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Human placental mesenchymal stem cells regulate inflammation via the NF‑κB signaling pathway

  • Authors:
    • Youyi Liu
    • Xiading Zhang
    • Yiwei Hu
    • Mingzhu Kang
    • Yibo Wu
    • Yuan Wang
    • Chao Deng
  • View Affiliations / Copyright

    Affiliations: Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, P.R. China, School of Pharmaceutical Science, Jiangnan University, Wuxi, Jiangsu 214122, P.R. China, Department of Obstetrics and Gynecology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu 214062, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 654
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    Published online on: September 7, 2022
       https://doi.org/10.3892/etm.2022.11591
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Abstract

Emerging evidence has indicated that mesenchymal stem cells (MSCs) are involved in the modulation of inflammation. Human placenta‑derived (HPL)‑MSCs exist in sufficient quantities and play a role in immune regulation. However, the exact roles of HPL‑MSCs in inflammation and the specific underlying mechanisms are not well defined. In the present study, HPL‑MSCs were obtained from human fetal placentas, and further purified using a commercial kit. Using ELISA, reverse transcription‑quantitative PCR, western blot, NO detection and other assays, the present study revealed that HPL‑MSCs may improve lipopolysaccharide‑induced macrophage inflammation by regulating macrophage polarization. Further mechanistic studies demonstrated that HPL‑MSCs attenuated the NF‑κB signaling pathway by regulating the expression of toll‑like receptor 4 and the phosphorylation of IκBα and p65, which resulted in a reduction in the levels of inflammation. The present study indicated that HPL‑MSCs may act as a novel target for the treatment of inflammation‑related diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Zhang X, Hu Y, Kang M, Wu Y, Wang Y and Deng C: Human placental mesenchymal stem cells regulate inflammation via the NF‑κB signaling pathway. Exp Ther Med 24: 654, 2022.
APA
Liu, Y., Zhang, X., Hu, Y., Kang, M., Wu, Y., Wang, Y., & Deng, C. (2022). Human placental mesenchymal stem cells regulate inflammation via the NF‑κB signaling pathway. Experimental and Therapeutic Medicine, 24, 654. https://doi.org/10.3892/etm.2022.11591
MLA
Liu, Y., Zhang, X., Hu, Y., Kang, M., Wu, Y., Wang, Y., Deng, C."Human placental mesenchymal stem cells regulate inflammation via the NF‑κB signaling pathway". Experimental and Therapeutic Medicine 24.5 (2022): 654.
Chicago
Liu, Y., Zhang, X., Hu, Y., Kang, M., Wu, Y., Wang, Y., Deng, C."Human placental mesenchymal stem cells regulate inflammation via the NF‑κB signaling pathway". Experimental and Therapeutic Medicine 24, no. 5 (2022): 654. https://doi.org/10.3892/etm.2022.11591
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Zhang X, Hu Y, Kang M, Wu Y, Wang Y and Deng C: Human placental mesenchymal stem cells regulate inflammation via the NF‑κB signaling pathway. Exp Ther Med 24: 654, 2022.
APA
Liu, Y., Zhang, X., Hu, Y., Kang, M., Wu, Y., Wang, Y., & Deng, C. (2022). Human placental mesenchymal stem cells regulate inflammation via the NF‑κB signaling pathway. Experimental and Therapeutic Medicine, 24, 654. https://doi.org/10.3892/etm.2022.11591
MLA
Liu, Y., Zhang, X., Hu, Y., Kang, M., Wu, Y., Wang, Y., Deng, C."Human placental mesenchymal stem cells regulate inflammation via the NF‑κB signaling pathway". Experimental and Therapeutic Medicine 24.5 (2022): 654.
Chicago
Liu, Y., Zhang, X., Hu, Y., Kang, M., Wu, Y., Wang, Y., Deng, C."Human placental mesenchymal stem cells regulate inflammation via the NF‑κB signaling pathway". Experimental and Therapeutic Medicine 24, no. 5 (2022): 654. https://doi.org/10.3892/etm.2022.11591
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