PEXS development.

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September-2022
Volume 24 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Mastronikolis S, Pagkalou M, Plotas P, Kagkelaris K and Georgakopoulos CD: Emerging roles of oxidative stress in the pathogenesis of pseudoexfoliation syndrome (Review). Exp Ther Med 24: 602, 2022
APA
Mastronikolis, S., Pagkalou, M., Plotas, P., Kagkelaris, K., & Georgakopoulos, C.D. (2022). Emerging roles of oxidative stress in the pathogenesis of pseudoexfoliation syndrome (Review). Experimental and Therapeutic Medicine, 24, 602. https://doi.org/10.3892/etm.2022.11539
MLA
Mastronikolis, S., Pagkalou, M., Plotas, P., Kagkelaris, K., Georgakopoulos, C. D."Emerging roles of oxidative stress in the pathogenesis of pseudoexfoliation syndrome (Review)". Experimental and Therapeutic Medicine 24.3 (2022): 602.
Chicago
Mastronikolis, S., Pagkalou, M., Plotas, P., Kagkelaris, K., Georgakopoulos, C. D."Emerging roles of oxidative stress in the pathogenesis of pseudoexfoliation syndrome (Review)". Experimental and Therapeutic Medicine 24, no. 3 (2022): 602. https://doi.org/10.3892/etm.2022.11539