Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2022 Volume 24 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2022 Volume 24 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.pdf
Article

Relationship of miRNA‑126 and miRNA‑122 expression with type 2 diabetes mellitus and related glucose metabolism parameters: A systematic review and meta‑analysis

  • Authors:
    • Yaling He
    • Yuqian Li
    • Zhihan Zhai
    • Pengling Liu
    • Luting Nie
    • Yiquan Zheng
    • Jian Hou
    • Wenqian Huo
    • Zhenxing Mao
    • Zhenzhong Zhang
    • Chongjian Wang
    • Xiaotian Liu
  • View Affiliations / Copyright

    Affiliations: Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China, Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China
  • Article Number: 652
    |
    Published online on: September 5, 2022
       https://doi.org/10.3892/etm.2022.11589
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

There are increasing numbers of studies investigating the potential link between microRNAs (miRNAs) and type 2 diabetes mellitus (T2DM) risk. Based on the prior evidence and the differentially expressed candidate plasma exosome miRNAs in our established discovery study, the current meta‑analysis studied miR‑126 and miR‑122 specifically. The purpose of the present study was to systematically and quantitatively evaluate the relationship of miR‑126 and miR‑22 expression level with T2DM risk as well as related glucose metabolism parameters. Moreover, the present study was performed based on the Preferred Reporting Items for Systematic Reviews and Meta‑Analyses guideline (PRISMA 2020 statement). PubMed, Embase, Web of Science, Cochrane and Chinese National Knowledge Infrastructure electronic databases were used to identify eligible original studies prior to May 3, 2022. The random‑effects models were employed to explore the overall effect estimates [odds ratio (OR) and 95% confidence interval (CI), or correlation coefficient (r, 95% CI)]. The subgroup analyses were conducted to examine the potential sources of heterogeneity. The potential publication bias was assessed by the Begg's funnel plot and Egger's tests. A total of 46 articles were included in the present meta‑analysis. The results revealed that higher exposure level of miR‑126 was related to lower T2DM risk in 5 analytical epidemiological studies [OR=0.73, 95% CI: (0.55, 0.96)], lower fasting blood glucose (FBG) [N=22, r=‑0.26, 95% CI: (‑0.42, ‑0.10)], and lower homeostasis model assessment of insulin resistance (HOMA‑IR) index [N=9, r=‑0.28, 95% CI: (‑0.52, ‑0.05)]. Besides, positive correlations were observed between miR-122 expression and FBG [N=10, r=0.34, 95% CI: (0.20, 0.48)], as well as HOMA-IR index [N=9, r=0.40, 95% CI: (0.16, 0.64)]. The relationship of miR‑126 and miR‑122 expression with T2DM risk and these glucose metabolism parameters may be influenced by study types, sample size, different source and mean age of participants. In conclusion, in the general healthy population, higher miR‑126 expression was related to lower T2DM risk, FBG level and HOMA‑IR index; higher miR-122 expression was closely correlated with higher FBG level and HOMA-IR index. These findings have notable clinical and public health implications for screening and control glucose metabolic disorders, insulin resistance and T2DM development.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: A systematic analysis for the global burden of disease study 2017. Lancet. 392:1789–1858. 2018.PubMed/NCBI View Article : Google Scholar

2 

Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, Colagiuri S, Guariguata L, Motala AA, Ogurtsova K, et al: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the international diabetes federation diabetes atlas, 9(th) edition. Diabetes Res Clin Pract. 157(107843)2019.PubMed/NCBI View Article : Google Scholar

3 

Lu TX and Rothenberg ME: MicroRNA. J Allergy Clin Immunol. 141:1202–1207. 2018.PubMed/NCBI View Article : Google Scholar

4 

Rezk NA, Sabbah NA and Saad MS: Role of MicroRNA 126 in screening, diagnosis, and prognosis of diabetic patients in Egypt. IUBMB Life. 68:452–458. 2016.PubMed/NCBI View Article : Google Scholar

5 

Zhang T, Li L, Shang Q, Lv C, Wang C and Su B: Circulating miR-126 is a potential biomarker to predict the onset of type 2 diabetes mellitus in susceptible individuals. Biochem Biophys Res Commun. 463:60–63. 2015.PubMed/NCBI View Article : Google Scholar

6 

Zampetaki A, Kiechl S, Drozdov I, Willeit P, Mayr U, Prokopi M, Mayr A, Weger S, Oberhollenzer F, Bonora E, et al: Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes. Circ Res. 107:810–817. 2010.PubMed/NCBI View Article : Google Scholar

7 

Guay C and Regazzi R: Circulating microRNAs as novel biomarkers for diabetes mellitus. Nat Rev Endocrinol. 9:513–521. 2013.PubMed/NCBI View Article : Google Scholar

8 

Nunez Lopez YO, Garufi G and Seyhan AA: Altered levels of circulating cytokines and microRNAs in lean and obese individuals with prediabetes and type 2 diabetes. Mol Biosyst. 13:106–121. 2016.PubMed/NCBI View Article : Google Scholar

9 

Jones A, Danielson KM, Benton MC, Ziegler O, Shah R, Stubbs RS, Das S and Macartney-Coxson D: miRNA signatures of insulin resistance in obesity. Obesity (Silver Spring). 25:1734–1744. 2017.PubMed/NCBI View Article : Google Scholar

10 

Mao Y, Mohan R, Zhang S and Tang X: MicroRNAs as pharmacological targets in diabetes. Pharmacol Res. 75:37–47. 2013.PubMed/NCBI View Article : Google Scholar

11 

Liu Y, Gao G, Yang C, Zhou K, Shen B, Liang H and Jiang X: The role of circulating microRNA-126 (miR-126): A novel biomarker for screening prediabetes and newly diagnosed type 2 diabetes mellitus. Int J Mol Sci. 15:10567–10577. 2014.PubMed/NCBI View Article : Google Scholar

12 

Willeit P, Skroblin P, Moschen AR, Yin X, Kaudewitz D, Zampetaki A, Barwari T, Whitehead M, Ramírez CM, Goedeke L, et al: Circulating MicroRNA-122 is associated with the risk of new-onset metabolic syndrome and type 2 diabetes. Diabetes. 66:347–357. 2017.PubMed/NCBI View Article : Google Scholar

13 

Regmi A, Liu G, Zhong X, Hu S, Ma R, Gou L, Zafar MI and Chen L: Evaluation of serum microRNAs in patients with diabetic kidney disease: A nested case-controlled study and bioinformatics analysis. Med Sci Monit. 25:1699–1708. 2019.PubMed/NCBI View Article : Google Scholar

14 

Tao H, Wang MM, Zhang M, Zhang SP, Wang CH, Yuan WJ, Sun T, He LJ and Hu QK: MiR-126 suppresses the glucose-stimulated proliferation via IRS-2 in INS-1 β cells. PLoS One. 11(e0149954)2016.PubMed/NCBI View Article : Google Scholar

15 

Hu Y, Li Y, Chen C, Zhu S, Guo M, Liu S, Zheng J, Qin N and Xu L: Identification of miR-126 knockdown mouse and the change of blood glucose. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 40:12–17. 2015.PubMed/NCBI View Article : Google Scholar : (In Chinese).

16 

Lin H, Tas E, Børsheim E and Mercer KE: Circulating miRNA signatures associated with insulin resistance in adolescents with obesity. Diabetes Metab Syndr Obes. 13:4929–4939. 2020.PubMed/NCBI View Article : Google Scholar

17 

Al-Kafaji G, Al-Mahroos G, Al-Muhtaresh HA, Skrypnyk C, Sabry MA and Ramadan AR: Decreased expression of circulating microRNA-126 in patients with type 2 diabetic nephropathy: A potential blood-based biomarker. Exp Ther Med. 12:815–822. 2016.PubMed/NCBI View Article : Google Scholar

18 

Weale CJ, Matshazi DM, Davids SFG, Raghubeer S, Erasmus RT, Kengne AP, Davison GM and Matsha TE: MicroRNAs-1299, -126-3p and -30e-3p as potential diagnostic biomarkers for prediabetes. Diagnostics (Basel). 11(949)2021.PubMed/NCBI View Article : Google Scholar

19 

Wells G, Shea B, O'Connell D, Peterson J, Welch V, Losos M and Tugwell P: The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa Health Research Institute, Ottawa, ON, 1999.

20 

Liu F, Chen G, Huo W, Wang C, Liu S, Li N, Mao S, Hou Y, Lu Y and Xiang H: Associations between long-term exposure to ambient air pollution and risk of type 2 diabetes mellitus: A systematic review and meta-analysis. Environ Pollut. 252:1235–1245. 2019.PubMed/NCBI View Article : Google Scholar

21 

Hamling J, Lee P, Weitkunat R and Ambühl M: Facilitating meta-analyses by deriving relative effect and precision estimates for alternative comparisons from a set of estimates presented by exposure level or disease category. Stat Med. 27:954–970. 2008.PubMed/NCBI View Article : Google Scholar

22 

DerSimonian R and Laird N: Meta-analysis in clinical trials revisited. Contemp Clin Trials. 45:139–145. 2015.PubMed/NCBI View Article : Google Scholar

23 

Cheung MW and Cheung SF: Random-effects models for meta-analytic structural equation modeling: Review, issues, and illustrations. Res Synth Methods. 7:140–155. 2016.PubMed/NCBI View Article : Google Scholar

24 

Nakagawa S and Cuthill IC: Effect size, confidence interval and statistical significance: A practical guide for biologists. Biol Rev Camb Philos Soc. 82:591–605. 2007.PubMed/NCBI View Article : Google Scholar

25 

Wei X, Zhang Y, Tao H, Tang H, Chen H and Zeng X: Meta analysis of correlation coefficient data using meta package and metafor package of R software. Chin J Evid-Based Med. 15:855–860. 2015.(In Chinese).

26 

Higgins JP and Thompson SG: Quantifying heterogeneity in a meta-analysis. Stat Med. 21:1539–1558. 2002.PubMed/NCBI View Article : Google Scholar

27 

Kulinskaya E and Dollinger MB: Commentary on ‘Misunderstandings about Q and ‘Cochran's Q test’ in meta analysis’. Stat Med. 35:501–502. 2016.PubMed/NCBI View Article : Google Scholar

28 

Liu X, Luo X, Liu Y, Sun X, Han C, Zhang L, Wang B, Ren Y, Zhao Y, Zhang D, et al: Resting heart rate and risk of metabolic syndrome in adults: A dose-response meta-analysis of observational studies. Acta Diabetol. 54:223–235. 2017.PubMed/NCBI View Article : Google Scholar

29 

Egger M, Smith GD, Schneider M and Minder C: Bias in meta-analysis detected by a simple, graphical test. BMJ. 315:629–634. 1997.PubMed/NCBI View Article : Google Scholar

30 

Begg CB and Mazumdar M: Operating characteristics of a rank correlation test for publication bias. Biometrics. 50:1088–1101. 1994.PubMed/NCBI

31 

Al-Kafaji G, Al-Mahroos G, Al-Muhtaresh HA, Sabry MA, Razzak RA and Salem AH: Circulating endothelium-enriched microRNA-126 as a potential biomarker for coronary artery disease in type 2 diabetes mellitus patients. Biomarkers. 22:268–278. 2017.PubMed/NCBI View Article : Google Scholar

32 

Wang X, Sundquist J, Zöller B, Memon AA, Palmér K, Sundquist K and Bennet L: Determination of 14 circulating microRNAs in Swedes and Iraqis with and without diabetes mellitus type 2. PLoS One. 9(e86792)2014.PubMed/NCBI View Article : Google Scholar

33 

Ezaz G, Trivedi HD, Connelly MA, Filozof C, Howard K, Parrish ML, Kim M, Herman MA, Nasser I, Afdhal NH, et al: Differential associations of circulating MicroRNAs with pathogenic factors in NAFLD. Hepatol Commun. 4:670–680. 2020.PubMed/NCBI View Article : Google Scholar

34 

Nie H, Hu H, Li Z, Wang R, He J, Li P, Li W, Cheng X, An J, Zhang Z, et al: Associations of plasma metal levels with type 2 diabetes and the mediating effects of microRNAs. Environ Pollut. 292(118452)2022.PubMed/NCBI View Article : Google Scholar

35 

Yuan JF: Serum miRNA expression and clinical value in patients with type 2 diabetes mellitus complicated with coronary atherosclerosis (Master thesis). Jiangsu University, R541.4; R587.1, 2019 (In Chinese).

36 

Wan SJ, Wang C, Wang J, Niu DM, Zhang CN and Wang JJ: Study on serum levels of miR-16, miR-126 and miR-221 and their clinical significance in type 2 diabetes patients with or without microvascular complications. J Modern Laboratory Medicine. 31:9–13. 2016.

37 

Zhang YD, Gao QC, Zhao R, Pu YF, Li SH and Wei JF: Correlation between serum miR-126, VEGF levels and insulin resistance in patients with newly diagnosed Type 2 Diabetes Mellitus. Int J Lab Med. 41:935–938. 2020.(In Chinese).

38 

Zhou N, Liang J, Teng F, Zou CY, Yang MQ, Qi L and Song HD: Effect of abnormal glucose metabolism on expression of serum microRNA in patients with coronary heart disease. Chin J Geriatr Heart Brain Vessel Dis. 15:14–17. 2013.(In Chinese).

39 

Wang L, Zeng N, Xie WP, Jiang YL, Li Z, Tang LZ, Long CD and Wu BL: Effect of intensive blood glucose and blood pressure control on exosomal effect microRNA in patients with diabetic foot. Chin Youjiang Med J. 49:97–102. 2021.(In Chinese).

40 

Lv YB and Pan ZQ: The impact of abnormal glucose metabolism on mir-126 in progenitor cells to patients with coronary heart disease. J Clin Cardiol (China). 31:1061–1064. 2015.(In Chinese).

41 

Gao W, Liu YZ, Wang LJ, Fang BH and Lei NY: Expression of miR-126 in PBMCs of diabetic retinopathy patients. Chin J Pract Ophthalmol. 34:322–325. 2016.(In Chinese).

42 

Chong XJ, Yu QY and Yang LX: Expression and clinical significance of miR-126 and sVCAM-1 in patients with type 2 diabetic nephropathy. Hebei Med J. 41:334–337+342. 2019.(In Chinese).

43 

Ren Y, Huang T and Shi X: The change of expression level of circulating miRNA-126 in patients with type 2 diabetes and its relative factors. Chin J Diabet. 22:633–636. 2014.(In Chinese).

44 

Ortega FJ, Mercader JM, Moreno-Navarrete JM, Rovira O, Guerra E, Esteve E, Xifra G, Martinez C, Ricart W, Rieusset J, et al: Profiling of circulating microRNAs reveals common microRNAs linked to type 2 diabetes that change with insulin sensitization. Diabetes Care. 37:1375–1383. 2014.PubMed/NCBI View Article : Google Scholar

45 

Olivieri F, Spazzafumo L, Bonafè M, Recchioni R, Prattichizzo F, Marcheselli F, Micolucci L, Mensà E, Giuliani A, Santini G, et al: MiR-21-5p and miR-126a-3p levels in plasma and circulating angiogenic cells: Relationship with type 2 diabetes complications. Oncotarget. 6:35372–35382. 2015.PubMed/NCBI View Article : Google Scholar

46 

Olivieri F, Bonafè M, Spazzafumo L, Gobbi M, Prattichizzo F, Recchioni R, Marcheselli F, La Sala L, Galeazzi R, Rippo MR, et al: Age- and glycemia-related miR-126-3p levels in plasma and endothelial cells. Aging (Albany NY). 6:771–787. 2014.PubMed/NCBI View Article : Google Scholar

47 

Giannella A, Radu CM, Franco L, Campello E, Simioni P, Avogaro A, de Kreutzenberg SV and Ceolotto G: Circulating levels and characterization of microparticles in patients with different degrees of glucose tolerance. Cardiovasc Diabetol. 16(118)2017.PubMed/NCBI View Article : Google Scholar

48 

Ghaneh T, Zeinali F, Babini H, Astaraki S and Hassan-Zadeh V: An increase in the expression of circulating miR30d-5p and miR126-3p is associated with intermediate hyperglycaemia in Iranian population. Arch Physiol Biochem. 1-8(1839105)2020.PubMed/NCBI View Article : Google Scholar

49 

Flowers E, Ramirez-Mares JD, Velazquez-Villafana M, Rangel-Salazar R, Sucher A, Kanaya AM, Aouizerat BE and de la Vega Monroy ML: Circulating microRNAs associated with prediabetes and geographic location in Latinos. Int J Diabetes Dev Ctries. 41:570–578. 2021.PubMed/NCBI View Article : Google Scholar

50 

Amr KS, Abdelmawgoud H, Ali ZY, Shehata S and Raslan HM: Potential value of circulating microRNA-126 and microRNA-210 as biomarkers for type 2 diabetes with coronary artery disease. Br J Biomed Sci. 75:82–87. 2018.PubMed/NCBI View Article : Google Scholar

51 

Hess AL, Larsen LH, Udesen PB, Sanz Y, Larsen TM and Dalgaard LT: Levels of circulating miR-122 are associated with weight loss and metabolic syndrome. Obesity (Silver Spring). 28:493–501. 2020.PubMed/NCBI View Article : Google Scholar

52 

Guo XL, Chen Y, Ma WG, Wang QY, Du Y and Li SS: Clinical significance of miR-126 as marker in the diagnosis of type 2 diabetic kidney disease. J Clin Nephrol. 17:361–365. 2017.(In Chinese).

53 

Bao W: Heme oxygenase-1, plasma ferritin levels and type 2 diabetes. PhD dissertation, Huazhong University of Science and Technology, R587.1, 2011 (In Chinese).

54 

Chen Q, Zhang YD, Wu SN, Chen YX, Liu XJ and Wei HY: Correlation between serum microRNA-122 and insulin resistance in obese children. Zhongguo Dang Dai Er Ke Za Zhi. 21:910–914. 2019.PubMed/NCBI View Article : Google Scholar : (In Chinese).

55 

Dong L, Hou X, Liu F, Tao H, Zhang Y, Zhao H and Song G: Regulation of insulin resistance by targeting the insulin-like growth factor 1 receptor with microRNA-122-5p in hepatic cells. Cell Biol Int. 43:553–564. 2019.PubMed/NCBI View Article : Google Scholar

56 

Wang R, Hong J, Cao Y, Shi J, Gu W, Ning G, Zhang Y and Wang W: Elevated circulating microRNA-122 is associated with obesity and insulin resistance in young adults. Eur J Endocrinol. 172:291–300. 2015.PubMed/NCBI View Article : Google Scholar

57 

Zhu JH, Wang JL, Feng ZX, Chen AL, Huang J and Du WS: Expression and clinical significance of miR-122 in patients with diabetes mellitus and chronic hepatitis B. Lab Med Clin Pract. 17:582–585. 2020.

58 

Mohany KM, Al Rugaie O, Al-Wutayd O and Al-Nafeesah A: Investigation of the levels of circulating miR-29a, miR-122, sestrin 2 and inflammatory markers in obese children with/without type 2 diabetes: A case control study. BMC Endocr Disord. 21(152)2021.PubMed/NCBI View Article : Google Scholar

59 

González-Arce LM, Lara-Riegos JC, Pérez-Mendoza GJ, Rubí-Castellanos R, Vega-Marcín M, Valencia-Pacheco G, Torres-Romero JC and González-Herrera L: High expression levels of circulating microRNA-122 and microRNA-222 are associated with obesity in children with Mayan ethnicity. Am J Hum Biol. 33(e23540)2020.PubMed/NCBI View Article : Google Scholar

60 

Refeat MM, Hassan NAM, Ahmad IH, Mostafa ERM and Amr KS: Correlation of circulating miRNA-33a and miRNA-122 with lipid metabolism among Egyptian patients with metabolic syndrome. J Genet Eng Biotechnol. 19(147)2021.PubMed/NCBI View Article : Google Scholar

61 

Krause BJ, Carrasco-Wong I, Dominguez A, Arnaiz P, Farías M, Barja S, Mardones F and Casanello P: Micro-RNAs Let7e and 126 in plasma as markers of metabolic dysfunction in 10 to 12 years old children. PLoS One. 10(e0128140)2015.PubMed/NCBI View Article : Google Scholar

62 

Seyhan AA, Nunez Lopez YO, Xie H, Yi F, Mathews C, Pasarica M and Pratley RE: Pancreas-enriched miRNAs are altered in the circulation of subjects with diabetes: a pilot cross-sectional study. Sci Rep. 6(31479)2016.PubMed/NCBI View Article : Google Scholar

63 

Song B, Fu L and Liu J: Association between serum miR-126 and non-alcoholic fatty liver disease in patients with newly diagnosed type 2 diabetes mellitus. Chin J Diabet. 26:812–816. 2018.(In Chinese).

64 

Lin MP and Wang JJ: Expression of microRNA-126 and microRNA-155 in patients of coronary heart disease combined with impaired glucose tolerance and intervention of acarbose. J Clin Intern Med. 36:108–112. 2019.(In Chinese).

65 

Zeinali F, Zarch SMA, Jahan-Mihan A, Kalantar SM, Mehrjardi MYV, Fallahzadeh H, Hosseinzadeh M, Rahmanian M and Mozaffari-Khosravi H: Circulating microRNA-122, microRNA-126-3p and microRNA-146a are associated with inflammation in patients with pre-diabetes and type 2 diabetes mellitus: A case control study. PLoS One. 16(e0251697)2021.PubMed/NCBI View Article : Google Scholar

66 

Flowers E, Kanaya AM, Zhang L and Aouizerat BE: The role of racial and ethnic factors in microRNA expression and risk for type 2 diabetes. Front Genet. 13(853633)2022.PubMed/NCBI View Article : Google Scholar

67 

Spanakis EK and Golden SH: Race/ethnic difference in diabetes and diabetic complications. Curr Diab Rep. 13:814–23. 2013.PubMed/NCBI View Article : Google Scholar

68 

Centers for Disease Control and Prevention (CDC): National Diabetes Statistics Report. CDC Atlanta, GA, 2020. https://www.cdc.gov/diabetes/data/statistics-report/. Accessed May 3, 2022.

69 

Meeks KA, Freitas-Da-Silva D, Adeyemo A, Beune EJ, Modesti PA, Stronks K, Zafarmand MH and Agyemang C: Disparities in type 2 diabetes prevalence among ethnic minority groups resident in Europe: A systematic review and meta-analysis. Intern Emerg Med. 11:327–340. 2016.PubMed/NCBI View Article : Google Scholar

70 

Zhang T, Lv C, Li L, Chen S, Liu S, Wang C and Su B: Plasma miR-126 is a potential biomarker for early prediction of type 2 diabetes mellitus in susceptible individuals. Biomed Res Int. 2013(761617)2013.PubMed/NCBI View Article : Google Scholar

71 

Ryu HS, Park SY, Ma D, Zhang J and Lee W: The induction of microRNA targeting IRS-1 is involved in the development of insulin resistance under conditions of mitochondrial dysfunction in hepatocytes. PLoS One. 6(e17343)2011.PubMed/NCBI View Article : Google Scholar

72 

Oses M, Sanchez JM, Portillo MP, Aguilera CM and Labayen I: Circulating miRNAs as biomarkers of obesity and obesity-associated comorbidities in children and adolescents: A systematic review. Nutrients. 11(2890)2019.PubMed/NCBI View Article : Google Scholar

73 

Heishima K, Ichikawa Y, Yoshida K, Iwasaki R, Sakai H, Nakagawa T, Tanaka Y, Hoshino Y, Okamura Y, Murakami M, et al: Circulating microRNA-214 and -126 as potential biomarkers for canine neoplastic disease. Sci Rep. 7(2301)2017.PubMed/NCBI View Article : Google Scholar

74 

Cantaluppi V, Biancone L, Figliolini F, Beltramo S, Medica D, Deregibus MC, Galimi F, Romagnoli R, Salizzoni M, Tetta C, et al: Microvesicles derived from endothelial progenitor cells enhance neoangiogenesis of human pancreatic islets. Cell Transplant. 21:1305–1320. 2012.PubMed/NCBI View Article : Google Scholar

75 

Castaño C, Kalko S, Novials A and Párrizas M: Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice. Proc Natl Acad Sci USA. 115:12158–12163. 2018.PubMed/NCBI View Article : Google Scholar

76 

Jamwal S and Sharma S: Vascular endothelium dysfunction: A conservative target in metabolic disorders. Inflamm Res. 67:391–405. 2018.PubMed/NCBI View Article : Google Scholar

77 

Wang S, Aurora AB, Johnson BA, Qi X, McAnally J, Hill JA, Richardson JA, Bassel-Duby R and Olson EN: The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell. 15:261–271. 2008.PubMed/NCBI View Article : Google Scholar

78 

Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, Ivey KN, Bruneau BG, Stainier DY and Srivastava D: miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell. 15:272–284. 2008.PubMed/NCBI View Article : Google Scholar

79 

Wang Y and Yan H: MicroRNA-126 contributes to niaspan treatment induced vascular restoration after diabetic retinopathy. Sci Rep. 6(26909)2016.PubMed/NCBI View Article : Google Scholar

80 

Nigi L, Grieco GE, Ventriglia G, Brusco N, Mancarella F, Formichi C, Dotta F and Sebastiani G: MicroRNAs as regulators of insulin signaling: Research updates and potential therapeutic perspectives in type 2 diabetes. Int J Mol Sci. 19(3705)2018.PubMed/NCBI View Article : Google Scholar

81 

Willeit P, Skroblin P, Kiechl S, Fernández-Hernando C and Mayr M: Liver microRNAs: potential mediators and biomarkers for metabolic and cardiovascular disease? Eur Heart J. 37:3260–3266. 2016.PubMed/NCBI View Article : Google Scholar

82 

Dedov I, Shestakova M, Benedetti MM, Simon D, Pakhomov I and Galstyan G: Prevalence of type 2 diabetes mellitus (T2DM) in the adult Russian population (NATION study). Diabetes Res Clin Pract. 115:90–95. 2016.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
He Y, Li Y, Zhai Z, Liu P, Nie L, Zheng Y, Hou J, Huo W, Mao Z, Zhang Z, Zhang Z, et al: Relationship of miRNA‑126 and miRNA‑122 expression with type 2 diabetes mellitus and related glucose metabolism parameters: A systematic review and meta‑analysis. Exp Ther Med 24: 652, 2022.
APA
He, Y., Li, Y., Zhai, Z., Liu, P., Nie, L., Zheng, Y. ... Liu, X. (2022). Relationship of miRNA‑126 and miRNA‑122 expression with type 2 diabetes mellitus and related glucose metabolism parameters: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 24, 652. https://doi.org/10.3892/etm.2022.11589
MLA
He, Y., Li, Y., Zhai, Z., Liu, P., Nie, L., Zheng, Y., Hou, J., Huo, W., Mao, Z., Zhang, Z., Wang, C., Liu, X."Relationship of miRNA‑126 and miRNA‑122 expression with type 2 diabetes mellitus and related glucose metabolism parameters: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 24.5 (2022): 652.
Chicago
He, Y., Li, Y., Zhai, Z., Liu, P., Nie, L., Zheng, Y., Hou, J., Huo, W., Mao, Z., Zhang, Z., Wang, C., Liu, X."Relationship of miRNA‑126 and miRNA‑122 expression with type 2 diabetes mellitus and related glucose metabolism parameters: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 24, no. 5 (2022): 652. https://doi.org/10.3892/etm.2022.11589
Copy and paste a formatted citation
x
Spandidos Publications style
He Y, Li Y, Zhai Z, Liu P, Nie L, Zheng Y, Hou J, Huo W, Mao Z, Zhang Z, Zhang Z, et al: Relationship of miRNA‑126 and miRNA‑122 expression with type 2 diabetes mellitus and related glucose metabolism parameters: A systematic review and meta‑analysis. Exp Ther Med 24: 652, 2022.
APA
He, Y., Li, Y., Zhai, Z., Liu, P., Nie, L., Zheng, Y. ... Liu, X. (2022). Relationship of miRNA‑126 and miRNA‑122 expression with type 2 diabetes mellitus and related glucose metabolism parameters: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 24, 652. https://doi.org/10.3892/etm.2022.11589
MLA
He, Y., Li, Y., Zhai, Z., Liu, P., Nie, L., Zheng, Y., Hou, J., Huo, W., Mao, Z., Zhang, Z., Wang, C., Liu, X."Relationship of miRNA‑126 and miRNA‑122 expression with type 2 diabetes mellitus and related glucose metabolism parameters: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 24.5 (2022): 652.
Chicago
He, Y., Li, Y., Zhai, Z., Liu, P., Nie, L., Zheng, Y., Hou, J., Huo, W., Mao, Z., Zhang, Z., Wang, C., Liu, X."Relationship of miRNA‑126 and miRNA‑122 expression with type 2 diabetes mellitus and related glucose metabolism parameters: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 24, no. 5 (2022): 652. https://doi.org/10.3892/etm.2022.11589
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team