Relationship of miRNA‑126 and miRNA‑122 expression with type 2 diabetes mellitus and related glucose metabolism parameters: A systematic review and meta‑analysis

  • Authors:
    • Yaling He
    • Yuqian Li
    • Zhihan Zhai
    • Pengling Liu
    • Luting Nie
    • Yiquan Zheng
    • Jian Hou
    • Wenqian Huo
    • Zhenxing Mao
    • Zhenzhong Zhang
    • Chongjian Wang
    • Xiaotian Liu
  • View Affiliations

  • Published online on: September 5, 2022     https://doi.org/10.3892/etm.2022.11589
  • Article Number: 652
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

There are increasing numbers of studies investigating the potential link between microRNAs (miRNAs) and type 2 diabetes mellitus (T2DM) risk. Based on the prior evidence and the differentially expressed candidate plasma exosome miRNAs in our established discovery study, the current meta‑analysis studied miR‑126 and miR‑122 specifically. The purpose of the present study was to systematically and quantitatively evaluate the relationship of miR‑126 and miR‑22 expression level with T2DM risk as well as related glucose metabolism parameters. Moreover, the present study was performed based on the Preferred Reporting Items for Systematic Reviews and Meta‑Analyses guideline (PRISMA 2020 statement). PubMed, Embase, Web of Science, Cochrane and Chinese National Knowledge Infrastructure electronic databases were used to identify eligible original studies prior to May 3, 2022. The random‑effects models were employed to explore the overall effect estimates [odds ratio (OR) and 95% confidence interval (CI), or correlation coefficient (r, 95% CI)]. The subgroup analyses were conducted to examine the potential sources of heterogeneity. The potential publication bias was assessed by the Begg's funnel plot and Egger's tests. A total of 46 articles were included in the present meta‑analysis. The results revealed that higher exposure level of miR‑126 was related to lower T2DM risk in 5 analytical epidemiological studies [OR=0.73, 95% CI: (0.55, 0.96)], lower fasting blood glucose (FBG) [N=22, r=‑0.26, 95% CI: (‑0.42, ‑0.10)], and lower homeostasis model assessment of insulin resistance (HOMA‑IR) index [N=9, r=‑0.28, 95% CI: (‑0.52, ‑0.05)]. Besides, positive correlations were observed between miR-122 expression and FBG [N=10, r=0.34, 95% CI: (0.20, 0.48)], as well as HOMA-IR index [N=9, r=0.40, 95% CI: (0.16, 0.64)]. The relationship of miR‑126 and miR‑122 expression with T2DM risk and these glucose metabolism parameters may be influenced by study types, sample size, different source and mean age of participants. In conclusion, in the general healthy population, higher miR‑126 expression was related to lower T2DM risk, FBG level and HOMA‑IR index; higher miR-122 expression was closely correlated with higher FBG level and HOMA-IR index. These findings have notable clinical and public health implications for screening and control glucose metabolic disorders, insulin resistance and T2DM development.
View Figures
View References

Related Articles

Journal Cover

November-2022
Volume 24 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
He Y, Li Y, Zhai Z, Liu P, Nie L, Zheng Y, Hou J, Huo W, Mao Z, Zhang Z, Zhang Z, et al: Relationship of miRNA‑126 and miRNA‑122 expression with type 2 diabetes mellitus and related glucose metabolism parameters: A systematic review and meta‑analysis. Exp Ther Med 24: 652, 2022.
APA
He, Y., Li, Y., Zhai, Z., Liu, P., Nie, L., Zheng, Y. ... Liu, X. (2022). Relationship of miRNA‑126 and miRNA‑122 expression with type 2 diabetes mellitus and related glucose metabolism parameters: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 24, 652. https://doi.org/10.3892/etm.2022.11589
MLA
He, Y., Li, Y., Zhai, Z., Liu, P., Nie, L., Zheng, Y., Hou, J., Huo, W., Mao, Z., Zhang, Z., Wang, C., Liu, X."Relationship of miRNA‑126 and miRNA‑122 expression with type 2 diabetes mellitus and related glucose metabolism parameters: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 24.5 (2022): 652.
Chicago
He, Y., Li, Y., Zhai, Z., Liu, P., Nie, L., Zheng, Y., Hou, J., Huo, W., Mao, Z., Zhang, Z., Wang, C., Liu, X."Relationship of miRNA‑126 and miRNA‑122 expression with type 2 diabetes mellitus and related glucose metabolism parameters: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 24, no. 5 (2022): 652. https://doi.org/10.3892/etm.2022.11589